mebeverine (BioDeep_00000272175)

   


代谢物信息卡片


mebeverine

化学式: C25H35NO5 (429.2515)
中文名称: 美贝维林
谱图信息: 最多检出来源 Viridiplantae(plant) 88.89%

分子结构信息

SMILES: C([H])(C([H])([H])[H])(C([H])([H])c(c([H])2)c([H])c([H])c(OC([H])([H])[H])c([H])2)N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])OC(=O)c(c([H])1)c([H])c(OC([H])([H])[H])c(OC([H])([H])[H])c([H])1
InChI: InChI=1S/C25H35NO5/c1-6-26(19(2)17-20-9-12-22(28-3)13-10-20)15-7-8-16-31-25(27)21-11-14-23(29-4)24(18-21)30-5/h9-14,18-19H,6-8,15-17H2,1-5H3

描述信息

A - Alimentary tract and metabolism > A03 - Drugs for functional gastrointestinal disorders > A03A - Drugs for functional gastrointestinal disorders > A03AA - Synthetic anticholinergics, esters with tertiary amino group
D018373 - Peripheral Nervous System Agents > D001337 - Autonomic Agents > D010276 - Parasympatholytics
C78272 - Agent Affecting Nervous System > C66880 - Anticholinergic Agent
D002491 - Central Nervous System Agents > D000927 - Anticonvulsants
CONFIDENCE standard compound; INTERNAL_ID 2744
CONFIDENCE standard compound; INTERNAL_ID 8523

