p-CHLOROAMPHETAMINE (BioDeep_00000272729)

   


代谢物信息卡片


p-CHLOROAMPHETAMINE

化学式: C9H12ClN (169.06582219999999)
中文名称:
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC(CC1=CC=C(C=C1)Cl)N
InChI: InChI=1S/C9H12ClN/c1-7(11)6-8-2-4-9(10)5-3-8/h2-5,7H,6,11H2,1H3

描述信息

D018377 - Neurotransmitter Agents > D018490 - Serotonin Agents

同义名列表

1 个代谢物同义名

p-CHLOROAMPHETAMINE



数据库引用编号

5 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。



文献列表

  • Eloir Gallegos, Marisol Ascona, Juana Monroy, Marta Elena Castro-Manrreza, Andrés Aragón-Martínez, María Elena Ayala. p-Chloroamphetamine decreases serotonin and induces apoptosis in granulosa cells and follicular atresia in prepubertal female rats. Reproductive toxicology (Elmsford, N.Y.). 2022 06; 110(?):150-160. doi: 10.1016/j.reprotox.2022.04.006. [PMID: 35460820]
  • Teri M Furlong, Lee S Leavitt, Kristen A Keefe, Jong-Hyun Son. Methamphetamine-, d-Amphetamine-, and p-Chloroamphetamine-Induced Neurotoxicity Differentially Effect Impulsive Responding on the Stop-Signal Task in Rats. Neurotoxicity research. 2016 May; 29(4):569-82. doi: 10.1007/s12640-016-9605-9. [PMID: 26846719]
  • Louis J De Felice, Krasnodara N Cameron. Comments on 'A quantitative model of amphetamine action on the serotonin transporter', by Sandtner et al., Br J Pharmacol 171: 1007-1018. British journal of pharmacology. 2015 Oct; 172(19):4772-4. doi: 10.1111/bph.12767. [PMID: 24824549]
  • D Schmid, X Koenig, S Bulusu, K Schicker, M Freissmuth, H H Sitte, W Sandtner. The conservative view: is it necessary to implant a stent into the dopamine transporter?. British journal of pharmacology. 2015 Oct; 172(19):4775-8. doi: 10.1111/bph.12766. [PMID: 24824446]
  • Luis García-García, Mercedes Delgado, Ahmed Anis Al-Sayed, Pablo Bascuñana, Rubén Fernández de la Rosa, Paloma Bermejo-Bescós, Sagrario Martín-Aragón, Miguel A Pozo. In vivo [¹⁸F] FDG PET imaging reveals that p-chloroamphetamine neurotoxicity is associated with long-term cortical and hippocampal hypometabolism. Molecular imaging and biology. 2015 Apr; 17(2):239-47. doi: 10.1007/s11307-014-0794-4. [PMID: 25267548]
  • Walter Sandtner, Diethart Schmid, Klaus Schicker, Klaus Gerstbrein, Xaver Koenig, Felix P Mayer, Stefan Boehm, Michael Freissmuth, Harald H Sitte. A quantitative model of amphetamine action on the 5-HT transporter. British journal of pharmacology. 2014 Feb; 171(4):1007-18. doi: 10.1111/bph.12520. [PMID: 24251585]
  • Tsz C Lin, Dong-Liang Lin, Ahai C Lua. Detection of p-chloroamphetamine in urine samples with mass spectrometry. Journal of analytical toxicology. 2011 May; 35(4):205-10. doi: 10.1093/anatox/35.4.205. [PMID: 21513613]
  • Julie L Wang, Shunichi Oya, Ajit K Parhi, Brian P Lieberman, Karl Ploessl, Catherine Hou, Hank F Kung. In vivo studies of the SERT-selective [18F]FPBM and VMAT2-selective [18F]AV-133 radiotracers in a rat model of Parkinson's disease. Nuclear medicine and biology. 2010 May; 37(4):479-86. doi: 10.1016/j.nucmedbio.2010.01.006. [PMID: 20447560]
  • Suzanne M Cloonan, John J Keating, Stephen G Butler, Andrew J S Knox, Anne M Jørgensen, Günther H Peters, Dilip Rai, Desmond Corrigan, David G Lloyd, D Clive Williams, Mary J Meegan. Synthesis and serotonin transporter activity of sulphur-substituted alpha-alkyl phenethylamines as a new class of anticancer agents. European journal of medicinal chemistry. 2009 Dec; 44(12):4862-88. doi: 10.1016/j.ejmech.2009.07.027. [PMID: 19717215]
  • Hitomi Kanno, Kyoji Sekiguchi, Takuji Yamaguchi, Kiyoshi Terawaki, Mitsutoshi Yuzurihara, Yoshio Kase, Yasushi Ikarashi. Effect of yokukansan, a traditional Japanese medicine, on social and aggressive behaviour of para-chloroamphetamine-injected rats. The Journal of pharmacy and pharmacology. 2009 Sep; 61(9):1249-56. doi: 10.1211/jpp/61.09.0016. [PMID: 19703376]
