xylazine (BioDeep_00000272121)
代谢物信息卡片
xylazine
化学式: C12H16N2S (220.1034)
中文名称: 赛拉嗪, 甲苯噻嗪
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC1=C(C(=CC=C1)C)NC2=NCCCS2
InChI: InChI=1S/C12H16N2S/c1-9-5-3-6-10(2)11(9)14-12-13-7-4-8-15-12/h3,5-6H,4,7-8H2,1-2H3,(H,13,14)
描述信息
D002491 - Central Nervous System Agents > D002492 - Central Nervous System Depressants > D006993 - Hypnotics and Sedatives
C78272 - Agent Affecting Nervous System > C29747 - Adrenergic Agent > C87053 - Adrenergic Agonist
D018377 - Neurotransmitter Agents > D018663 - Adrenergic Agents > D000322 - Adrenergic Agonists
D018373 - Peripheral Nervous System Agents > D018689 - Sensory System Agents
D018373 - Peripheral Nervous System Agents > D009465 - Neuromuscular Agents
D002491 - Central Nervous System Agents > D000700 - Analgesics
同义名列表
数据库引用编号
9 个数据库交叉引用编号
- ChEBI: CHEBI:92386
- KEGGdrug: D08683
- PubChem: 5707
- Metlin: METLIN43371
- DrugBank: DB11477
- ChEMBL: CHEMBL297362
- MeSH: Xylazine
- CAS: 7361-61-7
- PMhub: MS000003395
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
| 亚细胞结构定位 | 关联基因列表 |
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文献列表
- Shylo R Johnson, Christine K Ellis, Chad K Wickham, Molly R Selleck, Amy T Gilbert. Comparison of Ketamine-Xylazine, Butorphanol-Azaperone-Medetomidine, and Nalbuphine-Medetomidine-Azaperone for Raccoon (Procyon Lotor) Immobilization.
Journal of wildlife diseases.
2023 Nov; ?(?):. doi:
10.7589/jwd-d-23-00060. [PMID: 37924235] - Behnam Noorani, Ekram Ahmed Chowdhury, Faleh Alqahtani, Yeseul Ahn, Ehsan Nozohouri, Sumaih Zoubi, Dhavalkumar Patel, Laurence Wood, Juyang Huang, Muhammad Bilal Siddique, Abraham Al-Ahmad, Reza Mehvar, Ulrich Bickel. Effects of Volatile Anesthetics Versus Ketamine on Blood-Brain Barrier Permeability via Lipid-Mediated Alterations of Endothelial Cell Membranes.
The Journal of pharmacology and experimental therapeutics.
2023 Feb; ?(?):. doi:
10.1124/jpet.122.001281. [PMID: 36828631] - Chenyang Gu, Jiale Liu, Yajing Li, Qiankun Zhang, Chaoqun Lin, Jiajun Huang, Wenjie Duan, Yushu Deng, Waqas Ahmed, Rong Li, Jun Long, Ahsan Ali Khan, Lukui Chen. Comparison of ketamine/xylazine and isoflurane anesthesia on the establishment of mouse middle cerebral artery occlusion model.
Experimental animals.
2022 Nov; ?(?):. doi:
10.1538/expanim.22-0131. [PMID: 36418078] - Seyed Morteza Aghamiri, Amir Saeed Samimi, Mehdi Hajian, Amir Masoud Samimi, Amin Oroumieh. Effect of xylazine, detomidine, medetomidine and dexmedetomidine during laparoscopic SCNT embryo transfer on pregnancy rate and some physiological variables in goats.
BMC veterinary research.
2022 Mar; 18(1):98. doi:
10.1186/s12917-022-03194-8. [PMID: 35292035] - Tithipong Plangsangmas, Hathaipat Rattanathanya, Wanlaya Tipkantha, Saowaphang Sanannu, Umaporn Maikaew, Jessada Thaeonoen, Bencharong Sangkharak, Pornpiroon Chinson, Watcharin Hin-On, Nathavut Kanatiyanont, Boripat Siriaroonrat, Nantarika Chansue, Parntep Ratanakorn. Immobilization of captive plains zebras (Equus quagga) with a combination of etorphine hydrochloride, acepromazine, and xylazine hydrochloride.
The Journal of veterinary medical science.
