Imidocarb (BioDeep_00000272292)

   


代谢物信息卡片


Imidocarb

化学式: C19H20N6O (348.169851)
中文名称:
谱图信息: 最多检出来源 Viridiplantae(plant) 95%

分子结构信息

SMILES: c1cc(cc(c1)NC(=O)Nc1cccc(c1)C1=NCCN1)C1=NCCN1
InChI: InChI=1S/C19H20N6O/c26-19(24-15-5-1-3-13(11-15)17-20-7-8-21-17)25-16-6-2-4-14(12-16)18-22-9-10-23-18/h1-6,11-12H,7-10H2,(H,20,21)(H,22,23)(H2,24,25,26)

描述信息

D000890 - Anti-Infective Agents > D000977 - Antiparasitic Agents > D000981 - Antiprotozoal Agents
C254 - Anti-Infective Agent > C276 - Antiparasitic Agent > C277 - Antiprotozoal Agent
CONFIDENCE standard compound; INTERNAL_ID 1170

同义名列表

1 个代谢物同义名

Imidocarb



数据库引用编号

20 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Honglei Wang, Chen Chen, Maolin Liu, Xiaojie Chen, Chunshuang Liu, Yanyan Feng, Xinbo Yan, Yiming Liu, Xiubo Li. Pharmacokinetics and bioequivalence of two imidocarb formulations in cattle after subcutaneous injection. PloS one. 2022; 17(6):e0270130. doi: 10.1371/journal.pone.0270130. [PMID: 35749453]
  • Ellie L Milnes, Pauline Delnatte, Murray Woodbury, Adam Hering, Sam Lee, Dale A Smith, Nicole M Nemeth, Yu Gu, Ronette Gehring, Ron Johnson. Pharmacokinetics of imidocarb dipropionate in white-tailed deer (Odocoileus virginianus) after single intramuscular administration. Journal of veterinary pharmacology and therapeutics. 2020 Jan; 43(1):33-37. doi: 10.1111/jvp.12760. [PMID: 30933371]
  • Bruna Copat, Paulo Vinicius Bastiani, Fernanda Castellarin Jaconi, Wanderley Wallyson Damarem, André Felipe Streck, Eduardo Conceição de Oliveira, Luciana Sonne, Raqueli Teresinha França. Presentation of hemolytic and hemorrhagic rangeliosis in Cerdocyon thous. Ticks and tick-borne diseases. 2019 04; 10(3):690-693. doi: 10.1016/j.ttbdis.2019.02.010. [PMID: 30852178]
  • L N Wise, L S Kappmeyer, M G Silva, S N White, J F Grause, D P Knowles. Verification of post-chemotherapeutic clearance of Theileria equi through concordance of nested PCR and immunoblot. Ticks and tick-borne diseases. 2018 02; 9(2):135-140. doi: 10.1016/j.ttbdis.2017.08.007. [PMID: 28887100]
  • Rovaina L Doyle, Alexandro Fritzen, Nathieli B Bottari, Mariana S Alves, Aniélen D da Silva, Vera M Morsch, Maria Rosa C Schetinger, João R Martins, Julsan S Santos, Gustavo Machado, Aleksandro S da Silva. Imidocarb dipropionate in the treatment of Anaplasma marginale in cattle: Effects on enzymes of the antioxidant, cholinergic, and adenosinergic systems. Microbial pathogenesis. 2016 Aug; 97(?):226-30. doi: 10.1016/j.micpath.2016.06.001. [PMID: 27301742]
  • G Rossi, J Kuleš, R Barić Rafaj, V Mrljak, S Lauzi, A Giordano, S Paltrinieri. Relationship between paraoxonase 1 activity and high density lipoprotein concentration during naturally occurring babesiosis in dogs. Research in veterinary science. 2014 Oct; 97(2):318-24. doi: 10.1016/j.rvsc.2014.07.010. [PMID: 25104322]
  • W Zygner, O Gójska-Zygner. Association between decreased blood pressure and azotaemia in canine babesiosis. Polish journal of veterinary sciences. 2014; 17(1):173-5. doi: 10.2478/pjvs-2014-0024. [PMID: 24724487]
  • Juanita F Grause, Massaro W Ueti, Jeffrey T Nelson, Donald P Knowles, Lowell S Kappmeyer, Thomas O Bunn. Efficacy of imidocarb dipropionate in eliminating Theileria equi from experimentally infected horses. Veterinary journal (London, England : 1997). 2013 Jun; 196(3):541-6. doi: 10.1016/j.tvjl.2012.10.025. [PMID: 23199699]
