3-aminobenzamide (BioDeep_00000272778)
代谢物信息卡片
3-aminobenzamide
化学式: C7H8N2O (136.0637)
中文名称: 3-氨基苯甲酰胺
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1=CC(=CC(=C1)N)C(=O)N
InChI: InChI=1S/C7H8N2O/c8-6-3-1-2-5(4-6)7(9)10/h1-4H,8H2,(H2,9,10)
描述信息
D000970 - Antineoplastic Agents > D000067856 - Poly(ADP-ribose) Polymerase Inhibitors
D002491 - Central Nervous System Agents > D018696 - Neuroprotective Agents
D011838 - Radiation-Sensitizing Agents
D020011 - Protective Agents
D004791 - Enzyme Inhibitors
同义名列表
1 个代谢物同义名
数据库引用编号
7 个数据库交叉引用编号
- ChEBI: CHEBI:64042
- PubChem: 1645
- Metlin: METLIN44363
- ChEMBL: CHEMBL81977
- CAS: 3544-24-9
- PMhub: MS000004295
- RefMet: 3-Aminobenzamide
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
| 亚细胞结构定位 | 关联基因列表 |
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文献列表
- Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome.
Cell reports.
2021 04; 35(4):109040. doi:
10.1016/j.celrep.2021.109040. [PMID: 33910017] - Myoung-Jin Kim, Daeun Moon, Sumi Jung, Jehee Lee, Jinu Kim. Cisplatin nephrotoxicity is induced via poly(ADP-ribose) polymerase activation in adult zebrafish and mice.
American journal of physiology. Regulatory, integrative and comparative physiology.
2020 05; 318(5):R843-R854. doi:
10.1152/ajpregu.00130.2019. [PMID: 32186196] - Xingyu Wang, Roumen Parapanov, Anne Debonneville, Yabo Wang, Etienne Abdelnour-Berchtold, Michel Gonzalez, Fabrizio Gronchi, Jean-Yannis Perentes, Hans-Beat Ris, Philippe Eckert, Lise Piquilloud, Jérôme Lugrin, Igor Letovanec, Thorsten Krueger, Lucas Liaudet. Treatment with 3-aminobenzamide during ex vivo lung perfusion of damaged rat lungs reduces graft injury and dysfunction after transplantation.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.
2020 04; 20(4):967-976. doi:
10.1111/ajt.15695. [PMID: 31710417] - Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
Molecular pharmacology.
2019 11; 96(5):629-640. doi:
10.1124/mol.119.115964. [PMID: 31515284] - Marwa M El-Sheikh, Rania M El-Hazek, Aiman S El-Khatib, Mona A El-Ghazaly. Anti-apoptotic effect of 3-aminobenzamide, an inhibitor of poly (ADP-ribose) polymerase, against multiple organ damage induced by gamma irradiation in rats.
International journal of radiation biology.
2018 01; 94(1):45-53. doi:
10.1080/09553002.2018.1408977. [PMID: 29187017] - Raffaela Zaffini, Rosanna Di Paola, Salvatore Cuzzocrea, Marta Menegazzi. PARP inhibition treatment in a nonconventional experimental mouse model of chronic asthma.
Naunyn-Schmiedeberg's archives of pharmacology.
2016 Dec; 389(12):1301-1313. doi:
10.1007/s00210-016-1294-7. [PMID: 27604227] - Salim Kemal Tuncer, Seher Altinel, Mehmet Toygar, Hakan Istanbulluoglu, Kahraman Ates, Recai Ogur, Ozcan Altinel, Yildirim Karslioglu, Turgut Topal, Ahmet Korkmaz, Bulent Uysal. Poly-ADP-ribose polymerase inhibition provides protection against lung injury in a rat paraquat toxicity model.
Inflammopharmacology.
2016 Aug; 24(4):155-61. doi:
10.1007/s10787-016-0268-1. [PMID: 27271689] - Elina Shrestha, Maryem A Hussein, Jeffery N Savas, Mireille Ouimet, Tessa J Barrett, Sarah Leone, John R Yates, Kathryn J Moore, Edward A Fisher, Michael J Garabedian. Poly(ADP-ribose) Polymerase 1 Represses Liver X Receptor-mediated ABCA1 Expression and Cholesterol Efflux in Macrophages.
The Journal of biological chemistry.