同义名列表

1 个代谢物同义名

mebeverine



数据库引用编号

22 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表


文献列表

  • Francesca Bedussi, Elisabetta Acerbis, Roberta Noseda, Davide Demagistri, Emanuela Zamprogno, Alessandro Ceschi. False-positive urine screen test for MDMA in a patient exposed to mebeverine. British journal of clinical pharmacology. 2021 05; 87(5):2397-2398. doi: 10.1111/bcp.14624. [PMID: 33200465]
  • Natalia E Moskaleva, Pavel A Baranov, Natalia V Mesonzhnik, Svetlana A Appolonova. HPLC-MS/MS method for the simultaneous quantification of desmethylmebeverine acid, mebeverine acid and mebeverine alcohol in human plasma along with its application to a pharmacokinetics study. Journal of pharmaceutical and biomedical analysis. 2017 May; 138(?):118-125. doi: 10.1016/j.jpba.2017.02.006. [PMID: 28192719]
  • Thong T Nguyen, Duong T Dau, Dung C Nguyen, Huong T T G Nguyen, Phuong T B Ngo, Thai Q Nguyen, Bo Han, Ba X Hoang. Effects of Trang Phuc Linh Plus-Food Supplement on Irritable Bowel Syndrome Induced by Mustard Oil. Journal of medicinal food. 2017 Apr; 20(4):385-391. doi: 10.1089/jmf.2016.0129. [PMID: 28406734]
  • L Kiep, M Göhl, J Schmidt, K Seifert. Studies on the Biotransformation of Veratric Acid, a Human Metabolite of Mebeverine, by Using the Incubated Hen's Egg. Drug research. 2015 Sep; 65(9):500-4. doi: 10.1055/s-0034-1390457. [PMID: 25310250]
  • Haider A J Al Lawati, Zeiyana M Al Dahmani, Gouri B Varma, FakhrEldin O Suliman. Photoinduced oxidation of a tris(2,2'-bipyridyl)ruthenium(II)-peroxodisulfate chemiluminescence system for the analysis of mebeverine HCl pharmaceutical formulations and biological fluids using a two-chip device. Luminescence : the journal of biological and chemical luminescence. 2014 May; 29(3):275-83. doi: 10.1002/bio.2540. [PMID: 23760778]
  • Ahmed Salih Sahib. Treatment of irritable bowel syndrome using a selected herbal combination of Iraqi folk medicines. Journal of ethnopharmacology. 2013 Jul; 148(3):1008-12. doi: 10.1016/j.jep.2013.05.034. [PMID: 23707209]
  • Jan Kendall de Kruif, Jiyi Khoo, Roberto Bravo, Martin Kuentz. Novel quality by design tools for concentrated drug suspensions: surface energy profiling and the fractal concept of flocculation. Journal of pharmaceutical sciences. 2013 Mar; 102(3):994-1007. doi: 10.1002/jps.23435. [PMID: 23280339]
  • Mehdi Hatami, Khalil Farhadi, Amir Tukmechi. Fiber-based liquid-phase micro-extraction of mebeverine enantiomers followed by chiral high-performance liquid chromatography analysis and its application to pharmacokinetics study in rat plasma. Chirality. 2012 Aug; 24(8):634-9. doi: 10.1002/chir.22057. [PMID: 22700279]
  • Mohamed I Walash, Mohie M Kh Sharaf El-Din, Nahed M El-Enany, Manal I Eid, Shereen M Shalan. Simultaneous determination of sulpiride and mebeverine by HPLC method using fluorescence detection: application to real human plasma. Chemistry Central journal. 2012 Feb; 6(?):13. doi: 10.1186/1752-153x-6-13. [PMID: 22333299]
  • Yasuto Kido, Pär Matsson, Kathleen M Giacomini. Profiling of a prescription drug library for potential renal drug-drug interactions mediated by the organic cation transporter 2. Journal of medicinal chemistry. 2011 Jul; 54(13):4548-58. doi: 10.1021/jm2001629. [PMID: 21599003]
  • Shilan Mozaffari, Hadi Esmaily, Roja Rahimi, Maryam Baeeri, Yara Sanei, Azar Asadi-Shahmirzadi, Mohammad-Hossein Salehi-Surmaghi, Mohammad Abdollahi. Effects of Hypericum perforatum extract on rat irritable bowel syndrome. Pharmacognosy magazine. 2011 Jul; 7(27):213-23. doi: 10.4103/0973-1296.84235. [PMID: 21969792]
  • D P Grover, J L Zhou, P E Frickers, J W Readman. Improved removal of estrogenic and pharmaceutical compounds in sewage effluent by full scale granular activated carbon: impact on receiving river water. Journal of hazardous materials. 2011 Jan; 185(2-3):1005-11. doi: 10.1016/j.jhazmat.2010.10.005. [PMID: 21035257]
  • Ghassan Z Abdullah, Muthanna F Abdulkarim, Ibrahim M Salman, Omar Z Ameer, Mun F Yam, Ahmed F Mutee, Mallikarjun Chitneni, Elrashid S Mahdi, Mahiran Basri, Munavvar A Sattar, Azmin M Noor. In vitro permeation and in vivo anti-inflammatory and analgesic properties of nanoscaled emulsions containing ibuprofen for topical delivery. International journal of nanomedicine. 2011; 6(?):387-96. doi: 10.2147/ijn.s14667. [PMID: 21499428]
  • Muthanna F Abdulkarim, Ghassan Z Abdullah, Mallikarjun Chitneni, Ibrahim M Salman, Omar Z Ameer, Mun F Yam, Elrashid S Mahdi, Munavvar A Sattar, Mahiran Basri, Azmin M Noor. Topical piroxicam in vitro release and in vivo anti-inflammatory and analgesic effects from palm oil esters-based nanocream. International journal of nanomedicine. 2010 Nov; 5(?):915-24. doi: 10.2147/ijn.s13305. [PMID: 21116332]
  • M Walash, M Sharaf El-Din, Nahed El-Enany, M Eid, Sh Shalan. First derivative synchronous fluorescence spectroscopy for the simultaneous determination of sulpiride and mebeverine hydrochloride in their combined tablets and application to real human plasma. Journal of fluorescence. 2010 Nov; 20(6):1275-85. doi: 10.1007/s10895-010-0679-0. [PMID: 20607372]
  • Noel A Gomes, Avdhoot Laud, Ashutosh Pudage, Santosh S Joshi, Vikas V Vaidya, Jayram A Tandel. Validated LC-MS/MS method for determination of Alverine and one of its hydroxy metabolites in human plasma along with its application to a bioequivalence study. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2009 Jan; 877(3):197-206. doi: 10.1016/j.jchromb.2008.12.013. [PMID: 19110477]
  • Ma Soledad García, Joaquín A Ortuño, Ma Isabel Albero, Mustafa Salem Abuherba. Development of membrane selective electrode for determination of the antipsychotic sulpiride in pharmaceuticals and urine. Sensors (Basel, Switzerland). 2009; 9(6):4309-22. doi: 10.3390/s90604309. [PMID: 22408528]