  • Ozlem Derinbay Ekici, Nermin Isik. Alterations of blood parameters after intramuscular administration of imidocarb in healthy lambs. Drug and chemical toxicology. 2012 Apr; 35(2):162-6. doi: 10.3109/01480545.2011.589449. [PMID: 21834689]
  • Kristen A Phair, James W Carpenter, Nicole Smee, Carl B Myers, Lisa M Pohlman. Severe anemia caused by babesiosis in a maned wolf (Chrysocyon brachyurus). Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians. 2012 Mar; 43(1):162-7. doi: 10.1638/2010-0210.1. [PMID: 22448525]
  • Aleksandro S Da Silva, Vinicius R Fanfa, Mateus A Otto, Lucas T Gressler, Kaio C S Tavares, Cícera R Lazzarotto, Alexandre A Tonin, Luiz C Miletti, Marta M M F Duarte, Silvia G Monteiro. Susceptibility of mice to Trypanosoma evansi treated with human plasma containing different concentrations of apolipoprotein L-1. The Korean journal of parasitology. 2011 Dec; 49(4):427-30. doi: 10.3347/kjp.2011.49.4.427. [PMID: 22355213]
  • Sergey A Staroverov, Vladimir A Sidorkin, Alexander S Fomin, Sergey Yu Shchyogolev, Lev A Dykman. Biodynamic parameters of micellar diminazene in sheep erythrocytes and blood plasma. Journal of veterinary science. 2011 Dec; 12(4):303-7. doi: 10.4142/jvs.2011.12.4.303. [PMID: 22122895]
  • Gunnar Hasle, Gunnar A Bjune, Dan Christensson, Knut H Røed, Anne C Whist, Hans P Leinaas. Detection of Babesia divergens in southern Norway by using an immunofluorescence antibody test in cow sera. Acta veterinaria Scandinavica. 2010 Oct; 52(?):55. doi: 10.1186/1751-0147-52-55. [PMID: 20925923]
  • Zhongjie Wang, Xiubo Li, Dan Su, Yijing Li, Lianyong Wu, Yongjian Wang, Wenxue Wu. Residue depletion of imidocarb in Swine tissue. Journal of agricultural and food chemistry. 2009 Mar; 57(6):2324-8. doi: 10.1021/jf803251j. [PMID: 19243130]
  • Ł Adaszek, S Winiarczyk, M Skrzypczak. The clinical course of babesiosis in 76 dogs infected with protozoan parasites Babesia canis canis. Polish journal of veterinary sciences. 2009; 12(1):81-7. doi: NULL. [PMID: 19459444]
  • A Máthé, M Dobos-Kovács, K Vörös. Histological and ultrastructural studies of renal lesions in Babesia canis infected dogs treated with imidocarb. Acta veterinaria Hungarica. 2007 Dec; 55(4):511-23. doi: 10.1556/avet.55.2007.4.10. [PMID: 18277710]
  • D Su, X B Li, Z J Wang, L Wang, W X Wu, J Q Xu. Pharmacokinetics and bioavailability of imidocarb dipropionate in swine. Journal of veterinary pharmacology and therapeutics. 2007 Aug; 30(4):366-70. doi: 10.1111/j.1365-2885.2007.00872.x. [PMID: 17610411]
  • Vesna Matijatko, Vladimir Mrljak, Ivana Kis, Nada Kucer, Jadranka Forsek, Tanja Zivicnjak, Zeljko Romić, Zoran Simec, Jose Joaquin Ceron. Evidence of an acute phase response in dogs naturally infected with Babesia canis. Veterinary parasitology. 2007 Mar; 144(3-4):242-50. doi: 10.1016/j.vetpar.2006.10.004. [PMID: 17116368]
  • C Belloli, O R Lai, P Ormas, C Zizzadoro, G Sasso, G Crescenzo. Pharmacokinetics and mammary elimination of imidocarb in sheep and goats. Journal of dairy science. 2006 Jul; 89(7):2465-72. doi: 10.3168/jds.s0022-0302(06)72320-7. [PMID: 16772563]
  • V Naidoo, E Zweygarth, J N Eloff, G E Swan. Identification of anti-babesial activity for four ethnoveterinary plants in vitro. Veterinary parasitology. 2005 Jun; 130(1-2):9-13. doi: 10.1016/j.vetpar.2005.03.001. [PMID: 15893064]