2016 May; 291(21):11172-84. doi:
10.1074/jbc.m116.726729. [PMID: 27026705] - Alexander Biro, Hananya Vaknine, Malka Cohen-Armon, Zipora Matas, Asora Fux, Letizia Schreiber, Esther Berger, Michael Dan, Mona Boaz, Olga Gregoriev, Ze'ev Katzir. The effect of poly (ADP-ribose) polymerase inhibition on aminoglycoside-induced acute tubular necrosis in rats.
Clinical nephrology.
2016 Apr; 85(4):226-34. doi:
10.5414/cn108697. [PMID: 26951968] - Tarek El-Hamoly, Ezzeddin S El-Denshary, Shokry Mohamed Saad, Mona A El-Ghazaly. 3-aminobenzamide, a poly (ADP ribose) polymerase inhibitor, enhances wound healing in whole body gamma irradiated model.
Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society.
2015 Sep; 23(5):672-84. doi:
10.1111/wrr.12330. [PMID: 26080614] - Chandra Shaker Sriram, Ashok Jangra, Satendra Singh Gurjar, Md Iftikar Hussain, Probodh Borah, Mangala Lahkar, Pritam Mohan, Babul Kumar Bezbaruah. Poly (ADP-ribose) polymerase-1 inhibitor, 3-aminobenzamide pretreatment ameliorates lipopolysaccharide-induced neurobehavioral and neurochemical anomalies in mice.
Pharmacology, biochemistry, and behavior.
2015 Jun; 133(?):83-91. doi:
10.1016/j.pbb.2015.03.022. [PMID: 25863272] - Hailin Zhao, Jiaolin Ning, Alexandre Lemaire, Foteini-Stefania Koumpa, James J Sun, Anthony Fung, Jianteng Gu, Bin Yi, Kaizhi Lu, Daqing Ma. Necroptosis and parthanatos are involved in remote lung injury after receiving ischemic renal allografts in rats.
Kidney international.
2015 Apr; 87(4):738-48. doi:
10.1038/ki.2014.388. [PMID: 25517913] - Melahat Dönmez, Bülent Uysal, Yavuz Poyrazoğlu, Yeşim E R Öztas, Türker Türker, Ümit Kaldirim, Ahmet Korkmaz. PARP inhibition prevents acetaminophen-induced liver injury and increases survival rate in rats.
Turkish journal of medical sciences.
2015; 45(1):18-26. doi:
10.3906/sag-1308-48. [PMID: 25790525] - Lianshuang Zhang, Jinpeng Yao, Xifeng Wang, Hongxing Li, Tongshen Liu, Wei Zhao. Poly (ADP-ribose) synthetase inhibitor has a heart protective effect in a rat model of experimental sepsis.
International journal of clinical and experimental pathology.
2015; 8(9):9824-35. doi:
NULL. [PMID: 26617692] - Si-bo Liu, Jinjie Liu, Da-wei Liu, Xiao-ting Wang, Rong-li Yang. Inhibition of Poly-(ADP-Ribose) Polymerase Protects the Kidney in a Canine Model of Endotoxic Shock.
Nephron.
2015; 130(4):281-92. doi:
10.1159/000435815. [PMID: 26184635] - Ebru Menekse, Sezai Aydın, Aylin Sepici Dinçel, Abdullah Eroğlu, Mete Dolapçı, Osman Yıldırım, Ömer Cengiz. Effect of 3-aminobenzamide on perforation an experimental colitis model.
The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology.
2014 Dec; 25 Suppl 1(?):86-91. doi:
10.5152/tjg.2014.4288. [PMID: 25910375] - Ercan Malkoc, Bilal Fırat Alp, Zafer Demirer, Ali Guragac, Furkan Dursun, Ferhat Ates, Ibrahim Yildirim, Ramazan Yuksel, Bulent Uysal, Turgut Topal, Yasemin Gulcan Kurt, Ayhan Ozcan, Ahmet Guven. Efficacy of poly(adenosine diphosphate-ribose) polymerase inhibition in extracorporeal shock wave-induced renal injury.
Renal failure.
2014 Nov; 36(10):1564-9. doi:
10.3109/0886022x.2014.962423. [PMID: 25238491] - Ezgi Turunc Bayrakdar, Guliz Armagan, Yigit Uyanikgil, Lutfiye Kanit, Ersin Koylu, Ayfer Yalcin. Ex vivo protective effects of nicotinamide and 3-aminobenzamide on rat synaptosomes treated with Aβ(1-42).