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  • Marian Geldof, Jan Freijer, Ludy van Beijsterveldt, Patrick C M Vermote, Anton A Megens, Meindert Danhof. Pharmacokinetic-pharmacodynamic modeling of the effect of fluvoxamine on p-chloroamphetamine-induced behavior. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. 2007 Nov; 32(3):200-8. doi: 10.1016/j.ejps.2007.07.004. [PMID: 17825539]
  • Tao Xie, Liqiong Tong, Michael W McLane, George Hatzidimitriou, Jie Yuan, Una McCann, George Ricaurte. Loss of serotonin transporter protein after MDMA and other ring-substituted amphetamines. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 2006 Dec; 31(12):2639-51. doi: 10.1038/sj.npp.1301031. [PMID: 16452989]
  • Annabelle M Belcher, Steven J O'Dell, John F Marshall. Impaired object recognition memory following methamphetamine, but not p-chloroamphetamine- or d-amphetamine-induced neurotoxicity. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 2005 Nov; 30(11):2026-34. doi: 10.1038/sj.npp.1300771. [PMID: 15900317]
  • Chung-Ren Jan. Effect of p-chloroamphetamine on calcium movement and viability in renal tubular cells. Life sciences. 2005 Jun; 77(5):589-99. doi: 10.1016/j.lfs.2004.11.031. [PMID: 15904675]
  • Holger Rosenbrock, Anita Bloching, Carmen Weiss, Franco Borsini. Partial serotonergic denervation decreases progenitor cell proliferation in the adult rat hippocampus, but has no effect on rat behavior in the forced swimming test. Pharmacology, biochemistry, and behavior. 2005 Apr; 80(4):549-56. doi: 10.1016/j.pbb.2005.01.018. [PMID: 15820524]
  • D J De Silva, S J French, N Y Cheung, A K Swinson, C Bendotti, M Rattray. Rat brain serotonin neurones that express neuronal nitric oxide synthase have increased sensitivity to the substituted amphetamine serotonin toxins 3,4-methylenedioxymethamphetamine and p-chloroamphetamine. Neuroscience. 2005; 134(4):1363-75. doi: 10.1016/j.neuroscience.2005.05.016. [PMID: 16054768]
  • Xin-Xian Ye, Jyh-Cheng Chen, Ren-Shen Liu, Shiaw-Pyng Wey, Jin-Shin Lee, Chia-Chieh Chen, Ying-Kai Fu, Gann Ting, Jeng-Jong Hwang. Microautoradiography of [123I]ADAM in mice treated with fluoxetine and serotonin reuptake inhibitors. Nuclear medicine and biology. 2004 Jul; 31(5):557-62. doi: 10.1016/j.nucmedbio.2003.12.002. [PMID: 15219272]
  • Kun-Ju Lin, Tzu-Chen Yen, Shiaw-Pyng Wey, Jeng-Jong Hwang, Xin-Xian Ye, Kai-Yuan Tzen, Ying-Kai Fu, Jin-Chung Chen. Characterization of the binding sites for 123I-ADAM and the relationship to the serotonin transporter in rat and mouse brains using quantitative autoradiography. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 2004 Apr; 45(4):673-81. doi: NULL. [PMID: 15073265]
  • Yossef Itzhak, Cindy N Achat-Mendes, Syed F Ali, Karen L Anderson. Long-lasting behavioral sensitization to psychostimulants following p-chloroamphetamine-induced neurotoxicity in mice. Neuropharmacology. 2004 Jan; 46(1):74-84. doi: 10.1016/s0028-3908(03)00316-2. [PMID: 14654099]
  • Richard B Rothman, Subramaniam Jayanthi, Xiaoying Wang, Christina M Dersch, Jean L Cadet, Thomas Prisinzano, Kenner C Rice, Michael H Baumann. High-dose fenfluramine administration decreases serotonin transporter binding, but not serotonin transporter protein levels, in rat forebrain. Synapse (New York, N.Y.). 2003 Dec; 50(3):233-9. doi: 10.1002/syn.10266. [PMID: 14515341]
  • M Gobbi, M Moia, L Pirona, I Ceglia, M Reyes-Parada, C Scorza, T Mennini. p-Methylthioamphetamine and 1-(m-chlorophenyl)piperazine, two non-neurotoxic 5-HT releasers in vivo, differ from neurotoxic amphetamine derivatives in their mode of action at 5-HT nerve endings in vitro. Journal of neurochemistry. 2002 Sep; 82(6):1435-43. doi: 10.1046/j.1471-4159.2002.01073.x. [PMID: 12354291]
