6(5H)-Phenanthridinone (BioDeep_00000273539)
代谢物信息卡片
Phenanthridin-6(5H)-one
化学式: C13H9NO (195.06841039999998)
中文名称: 6-(5H)-菲啶酮
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1=CC=C2C(=C1)C3=CC=CC=C3NC2=O
InChI: InChI=1S/C13H9NO/c15-13-11-7-2-1-5-9(11)10-6-3-4-8-12(10)14-13/h1-8H,(H,14,15)
描述信息
D000970 - Antineoplastic Agents > D000067856 - Poly(ADP-ribose) Polymerase Inhibitors
D004791 - Enzyme Inhibitors
同义名列表
2 个代谢物同义名
数据库引用编号
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Shidan Zhang, Shiyu Zhang, Yiting Wang, Yumin Zhang, Song Liang, Shirui Fan, Duozhi Chen, Guangjin Liu. Discovery of novel phenanthridone derivatives with anti-streptococcal activity.
Archives of microbiology.
2023 Nov; 205(12):371. doi:
10.1007/s00203-023-03705-7. [PMID: 37930433] - Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome.
Cell reports.
2021 04; 35(4):109040. doi:
10.1016/j.celrep.2021.109040. [PMID: 33910017] - Minghao Feng, Bingqing Tang, Nengzhong Wang, Hong-Xi Xu, Xuefeng Jiang. Ligand Controlled Regiodivergent C1 Insertion on Arynes for Construction of Phenanthridinone and Acridone Alkaloids.
Angewandte Chemie (International ed. in English).
2015 Dec; 54(49):14960-4. doi:
10.1002/anie.201508340. [PMID: 26478001] - Yuko Nishiyama, Masahiko Nakamura, Takashi Misawa, Madoka Nakagomi, Makoto Makishima, Minoru Ishikawa, Yuichi Hashimoto. Structure-activity relationship-guided development of retinoic acid receptor-related orphan receptor gamma (RORγ)-selective inverse agonists with a phenanthridin-6(5H)-one skeleton from a liver X receptor ligand.
Bioorganic & medicinal chemistry.
2014 May; 22(9):2799-808. doi:
10.1016/j.bmc.2014.03.007. [PMID: 24702856] - Jerald J Nair, Johannes van Staden. Pharmacological and toxicological insights to the South African Amaryllidaceae.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.
2013 Dec; 62(?):262-75. doi:
10.1016/j.fct.2013.08.042. [PMID: 23994658] - Sabrin R M Ibrahim, Gamal A Mohamed, Lamiaa A Shaala, Diaa T A Youssef, Khalid A El Sayed. New alkaloids from Pancratium maritimum.
Planta medica.
2013 Oct; 79(15):1480-4. doi:
10.1055/s-0033-1350741. [PMID: 23970422] - Marek Banasik, Todd Stedeford, Robert P Strosznajder, Masanori Takehashi, Seigo Tanaka, Kunihiro Ueda. Inhibition of poly(ADP-ribose) polymerase-1 attenuates the toxicity of carbon tetrachloride.
Journal of enzyme inhibition and medicinal chemistry.
2011 Dec; 26(6):883-9. doi:
10.3109/14756366.2011.557315. [PMID: 21395487] - James D McCluskey, Dmytro Sava, Stephen C Harbison, Carlos A Muro-Cacho, Johnson T Giffe, Xu Ping, Raymond D Harbison. Hepatoprotective effects of select water-soluble PARP inhibitors in a carbon tetrachloride model.
International journal of critical illness and injury science.
2011 Jul; 1(2):97-103. doi:
10.4103/2229-5151.84788. [PMID: 22229131] - Mohammad-Reza Rashidi, Kaveh Amini, Mohammad-Yaser Khani, Akram Faridi, Jalal Hanaee, Mohammad-Hossein Sorouraddin. A highly sensitive RP-HPLC-fluorescence method to study aldehyde oxidase activity.
Journal of AOAC International.
2011 Mar; 94(2):550-4. doi:
10.1093/jaoac/94.2.550. [PMID: 21563690] - Kelly W Hall, Carlos Muro-Cacho, Alison Abritis, Giffe T Johnson, Raymond D Harbison. Attenuation of bromobenzene-induced hepatotoxicity by poly(ADP-ribose) polymerase inhibitors.
Research communications in molecular pathology and pharmacology.
2009 201; 122-123(1-6):79-95. doi:
. [PMID: 22032092] - Kelly W Hall, Carlos Muro-Cacho, Alison Abritis, Giffe T Johnson, Raymond D Harbison. Attenuation of bromobenzene-induced hepatotoxicity by poly(ADP-ribose) polymerase inhibitors.
Research communications in molecular pathology and pharmacology.
2009 201; 122-123(?):79-95. doi:
. [PMID: 25022032] - Marek Banasik, Todd Stedeford, Kunihiro Ueda, Carlos Muro-Cacho, Phi-Huynh Su, Seigo Tanaka, Raymond D Harbison. Hepatoprotective effects of 6(5H)-phenanthridinone from chemical-induced centrilobular necrosis.
Research communications in molecular pathology and pharmacology.
2004; 115-116(?):15-20. doi:
NULL. [PMID: 17564302] - Prakash Jagtap, Francisco Garcia Soriano, László Virág, Lucas Liaudet, Jon Mabley, Eva Szabó, György Haskó, Anita Marton, Clara Batista Lorigados, Ferenc Gallyas, Balázs Sümegi, Dale G Hoyt, Erkan Baloglu, John VanDuzer, Andrew L Salzman, Garry J Southan, Csaba Szabó. Novel phenanthridinone inhibitors of poly (adenosine 5'-diphosphate-ribose) synthetase: potent cytoprotective and antishock agents.
Critical care medicine.
2002 May; 30(5):1071-82. doi:
10.1097/00003246-200205000-00019. [PMID: 12006805] - J S Dutcher, C E Mitchell. Distribution and elimination of inhaled phenanthridone in Fischer-344 rats.
Journal of toxicology and environmental health.
1983 Oct; 12(4-6):709-19. doi:
10.1080/15287398309530462. [PMID: 6668619]