Cell biochemistry and function.
2014 Oct; 32(7):557-64. doi:
10.1002/cbf.3049. [PMID: 25111857] - A Tas Hekimoglu, G Toprak, H Akkoc, O Evliyaoglu, T Tas, I Kelle, L Colpan. Protective effect of 3-aminobenzamide, an inhibitor of poly (ADP-ribose) polymerase in distant liver injury induced by renal ischemia-reperfusion in rats.
European review for medical and pharmacological sciences.
2014; 18(1):34-8. doi:
NULL. [PMID: 24452939] - Kara A Boltz, Madhu Jasti, Jennifer M Townley, Dorothy E Shippen. Analysis of poly(ADP-Ribose) polymerases in Arabidopsis telomere biology.
PloS one.
2014; 9(2):e88872. doi:
10.1371/journal.pone.0088872. [PMID: 24551184] - May Khin Hnin Si, Chieko Mitaka, Miniwan Tulafu, Shinya Abe, Masanobu Kitagawa, Satoshi Ikeda, Yoshinobu Eishi, Shunichi Kurata, Makoto Tomita. Inhibition of poly (adenosine diphosphate-ribose) polymerase attenuates lung-kidney crosstalk induced by intratracheal lipopolysaccharide instillation in rats.
Respiratory research.
2013 Nov; 14(?):126. doi:
10.1186/1465-9921-14-126. [PMID: 24229378] - Yan Wang, Lin Wang, Fengxiao Zhang, Chun Zhang, Shan Deng, Rui Wang, Yun Zhang, Dan Huang, Kai Huang. Inhibition of PARP prevents angiotensin II-induced aortic fibrosis in rats.
International journal of cardiology.
2013 Sep; 167(5):2285-93. doi:
10.1016/j.ijcard.2012.06.050. [PMID: 22846599] - Kyoung-Jin Kim, Han-A Kim, Kook Heon Seo, Hern-Ku Lee, Bok Yun Kang, Suhn-Young Im. Cholera toxin breakdowns oral tolerance via activation of canonical NF-κB.
Cellular immunology.
2013 Sep; 285(1-2):92-9. doi:
10.1016/j.cellimm.2013.09.006. [PMID: 24140867] - Jia Yu, Wenhong Deng, Weixing Wang, Youming Ding, Hao Jin, Chen Chen, Xiaoyan Chen, Xingcheng Xiong, Sheng Xu. Inhibition of poly(ADP-ribose) polymerase attenuates acute kidney injury in sodium taurocholate-induced acute pancreatitis in rats.
Pancreas.
2012 Nov; 41(8):1299-305. doi:
10.1097/mpa.0b013e318252dbc3. [PMID: 22750969] - Chunyan Wang, Biju George, Shali Chen, Biao Feng, Xiaokun Li, Subrata Chakrabarti. Genotoxic stress and activation of novel DNA repair enzymes in human endothelial cells and in the retinas and kidneys of streptozotocin diabetic rats.
Diabetes/metabolism research and reviews.
2012 May; 28(4):329-37. doi:
10.1002/dmrr.2279. [PMID: 22228707] - Mohsen Minaiyan, Ali-Reza Ghannadi, Parvin Mahzouni, Ali-Reza Abed. Preventive Effect of Cichorium Intybus L. Two Extracts on Cerulein-induced Acute Pancreatitis in Mice.
International journal of preventive medicine.
2012 May; 3(5):351-7. doi:
NULL. [PMID: 22708031] - Elie Toledano, Vasily Ogryzko, Antoine Danchin, Daniel Ladant, Undine Mechold. 3'-5' phosphoadenosine phosphate is an inhibitor of PARP-1 and a potential mediator of the lithium-dependent inhibition of PARP-1 in vivo.
The Biochemical journal.
2012 Apr; 443(2):485-90. doi:
10.1042/bj20111057. [PMID: 22240080] - Philipp Schulz, Jenny Neukermans, Katrien Van der Kelen, Per Mühlenbock, Frank Van Breusegem, Graham Noctor, Markus Teige, Michael Metzlaff, Matthew A Hannah. Chemical PARP inhibition enhances growth of Arabidopsis and reduces anthocyanin accumulation and the activation of stress protective mechanisms.
PloS one.