2022 Jan; 84(1):181-185. doi:
10.1292/jvms.21-0458. [PMID: 34866094] - Daniela Fux, Moritz Metzner, Johanna Brandl, Melanie Feist, Magdalena Behrendt-Wippermann, Anne von Thaden, Christine Baumgartner. Pharmacokinetics of metamizole (dipyrone) as an add-on in calves undergoing umbilical surgery.
PloS one.
2022; 17(3):e0265305. doi:
10.1371/journal.pone.0265305. [PMID: 35290991] - Magdy Adam, Jere Lindén, Marja Raekallio, Ahmed Abu-Shahba, Bettina Mannerström, Riitta Seppänen-Kaijansinkko, Anna Meller, Kati Salla. Concentrations of vatinoxan and xylazine in plasma, cerebrospinal fluid and brain tissue following intravenous administration in sheep.
Veterinary anaesthesia and analgesia.
2021 Nov; 48(6):900-905. doi:
10.1016/j.vaa.2021.08.003. [PMID: 34561183] - Magdy Adam, Kati Salla, Riikka Aho, Laura Hänninen, Suvi Taponen, Marianna Norring, Marja Raekallio, Ann-Helena Hokkanen. A comparison of sedative effects of xylazine alone or combined with levomethadone or ketamine in calves prior to disbudding.
Veterinary anaesthesia and analgesia.
2021 Nov; 48(6):906-913. doi:
10.1016/j.vaa.2021.08.004. [PMID: 34602358] - Warren R Korn, Matthew D Stone, Kaddie L Haviland, Joanne M Toohey, Douglas F Stickle. High prevalence of xylazine among fentanyl screen-positive urines from hospitalized patients, Philadelphia, 2021.
Clinica chimica acta; international journal of clinical chemistry.
2021 Oct; 521(?):151-154. doi:
10.1016/j.cca.2021.07.010. [PMID: 34265257] - Charles Verney, David Legouis, Sandrine Placier, Tiffany Migeon, Philippe Bonnin, David Buob, Juliette Hadchouel, Pierre Galichon. Anaesthesia-Induced Transcriptomic Changes in the Context of Renal Ischemia Uncovered by the Use of a Novel Clamping Device.
International journal of molecular sciences.
2021 Sep; 22(18):. doi:
10.3390/ijms22189840. [PMID: 34576005] - Zahir Shah, Shakoor Ahmad, Ijaz Ahmad, Taif Shah, Farhan Anwar Khan, Haq Amanullah. Antinociceptive, physiologic and biochemical effects of electroacupuncture combined with xylazine in hybrid goats.
Veterinary anaesthesia and analgesia.
2021 Sep; 48(5):671-678. doi:
10.1016/j.vaa.2021.06.014. [PMID: 34364789] - Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome.
Cell reports.
2021 04; 35(4):109040. doi:
10.1016/j.celrep.2021.109040. [PMID: 33910017] - Maria Gláucia Carlos de Oliveira, Stelio P L Luna, Talyta Lins Nunes, Paulo R Firmino, Amara Gyane A de Lima, Josiel Ferreira, Pedro H E Trindade, Raimundo A B Júnior, Valéria Veras de Paula. Post-operative pain behaviour associated with surgical castration in donkeys (Equus asinus).
Equine veterinary journal.
2021 Mar; 53(2):261-266. doi:
10.1111/evj.13306. [PMID: 32525236] - M Wang, X-F Cai, S-M Zhang, S-Y Xia, W-H Du, Y-L Ma. Alprostadil alleviates liver injury in septic rats via TLR4/NF-κB pathway.
European review for medical and pharmacological sciences.
2021 02; 25(3):1592-1599. doi:
10.26355/eurrev_202102_24869. [PMID: 33629328] - Tanya Duke-Novakovski, Carolina Palacios Jimenez, Masako Fujiyama, Shannon G Beazley. Plasma histamine concentrations in horses administered sodium penicillin, guaifenesin-xylazine-ketamine and isoflurane with morphine or butorphanol.
Veterinary anaesthesia and analgesia.
