Furafylline (BioDeep_00000272961)

   


代谢物信息卡片


Furafylline

化学式: C12H12N4O3 (260.0909362)
中文名称: 呋拉茶碱
谱图信息: 最多检出来源 Ailuropoda melanoleuca(viridiplantae) 18.18%

分子结构信息

SMILES: CC1=NC2=C(N1)C(=O)N(C(=O)N2CC3=CC=CO3)C
InChI: InChI=1S/C12H12N4O3/c1-7-13-9-10(14-7)16(6-8-4-3-5-19-8)12(18)15(2)11(9)17/h3-5H,6H2,1-2H3,(H,13,14)

描述信息

D004791 - Enzyme Inhibitors > D065607 - Cytochrome P-450 Enzyme Inhibitors > D065609 - Cytochrome P-450 CYP1A2 Inhibitors
C78273 - Agent Affecting Respiratory System > C29712 - Anti-asthmatic Agent > C319 - Bronchodilator
C471 - Enzyme Inhibitor > C744 - Phosphodiesterase Inhibitor

同义名列表

1 个代谢物同义名

Furafylline



数据库引用编号

7 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
  • Tomonori Miura, Shotaro Uehara, Makiko Shimizu, Norie Murayama, Hiroshi Suemizu, Hiroshi Yamazaki. Roles of human cytochrome P450 1A2 in coumarin 3,4-epoxidation mediated by untreated hepatocytes and by those metabolically inactivated with furafylline in previously transplanted chimeric mice. The Journal of toxicological sciences. 2021; 46(11):525-530. doi: 10.2131/jts.46.525. [PMID: 34719555]
  • Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology. 2019 11; 96(5):629-640. doi: 10.1124/mol.119.115964. [PMID: 31515284]
  • Ziru Dai, Guibo Sun, Jiada Yang, Jie Hou, Ping Zhou, Weijie Xie, Guangbo Ge, Xiaobo Sun, Ling Yang. Interspecies Variation in NCMN-O-Demethylation in Liver Microsomes from Various Species. Molecules (Basel, Switzerland). 2019 Jul; 24(15):. doi: 10.3390/molecules24152765. [PMID: 31366067]
  • Brian Metcalf, Chihyuan Chuang, Kobina Dufu, Mira P Patel, Abel Silva-Garcia, Carl Johnson, Qing Lu, James R Partridge, Larysa Patskovska, Yury Patskovsky, Steven C Almo, Matthew P Jacobson, Lan Hua, Qing Xu, Stephen L Gwaltney, Calvin Yee, Jason Harris, Bradley P Morgan, Joyce James, Donghong Xu, Athiwat Hutchaleelaha, Kumar Paulvannan, Donna Oksenberg, Zhe Li. Discovery of GBT440, an Orally Bioavailable R-State Stabilizer of Sickle Cell Hemoglobin. ACS medicinal chemistry letters. 2017 Mar; 8(3):321-326. doi: 10.1021/acsmedchemlett.6b00491. [PMID: 28337324]
  • C W Locuson, P Williams, J M Adcock, J S Daniels. Evaluation of tizanidine as a marker of canine CYP1A2 activity. Journal of veterinary pharmacology and therapeutics. 2016 Apr; 39(2):122-30. doi: 10.1111/jvp.12256. [PMID: 26228837]
  • Volker M Arlt, Kateřina Levová, František Bárta, Zhanquan Shi, James D Evans, Eva Frei, Heinz H Schmeiser, Daniel W Nebert, David H Phillips, Marie Stiborová. Role of P450 1A1 and P450 1A2 in bioactivation versus detoxication of the renal carcinogen aristolochic acid I: studies in Cyp1a1-/-, Cyp1a2-/-, and Cyp1a1/1a2-/- mice. Chemical research in toxicology. 2011 Oct; 24(10):1710-9. doi: 10.1021/tx200259y. [PMID: 21932800]
  • Yu-Qi He, Li Yang, Yong Liu, Jiang-Wei Zhang, Jun Tang, Juan Su, Yuan-Yuan Li, Yan-Liu Lu, Chang-Hong Wang, Ling Yang, Zheng-Tao Wang. Characterization of cardamonin metabolism by P450 in different species via HPLC-ESI-ion trap and UPLC-ESI-quadrupole mass spectrometry. Acta pharmacologica Sinica. 2009 Oct; 30(10):1462-70. doi: 10.1038/aps.2009.127. [PMID: 19767764]
  • Vijaya M Lakshmi, Fong-Fu Hsu, Terry V Zenser. Identification of new 2-amino-3-methylimidazo[4,5-f]quinoline urinary metabolites from beta-naphthoflavone-treated mice. Drug metabolism and disposition: the biological fate of chemicals. 2009 Aug; 37(8):1690-7. doi: 10.1124/dmd.109.027342. [PMID: 19451400]
  • Fengping Li, Mahendra D Chordia, Tao Huang, Timothy L Macdonald. In vitro nimesulide studies toward understanding idiosyncratic hepatotoxicity: diiminoquinone formation and conjugation. Chemical research in toxicology. 2009 Jan; 22(1):72-80. doi: 10.1021/tx800152r. [PMID: 19053182]
  • Simon Lucas, Ralf Heim, Christina Ries, Katarzyna E Schewe, Barbara Birk, Rolf W Hartmann. In vivo active aldosterone synthase inhibitors with improved selectivity: lead optimization providing a series of pyridine substituted 3,4-dihydro-1H-quinolin-2-one derivatives. Journal of medicinal chemistry. 2008 Dec; 51(24):8077-87. doi: 10.1021/jm800888q. [PMID: 19049427]
  • Raghvendra K Dubey, Edwin K Jackson, Delbert G Gillespie, Marinella Rosselli, Federica Barchiesi, Andree Krust, Hansjoerg Keller, Lefteris C Zacharia, Bruno Imthurn. Cytochromes 1A1/1B1- and catechol-O-methyltransferase-derived metabolites mediate estradiol-induced antimitogenesis in human cardiac fibroblast. The Journal of clinical endocrinology and metabolism. 2005 Jan; 90(1):247-55. doi: 10.1210/jc.2003-032154. [PMID: 15507517]