2012; 7(5):e37287. doi:
10.1371/journal.pone.0037287. [PMID: 22662141] - Masakazu Ishii, Ryouta Iizuka, Yuji Kiuchi, Yasuo Mori, Shunichi Shimizu. Neuroprotection by lomerizine, a prophylactic drug for migraine, against hydrogen peroxide-induced hippocampal neurotoxicity.
Molecular and cellular biochemistry.
2011 Dec; 358(1-2):1-11. doi:
10.1007/s11010-011-0913-3. [PMID: 21656126] - Marek Banasik, Todd Stedeford, Robert P Strosznajder, Masanori Takehashi, Seigo Tanaka, Kunihiro Ueda. Inhibition of poly(ADP-ribose) polymerase-1 attenuates the toxicity of carbon tetrachloride.
Journal of enzyme inhibition and medicinal chemistry.
2011 Dec; 26(6):883-9. doi:
10.3109/14756366.2011.557315. [PMID: 21395487] - James D McCluskey, Dmytro Sava, Stephen C Harbison, Carlos A Muro-Cacho, Johnson T Giffe, Xu Ping, Raymond D Harbison. Hepatoprotective effects of select water-soluble PARP inhibitors in a carbon tetrachloride model.
International journal of critical illness and injury science.
2011 Jul; 1(2):97-103. doi:
10.4103/2229-5151.84788. [PMID: 22229131] - Kashyap G Pandya, Maulik R Patel, Cesar A Lau-Cam. Comparative study of the binding characteristics to and inhibitory potencies towards PARP and in vivo antidiabetogenic potencies of taurine, 3-aminobenzamide and nicotinamide.
Journal of biomedical science.
2010 Aug; 17 Suppl 1(?):S16. doi:
10.1186/1423-0127-17-s1-s16. [PMID: 20804590] - Devita Surjana, Gary M Halliday, Diona L Damian. Role of nicotinamide in DNA damage, mutagenesis, and DNA repair.
Journal of nucleic acids.
2010 Jul; 2010(?):. doi:
10.4061/2010/157591. [PMID: 20725615] - Liesbeth Geraets, Astrid Haegens, Antje R Weseler, Karen Brauers, Juanita H J Vernooy, Emiel F M Wouters, Aalt Bast, Geja J Hageman. Inhibition of acute pulmonary and systemic inflammation by 1,7-dimethylxanthine.
European journal of pharmacology.
2010 Mar; 629(1-3):132-9. doi:
10.1016/j.ejphar.2009.11.064. [PMID: 19962977] - Lori Adams-Phillips, Amy G Briggs, Andrew F Bent. Disruption of poly(ADP-ribosyl)ation mechanisms alters responses of Arabidopsis to biotic stress.
Plant physiology.
2010 Jan; 152(1):267-80. doi:
10.1104/pp.109.148049. [PMID: 19889874] - Jiang-Jiao Xie, Xian Yu, Yu-Hua Liao, Jian Chen, Rui Yao, Yong Chen, Meng-Yang Liao, Ying-Jun Ding, Ting-Ting Tang, Xiang Cheng. Poly (ADP-Ribose) polymerase inhibition attenuates atherosclerotic plaque development in ApoE-/- mice with hyperhomocysteinemia.
Journal of atherosclerosis and thrombosis.
2009 Oct; 16(5):641-53. doi:
10.5551/jat.1586. [PMID: 19776495] - Francisco O'Valle, Raimundo G M Del Moral, María del Carmén Benítez, David Martín-Oliva, Mercedes Gómez-Morales, David Aguilar, José Aneiros-Fernández, Pedro Hernández-Cortés, Antonio Osuna, Francesc Moreso, Daniel Serón, Francisco J Oliver, Raimundo G Del Moral. Poly[ADP-ribose] polymerase-1 expression is related to cold ischemia, acute tubular necrosis, and delayed renal function in kidney transplantation.
PloS one.
2009 Sep; 4(9):e7138. doi:
10.1371/journal.pone.0007138. [PMID: 19784367] - Reda Z Mahfouz, Rakesh K Sharma, Kerstin Poenicke, Rajesh Jha, Uwe Paasch, Sonja Grunewald, Ashok Agarwal. Evaluation of poly(ADP-ribose) polymerase cleavage (cPARP) in ejaculated human sperm fractions after induction of apoptosis.
Fertility and sterility.
