PYROVALERONE (BioDeep_00000272570)

   

Volatile Flavor Compounds


代谢物信息卡片


PYROVALERONE

化学式: C16H23NO (245.17795479999998)
中文名称: 吡咯戊酮
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CCCC(C(=O)C1=CC=C(C=C1)C)N2CCCC2
InChI: InChI=1S/C16H23NO/c1-3-6-15(17-11-4-5-12-17)16(18)14-9-7-13(2)8-10-14/h7-10,15H,3-6,11-12H2,1-2H3

描述信息

D002491 - Central Nervous System Agents > D000697 - Central Nervous System Stimulants
C78272 - Agent Affecting Nervous System > C47795 - CNS Stimulant

同义名列表

2 个代谢物同义名

PYROVALERONE; Pyrovalerone



数据库引用编号

6 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Karolina E Kolaczynska, Jan Thomann, Marius C Hoener, Matthias E Liechti. The Pharmacological Profile of Second Generation Pyrovalerone Cathinones and Related Cathinone Derivative. International journal of molecular sciences. 2021 Jul; 22(15):. doi: 10.3390/ijms22158277. [PMID: 34361040]
  • Christopher Laurence Souders, Robert H Davis, Hua Qing, Xuefang Liang, Marcelo Febo, Christopher J Martyniuk. The psychoactive cathinone derivative pyrovalerone alters locomotor activity and decreases dopamine receptor expression in zebrafish (Danio rerio). Brain and behavior. 2019 11; 9(11):e01420. doi: 10.1002/brb3.1420. [PMID: 31625691]
  • Jakub Wojcieszak, Dariusz Andrzejczak, Marta Kedzierska, Katarzyna Milowska, Jolanta B Zawilska. Cytotoxicity of α-Pyrrolidinophenones: an Impact of α-Aliphatic Side-chain Length and Changes in the Plasma Membrane Fluidity. Neurotoxicity research. 2018 Oct; 34(3):613-626. doi: 10.1007/s12640-018-9923-1. [PMID: 29951896]
  • Olof Beck, Matilda Bäckberg, Patrick Signell, Anders Helander. Intoxications in the STRIDA project involving a panorama of psychostimulant pyrovalerone derivatives, MDPV copycats. Clinical toxicology (Philadelphia, Pa.). 2018 04; 56(4):256-263. doi: 10.1080/15563650.2017.1370097. [PMID: 28895757]
  • Toshiyuki Matsunaga, Yoshifumi Morikawa, Kyohei Kamata, Akinobu Shibata, Hidetoshi Miyazono, Yasuhide Sasajima, Koichi Suenami, Kiyohito Sato, Yuji Takekoshi, Satoshi Endo, Ossama El-Kabbani, Akira Ikari. α-Pyrrolidinononanophenone provokes apoptosis of neuronal cells through alterations in antioxidant properties. Toxicology. 2017 07; 386(?):93-102. doi: 10.1016/j.tox.2017.05.017. [PMID: 28578026]
  • Barbara Potocka-Banaś, Tomasz Janus, Sławomir Majdanik, Tomasz Banaś, Teresa Dembińska, Krzysztof Borowiak. Fatal Intoxication with α-PVP, a Synthetic Cathinone Derivative. Journal of forensic sciences. 2017 Mar; 62(2):553-556. doi: 10.1111/1556-4029.13326. [PMID: 28028802]
  • V N Bekhterev, S N Gavrilova, E V Koshkareva, I N Shipanov. [The determination of pyrovaleron in the urine by gas chromatography in the combination with the method of extractive chilling-out and centrifugation]. Sudebno-meditsinskaia ekspertiza. 2017 ; 60(3):27-31. doi: 10.17116/sudmed201760327-31. [PMID: 28656950]
  • Bertha K Madras. The Growing Problem of New Psychoactive Substances (NPS). Current topics in behavioral neurosciences. 2017 ; 32(?):1-18. doi: 10.1007/7854_2016_34. [PMID: 27571747]
  • Anna Rickli, Marius C Hoener, Matthias E Liechti. Monoamine transporter and receptor interaction profiles of novel psychoactive substances: para-halogenated amphetamines and pyrovalerone cathinones. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. 2015 Mar; 25(3):365-76. doi: 10.1016/j.euroneuro.2014.12.012. [PMID: 25624004]
  • Jane M Prosser, Lewis S Nelson. The toxicology of bath salts: a review of synthetic cathinones. Journal of medical toxicology : official journal of the American College of Medical Toxicology. 2012 Mar; 8(1):33-42. doi: 10.1007/s13181-011-0193-z. [PMID: 22108839]
  • Christoph Sauer, Kerstin Hoffmann, Ulrich Schimmel, Frank T Peters. Acute poisoning involving the pyrrolidinophenone-type designer drug 4'-methyl-alpha-pyrrolidinohexanophenone (MPHP). Forensic science international. 2011 May; 208(1-3):e20-5. doi: 10.1016/j.forsciint.2011.02.026. [PMID: 21444164]
  • Sabina Strano-Rossi, Amy B Cadwallader, Xavier de la Torre, Francesco Botrè. Toxicological determination and in vitro metabolism of the designer drug methylenedioxypyrovalerone (MDPV) by gas chromatography/mass spectrometry and liquid chromatography/quadrupole time-of-flight mass spectrometry. Rapid communications in mass spectrometry : RCM. 2010 Sep; 24(18):2706-14. doi: 10.1002/rcm.4692. [PMID: 20814976]
  • David J Lapinsky, Shaili Aggarwal, Yurong Huang, Christopher K Surratt, John R Lever, James D Foster, Roxanne A Vaughan. A novel photoaffinity ligand for the dopamine transporter based on pyrovalerone. Bioorganic & medicinal chemistry. 2009 Jun; 17(11):3770-4. doi: 10.1016/j.bmc.2009.04.057. [PMID: 19442525]
  • Peter C Meltzer, David Butler, Jeffrey R Deschamps, Bertha K Madras. 1-(4-Methylphenyl)-2-pyrrolidin-1-yl-pentan-1-one (Pyrovalerone) analogues: a promising class of monoamine uptake inhibitors. Journal of medicinal chemistry. 2006 Feb; 49(4):1420-32. doi: 10.1021/jm050797a. [PMID: 16480278]
  • A Tidjane Corera, J C Do-Régo, J Costentin, J J Bonnet. Differential sensitivity to NaCl for inhibitors and substrates that recognize mutually exclusive binding sites on the neuronal transporter of dopamine in rat striatal membranes. Neuroscience research. 2001 Mar; 39(3):319-25. doi: 10.1016/s0168-0102(00)00230-3. [PMID: 11248372]
  • D S Lho, J Lee, S Kim, J Park, H S Shin. Identification of a pyrovalerone metabolite in the rat by gas chromatography-mass spectrometry and determination of pyrovalerone by gas chromatography-nitrogen-phosphorus detection. Journal of chromatography. B, Biomedical applications. 1996 Dec; 687(1):253-9. doi: 10.1016/s0378-4347(96)00183-1. [PMID: 9001971]
  • H S Shin, Y S Shin, S Lee, B B Park. Detection and identification of pyrovalerone and its hydroxylated metabolite in the rat. Journal of analytical toxicology. 1996 Nov; 20(7):568-72. doi: 10.1093/jat/20.7.568. [PMID: 8934308]
  • C Héron, J Costentin, J J Bonnet. Evidence that pure uptake inhibitors including cocaine interact slowly with the dopamine neuronal carrier. European journal of pharmacology. 1994 Nov; 264(3):391-8. doi: 10.1016/0014-2999(94)00502-8. [PMID: 7698180]