nefopam (BioDeep_00000272892)
代谢物信息卡片
nefopam
化学式: C17H19NO (253.14665639999998)
中文名称: 奈福泮
谱图信息:
最多检出来源 Viridiplantae(plant) 75%
分子结构信息
SMILES: CN1CCOC(C2=CC=CC=C2C1)C3=CC=CC=C3
InChI: InChI=1S/C17H19NO/c1-18-11-12-19-17(14-7-3-2-4-8-14)16-10-6-5-9-15(16)13-18/h2-10,17H,11-13H2,1H3
描述信息
C78272 - Agent Affecting Nervous System > C29756 - Sedative and Hypnotic > C1012 - Benzodiazepine
D018373 - Peripheral Nervous System Agents > D018689 - Sensory System Agents
C78272 - Agent Affecting Nervous System > C28197 - Antianxiety Agent
D002491 - Central Nervous System Agents > D000700 - Analgesics
N - Nervous system > N02 - Analgesics
同义名列表
1 个代谢物同义名
数据库引用编号
9 个数据库交叉引用编号
- ChEBI: CHEBI:88318
- KEGGdrug: D08258
- PubChem: 4450
- Metlin: METLIN1482
- DrugBank: DB12293
- ChEMBL: CHEMBL465026
- MeSH: Nefopam
- CAS: 13669-70-0
- PMhub: MS000004477
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
Molecular pharmacology.
2019 11; 96(5):629-640. doi:
10.1124/mol.119.115964. [PMID: 31515284] - Aravind Mittur. A Simultaneous Mixed-Effects Pharmacokinetic Model for Nefopam, N-desmethylnefopam, and Nefopam N-Oxide in Human Plasma and Urine.
European journal of drug metabolism and pharmacokinetics.
2018 Aug; 43(4):391-404. doi:
10.1007/s13318-017-0457-3. [PMID: 29305813] - Mahesh Gokara, Vidadala V Narayana, Vineet Sadarangani, Shatabdi Roy Chowdhury, Sreelaxmi Varkala, Dhevalapally B Ramachary, Rajagopal Subramanyam. Unravelling the binding mechanism and protein stability of human serum albumin while interacting with nefopam analogues: a biophysical and insilico approach.
Journal of biomolecular structure & dynamics.
2017 Aug; 35(10):2280-2292. doi:
10.1080/07391102.2016.1216895. [PMID: 27453381] - N E Baka, F Vial, G Iohom, P Guerci, C Hubert, M Rouabah, H Bouaziz. The effect of nefopam on lactation after caesarean section: a single-blind randomised trial.
International journal of obstetric anesthesia.
2017 May; 31(?):84-90. doi:
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Xenobiotica; the fate of foreign compounds in biological systems.
2016 Nov; 46(11):1026-48. doi:
10.3109/00498254.2016.1145755. [PMID: 26927982] - Madhu Sanga, John Banach, Aaron Ledvina, Nishit B Modi, Aravind Mittur. Pharmacokinetics, metabolism, and excretion of nefopam, a dual reuptake inhibitor in healthy male volunteers.
Xenobiotica; the fate of foreign compounds in biological systems.
2016 Nov; 46(11):1001-16. doi:
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Acta anaesthesiologica Scandinavica.
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Journal of analytical toxicology.
2015 Jul; 39(6):486-9. doi:
10.1093/jat/bkv036. [PMID: 25855761] - Meng Lv, Xuetao Wang, Wendong Qu, Mengjie Liu, Yuelan Wang. Nefopam for the prevention of perioperative shivering: a meta-analysis of randomized controlled trials.
BMC anesthesiology.
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Anesteziologiia i reanimatologiia.
2014 Sep; 59(5):27-32. doi:
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British journal of clinical pharmacology.
2014 Jun; 77(6):1027-38. doi:
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Neuroscience letters.
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British journal of anaesthesia.
2012 May; 108(5):784-91. doi:
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10.1155/2012/794540. [PMID: 22319538] - Mahmood Ahmad, Muhammad Yaqoob, Ghulam Murtaza. Study of pharmacokinetics and comparative bioavailability of nefopam 30 mg tablets in twelve fasting healthy Pakistani male young subjects: single-dose, randomized, two-period, two-treatment and two-way cross-over design.
Medical principles and practice : international journal of the Kuwait University, Health Science Centre.
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Anesthesia and analgesia.
2010 Nov; 111(5):1146-53. doi:
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Journal of endourology.
2009 Dec; 23(12):2021-7. doi:
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European journal of medicinal chemistry.
2009 Nov; 44(11):4455-60. doi:
10.1016/j.ejmech.2009.06.004. [PMID: 19586686] - Pintu De, N Damodharan, Subrata Mallick, Biswajit Mukherjee. Development and evaluation of nefopam transdermal matrix patch system in human volunteers.
PDA journal of pharmaceutical science and technology.
2009 Nov; 63(6):537-46. doi:
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Journal of psychopharmacology (Oxford, England).
2009 Nov; 23(8):997. doi:
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Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2009 Jul; 877(20-21):1937-42. doi:
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2009 Mar; 52(6):1693-700. doi:
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Drug metabolism and disposition: the biological fate of chemicals.
2008 Jul; 36(7):1385-405. doi:
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Annales francaises d'anesthesie et de reanimation.
2007 Jan; 26(1):74-6. doi:
10.1016/j.annfar.2006.07.080. [PMID: 17158020] - Oliver Kimberger, Syed Z Ali, Monica Markstaller, Sandra Zmoos, Rolf Lauber, Corinne Hunkeler, Andrea Kurz. Meperidine and skin surface warming additively reduce the shivering threshold: a volunteer study.
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2007; 11(1):R29. doi:
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Journal of pharmaceutical and biomedical analysis.
2006 Nov; 42(5):593-600. doi:
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Anesthesiology.
2004 Jan; 100(1):37-43. doi:
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1977 Jun; 136(1):154-8. doi:
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