2009 May; 91(5 Suppl):2210-20. doi:
10.1016/j.fertnstert.2008.02.173. [PMID: 18501896] - Xian Yu, Xiang Cheng, Jiang-jiao Xie, Meng-yang Liao, Rui Yao, Yong Chen, Ying-jun Ding, Ting-ting Tang, Yu-hua Liao. Poly (ADP-ribose) polymerase inhibition improves endothelial dysfunction induced by hyperhomocysteinemia in rats.
Cardiovascular drugs and therapy.
2009 Apr; 23(2):121-7. doi:
10.1007/s10557-008-6146-3. [PMID: 18949543] - Rajesh Jha, Ashok Agarwal, Reda Mahfouz, Uwe Paasch, Sonja Grunewald, Edmund Sabanegh, Satya P Yadav, Rakesh Sharma. Determination of Poly (ADP-ribose) polymerase (PARP) homologues in human ejaculated sperm and its correlation with sperm maturation.
Fertility and sterility.
2009 Mar; 91(3):782-90. doi:
10.1016/j.fertnstert.2007.12.079. [PMID: 18339380] - Emin Oztas, Ahmet Guven, Erdal Turk, Bulent Uysal, Emin Ozgur Akgul, Tuncer Cayci, Nail Ersoz, Ahmet Korkmaz. 3-aminobenzamide, a poly ADP ribose polymerase inhibitor, attenuates renal ischemia/reperfusion injury.
Renal failure.
2009; 31(5):393-9. doi:
10.1080/08860220902882741. [PMID: 19839840] - Maria Jacewicz, Grzegorz A Czapski, Inna Katkowska, Robert P Strosznajder. Systemic administration of lipopolysaccharide impairs glutathione redox state and object recognition in male mice. The effect of PARP-1 inhibitor.
Folia neuropathologica.
2009; 47(4):321-8. doi:
". [PMID: 20054784] - Bingying Xu, Jane Chiu, Biao Feng, Shali Chen, Subrata Chakrabarti. PARP activation and the alteration of vasoactive factors and extracellular matrix protein in retina and kidney in diabetes.
Diabetes/metabolism research and reviews.
2008 Jul; 24(5):404-12. doi:
10.1002/dmrr.842. [PMID: 18351623] - Jane Chiu, Bing Ying Xu, Shali Chen, Biao Feng, Subrata Chakrabarti. Oxidative stress-induced, poly(ADP-ribose) polymerase-dependent upregulation of ET-1 expression in chronic diabetic complications.
Canadian journal of physiology and pharmacology.
2008 Jun; 86(6):365-72. doi:
10.1139/y08-033. [PMID: 18516100] - Ahmet Korkmaz, Bülent Kurt, Ibrahim Yildirim, Seref Basal, Turgut Topal, Serdar Sadir, Sükrü Oter. Effects of poly(ADP-ribose) polymerase inhibition in bladder damage caused by cyclophosphamide in rats.
Experimental biology and medicine (Maywood, N.J.).
2008 Mar; 233(3):338-43. doi:
10.3181/0706-rm-151. [PMID: 18296739] - Lisa D Kalischuk, G Douglas Inglis, Andre G Buret. Strain-dependent induction of epithelial cell oncosis by Campylobacter jejuni is correlated with invasion ability and is independent of cytolethal distending toxin.
Microbiology (Reading, England).
2007 Sep; 153(Pt 9):2952-2963. doi:
10.1099/mic.0.2006/003962-0. [PMID: 17768238] - Travis C Jackson, Zaichuan Mi, Sheldon I Bastacky, Teresa McHale, Mona F Melhem, Prajakta A Sonalker, Stevan P Tofovic, Edwin K Jackson. PPAR alpha agonists improve renal preservation in kidneys subjected to chronic in vitro perfusion: interaction with mannitol.
Transplant international : official journal of the European Society for Organ Transplantation.
2007 Mar; 20(3):277-90. doi:
10.1111/j.1432-2277.2006.00431.x. [PMID: 17291221] - Martyna Songin, Henryk Jeśko, Grzegorz Czapski, Agata Adamczyk, Robert P Strosznajder. GSK-3beta and oxidative stress in aged brain. Role of poly(ADP- -ribose) polymerase-1.
Folia neuropathologica.