  • C Meyer, A J Guthrie, K B Stevens. Clinical and clinicopathological changes in 6 healthy ponies following intramuscular administration of multiple doses of imidocarb dipropionate. Journal of the South African Veterinary Association. 2005 Mar; 76(1):26-32. doi: 10.4102/jsava.v76i1.390. [PMID: 15900897]
  • A J Birkenheuer, J Neel, D Ruslander, M G Levy, E B Breitschwerdt. Detection and molecular characterization of a novel large Babesia species in a dog. Veterinary parasitology. 2004 Oct; 124(3-4):151-60. doi: 10.1016/j.vetpar.2004.07.008. [PMID: 15381295]
  • Allison D Tuttle, Adam J Birkenheuer, Tarja Juopperi, Michael G Levy, Edward B Breitschwerdt. Concurrent bartonellosis and babesiosis in a dog with persistent thrombocytopenia. Journal of the American Veterinary Medical Association. 2003 Nov; 223(9):1306-10, 1280. doi: 10.2460/javma.2003.223.1306. [PMID: 14621218]
  • Toyoko Katayama, Yasuhiro Hayashi, Kazuhiro Nagahira, Kyoko Konishi, Kozo Yamaichi, Shinzo Oikawa. Imidocarb, a potent anti-protozoan drug, up-regulates interleukin-10 production by murine macrophages. Biochemical and biophysical research communications. 2003 Sep; 309(2):414-8. doi: 10.1016/j.bbrc.2003.08.017. [PMID: 12951065]
  • C Belloli, G Crescenzo, O Lai, V Carofiglio, O Marang, P Ormas. Pharmacokinetics of imidocarb dipropionate in horses after intramuscular administration. Equine veterinary journal. 2002 Sep; 34(6):625-9. doi: 10.2746/042516402776180124. [PMID: 12358005]
  • Olimpia Lai, Chiara Belloli, Giuseppe Crescenzo, Vito Carofiglio, Paolo Ormas, Oronzo Marangi, Petra Cagnardi. Depletion and bioavailability of imidocarb residues in sheep and goat tissues. Veterinary and human toxicology. 2002 Apr; 44(2):79-83. doi: NULL. [PMID: 11931508]
  • A Sainz, M A Tesouro, I Amusategui, F Rodríguez, F Mazzucchelli, M Rodríguez. Prospective comparative study of 3 treatment protocols using doxycycline or imidocarb dipropionate in dogs with naturally occurring ehrlichiosis. Journal of veterinary internal medicine. 2000 Mar; 14(2):134-9. doi: 10.1892/0891-6640(2000)014<0134:pcsotp>2.3.co;2. [PMID: 10772483]
  • I Marco, R Velarde, J Castellà, D Ferrer, S Lavín. Presumptive Babesia ovis infection in a spanish ibex (Capra pyrenaica). Veterinary parasitology. 2000 Jan; 87(2-3):217-21. doi: 10.1016/s0304-4017(99)00170-3. [PMID: 10622613]
  • G A Soliman. Effect of sodium methyl arsinate and imidocarb dipropionate antiprotozoal drugs on the pharmacokinetic of gentamicin in equines. DTW. Deutsche tierarztliche Wochenschrift. 1998 Jul; 105(7):274-6. doi: NULL. [PMID: 9697352]
  • N Q Hailat, S Q Lafi, A M al-Darraji, F K al-Ani. Equine babesiosis associated with strenuous exercise: clinical and pathological studies in Jordan. Veterinary parasitology. 1997 Apr; 69(1-2):1-8. doi: 10.1016/s0304-4017(96)01100-4. [PMID: 9187024]
  • A S Moore, N G Coldham, M J Sauer. A cellular mechanism for imidocarb retention in edible bovine tissues. Toxicology letters. 1996 Oct; 87(2-3):61-8. doi: 10.1016/0378-4274(96)03705-8. [PMID: 8914612]
  • B Gummow, J L du Preez, G E Swan. Paired-ion extraction and high-performance liquid chromatographic determination of diminazene in cattle plasma: a modified method. The Onderstepoort journal of veterinary research. 1995 Mar; 62(1):1-4. doi: NULL. [PMID: 8539029]
  • M Aktas, P Vinclair, H P Lefebvre, P L Toutain, J P Braun. In vivo quantification of muscle damage in dogs after intramuscular administration of drugs. The British veterinary journal. 1995 Mar; 151(2):189-96. doi: 10.1016/s0007-1935(95)80010-7. [PMID: 8920114]