2021 Jan; 48(1):17-25. doi:
10.1016/j.vaa.2020.10.003. [PMID: 33229232] - Klaus Hopster, Lawrence R Soma, Xiaoqing Li, Charlotte Hopster-Iversen, Raymond C Boston, Bernd Driessen. Pharmacokinetics of xylazine after 2-, 4-, and 6-hr durations of continuous rate infusions in horses.
Journal of veterinary pharmacology and therapeutics.
2020 Nov; 43(6):557-564. doi:
10.1111/jvp.12873. [PMID: 32424949] - T S Tschoner, Y Zablotski, G Knubben-Schweizer, M Feist. Effect of xylazine administration before laparoscopic abomasopexy to correct left displaced abomasum on markers of stress in dairy cows.
Journal of dairy science.
2020 Oct; 103(10):9318-9331. doi:
10.3168/jds.2020-18523. [PMID: 32747093] - Bin Tu, Tao Zhang, Yuping Wang, Li Hu, Jin Li, Ling Zheng, Yi Zhou, Jialian Li, Fengyin Xue, Xiaobo Zhu, Hua Yuan, Weilan Chen, Peng Qin, Bingtian Ma, Shigui Li. Membrane-associated xylanase-like protein OsXYN1 is required for normal cell wall deposition and plant development in rice.
Journal of experimental botany.
2020 08; 71(16):4797-4811. doi:
10.1093/jxb/eraa200. [PMID: 32337581] - Alonso Guedes, Heather Knych, Laura Tucker, Daniel C Almeida, Caroline F Baldo, Erin Wendt-Hornickle, Sandra Allweiler. Pharmacokinetics and clinical effects of xylazine and dexmedetomidine in horses recovering from isoflurane anesthesia.
Journal of veterinary pharmacology and therapeutics.
2020 Jul; 43(4):369-376. doi:
10.1111/jvp.12855. [PMID: 32166760] - Fatih Kar, Ceyhan Hacioglu, Hakan Senturk, Dilek Burukoglu Donmez, Gungor Kanbak. The Role of Oxidative Stress, Renal Inflammation, and Apoptosis in Post Ischemic Reperfusion Injury of Kidney Tissue: the Protective Effect of Dose-Dependent Boric Acid Administration.
Biological trace element research.
2020 May; 195(1):150-158. doi:
10.1007/s12011-019-01824-1. [PMID: 31372827] - Joju Johns, Nigel Caulkett, George Chandy, Jacob Alexander, Syam K Venugopal, Sooryadas Surendran, Ajithkumar Sreedharannair. ORAL HALOPERIDOL PREMEDICATION TO REDUCE CAPTURE STRESS PRIOR TO XYLAZINE-KETAMINE ANESTHESIA IN CAPTIVE SPOTTED DEER (AXIS AXIS).
Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians.
2020 Mar; 51(1):88-95. doi:
10.1638/2017-0034. [PMID: 32212550] - Fang-Hsin Chen, Ching-Fang Yu, Chung-Lin Yang, Yu-Chun Lin, Gigin Lin, Chun-Chieh Wang, Huang-Ping Yu, Jui Fang, Ning-Fang Chang, Ji-Hong Hong. Multimodal imaging reveals transient liver metabolic disturbance and sinusoidal circulation obstruction after a single administration of ketamine/xylazine mixture.
Scientific reports.
2020 02; 10(1):3657. doi:
10.1038/s41598-020-60347-1. [PMID: 32108154] - Turke Shawaf, Adel Al Mubarak, Housam Eidi, Sabry M El-Bahr. Season's Effects on Some Clinical, Hematological Parameters and Blood Cortisol Level in Sedated Arabian Horses With Xylazine.
Journal of equine veterinary science.
2020 01; 84(?):102835. doi:
10.1016/j.jevs.2019.102835. [PMID: 31864466] - Jocelyn Habershon-Butcher, Charlotte Cutler, Marjaana Viljanto, Pamela R Hincks, Simon Biddle, Stuart W Paine. Re-evaluation of the pharmacokinetics of xylazine administered to Thoroughbred horses.
Journal of veterinary pharmacology and therapeutics.
2020 Jan; 43(1):6-12. doi:
10.1111/jvp.12820. [PMID: 31652007] - T M S Cavalero, F O Papa, R A Schmith, V F C Scheeren, L E F Canuto, M L M Gobato, L T Rodrigues, C P Freitas-Dell'aqua. Protocols using detomidine and oxytocin induce ex copula ejaculation in stallions.
