nimetazepam (BioDeep_00000272706)
Volatile Flavor Compounds
代谢物信息卡片
化学式: C16H13N3O3 (295.0956868)
中文名称: 尼美西泮, 硝甲西泮
谱图信息:
最多检出来源 Viridiplantae(plant) 75%
分子结构信息
SMILES: CN1C(=O)CN=C(C2=C1C=CC(=C2)[N+](=O)[O-])C3=CC=CC=C3
InChI: InChI=1S/C16H13N3O3/c1-18-14-8-7-12(19(21)22)9-13(14)16(17-10-15(18)20)11-5-3-2-4-6-11/h2-9H,10H2,1H3
描述信息
D002491 - Central Nervous System Agents > D002492 - Central Nervous System Depressants > D006993 - Hypnotics and Sedatives
N - Nervous system > N05 - Psycholeptics > N05C - Hypnotics and sedatives > N05CD - Benzodiazepine derivatives
D002492 - Central Nervous System Depressants > D014149 - Tranquilizing Agents > D014151 - Anti-Anxiety Agents
D002491 - Central Nervous System Agents > D011619 - Psychotropic Drugs > D014149 - Tranquilizing Agents
C78272 - Agent Affecting Nervous System > C29756 - Sedative and Hypnotic > C1012 - Benzodiazepine
D018377 - Neurotransmitter Agents > D018682 - GABA Agents > D018757 - GABA Modulators
C78272 - Agent Affecting Nervous System > C28197 - Antianxiety Agent
D002491 - Central Nervous System Agents > D000927 - Anticonvulsants
同义名列表
2 个代谢物同义名
数据库引用编号
8 个数据库交叉引用编号
- ChEBI: CHEBI:31912
- KEGGdrug: D01593
- PubChem: 4496
- ChEMBL: CHEMBL13341
- CAS: 2011-67-8
- MoNA: FiehnHILIC002182
- MoNA: FiehnHILIC000615
- PMhub: MS000004210
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome.
Cell reports.
2021 04; 35(4):109040. doi:
10.1016/j.celrep.2021.109040. [PMID: 33910017] - Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
Molecular pharmacology.
2019 11; 96(5):629-640. doi:
10.1124/mol.119.115964. [PMID: 31515284] - Hei Hwa Lee, Jong Feng Lee, Sin Yu Lin, Yan Yin Lin, Chia Fang Wu, Ming Tsang Wu, Bai Hsiun Chen. Simultaneous quantification of urine flunitrazepam, nimetazepam and nitrazepam by using liquid chromatography tandem mass spectrometry.
Clinica chimica acta; international journal of clinical chemistry.
2013 May; 420(?):134-9. doi:
10.1016/j.cca.2012.10.023. [PMID: 23085494] - Kuang-Chuan Wang, Min-Chi Cheng, Chin-Lin Hsieh, Jung-Fa Hsu, Jen-Der Wu, Ching-Kuo Lee. Determination of nimetazepam and 7-aminonimetazepam in human urine by using liquid chromatography-tandem mass spectrometry.
Forensic science international.
2013 Jan; 224(1-3):84-9. doi:
10.1016/j.forsciint.2012.11.001. [PMID: 23245766] - Yasuto Kido, Pär Matsson, Kathleen M Giacomini. Profiling of a prescription drug library for potential renal drug-drug interactions mediated by the organic cation transporter 2.
Journal of medicinal chemistry.
2011 Jul; 54(13):4548-58. doi:
10.1021/jm2001629. [PMID: 21599003] - J Brandys, A Negrusz. Investigations of binding of nimetazepam and some other basic or acid drugs with human and bovine albumin.
Die Pharmazie.
1987 May; 42(5):350. doi:
NULL. [PMID: 2823298] - H Saito, H Kobayashi, S Takeno, T Sakai, H Ishii. In vivo and in vitro studies on fetal toxicity of benzodiazepines in rats.
Research communications in chemical pathology and pharmacology.
1986 Jun; 52(3):295-304. doi:
NULL. [PMID: 2874598] - H Saito, H Kobayashi, S Takeno, T Sakai. Fetal toxicity of benzodiazepines in rats.
Research communications in chemical pathology and pharmacology.
1984 Dec; 46(3):437-47. doi:
NULL. [PMID: 6151222] - A Kobiela. Polarographic determinations of nimetrazepam in serum and whole blood.
Die Pharmazie.
1977 Nov; 32(11):693-4. doi:
NULL. [PMID: 609588] - Y Yanagi, F Haga, M Endo, S Kitagawa. Comparative metabolic study of nimetazepam and its desmethyl derivative (nitrazepam) in dogs.
Xenobiotica; the fate of foreign compounds in biological systems.
1976 Feb; 6(2):101-12. doi:
10.3109/00498257609151619. [PMID: 1274372]