  • Alexander C Ford, Nicholas J Talley, Brennan M R Spiegel, Amy E Foxx-Orenstein, Lawrence Schiller, Eamonn M M Quigley, Paul Moayyedi. Effect of fibre, antispasmodics, and peppermint oil in the treatment of irritable bowel syndrome: systematic review and meta-analysis. BMJ (Clinical research ed.). 2008 Nov; 337(?):a2313. doi: 10.1136/bmj.a2313. [PMID: 19008265]
  • E M Lipnitskiĭ, O V Isakova, A D Dzhadzhanidze, M D Ardatskaia. [Efficacy of duspatalin in the treatment and prophylaxis of postcholecystectomic syndrome]. Eksperimental'naia i klinicheskaia gastroenterologiia = Experimental & clinical gastroenterology. 2008; ?(3):86-93. doi: NULL. [PMID: 19145887]
  • Hosny Ibrahim, Y M Issa, Hazem M Abu-Shawish. Improving the detection limits of antispasmodic drugs electrodes by using modified membrane sensors with inner solid contact. Journal of pharmaceutical and biomedical analysis. 2007 May; 44(1):8-15. doi: 10.1016/j.jpba.2007.01.018. [PMID: 17383844]
  • Simon Elliott, Victoria Burgess. Investigative implications of the instability and metabolism of mebeverine. Journal of analytical toxicology. 2006 Mar; 30(2):91-7. doi: 10.1093/jat/30.2.91. [PMID: 16620538]
  • Mahasen A Radwan, Heba H Abdine, Hassan Y Aboul-Enein. A validated chiral HPLC method for the determination of mebeverine HCl enantiomers in pharmaceutical dosage forms and spiked rat plasma. Biomedical chromatography : BMC. 2006 Feb; 20(2):211-6. doi: 10.1002/bmc.556. [PMID: 16145657]
  • Hosny Ibrahim, Yousry M Issa, Hazem M Abu-Shawish. Potentiometric flow injection analysis of mebeverine hydrochloride in serum and urine. Journal of pharmaceutical and biomedical analysis. 2005 Jan; 36(5):1053-61. doi: 10.1016/j.jpba.2004.08.032. [PMID: 15620532]
  • Arnel Stockis, P J M Guelen, D de Vos. Identification of mebeverine acid as the main circulating metabolite of mebeverine in man. Journal of pharmaceutical and biomedical analysis. 2002 Jun; 29(1-2):335-40. doi: 10.1016/s0731-7085(02)00023-7. [PMID: 12062694]
  • T Kraemer, R Wennig, H H Maurer. The antispasmodic drug mebeverine leads to positive amphetamine results by fluorescence polarization immunoassay (FPIA)--studies on the toxicological analysis of urine by FPIA and GC-MS. Journal of analytical toxicology. 2001 Jul; 25(5):333-8. doi: 10.1093/jat/25.5.333. [PMID: 11499887]
  • C L Lu, C Y Chen, F Y Chang, S S Chang, L J Kang, R H Lu, S D Lee. Effect of a calcium channel blocker and antispasmodic in diarrhoea-predominant irritable bowel syndrome. Journal of gastroenterology and hepatology. 2000 Aug; 15(8):925-30. doi: 10.1046/j.1440-1746.2000.02230.x. [PMID: 11022835]
  • T Kraemer, J Bickeboeller-Friedrich, H H Maurer. On the metabolism of the amphetamine-derived antispasmodic drug mebeverine: gas chromatography-mass spectrometry studies on rat liver microsomes and on human urine. Drug metabolism and disposition: the biological fate of chemicals. 2000 Mar; 28(3):339-47. doi: NULL. [PMID: 10681380]
  • P Rivera, S Pamos, J Cuquerella, L Ferrer, A Tomé, E Ortí, I Salvador, E Medina. [Collagenous colitis: presentation of 12 cases]. Gastroenterologia y hepatologia. 1997 Dec; 20(10):484-9. doi: NULL. [PMID: 9508483]
  • D K Sommers, J R Snyman, M van Wyk, J N Eloff. Lack of bioavailability of mebeverine even after pretreatment with pyridostigmine. European journal of clinical pharmacology. 1997; 53(3-4):247-9. doi: 10.1007/s002280050370. [PMID: 9476039]
  • L J Tulich, J L Randall, G R Kelm, K R Wehmeyer. Determination of two mebeverine metabolites, mebeverine alcohol and desmethylmebeverine alcohol, in human plasma by a dual stable isotope-based gas chromatographic-mass spectrometric method. Journal of chromatography. B, Biomedical applications. 1996 Jul; 682(2):273-81. doi: 10.1016/0378-4347(96)00039-4. [PMID: 8844420]
  • J Kristinsson, I Snorradóttir, M Jóhannsson. The metabolism of mebeverine in man: identification of urinary metabolites by gas chromatography/mass spectrometry. Pharmacology & toxicology. 1994 Mar; 74(3):174-80. doi: 10.1111/j.1600-0773.1994.tb01095.x. [PMID: 8008724]
  • J D Pinkston, C J Venkatramani, L J Tulich, D J Bowling, K R Wehmeyer. Evaluation of capillary supercritical fluid chromatography with mass spectrometric detection for the analysis of a drug (mebeverine) in a dog plasma matrix. Journal of chromatography. 1993 Dec; 622(2):209-14. doi: 10.1016/0378-4347(93)80267-8. [PMID: 8150867]
  • H Liu, L M Cooper, D E Raynie, J D Pinkston, K R Wehmeyer. Combined supercritical fluid extraction/solid-phase extraction with octadecylsilane cartridges as a sample preparation technique for the ultratrace analysis of a drug metabolite in plasma. Analytical chemistry. 1992 Apr; 64(7):802-6. doi: 10.1021/ac00031a018. [PMID: 1524224]
  • R G Dickinson, P V Baker, M E Franklin, W D Hooper. Facile hydrolysis of mebeverine in vitro and in vivo: negligible circulating concentrations of the drug after oral administration. Journal of pharmaceutical sciences. 1991 Oct; 80(10):952-7. doi: 10.1002/jps.2600801010. [PMID: 1784004]
  • G Hoogewijs, D L Massart. Development of a standardized analysis strategy for basic drugs using ion-pair extraction and high-performance liquid chromatography. VIII. Method construction for the determination of mebeverine in tablets and biological fluids. Journal of chromatography. 1986 Apr; 377(?):391-8. doi: 10.1016/s0378-4347(00)80799-9. [PMID: 3711233]
  • J Eisenburg, W Kruis, P Schüssler, M Weinzierl. [The irritable colon syndrome. New therapeutic possibilities in the treatment of a frequent syndrome]. Fortschritte der Medizin. 1978 Nov; 96(41):2064-70. doi: NULL. [PMID: 700592]