2007; 45(4):220-9. doi:
". [PMID: 18176896] - Claudia Cerella, Cristina Mearelli, Sergio Ammendola, Milena De Nicola, Maria D'Alessio, Andrea Magrini, Antonio Bergamaschi, Lina Ghibelli. Molecular determinants involved in the increase of damage-induced apoptosis and delay of secondary necrosis due to inhibition of mono(ADP-ribosyl)ation.
Annals of the New York Academy of Sciences.
2006 Dec; 1090(?):50-8. doi:
10.1196/annals.1378.005. [PMID: 17384246] - Grzegorz A Czapski, Magdalena Cakala, Barbara Gajkowska, Joanna B Strosznajder. Poly(ADP-ribose) polymerase-1 inhibition protects the brain against systemic inflammation.
Neurochemistry international.
2006 Dec; 49(8):751-5. doi:
10.1016/j.neuint.2006.06.006. [PMID: 16904242] - Emanuela Mazzon, Tiziana Genovese, Rosanna Di Paola, Carmelo Muià, Concetta Crisafulli, Giuseppe Malleo, Emanuela Esposito, Rosaria Meli, Edoardo Sessa, Salvatore Cuzzocrea. Effects of 3-aminobenzamide, an inhibitor of poly (ADP-ribose) polymerase, in a mouse model of acute pancreatitis induced by cerulein.
European journal of pharmacology.
2006 Nov; 549(1-3):149-56. doi:
10.1016/j.ejphar.2006.08.008. [PMID: 16979620] - Csaba Szabó, Alisha Biser, Rita Benko, Erwin Böttinger, Katalin Suszták. Poly(ADP-ribose) polymerase inhibitors ameliorate nephropathy of type 2 diabetic Leprdb/db mice.
Diabetes.
2006 Nov; 55(11):3004-12. doi:
10.2337/db06-0147. [PMID: 17065336] - Joseph A De Soto, Chu-Xia Deng. PARP-1 inhibitors: are they the long-sought genetically specific drugs for BRCA1/2-associated breast cancers?.
International journal of medical sciences.
2006 Jul; 3(4):117-23. doi:
10.7150/ijms.3.117. [PMID: 16906222] - Mairéad A Carroll, Anabel B Doumad, Jing Li, Monica K Cheng, J R Falck, John C McGiff. Adenosine2A receptor vasodilation of rat preglomerular microvessels is mediated by EETs that activate the cAMP/PKA pathway.
American journal of physiology. Renal physiology.
2006 Jul; 291(1):F155-61. doi:
10.1152/ajprenal.00231.2005. [PMID: 16478979] - Chi-Hsiao Yeh, Tzu-Ping Chen, Chieh-Hung Lee, Yi-Chen Wu, Yu-Min Lin, Pyng Jing Lin. Inhibition of poly(adp-ribose) polymerase reduces cardiomyocytic apoptosis after global cardiac arrest under cardiopulmonary bypass.
Shock (Augusta, Ga.).
2006 Feb; 25(2):168-75. doi:
10.1097/01.shk.0000188709.04777.48. [PMID: 16525356] - Joseph A De Soto, Xianyan Wang, Yohei Tominaga, Rui-Hong Wang, Liu Cao, Wenhui Qiao, Cuiling Li, Xiaoling Xu, Amanda P Skoumbourdis, Sheila A Prindiville, Craig J Thomas, Chu-Xia Deng. The inhibition and treatment of breast cancer with poly (ADP-ribose) polymerase (PARP-1) inhibitors.
International journal of biological sciences.
2006; 2(4):179-85. doi:
10.7150/ijbs.2.179. [PMID: 16810332] - Seong-Ho Koh, Dae-Il Chang, Hee-Tae Kim, Juhan Kim, Myung-Ho Kim, Kyung Suk Kim, Inhee Bae, Haekwon Kim, Dong Won Kim, Seung Hyun Kim. Effect of 3-aminobenzamide, PARP inhibitor, on matrix metalloproteinase-9 level in plasma and brain of ischemic stroke model.
Toxicology.
2005 Oct; 214(1-2):131-9. doi:
10.1016/j.tox.2005.06.023. [PMID: 16085349] - Ruben A Mota, Francisco Sánchez-Bueno, Luis Saenz, David Hernández-Espinosa, Jaime Jimeno, Pedro L Tornel, Alejandro Martínez-Torrano, Pablo Ramírez, Pascual Parrilla, José Yélamos. Inhibition of poly(ADP-ribose) polymerase attenuates the severity of acute pancreatitis and associated lung injury.
