proadifen (BioDeep_00000272645)

   


代谢物信息卡片


proadifen

化学式: C23H31NO2 (353.2354666)
中文名称:
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CCCC(C(=O)OCCN(CC)CC)(c1ccccc1)c1ccccc1
InChI: InChI=1S/C23H31NO2/c1-4-17-23(20-13-9-7-10-14-20,21-15-11-8-12-16-21)22(25)26-19-18-24(5-2)6-3/h7-16H,4-6,17-19H2,1-3H3

描述信息

C471 - Enzyme Inhibitor > C29574 - Nitric Oxide Synthase Inhibitor
D004791 - Enzyme Inhibitors

同义名列表

1 个代谢物同义名

proadifen



数据库引用编号

7 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。



文献列表

  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
  • Weicang Wang, Jun Yang, Matthew L Edin, Yuxin Wang, Ying Luo, Debin Wan, Haixia Yang, Chun-Qing Song, Wen Xue, Katherine Z Sanidad, Mingyue Song, Heather A Bisbee, Jennifer A Bradbury, Guanjun Nan, Jianan Zhang, Pei-An Betty Shih, Kin Sing Stephen Lee, Lisa M Minter, Daeyoung Kim, Hang Xiao, Jun-Yan Liu, Bruce D Hammock, Darryl C Zeldin, Guodong Zhang. Targeted Metabolomics Identifies the Cytochrome P450 Monooxygenase Eicosanoid Pathway as a Novel Therapeutic Target of Colon Tumorigenesis. Cancer research. 2019 04; 79(8):1822-1830. doi: 10.1158/0008-5472.can-18-3221. [PMID: 30803995]
  • Daniel J Warner, Hongming Chen, Louis-David Cantin, J Gerry Kenna, Simone Stahl, Clare L Walker, Tobias Noeske. Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification. Drug metabolism and disposition: the biological fate of chemicals. 2012 Dec; 40(12):2332-41. doi: 10.1124/dmd.112.047068. [PMID: 22961681]
  • Wan-Ling Chang-Liao, Chao-Feng Chien, Lie-Chwen Lin, Tung-Hu Tsai. Isolation of gentiopicroside from Gentianae Radix and its pharmacokinetics on liver ischemia/reperfusion rats. Journal of ethnopharmacology. 2012 Jun; 141(2):668-73. doi: 10.1016/j.jep.2011.08.001. [PMID: 21855624]
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  • Hang Ruan, Zhen Zhang, Xin-fang Liang, Yan Fu, Mei-qin Su, Qi-lin Liu, Xiu-min Wang, Xuan Zhu. Metabolism of dl-praeruptorin A in rat liver microsomes using HPLC-electrospray ionization tandem mass spectrometry. Archives of pharmacal research. 2011 Aug; 34(8):1311-21. doi: 10.1007/s12272-011-0811-y. [PMID: 21910053]
  • Yasuhiro Ishihara, Satomi Ishii, Yufu Sakai, Nobue Yamamura, Yukiko Onishi, Norio Shimamoto. Crucial role of cytochrome P450 in hepatotoxicity induced by 2,3-dimethoxy-1,4-naphthoquinone in rats. Journal of applied toxicology : JAT. 2011 Mar; 31(2):173-8. doi: 10.1002/jat.1578. [PMID: 20803752]
  • Delphine Waniusiow, Pierre Campo, Thomas Venet, Benoît Cossec, Frédéric Cosnier, Dominique Beydon, Benoît Rieger, Manuella Burgart, Luc Ferrari, Cécile Parietti-Winkler. Toluene-induced hearing loss in the guinea pig. Toxicological sciences : an official journal of the Society of Toxicology. 2009 Oct; 111(2):362-71. doi: 10.1093/toxsci/kfp169. [PMID: 19635754]
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  • Soo K Bae, Eun J Kim, Jong W Kwon, Won B Kim, Inchul Lee, Myung G Lee. Excretion and metabolism of DA-7867, a new oxazolidinone, in rats. Biopharmaceutics & drug disposition. 2005 Mar; 26(2):67-75. doi: 10.1002/bdd.434. [PMID: 15617136]
  • Pi-Lo Tsai, Tung-Hu Tsai. Pharmacokinetics of baicalin in rats and its interactions with cyclosporin A, quinidine and SKF-525A: a microdialysis study. Planta medica. 2004 Nov; 70(11):1069-74. doi: 10.1055/s-2004-832649. [PMID: 15549664]
  • Alan H Tseng, Joseph W Harding, Rebecca M Craft. Pharmacokinetic factors in sex differences in Delta 9-tetrahydrocannabinol-induced behavioral effects in rats. Behavioural brain research. 2004 Sep; 154(1):77-83. doi: 10.1016/j.bbr.2004.01.029. [PMID: 15302113]
  • Hiroko Moroe, Hiroyuki Fujii, Hideo Honda, Katsunori Arai, Masao Kanazawa, Yoko Notoya, Hiroshi Kogo. Characterization of endothelium-dependent relaxation and modulation by treatment with pioglitazone in the hypercholesterolemic rabbit renal artery. European journal of pharmacology. 2004 Aug; 497(3):317-25. doi: 10.1016/j.ejphar.2004.06.062. [PMID: 15336950]
