4-Methylthioamphetamine (BioDeep_00000272235)

Main id: BioDeep_00000174459

 


代谢物信息卡片


4-Methylthioamphetamine

化学式: C10H15NS (181.092515)
中文名称:
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC(CC1=CC=C(C=C1)SC)N
InChI: InChI=1S/C10H15NS/c1-8(11)7-9-3-5-10(12-2)6-4-9/h3-6,8H,7,11H2,1-2H3

描述信息

D002491 - Central Nervous System Agents > D000697 - Central Nervous System Stimulants

同义名列表

1 个代谢物同义名

4-Methylthioamphetamine



数据库引用编号

10 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Fabrizzio G Guajardo, Victoria B Velásquez, Daniela Raby, Gabriel Núñez-Vivanco, Patricio Iturriaga-Vásquez, Rodrigo A España, Miguel Reyes-Parada, Ramón Sotomayor-Zárate. Pharmacological Characterization of 4-Methylthioamphetamine Derivatives. Molecules (Basel, Switzerland). 2020 Nov; 25(22):. doi: 10.3390/molecules25225310. [PMID: 33203055]
  • Diana Dias da Silva, Elisabete Silva, Helena Carmo. Combination effects of amphetamines under hyperthermia - the role played by oxidative stress. Journal of applied toxicology : JAT. 2014 Jun; 34(6):637-50. doi: 10.1002/jat.2889. [PMID: 23765447]
  • Ramón Sotomayor-Zárate, Gabriel Quiroz, Katherine A Araya, Jorge Abarca, María R Ibáñez, Alejandro Montecinos, Carlos Guajardo, Gabriel Núñez, Angélica Fierro, Pablo R Moya, Patricio Iturriaga-Vásquez, Cristóbal Gómez-Molina, Katia Gysling, Miguel Reyes-Parada. 4-Methylthioamphetamine increases dopamine in the rat striatum and has rewarding effects in vivo. Basic & clinical pharmacology & toxicology. 2012 Dec; 111(6):371-9. doi: 10.1111/j.1742-7843.2012.00926.x. [PMID: 22788961]
  • Sarah Kerrigan, Stephanie Banuelos, Laura Perrella, Brittany Hardy. Simultaneous detection of ten psychedelic phenethylamines in urine by gas chromatography-mass spectrometry. Journal of analytical toxicology. 2011 Sep; 35(7):459-69. doi: 10.1093/anatox/35.7.459. [PMID: 21871155]
  • Yvonne M McNamara, Suzanne M Cloonan, Andrew J S Knox, John J Keating, Stephen G Butler, Günther H Peters, Mary J Meegan, D Clive Williams. Synthesis and serotonin transporter activity of 1,3-bis(aryl)-2-nitro-1-propenes as a new class of anticancer agents. Bioorganic & medicinal chemistry. 2011 Feb; 19(3):1328-48. doi: 10.1016/j.bmc.2010.11.054. [PMID: 21227702]
  • Suzanne M Cloonan, John J Keating, Stephen G Butler, Andrew J S Knox, Anne M Jørgensen, Günther H Peters, Dilip Rai, Desmond Corrigan, David G Lloyd, D Clive Williams, Mary J Meegan. Synthesis and serotonin transporter activity of sulphur-substituted alpha-alkyl phenethylamines as a new class of anticancer agents. European journal of medicinal chemistry. 2009 Dec; 44(12):4862-88. doi: 10.1016/j.ejmech.2009.07.027. [PMID: 19717215]
  • Marco Gobbi, Marcella Funicello, Klaus Gerstbrein, Marion Holy, Pablo R Moya, Ramón Sotomayor, María Inés Forray, Katia Gysling, Silvio Paluzzi, Giambattista Bonanno, Miguel Reyes-Parada, Harald H Sitte, Tiziana Mennini. N,N-dimethyl-thioamphetamine and methyl-thioamphetamine, two non-neurotoxic substrates of 5-HT transporters, have scant in vitro efficacy for the induction of transporter-mediated 5-HT release and currents. Journal of neurochemistry. 2008 Jun; 105(5):1770-80. doi: 10.1111/j.1471-4159.2008.05272.x. [PMID: 18248615]