Laboratory investigation; a journal of technical methods and pathology.
2005 Oct; 85(10):1250-62. doi:
10.1038/labinvest.3700326. [PMID: 16127429] - Rosanna Di Paola, Emanuela Mazzon, Carmelo Muià, Tiziana Genovese, Marta Menegazzi, Raffaela Zaffini, Hisanory Suzuki, Salvatore Cuzzocrea. Green tea polyphenol extract attenuates lung injury in experimental model of carrageenan-induced pleurisy in mice.
Respiratory research.
2005 Jun; 6(?):66. doi:
10.1186/1465-9921-6-66. [PMID: 15987519] - Dinçer Avlan, Ali Unlü, Lokman Ayaz, Handan Camdeviren, Ali Nayci, Selim Aksöyek. Poly (adp-ribose) synthetase inhibition reduces oxidative and nitrosative organ damage after thermal injury.
Pediatric surgery international.
2005 Jun; 21(6):449-55. doi:
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Pharmacological research.
2005 May; 51(5):453-62. doi:
10.1016/j.phrs.2004.11.007. [PMID: 15749460] - Dinçer Avlan, Hakan Taşkinlar, Ali Unlü, Candan Oztürk, Leyla Cinel, Ali Nayci, Ismail Cinel, Selim Aksöyek. The role of poly(ADP-ribose) synthetase inhibition on the intestinal mucosal barrier after thermal injury.
Burns : journal of the International Society for Burn Injuries.
2004 Dec; 30(8):785-92. doi:
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American journal of physiology. Lung cellular and molecular physiology.
2004 Oct; 287(4):L867-78. doi:
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The Journal of pharmacology and experimental therapeutics.
2004 Sep; 310(3):1114-24. doi:
10.1124/jpet.104.068932. [PMID: 15113847] - Rainer Kiefmann, Kai Heckel, Martina Doerger, Sonja Schenkat, Christian Kupatt, Mechthild Stoeckelhuber, Józefa Wesierska-Gadek, Alwin E Goetz. Role of PARP on iNOS pathway during endotoxin-induced acute lung injury.
Intensive care medicine.
2004 Jul; 30(7):1421-31. doi:
10.1007/s00134-004-2301-x. [PMID: 15197441] - Irina G Obrosova, Alexander G Minchenko, Robert N Frank, Gail M Seigel, Zsuzsanna Zsengeller, Pál Pacher, Martin J Stevens, Csaba Szabó. Poly(ADP-ribose) polymerase inhibitors counteract diabetes- and hypoxia-induced retinal vascular endothelial growth factor overexpression.
International journal of molecular medicine.
2004 Jul; 14(1):55-64. doi:
10.3892/ijmm.14.1.55. [PMID: 15202016] - Grzegorz A Czapski, Magdalena Cakala, Dorota Kopczuk, Joanna B Strosznajder. Effect of poly(ADP-ribose) polymerase inhibitors on oxidative stress evoked hydroxyl radical level and macromolecules oxidation in cell free system of rat brain cortex.
Neuroscience letters.
2004 Feb; 356(1):45-8. doi:
10.1016/j.neulet.2003.11.022. [PMID: 14746898] - Csaba Szabó, Pál Pacher, Zsuzsanna Zsengellér, Anne Vaslin, Katalin Komjáti, Rita Benkö, Min Chen, Jon G Mabley, Márk Kollai. Angiotensin II-mediated endothelial dysfunction: role of poly(ADP-ribose) polymerase activation.
Molecular medicine (Cambridge, Mass.).
2004 Jan; 10(1-6):28-35. doi:
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Free radical biology & medicine.
2003 Oct; 35(8):966-77. doi:
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International journal of molecular medicine.
2003 Oct; 12(4):533-40. doi:
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Pharmacological research.
2003 Aug; 48(2):139-49. doi:
10.1016/s1043-6618(03)00100-2. [PMID: 12798666] - Alexander G Minchenko, Martin J Stevens, Lauren White, Omorodola I Abatan, Katalin Komjáti, Pal Pacher, Csaba Szabó, Irina G Obrosova. Diabetes-induced overexpression of endothelin-1 and endothelin receptors in the rat renal cortex is mediated via poly(ADP-ribose) polymerase activation.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
2003 Aug; 17(11):1514-6. doi:
10.1096/fj.03-0013fje. [PMID: 12824290] - Basilia Zingarelli, Michael O'Connor, Paul W Hake. Inhibitors of poly (ADP-ribose) polymerase modulate signal transduction pathways in colitis.