Theriogenology.
2019 Dec; 140(?):93-98. doi:
10.1016/j.theriogenology.2019.08.024. [PMID: 31454723] - Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
Molecular pharmacology.
2019 11; 96(5):629-640. doi:
10.1124/mol.119.115964. [PMID: 31515284] - Laura E Burns, David J Borts. Rapid untargeted screening for drug residues in animal tissues with liquid microjunction surface sampling probe mass spectrometry.
Analytica chimica acta.
2019 Jul; 1063(?):75-81. doi:
10.1016/j.aca.2019.01.029. [PMID: 30967188] - Patricia Steckeler, Daniela Fux, Moritz Metzner, Gabriela Knubben, Anna Rieger, Christine Baumgartner. The course of plasma cortisol concentration after three different doses of ketamine in xylazine-premedicated calves.
Veterinary anaesthesia and analgesia.
2019 May; 46(3):335-343. doi:
10.1016/j.vaa.2018.11.005. [PMID: 30956016] - Manal A El-Shal, Hassan A M Hendawy. Highly Sensitive Voltammetric Sensor Using Carbon Nanotube and an Ionic Liquid Composite Electrode for Xylazine Hydrochloride.
Analytical sciences : the international journal of the Japan Society for Analytical Chemistry.
2019 Feb; 35(2):189-194. doi:
10.2116/analsci.18p368. [PMID: 30298818] - Krista M Gibbs, Jenelle M Izer, W Brian Reeves, Ronald P Wilson, Timothy K Cooper. Effects of General Anesthesia on 2 Urinary Biomarkers of Kidney Injury-Hepatitis A Virus Cellular Receptor 1 and Lipocalin 2-in Male C57BL/6J Mice.
Journal of the American Association for Laboratory Animal Science : JAALAS.
2019 01; 58(1):21-29. doi:
10.30802/aalas-jaalas-18-000062. [PMID: 30538007] - Andrea K Herndon, Jessica M Quimby, Liberty G Sieberg, Leigh Davis, Amber L Caress, Sabina Ligas, Ryan J Hansen, Luke A Wittenburg, Danial L Gustafson. Preliminary pharmacokinetics of intravenous and subcutaneous dolasetron and pharmacodynamics of subcutaneous dolasetron in healthy cats.
Journal of feline medicine and surgery.
2018 08; 20(8):721-727. doi:
10.1177/1098612x17729310. [PMID: 28905667] - M Z Johnson, P D Crowley, A G Foley, C Xue, C Connolly, H C Gallagher, D J Buggy. Effect of perioperative lidocaine on metastasis after sevoflurane or ketamine-xylazine anaesthesia for breast tumour resection in a murine model.
British journal of anaesthesia.
2018 Jul; 121(1):76-85. doi:
10.1016/j.bja.2017.12.043. [PMID: 29935598] - Jatupon Krongvorakul, Saranya Auparakkitanon, Satariya Trakulsrichai, Pitsucha Sanguanwit, Jetjamnong Sueajai, Nantida Noumjad, Winai Wananukul. Use of Xylazine in Drug-Facilitated Crimes.
Journal of forensic sciences.
2018 Jul; 63(4):1325-1330. doi:
10.1111/1556-4029.13684. [PMID: 29098704] - Aline D de Lima, Maria C Guido, Elaine R Tavares, Priscila O Carvalho, Alyne F Marques, Marcelo D T de Melo, Vera M C Salemi, Roberto Kalil-Filho, Raul C Maranhão. The Expression of Lipoprotein Receptors Is Increased in the Infarcted Area After Myocardial Infarction Induced in Rats With Cardiac Dysfunction.
Lipids.
2018 02; 53(2):177-187. doi:
10.1002/lipd.12014. [PMID: 29394450] - Heather K Knych, Scott D Stanley, Daniel S McKemie, Rick M Arthur, Phil H Kass. Pharmacokinetic and pharmacodynamics of xylazine administered to exercised thoroughbred horses.
Drug testing and analysis.