  • F P Bymaster, L J Dreshfield-Ahmad, P G Threlkeld, J L Shaw, L Thompson, D L Nelson, S K Hemrick-Luecke, D T Wong. Comparative affinity of duloxetine and venlafaxine for serotonin and norepinephrine transporters in vitro and in vivo, human serotonin receptor subtypes, and other neuronal receptors. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 2001 Dec; 25(6):871-80. doi: 10.1016/s0893-133x(01)00298-6. [PMID: 11750180]
  • E J Manzana, W J Chen, T H Champney. Acute melatonin and para-chloroamphetamine interactions on pineal, brain and serum serotonin levels as well as stress hormone levels. Brain research. 2001 Aug; 909(1-2):127-37. doi: 10.1016/s0006-8993(01)02656-7. [PMID: 11478929]
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  • M J Millan, A Dekeyne, M Papp, C D La Rochelle, C MacSweeny, J L Peglion, M Brocco. S33005, a novel ligand at both serotonin and norepinephrine transporters: II. Behavioral profile in comparison with venlafaxine, reboxetine, citalopram, and clomipramine. The Journal of pharmacology and experimental therapeutics. 2001 Aug; 298(2):581-91. doi: . [PMID: 11454919]
  • F Fernandez, S Aguerre, P Mormède, F Chaouloff. Differential sensitivities to the lethal, but not the neurotoxic, effects of p-chloroamphetamine in inbred rat strains. Neuroscience letters. 2001 Jan; 297(1):53-7. doi: 10.1016/s0304-3940(00)01667-0. [PMID: 11114483]
  • A A Wilson, N Ginovart, M Schmidt, J H Meyer, P G Threlkeld, S Houle. Novel radiotracers for imaging the serotonin transporter by positron emission tomography: synthesis, radiosynthesis, and in vitro and ex vivo evaluation of (11)C-labeled 2-(phenylthio)araalkylamines. Journal of medicinal chemistry. 2000 Aug; 43(16):3103-10. doi: 10.1021/jm000079i. [PMID: 10956218]
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  • P Brown, M E Molliver. Dual serotonin (5-HT) projections to the nucleus accumbens core and shell: relation of the 5-HT transporter to amphetamine-induced neurotoxicity. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2000 Mar; 20(5):1952-63. doi: 10.1523/jneurosci.20-05-01952.2000. [PMID: 10684896]
  • H H Sitte, P Scholze, P Schloss, C Pifl, E A Singer. Characterization of carrier-mediated efflux in human embryonic kidney 293 cells stably expressing the rat serotonin transporter: a superfusion study. Journal of neurochemistry. 2000 Mar; 74(3):1317-24. doi: 10.1046/j.1471-4159.2000.741317.x. [PMID: 10693966]
  • I Misane, S O Ogren. Multiple 5-HT receptors in passive avoidance: comparative studies of p-chloroamphetamine and 8-OH-DPAT. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 2000 Feb; 22(2):168-90. doi: 10.1016/s0893-133x(99)00109-8. [PMID: 10649830]
  • M T Hsieh, Y T Lin, Y H Lin, C R Wu. Radix Angelica Sinensis extracts ameliorate scopolamine- and cycloheximide-induced amnesia, but not p-chloroamphetamine-induced amnesia in rats. The American journal of Chinese medicine. 2000; 28(2):263-72. doi: 10.1142/s0192415x00000313. [PMID: 10999445]
  • G A Jahn, V Kalia, D Hole, C A Wilson, R P Deis. Receptors and neurotransmitters involved in the dual modulation of prolactin release by the serotoninergic system in pregnant and lactating rats. Journal of reproduction and fertility. 1999 Jul; 116(2):261-8. doi: 10.1530/jrf.0.1160261. [PMID: 10615251]
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  • R I Westphalen, P R Dodd. Using the 5-HT transporter dependency of p-chloroamphetamine-stimulated 5-HT release to determine the nature of fenfluramine-induced 5-HT transporter loss. Annals of the New York Academy of Sciences. 1996 Oct; 801(?):168-73. doi: 10.1111/j.1749-6632.1996.tb17439.x. [PMID: 8959031]
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