European journal of pharmacology.
2003 May; 469(1-3):183-94. doi:
10.1016/s0014-2999(03)01726-6. [PMID: 12782201] - Murat Bozlu, Gülçin Eskandari, Selahittin Cayan, Bülent Canpolat, Erdem Akbay, Uğur Atik. The effect of poly (adenosine diphosphate-ribose) polymerase inhibitors on biochemical changes in testicular ischemia-reperfusion injury.
The Journal of urology.
2003 May; 169(5):1870-3. doi:
10.1097/01.ju.0000049228.37887.4d. [PMID: 12686864] - Yingchang Mi, Shelia D Thomas, Xiaohua Xu, Lavona K Casson, Donald M Miller, Paula J Bates. Apoptosis in leukemia cells is accompanied by alterations in the levels and localization of nucleolin.
The Journal of biological chemistry.
2003 Mar; 278(10):8572-9. doi:
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Free radical research.
2003 Mar; 37(3):331-9. doi:
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Critical care medicine.
2003 Feb; 31(2):353-8. doi:
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Pharmacology & toxicology.
2003 Jan; 92(1):43-50. doi:
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Nephron. Physiology.
2003; 95(1):p1-9. doi:
10.1159/000073023. [PMID: 14520006] - Ismail Cinel, Kanso Buyukafsar, Leyla Cinel, Ayşe Polat, Sebnem Atici, Lulufer Tamer, Ugur Oral. The role of poly(ADP-ribose) synthetase inhibition in preventing endotoxemia-induced intestinal epithelial apoptosis.
Pharmacological research.
2002 Aug; 46(2):119-27. doi:
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Pharmacological research.
2002 Jul; 46(1):67-73. doi:
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Developmental cell.
2002 Jul; 3(1):51-61. doi:
10.1016/s1534-5807(02)00200-9. [PMID: 12110167] - Prakash Jagtap, Francisco Garcia Soriano, László Virág, Lucas Liaudet, Jon Mabley, Eva Szabó, György Haskó, Anita Marton, Clara Batista Lorigados, Ferenc Gallyas, Balázs Sümegi, Dale G Hoyt, Erkan Baloglu, John VanDuzer, Andrew L Salzman, Garry J Southan, Csaba Szabó. Novel phenanthridinone inhibitors of poly (adenosine 5'-diphosphate-ribose) synthetase: potent cytoprotective and antishock agents.
Critical care medicine.
2002 May; 30(5):1071-82. doi:
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Genetika.
2002 Mar; 38(3):306-9. doi:
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Genetika.
2002 Mar; 38(3):422-5. doi:
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Neuroscience letters.
2001 Nov; 314(1-2):82-6. doi:
10.1016/s0304-3940(01)02273-x. [PMID: 11698152] - L Palomba, A Guidarelli, A I Scovassi, O Cantoni. Different effects of tert-butylhydroperoxide-induced peroxynitrite-dependent and -independent DNA single-strand breakage on PC12 cell poly(ADP-ribose) polymerase activity.
European journal of biochemistry.
2001 Oct; 268(20):5223-8. doi:
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Shock (Augusta, Ga.).
2001 Aug; 16(2):137-42. doi:
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Cellular and molecular neurobiology.
2001 Aug; 21(4):317-24. doi:
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Molecular pharmacology.
2001 Aug; 60(2):394-402. doi:
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American journal of physiology. Lung cellular and molecular physiology.
2001 Jul; 281(1):L243-9. doi:
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Molecular pharmacology.
2001 Jun; 59(6):1497-505. doi:
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Neurological research.
2001 Jun; 23(4):410-6. doi:
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Neurochemical research.
2001 Apr; 26(4):337-43. doi:
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Cancer chemotherapy and pharmacology.
2001 Apr; 47(4):361-9. doi:
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Molecular pharmacology.
2001 Jan; 59(1):16-23. doi:
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American journal of physiology. Regulatory, integrative and comparative physiology.
2000 Nov; 279(5):R1834-40. doi:
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PDA journal of pharmaceutical science and technology.
2000 Nov; 54(6):442-8. doi:
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The Journal of neuroscience : the official journal of the Society for Neuroscience.
2000 Sep; 20(18):6920-6. doi:
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