Fluanisone (BioDeep_00000272959)
代谢物信息卡片
化学式: C21H25FN2O2 (356.18999619999994)
中文名称: 氟阿尼酮
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: COC1=CC=CC=C1N2CCN(CC2)CCCC(=O)C3=CC=C(C=C3)F
InChI: InChI=1S/C21H25FN2O2/c1-26-21-7-3-2-5-19(21)24-15-13-23(14-16-24)12-4-6-20(25)17-8-10-18(22)11-9-17/h2-3,5,7-11H,4,6,12-16H2,1H3
描述信息
D002491 - Central Nervous System Agents > D002492 - Central Nervous System Depressants > D006993 - Hypnotics and Sedatives
D002492 - Central Nervous System Depressants > D014149 - Tranquilizing Agents > D014150 - Antipsychotic Agents
D002491 - Central Nervous System Agents > D011619 - Psychotropic Drugs > D014149 - Tranquilizing Agents
N - Nervous system > N05 - Psycholeptics > N05A - Antipsychotics > N05AD - Butyrophenone derivatives
C78272 - Agent Affecting Nervous System > C29710 - Antipsychotic Agent
同义名列表
1 个代谢物同义名
数据库引用编号
7 个数据库交叉引用编号
- ChEBI: CHEBI:177744
- KEGGdrug: D02621
- PubChem: 15139
- DrugBank: DB13665
- ChEMBL: CHEMBL58792
- CAS: 1480-19-9
- PMhub: MS000004608
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
Molecular pharmacology.
2019 11; 96(5):629-640. doi:
10.1124/mol.119.115964. [PMID: 31515284] - Haiyun Qi, Christian Østergaard Mariager, Jakob Lindhardt, Per Mose Nielsen, Hans Stødkilde-Jørgensen, Christoffer Laustsen. Effects of anesthesia on renal function and metabolism in rats assessed by hyperpolarized MRI.
Magnetic resonance in medicine.
2018 11; 80(5):2073-2080. doi:
10.1002/mrm.27165. [PMID: 29520870] - Niels Secher, Christian Lind Malte, Else Tønnesen, Leif Østergaard, Asger Granfeldt. Comparing anesthesia with isoflurane and fentanyl/fluanisone/midazolam in a rat model of cardiac arrest.
Journal of applied physiology (Bethesda, Md. : 1985).
2017 Nov; 123(4):867-875. doi:
10.1152/japplphysiol.00998.2015. [PMID: 27125849] - Julie A Bourdon, Sabina Halappanavar, Anne T Saber, Nicklas R Jacobsen, Andrew Williams, Håkan Wallin, Ulla Vogel, Carole L Yauk. Hepatic and pulmonary toxicogenomic profiles in mice intratracheally instilled with carbon black nanoparticles reveal pulmonary inflammation, acute phase response, and alterations in lipid homeostasis.
Toxicological sciences : an official journal of the Society of Toxicology.
2012 Jun; 127(2):474-84. doi:
10.1093/toxsci/kfs119. [PMID: 22461453] - Amarnadh Nalla, Inge Buch, Maibritt Sigvardt, Rasmus Poul Bodholdt, Andreas Kjaer, Birger Hesse. (111)Indium Labelling of Recombinant Activated Coagulation Factor VII: In Vitro and Preliminary In Vivo Studies in Healthy Rats.
International journal of molecular imaging.
2012; 2012(?):464810. doi:
10.1155/2012/464810. [PMID: 22518302] - Justin Wai-Chung Leung, Wing Tak Wong, Hon Wai Koon, Fong Ming Mo, Sidney Tam, Yu Huang, Paul M Vanhoutte, Stephen Sum Man Chung, Sookja Kim Chung. Transgenic mice over-expressing ET-1 in the endothelial cells develop systemic hypertension with altered vascular reactivity.
PloS one.
2011; 6(11):e26994. doi:
10.1371/journal.pone.0026994. [PMID: 22096514] - Ingrid Stroo, Geurt Stokman, Gwen J D Teske, Anje Raven, Loes M Butter, Sandrine Florquin, Jaklien C Leemans. Chemokine expression in renal ischemia/reperfusion injury is most profound during the reparative phase.
International immunology.
2010 Jun; 22(6):433-42. doi:
10.1093/intimm/dxq025. [PMID: 20410256] - Geoffrey van der Plasse, Dorie T J Meerkerk, Cindy K J Lieben, Arjan Blokland, Matthijs G P Feenstra. Lack of evidence for reduced prefrontal cortical serotonin and dopamine efflux after acute tryptophan depletion.
Psychopharmacology.
2007 Dec; 195(3):377-85. doi:
10.1007/s00213-007-0908-7. [PMID: 17713760] - Claude Sadis, Gwen Teske, Geurt Stokman, Carole Kubjak, Nike Claessen, Fabrice Moore, Patrizia Loi, Bilo Diallo, Luc Barvais, Michel Goldman, Sandrine Florquin, Alain Le Moine. Nicotine protects kidney from renal ischemia/reperfusion injury through the cholinergic anti-inflammatory pathway.
PloS one.
2007 May; 2(5):e469. doi:
10.1371/journal.pone.0000469. [PMID: 17520028] - M Cemazar, I Wilson, V E Prise, K M Bell, S A Hill, G M Tozer. The endothelin B (ETB) receptor agonist IRL 1620 is highly vasoconstrictive in two syngeneic rat tumour lines: potential for selective tumour blood flow modification.
British journal of cancer.
2005 Jul; 93(1):98-106. doi:
10.1038/sj.bjc.6602672. [PMID: 15970923] - Vladimir Kuklin, Mikhail Sovershaev, Thomas Andreasen, Vegard Skogen, Kirsti Ytrehus, Lars Bjertnaes. Tezosentan reduces the microvascular filtration coefficient in isolated lungs from rats subjected to cecum ligation and puncture.
Critical care (London, England).
2005; 9(6):R677-86. doi:
10.1186/cc3882. [PMID: 16280068] - G Van Roey, P Lijnen, R Verbesselt, A Verbruggen, J Fevery. Effect of narcotic agents and of bleeding on systemic and renal haemodynamics in healthy and CCl4-treated cirrhotic rats.
Clinical science (London, England : 1979).
1997 Dec; 93(6):549-56. doi:
10.1042/cs0930549. [PMID: 9497792] - K C Skolleborg, J E Grönbech, K Grong, F E Abyholm, J Lekven. Distribution of cardiac output during pentobarbital versus midazolam/fentanyl/fluanisone anaesthesia in the rat.
Laboratory animals.
1990 Jul; 24(3):221-7. doi:
10.1258/002367790780866100. [PMID: 2144326] - M P Quaglio, A M Bellini. A gas chromatographic method for the determination of fluanisone, moperone, aceperone and pipamperone in human plasma.
Il Farmaco; edizione pratica.
1981 Apr; 36(4):204-14. doi:
NULL. [PMID: 6112157] - S H Unger, G H Chiang. Octanol-physiological buffer distribution coefficients of lipophilic amines by reversed-phase high-performance liquid chromatography and their correlation with biological activity.
Journal of medicinal chemistry.
1981 Mar; 24(3):262-70. doi:
10.1021/jm00135a006. [PMID: 6167716] - A SOULAIRAC, S GEIER, OCHONISKY, POYART. [ANALYSIS OF THE ACTION OF MD 2028 IN CHRONIC PSYCHOSES BY J.R.WITTENBORN'S PSYCHIATRIC EVALUATION SCALE].
Annales medico-psychologiques.
1964 Feb; 122(?):271-5. doi:
NULL. [PMID: 14136390]