  • P Fernández, L Buján, A M Bermejo, M J Tabernero. Gas chromatographic determination of cocaine and its metabolites in blood and urine from cocaine users in northwestern Spain. Journal of applied toxicology : JAT. 2004 Jul; 24(4):283-7. doi: 10.1002/jat.994. [PMID: 15300716]
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  • Hiroto Matsuda, Koichi Hayashi, Shu Wakino, Eiji Kubota, Masanori Honda, Hirobumi Tokuyama, Ichiro Takamatsu, Satoru Tatematsu, Takao Saruta. Role of endothelium-derived hyperpolarizing factor in ACE inhibitor-induced renal vasodilation in vivo. Hypertension (Dallas, Tex. : 1979). 2004 Mar; 43(3):603-9. doi: 10.1161/01.hyp.0000118053.42262.71. [PMID: 14769805]
  • Nina Doroshenko, Petro Doroshenko. Ca2+ influx is not involved in acute cytotoxicity of arachidonic acid. Biochemical pharmacology. 2004 Mar; 67(5):903-9. doi: 10.1016/j.bcp.2003.10.005. [PMID: 15104243]
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  • Vincent Tong, Thomas K H Chang, Jie Chen, Frank S Abbott. The effect of valproic acid on hepatic and plasma levels of 15-F2t-isoprostane in rats. Free radical biology & medicine. 2003 Jun; 34(11):1435-46. doi: 10.1016/s0891-5849(03)00151-5. [PMID: 12757854]
  • Marina Sergeeva, Mikhail Strokin, Hong Wang, Joachim J Ubl, Georg Reiser. Arachidonic acid in astrocytes blocks Ca(2+) oscillations by inhibiting store-operated Ca(2+) entry, and causes delayed Ca(2+) influx. Cell calcium. 2003 Apr; 33(4):283-92. doi: 10.1016/s0143-4160(03)00011-3. [PMID: 12618149]
  • Fábio E Mingatto, Tiago Rodrigues, Acácio A Pigoso, Sérgio A Uyemura, Carlos Curti, Antonio C Santos. The critical role of mitochondrial energetic impairment in the toxicity of nimesulide to hepatocytes. The Journal of pharmacology and experimental therapeutics. 2002 Nov; 303(2):601-7. doi: 10.1124/jpet.102.038620. [PMID: 12388641]
  • R A Towner, R P Mason, L A Reinke. In vivo detection of aflatoxin-induced lipid free radicals in rat bile. Biochimica et biophysica acta. 2002 Oct; 1573(1):55-62. doi: 10.1016/s0304-4165(02)00326-4. [PMID: 12383942]
  • Ramez Labib, Rita Turkall, Mohamed S Abdel-Rahman. Inhibition of cocaine oxidative metabolism attenuates endotoxin potentiation of cocaine mediated hepatotoxicity. Toxicology. 2002 Sep; 179(1-2):9-19. doi: 10.1016/s0300-483x(02)00247-0. [PMID: 12204538]
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  • Hirokazu Doi, Hiromi Iwasaki, Yasuhiro Masubuchi, Ryuichiro Nishigaki, Toshiharu Horie. Chemiluminescence associated with the oxidative metabolism of salicylic acid in rat liver microsomes. Chemico-biological interactions. 2002 May; 140(2):109-19. doi: 10.1016/s0009-2797(02)00004-2. [PMID: 12076519]
  • Jianxin Sun, XinXin Sui, J Alyce Bradbury, Darryl C Zeldin, Michael S Conte, James K Liao. Inhibition of vascular smooth muscle cell migration by cytochrome p450 epoxygenase-derived eicosanoids. Circulation research. 2002 May; 90(9):1020-7. doi: 10.1161/01.res.0000017727.35930.33. [PMID: 12016269]
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  • A I Archakov, I I Karuzina, N A Petushkova, A V Lisitsa, V G Zgoda. Production of carbon monoxide by cytochrome P450 during iron-dependent lipid peroxidation. Toxicology in vitro : an international journal published in association with BIBRA. 2002 Feb; 16(1):1-10. doi: 10.1016/s0887-2333(01)00094-7. [PMID: 11812634]
  • B S Cummings, J C Parker, L H Lash. Cytochrome p450-dependent metabolism of trichloroethylene in rat kidney. Toxicological sciences : an official journal of the Society of Toxicology. 2001 Mar; 60(1):11-9. doi: 10.1093/toxsci/60.1.11. [PMID: 11222868]
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