  • Andreas H Ewald, Frank T Peters, Magdalene Weise, Hans H Maurer. Studies on the metabolism and toxicological detection of the designer drug 4-methylthioamphetamine (4-MTA) in human urine using gas chromatography-mass spectrometry. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2005 Sep; 824(1-2):123-31. doi: 10.1016/j.jchromb.2005.07.007. [PMID: 16027051]
  • M E Soares, M Carvalho, H Carmo, F Remião, F Carvalho, M L Bastos. Simultaneous determination of amphetamine derivatives in human urine after SPE extraction and HPLC-UV analysis. Biomedical chromatography : BMC. 2004 Mar; 18(2):125-31. doi: 10.1002/bmc.315. [PMID: 15039965]
  • Frank T Peters, Simone Schaefer, Roland F Staack, Thomas Kraemer, Hans H Maurer. Screening for and validated quantification of amphetamines and of amphetamine- and piperazine-derived designer drugs in human blood plasma by gas chromatography/mass spectrometry. Journal of mass spectrometry : JMS. 2003 Jun; 38(6):659-76. doi: 10.1002/jms.483. [PMID: 12827635]
  • M Gobbi, M Moia, L Pirona, I Ceglia, M Reyes-Parada, C Scorza, T Mennini. p-Methylthioamphetamine and 1-(m-chlorophenyl)piperazine, two non-neurotoxic 5-HT releasers in vivo, differ from neurotoxic amphetamine derivatives in their mode of action at 5-HT nerve endings in vitro. Journal of neurochemistry. 2002 Sep; 82(6):1435-43. doi: 10.1046/j.1471-4159.2002.01073.x. [PMID: 12354291]
  • Helena Carmo, Douwe de Boer, Fernando Remião, Félix Carvalho, Lesseps A dos Reys, Maria de Lourdes Bastos. Identification of 4-methylthioamphetamine and some of its metabolites in mouse urine by GC-MS after acute administration. Journal of analytical toxicology. 2002 May; 26(4):228-32. doi: 10.1093/jat/26.4.228. [PMID: 12054364]
  • T Decaestecker, E De Letter, K Clauwaert, M P Bouche, W Lambert, J Van Bocxlaer, M Piette, E Van den Eeckhout, C Van Peteghem, A De Leenheer. Fatal 4-MTA intoxication: development of a liquid chromatographic-tandem mass spectrometric assay for multiple matrices. Journal of analytical toxicology. 2001 Nov; 25(8):705-10. doi: 10.1093/jat/25.8.705. [PMID: 11765028]
  • S P Elliott. Analysis of 4-methylthioamphetamine in clinical specimens. Annals of clinical biochemistry. 2001 Jul; 38(Pt 4):339-47. doi: 10.1258/0004563011900858. [PMID: 11471875]
  • E A De Letter, V A Coopman, J A Cordonnier, M H Piette. One fatal and seven non-fatal cases of 4-methylthioamphetamine (4-MTA) intoxication: clinico-pathological findings. International journal of legal medicine. 2001; 114(6):352-6. doi: 10.1007/s004140100204. [PMID: 11508803]
  • S P Elliott. Fatal poisoning with a new phenylethylamine: 4-methylthioamphetamine (4-MTA). Journal of analytical toxicology. 2000 Mar; 24(2):85-9. doi: 10.1093/jat/24.2.85. [PMID: 10732944]
  • Q Li, I Murakami, S Stall, A D Levy, M S Brownfield, D E Nichols, L D Van de Kar. Neuroendocrine pharmacology of three serotonin releasers: 1-(1,3-benzodioxol-5-yl)-2-(methylamino)butane (MBDB), 5-methoxy-6-methyl-2-aminoindan (MMAi) and p-methylthioamphetamine (MTA). The Journal of pharmacology and experimental therapeutics. 1996 Dec; 279(3):1261-7. doi: NULL. [PMID: 8968349]