CYTOSPORONE B (BioDeep_00000272651)
Main id: BioDeep_00000177876
PANOMIX_OTCML-2023 natural product
代谢物信息卡片
化学式: C18H26O5 (322.1780146)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CCCCCCCC(=O)C1=C(C=C(C=C1O)O)CC(=O)OCC
InChI: InChI=1S/C18H26O5/c1-3-5-6-7-8-9-15(20)18-13(11-17(22)23-4-2)10-14(19)12-16(18)21/h10,12,19,21H,3-9,11H2,1-2H3
描述信息
Cytosporone B (Csn-B; Dothiorelone G) is a naturally occurring nuclear orphan receptor Nur77/NR4A1 agonist with an EC50 of 0.278 nM.
同义名列表
3 个代谢物同义名
数据库引用编号
8 个数据库交叉引用编号
- ChEBI: CHEBI:95039
- PubChem: 10687292
- ChEMBL: CHEMBL1221517
- KNApSAcK: C00033748
- CAS: 321661-62-5
- PMhub: MS000004054
- medchemexpress: HY-N2148
- LOTUS: LTS0075422
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
11 个相关的物种来源信息
- 4890 - Ascomycota: LTS0075422
- 117544 - Cytospora: 10.1021/OL006680S
- 117544 - Cytospora: LTS0075422
- 767018 - Diaporthaceae: LTS0075422
- 36922 - Diaporthe: 10.1021/OL006680S
- 36922 - Diaporthe: LTS0075422
- 2759 - Eukaryota: LTS0075422
- 4751 - Fungi: LTS0075422
- 34399 - Phomopsis: 10.1016/J.PHYTOCHEM.2008.02.002
- 147550 - Sordariomycetes: LTS0075422
- 5117 - Valsaceae: LTS0075422
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:
- PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。
文献列表
- M-F Ma, Z-Y Chen, L-J Wang, N Li, B-Y Guo. Orphan nuclear receptor 4 A1 involvement in transforming growth factor beta1-induced myocardial fibrosis in diabetic mice.
Journal of physiology and pharmacology : an official journal of the Polish Physiological Society.
2023 Dec; 74(6):. doi:
10.26402/jpp.2023.6.04
. [PMID: 38345443] - Peng-Bo Yang, Pei-Pei Hou, Fu-Yuan Liu, Wen-Bin Hong, Hang-Zi Chen, Xiao-Yu Sun, Peng Li, Yi Zhang, Cui-Yu Ju, Li-Juan Luo, Sheng-Fu Wu, Jia-Xin Zhou, Zhi-Jing Wang, Jian-Ping He, Li Li, Tong-Jin Zhao, Xianming Deng, Tianwei Lin, Qiao Wu. Blocking PPARγ interaction facilitates Nur77 interdiction of fatty acid uptake and suppresses breast cancer progression.
Proceedings of the National Academy of Sciences of the United States of America.
2020 11; 117(44):27412-27422. doi:
10.1073/pnas.2002997117
. [PMID: 33087562] - Chunxiao Yin, Hongxin Liu, Yang Shan, Vijai Kumar Gupta, Yueming Jiang, Weimin Zhang, Haibo Tan, Liang Gong. Cytosporone B as a Biological Preservative: Purification, Fungicidal Activity and Mechanism of Action against Geotrichum citri-aurantii.
Biomolecules.
2019 03; 9(4):. doi:
10.3390/biom9040125
. [PMID: 30934892] - Alexandre Brunet, Manon LeBel, Benoit Egarnes, Carine Paquet-Bouchard, Anne-Julie Lessard, Jacques P Brown, Jean Gosselin. NR4A1-dependent Ly6Clow monocytes contribute to reducing joint inflammation in arthritic mice through Treg cells.
European journal of immunology.
2016 12; 46(12):2789-2800. doi:
10.1002/eji.201646406
. [PMID: 27600773] - Yujie Jiang, Yi Zeng, Xia Huang, Yueqiu Qin, Weigui Luo, Shulin Xiang, Suren R Sooranna, Liao Pinhu. Nur77 attenuates endothelin-1 expression via downregulation of NF-κB and p38 MAPK in A549 cells and in an ARDS rat model.
American journal of physiology. Lung cellular and molecular physiology.
2016 Dec; 311(6):L1023-L1035. doi:
10.1152/ajplung.00043.2016
. [PMID: 27765761] - Xina Xie, Xuhong Song, Song Yuan, Haitao Cai, Yequn Chen, Xiaolan Chang, Bin Liang, Dongyang Huang. Histone acetylation regulates orphan nuclear receptor NR4A1 expression in hypercholesterolaemia.
Clinical science (London, England : 1979).
2015 Dec; 129(12):1151-61. doi:
10.1042/cs20150346
. [PMID: 26396259] - Jingjing Luan, Dianrui Zhang, Leilei Hao, Lisi Qi, Xinquan Liu, Hejian Guo, Caiyun Li, Yuanyuan Guo, Tingting Li, Qiang Zhang, Guangxi Zhai. Preparation, characterization and pharmacokinetics of Amoitone B-loaded long circulating nanostructured lipid carriers.
Colloids and surfaces. B, Biointerfaces.
2014 Feb; 114(?):255-60. doi:
10.1016/j.colsurfb.2013.10.018
. [PMID: 24211416] - Yan-Wei Hu, Peng Zhang, Jun-Yao Yang, Jin-Lan Huang, Xin Ma, Shu-Fen Li, Jia-Yi Zhao, Ya-Rong Hu, Yan-Chao Wang, Ji-Juan Gao, Yan-Hua Sha, Lei Zheng, Qian Wang. Nur77 decreases atherosclerosis progression in apoE(-/-) mice fed a high-fat/high-cholesterol diet.
PloS one.
2014; 9(1):e87313. doi:
10.1371/journal.pone.0087313
. [PMID: 24498071]