URB937 (BioDeep_00000272214)

   


代谢物信息卡片


URB937

  化学式: C20H22N2O4 (354.1579)
中文名称:
  谱图信息: 最多检出来源 () %

分子结构信息

SMILES: N=C(O)c1cccc(-c2cc(OC(O)=NC3CCCCC3)ccc2O)c1
InChI:


描述信息

URB937 is an orally active and peripherally restricted FAAH inhibitor (IC50=26.8 nM) and increases anandamide levels. URB937 fails to affect FAAH activity in the brain (not penetrate the blood-brain barrier)[1].

同义名列表

1 个代谢物同义名

URB937



数据库引用编号

5 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome()

BioCyc()

PlantCyc()

代谢反应

个相关的代谢反应过程信息。

Reactome()

BioCyc()

WikiPathways()

Plant Reactome()

INOH()

PlantCyc()

COVID-19 Disease Map()

PathBank()

PharmGKB()

个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表


文献列表

  • Valentina Vozella, Faizy Ahmed, Paoula Choobchian, Collin B Merrill, Cristina Zibardi, Giorgio Tarzia, Marco Mor, Andrea Duranti, Andrea Tontini, Silvia Rivara, Daniele Piomelli. Pharmacokinetics, pharmacodynamics and safety studies on URB937, a peripherally restricted fatty acid amide hydrolase inhibitor, in rats. The Journal of pharmacy and pharmacology. 2019 Dec; 71(12):1762-1773. doi: 10.1111/jphp.13166. [PMID: 31579946]
  • Rui Li, Guo Chen, Lin Zhou, He Xu, Fei Tang, Jie Lan, Ruizhan Tong, Lei Deng, Jianxin Xue, You Lu. The Fatty Acid Amide Hydrolase Inhibitor URB937 Ameliorates Radiation-Induced Lung Injury in a Mouse Model. Inflammation. 2017 Aug; 40(4):1254-1263. doi: 10.1007/s10753-017-0568-7. [PMID: 28478515]
  • Oscar Sasso, Karen Wagner, Christophe Morisseau, Bora Inceoglu, Bruce D Hammock, Daniele Piomelli. Peripheral FAAH and soluble epoxide hydrolase inhibitors are synergistically antinociceptive. Pharmacological research. 2015 Jul; 97(?):7-15. doi: 10.1016/j.phrs.2015.04.001. [PMID: 25882247]
  • Guillermo Moreno-Sanz, Borja Barrera, Andrea Armirotti, Sine M Bertozzi, Rita Scarpelli, Tiziano Bandiera, Julio G Prieto, Andrea Duranti, Giorgio Tarzia, Gracia Merino, Daniele Piomelli. Structural determinants of peripheral O-arylcarbamate FAAH inhibitors render them dual substrates for Abcb1 and Abcg2 and restrict their access to the brain. Pharmacological research. 2014 Sep; 87(?):87-93. doi: 10.1016/j.phrs.2014.06.004. [PMID: 24993496]
  • Josée Guindon, Yvonne Lai, Sara M Takacs, Heather B Bradshaw, Andrea G Hohmann. Alterations in endocannabinoid tone following chemotherapy-induced peripheral neuropathy: effects of endocannabinoid deactivation inhibitors targeting fatty-acid amide hydrolase and monoacylglycerol lipase in comparison to reference analgesics following cisplatin treatment. Pharmacological research. 2013 Jan; 67(1):94-109. doi: 10.1016/j.phrs.2012.10.013. [PMID: 23127915]
  • Oscar Sasso, Rosalia Bertorelli, Tiziano Bandiera, Rita Scarpelli, Giampiero Colombano, Andrea Armirotti, Guillermo Moreno-Sanz, Angelo Reggiani, Daniele Piomelli. Peripheral FAAH inhibition causes profound antinociception and protects against indomethacin-induced gastric lesions. Pharmacological research. 2012 May; 65(5):553-63. doi: 10.1016/j.phrs.2012.02.012. [PMID: 22420940]
  • Guillermo Moreno-Sanz, Borja Barrera, Ana Guijarro, Ilaria d'Elia, Jon Andoni Otero, Ana I Alvarez, Tiziano Bandiera, Gracia Merino, Daniele Piomelli. The ABC membrane transporter ABCG2 prevents access of FAAH inhibitor URB937 to the central nervous system. Pharmacological research. 2011 Oct; 64(4):359-63. doi: 10.1016/j.phrs.2011.07.001. [PMID: 21767647]