Triclabendazole sulfoxide (BioDeep_00000272291)
代谢物信息卡片
化学式: C14H9Cl3N2O2S (373.9450304)
中文名称: 三氯苯达唑亚砜
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CS(=O)C1=NC2=CC(=C(C=C2N1)Cl)OC3=C(C(=CC=C3)Cl)Cl
InChI: InChI=1S/C14H9Cl3N2O2S/c1-22(20)14-18-9-5-8(16)12(6-10(9)19-14)21-11-4-2-3-7(15)13(11)17/h2-6H,1H3,(H,18,19)
描述信息
D000890 - Anti-Infective Agents > D000977 - Antiparasitic Agents > D000871 - Anthelmintics
同义名列表
1 个代谢物同义名
相关代谢途径
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代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
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0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Nuria Boix, Elisabet Teixido, Marta Vila-Cejudo, Pedro Ortiz, Elena Ibáñez, Juan M Llobet, Marta Barenys. Triclabendazole sulfoxide causes stage-dependent embryolethality in zebrafish and mouse in vitro.
PloS one.
2015; 10(3):e0121308. doi:
10.1371/journal.pone.0121308. [PMID: 25793498] - Sandra Halwachs, Louise Wassermann, Walther Honscha. A novel MDCKII in vitro model for assessing ABCG2-drug interactions and regulation of ABCG2 transport activity in the caprine mammary gland by environmental pollutants and pesticides.
Toxicology in vitro : an international journal published in association with BIBRA.
2014 Apr; 28(3):432-41. doi:
10.1016/j.tiv.2013.12.015. [PMID: 24389113] - Laura Moreno, Laura Ceballos, Ian Fairweather, Carlos Lanusse, Luis Alvarez. Time-course and accumulation of triclabendazole and its metabolites in bile, liver tissues and flukes collected from treated sheep.
Experimental parasitology.
2014 Jan; 136(?):14-9. doi:
10.1016/j.exppara.2013.10.014. [PMID: 24211244] - Borja Barrera, Lucía González-Lobato, Jon A Otero, Rebeca Real, Julio G Prieto, Ana I Álvarez, Gracia Merino. Effects of triclabendazole on secretion of danofloxacin and moxidectin into the milk of sheep: role of triclabendazole metabolites as inhibitors of the ruminant ABCG2 transporter.
Veterinary journal (London, England : 1997).
2013 Nov; 198(2):429-36. doi:
10.1016/j.tvjl.2013.07.033. [PMID: 23981352] - A M Massoud, H A Shalaby, R M El Khateeb, M S Mahmoud, M A Kutkat. Effects of Mirazid(®) and myrrh volatile oil on adult Fasciola gigantica under laboratory conditions.
Asian Pacific journal of tropical biomedicine.
2012 Nov; 2(11):875-84. doi:
10.1016/s2221-1691(12)60246-9. [PMID: 23569864] - Borja Barrera, Jon A Otero, Estefanía Egido, Julio G Prieto, Anna Seelig, Ana I Álvarez, Gracia Merino. The anthelmintic triclabendazole and its metabolites inhibit the membrane transporter ABCG2/BCRP.
Antimicrobial agents and chemotherapy.
2012 Jul; 56(7):3535-43. doi:
10.1128/aac.06345-11. [PMID: 22508302] - F Imperiale, P Ortiz, M Cabrera, C Farias, J M Sallovitz, S Iezzi, J Pérez, L Alvarez, C Lanusse. Residual concentrations of the flukicidal compound triclabendazole in dairy cows' milk and cheese.
Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment.
2011 Apr; 28(4):438-45. doi:
10.1080/19440049.2010.551422. [PMID: 21337234] - Laura Ceballos, Laura Moreno, Luis Alvarez, Laura Shaw, Ian Fairweather, Carlos Lanusse. Unchanged triclabendazole kinetics after co-administration with ivermectin and methimazole: failure of its therapeutic activity against triclabendazole-resistant liver flukes.
BMC veterinary research.
2010 Feb; 6(?):8. doi:
10.1186/1746-6148-6-8. [PMID: 20128898] - N Mestorino, E A Formentini, M F Lucas, C Fernandez, P Modamio, E Mariño Hernández, J O Errecalde. Pharmacokinetic disposition of triclabendazole in cattle and sheep; discrimination of the order and the rate of the absorption process of its active metabolite triclabendazole sulfoxide.
Veterinary research communications.
2008 Jan; 32(1):21-33. doi:
10.1007/s11259-007-9000-3. [PMID: 17457687] - Jennifer Keiser, Nadia Abou El Ela, Engy El Komy, Naglaa El Lakkany, Tarek Diab, Jacques Chollet, Jürg Utzinger, Rashida Barakat. Triclabendazole and its two main metabolites lack activity against Schistosoma mansoni in the mouse model.
The American journal of tropical medicine and hygiene.
2006 Aug; 75(2):287-91. doi:
10.4269/ajtmh.2006.75.287. [PMID: 16896134]