5-Hydroxypiroxicam (BioDeep_00000273731)

   


Metabolite Card


5-Hydroxypiroxicam

Formula: C15H13N3O5S (347.0576)
Chinese Names:
Spectrum Hits: Top Source () 0%

Molecular Structure

SMILES: CN1C(=C(C2=CC=CC=C2S1(=O)=O)O)C(=O)NC3=NC=C(C=C3)O
InChI: InChI=1S/C15H13N3O5S/c1-18-13(15(21)17-12-7-6-9(19)8-16-12)14(20)10-4-2-3-5-11(10)24(18,22)23/h2-8,19-20H,1H3,(H,16,17,21)

Description

Synonyms

1 synonym names

5-Hydroxypiroxicam



Cross Reference

6 cross reference id

Classification Terms

Related Pathways

Reactome(0)

BioCyc(0)

PlantCyc(0)

Biological Process

0 related biological process reactions.

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 organism taxonomy source information

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。



Literature Reference

  • Adriana Maria Calvo, Mariel Tavares de Oliveira Prado, Thiago José Dionísio, Maria Paula Marques, Daniel Thomas Brozoski, Vera Lúcia Lanchote, Flávio Augusto Cardoso Faria, Carlos Ferreira Santos. Effective method for the detection of piroxicam in human plasma using HPLC. Brazilian oral research. 2016 May; 30(1):. doi: 10.1590/1807-3107bor-2016.vol30.0058. [PMID: 27223141]
  • Adriana Maria Calvo, Gabriel Mulinari Santos, Thiago José Dionísio, Maria Paula Marques, Daniel Thomas Brozoski, Vera Lúcia Lanchote, Maria Helena Raposo Fernandes, Flávio Augusto Cardoso Faria, Carlos Ferreira Santos. Quantification of piroxicam and 5'-hydroxypiroxicam in human plasma and saliva using liquid chromatography-tandem mass spectrometry following oral administration. Journal of pharmaceutical and biomedical analysis. 2016 Feb; 120(?):212-20. doi: 10.1016/j.jpba.2015.12.042. [PMID: 26760238]
  • V Ródenas, M S García, C Sánchez-Pedreño, M I Albero. Simultaneous determination of piroxicam and its major metabolite 5'-hydroxypiroxicam in human plasma by derivative spectrophotometry. The Analyst. 1998 Aug; 123(8):1749-52. doi: 10.1039/a802318b. [PMID: 10071388]
  • A Klopas, I Panderi, M Parissi-Poulou. Determination of piroxicam and its major metabolite 5-hydroxypiroxicam in human plasma by zero-crossing first-derivative spectrophotometry. Journal of pharmaceutical and biomedical analysis. 1998 Jul; 17(3):515-24. doi: 10.1016/s0731-7085(97)00230-6. [PMID: 9656164]
  • A Avgerinos, S Axarlis, J Dragatsis, T Karidas, S Malamataris. Extractionless high-performance liquid chromatographic method for the simultaneous determination of piroxicam and 5'-hydroxypiroxicam in human plasma and urine. Journal of chromatography. B, Biomedical applications. 1995 Nov; 673(1):142-6. doi: 10.1016/0378-4347(95)00248-h. [PMID: 8925068]
  • A C Rudy, N L Figueroa, S D Hall, D C Brater. The pharmacokinetics of piroxicam in elderly persons with and without renal impairment. British journal of clinical pharmacology. 1994 Jan; 37(1):1-5. doi: 10.1111/j.1365-2125.1994.tb04230.x. [PMID: 8148211]
  • P A Milligan. Determination of piroxicam and its major metabolites in the plasma, urine and bile of humans by high-performance liquid chromatography. Journal of chromatography. 1992 Apr; 576(1):121-8. doi: 10.1016/0378-4347(92)80182-p. [PMID: 1500446]
  • B A Mueller, D K Rex, N Figueroa, P Greene, D C Brater. A pharmacokinetic and endoscopic comparison of an oral and an experimental buccal piroxicam formulation. Pharmacotherapy. 1992; 12(2):93-7. doi: NULL. [PMID: 1570233]
  • A Kinawi, D Siebler. [The binding of oxicam derivatives to human serum albumin]. Arzneimittel-Forschung. 1988 Aug; 38(8):1089-92. doi: NULL. [PMID: 3264167]
  • C J Richardson, K L Blocka, S G Ross, R K Verbeeck. Piroxicam and 5'-hydroxypiroxicam kinetics following multiple dose administration of piroxicam. European journal of clinical pharmacology. 1987; 32(1):89-91. doi: 10.1007/bf00609964. [PMID: 3582473]
  • C J Richardson, S G Ross, K L Blocka, R K Verbeeck. High-performance liquid chromatographic analysis of piroxicam and its major metabolite 5'-hydroxypiroxicam in human plasma and urine. Journal of chromatography. 1986 Oct; 382(?):382-8. doi: 10.1016/s0378-4347(00)83548-3. [PMID: 3782409]