  • Shigeru Furuta, Emiko Kamada, Takeshi Omata, Tohru Sugimoto, Yoshihiro Kawabata, Keiko Yonezawa, Xiaochun Cheryl Wu, Tadashi Kurimoto. Drug-drug interactions of Z-338, a novel gastroprokinetic agent, with terfenadine, comparison with cisapride, and involvement of UGT1A9 and 1A8 in the human metabolism of Z-338. European journal of pharmacology. 2004 Aug; 497(2):223-31. doi: 10.1016/j.ejphar.2004.06.040. [PMID: 15306208]
  • R Hyland, B C Jones, D A Smith. Identification of the cytochrome P450 enzymes involved in the N-oxidation of voriconazole. Drug metabolism and disposition: the biological fate of chemicals. 2003 May; 31(5):540-7. doi: 10.1124/dmd.31.5.540. [PMID: 12695341]
  • Yune-Fang Ueng, Woan-Ching Jan, Lie-Chwen Lin, Ta-Liang Chen, F Peter Guengerich, Chieh-Fu Chen. The alkaloid rutaecarpine is a selective inhibitor of cytochrome P450 1A in mouse and human liver microsomes. Drug metabolism and disposition: the biological fate of chemicals. 2002 Mar; 30(3):349-53. doi: 10.1124/dmd.30.3.349. [PMID: 11854157]
  • Lars Brachtendorf, Alexander Jetter, K Tobias Beckurts, Arnulf H Hölscher, Uwe Fuhr. Cytochrome P450 enzymes contributing to demethylation of maprotiline in man. Pharmacology & toxicology. 2002 Mar; 90(3):144-9. doi: 10.1034/j.1600-0773.2002.900306.x. [PMID: 12071336]
  • S Langouët, D H Welti, N Kerriguy, L B Fay, T Huynh-Ba, J Markovic, F P Guengerich, A Guillouzo, R J Turesky. Metabolism of 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline in human hepatocytes: 2-amino-3-methylimidazo[4,5-f]quinoxaline-8-carboxylic acid is a major detoxification pathway catalyzed by cytochrome P450 1A2. Chemical research in toxicology. 2001 Feb; 14(2):211-21. doi: 10.1021/tx000176e. [PMID: 11258970]
  • M Watanabe, T Tateishi, M Tanaka, T Kumai, S Kobayashi. Role of CYP3A in bromperidol metabolism in rat in vitro and in vivo. Xenobiotica; the fate of foreign compounds in biological systems. 1999 Aug; 29(8):839-46. doi: 10.1080/004982599238281. [PMID: 10553724]
  • S Gates, J O Miners. Cytochrome P450 isoform selectivity in human hepatic theobromine metabolism. British journal of clinical pharmacology. 1999 Mar; 47(3):299-305. doi: 10.1046/j.1365-2125.1999.00890.x. [PMID: 10215755]
  • T G Schulz, D Neubert, D S Davies, R J Edwards. Inducibility of cytochromes P-450 by dioxin in liver and extrahepatic tissues of the marmoset monkey (Callithrix jacchus). Biochimica et biophysica acta. 1996 Nov; 1298(1):131-40. doi: 10.1016/s0167-4838(96)88917-5. [PMID: 8948497]
  • A R Boobis, A M Lynch, S Murray, R de la Torre, A Solans, M Farré, J Segura, N J Gooderham, D S Davies. CYP1A2-catalyzed conversion of dietary heterocyclic amines to their proximate carcinogens is their major route of metabolism in humans. Cancer research. 1994 Jan; 54(1):89-94. doi: . [PMID: 8261468]
  • D Sesardic, A R Boobis, B P Murray, S Murray, J Segura, R de la Torre, D S Davies. Furafylline is a potent and selective inhibitor of cytochrome P450IA2 in man. British journal of clinical pharmacology. 1990 Jun; 29(6):651-63. doi: 10.1111/j.1365-2125.1990.tb03686.x. [PMID: 2378786]
  • J Segura, D J Roberts, E Tarrus. The influence of structure on the accumulation of caffeine induced by methyl xanthine derivatives. The Journal of pharmacy and pharmacology. 1989 Feb; 41(2):129-31. doi: 10.1111/j.2042-7158.1989.tb06409.x. [PMID: 2568423]
  • E Tarrús, I García, D J Roberts, J Segura. An animal model for the detection of drug-induced inhibition of caffeine metabolism. Methods and findings in experimental and clinical pharmacology. 1987 May; 9(5):311-6. doi: NULL. [PMID: 3613760]
  • E Tarrus, J Cami, D J Roberts, R G Spickett, E Celdran, J Segura. Accumulation of caffeine in healthy volunteers treated with furafylline. British journal of clinical pharmacology. 1987 Jan; 23(1):9-18. doi: 10.1111/j.1365-2125.1987.tb03003.x. [PMID: 3814465]
  • J Segura, I Garcia, E Tarrus. Some pharmacokinetic characteristics of furafylline, a new 1,3,8-trisubstituted xanthine. The Journal of pharmacy and pharmacology. 1986 Aug; 38(8):615-8. doi: 10.1111/j.2042-7158.1986.tb03092.x. [PMID: 2876080]