  • L A Matthewman, P J Kelly, P Brouqui, D Raoult. Further evidence for the efficacy of imidocarb dipropionate in the treatment of Ehrlichia canis infection. Journal of the South African Veterinary Association. 1994 Sep; 65(3):104-7. doi: NULL. [PMID: 7595915]
  • M J Freeman, B M Kirby, D L Panciera, R A Henik, E Rosin, L J Sullivan. Hypotensive shock syndrome associated with acute Babesia canis infection in a dog. Journal of the American Veterinary Medical Association. 1994 Jan; 204(1):94-6. doi: NULL. [PMID: 8125828]
  • J A Tarbin, G Shearer. High-performance liquid chromatographic determination of imidocarb in cattle kidney with cation-exchange clean-up. Journal of chromatography. 1992 Jun; 577(2):376-81. doi: 10.1016/0378-4347(92)80263-p. [PMID: 1400770]
  • J S Gray, P Gannon. Preliminary development of a live drug-controlled vaccine against bovine babesiosis using the Mongolian gerbil, Meriones unguiculatus. Veterinary parasitology. 1992 May; 42(3-4):179-88. doi: 10.1016/0304-4017(92)90060-m. [PMID: 1496778]
  • A R Michell, D G White, A J Higgins, P Moss, P Lees. Effect of induced hypomagnesaemia on the toxicity of imidocarb in calves. Research in veterinary science. 1986 Mar; 40(2):264-70. doi: 10.1016/s0034-5288(18)30525-3. [PMID: 3704346]
  • B H Ali, T Hassan, H B Suliman, E B Abdelsalam. Some effects of imidocarb in goats. Veterinary and human toxicology. 1985 Dec; 27(6):477-80. doi: . [PMID: 4082455]
  • A S Abdullah, J D Baggot. Influence of Escherichia coli endotoxin-induced fever on pharmacokinetics of imidocarb in dogs and goats. American journal of veterinary research. 1984 Dec; 45(12):2645-8. doi: NULL. [PMID: 6395743]
  • A S Abdullah, A R Sheikh-Omar, J D Baggot, M Zamri. Adverse effects of imidocarb dipropionate (Imizol) in a dog. Veterinary research communications. 1984 Feb; 8(1):55-9. doi: 10.1007/bf02214695. [PMID: 6719828]
  • A S Abdullah, J D Baggot. Pharmacokinetics of imidocarb in normal dogs and goats. Journal of veterinary pharmacology and therapeutics. 1983 Sep; 6(3):195-9. doi: 10.1111/j.1365-2885.1983.tb00464.x. [PMID: 6632076]
  • L G Adams. Clinicopathological aspects of imidocarb dipropionate toxicity in horses. Research in veterinary science. 1981 Jul; 31(1):54-61. doi: 10.1016/s0034-5288(18)32521-9. [PMID: 7313320]
  • L G Adams, D E Corrier, J D Williams. A study of the toxicity of imidocarb dipropionate in cattle. Research in veterinary science. 1980 Mar; 28(2):172-7. doi: 10.1016/s0034-5288(18)32741-3. [PMID: 7414062]
  • C F Simpson, F C Neal. Ultrastructure of Babesia equi in ponies treated with imidocarb. American journal of veterinary research. 1980 Feb; 41(2):267-71. doi: NULL. [PMID: 7369599]
  • Y O Aliu, R H Davis, B J Camp, K L Kuttler. Absorption, distribution, and excretion of imidocarb dipropionate in sheep. American journal of veterinary research. 1977 Dec; 38(12):2001-7. doi: NULL. [PMID: 596699]
  • D E Corrier, L G Adams. Ultrastructural renal lesions in goats given a lethal dose of imidocarb diproprionate. American journal of veterinary research. 1977 Feb; 38(2):217-22. doi: NULL. [PMID: 842919]
  • D E Corrier, L G Adams. Clinical, histologic, and histochemical study of imidocarb diproprionate toxicosis in goats. American journal of veterinary research. 1976 Jul; 37(7):811-6. doi: NULL. [PMID: 132883]