2017 May; 9(5):713-720. doi:
10.1002/dta.2047. [PMID: 27492623] - Oksana N Khokhlova, Elena A Tukhovskaya, Irina N Kravchenko, Elena S Sadovnikova, Irina A Pakhomova, Elena A Kalabina, Alexander V Lobanov, Elvira R Shaykhutdinova, Alina M Ismailova, Arkady N Murashev. Using Tiletamine-Zolazepam-Xylazine Anesthesia Compared to CO2-inhalation for Terminal Clinical Chemistry, Hematology, and Coagulation Analysis in Mice.
Journal of pharmacological and toxicological methods.
2017 Mar; 84(?):11-19. doi:
10.1016/j.vascn.2016.10.005. [PMID: 27773843] - Kristina Behnke, Ursula R Sorg, Helmut E Gabbert, Klaus Pfeffer. The Lymphotoxin β Receptor Is Essential for Upregulation of IFN-Induced Guanylate-Binding Proteins and Survival after Toxoplasma gondii Infection.
Mediators of inflammation.
2017; 2017(?):7375818. doi:
10.1155/2017/7375818. [PMID: 28845089] - Masoud Alirezaei, Maryam Rezaei, Shahin Hajighahramani, Ali Sookhtehzari, Katayoun Kiani. Oleuropein attenuates cognitive dysfunction and oxidative stress induced by some anesthetic drugs in the hippocampal area of rats.
The journal of physiological sciences : JPS.
2017 Jan; 67(1):131-139. doi:
10.1007/s12576-016-0446-3. [PMID: 27023715] - Hilke Andresen-Streichert, Stefanie Iwersen-Bergmann, Alexander Mueller, Sven Anders. Attempted Drug-facilitated Sexual Assault-Xylazine Intoxication in a Child.
Journal of forensic sciences.
2017 Jan; 62(1):270-273. doi:
10.1111/1556-4029.13270. [PMID: 27864965] - Rojin Sharif, Mehdi Aghsami, Mehdi Gharghabi, Mehdi Sanati, Tina Khorshidahmad, Gelareh Vakilzadeh, Hajar Mehdizadeh, Shervin Gholizadeh, Ghorban Taghizadeh, Mohammad Sharifzadeh. Melatonin reverses H-89 induced spatial memory deficit: Involvement of oxidative stress and mitochondrial function.
Behavioural brain research.
2017 01; 316(?):115-124. doi:
10.1016/j.bbr.2016.08.040. [PMID: 27555536] - Veronika Kovacova, Ehdaa Eltayeb Eltigani Abdelsalam, Hana Bandouchova, Jiri Brichta, Barbora Havelkova, Vladimir Piacek, Frantisek Vitula, Jiri Pikula. Cytotoxicity of ketamine, xylazine and Hellabrunn mixture in liver-, heart- and kidney-derived cells from fallow deer.
Neuro endocrinology letters.
2016 Dec; 37(Suppl1):78-83. doi:
NULL. [PMID: 28263534] - G Daş, A Vernunft, S Görs, E Kanitz, J M Weitzel, K-P Brüssow, C C Metges. Acute effects of general anesthesia with propofol, pentobarbital or isoflurane plus propofol on plasma metabolites and hormones in adult pigs.
Journal of animal science.
2016 Dec; 94(12):5182-5191. doi:
10.2527/jas.2016-1018. [PMID: 28046175] - Yusuke Sano, Shogo Ito, Mamoru Yoneda, Kai Nagasawa, Natsumi Matsuura, Yuichiro Yamada, Ayako Uchinaka, Yasuko K Bando, Toyoaki Murohara, Kohzo Nagata. Effects of various types of anesthesia on hemodynamics, cardiac function, and glucose and lipid metabolism in rats.
American journal of physiology. Heart and circulatory physiology.
2016 12; 311(6):H1360-H1366. doi:
10.1152/ajpheart.00181.2016. [PMID: 27694213] - Daniela Dimer Leffa, Bruno Nunes Bristot, Adriani Paganini Damiani, Gabriela Daminelli Borges, Francine Daumann, Gabriela Maria Zambon, Gabriela Elibio Fagundes, Vanessa Moraes de Andrade. Anesthetic Ketamine-Induced DNA Damage in Different Cell Types In Vivo.
Molecular neurobiology.
2016 10; 53(8):5575-81. doi:
10.1007/s12035-015-9476-8. [PMID: 26476838] - P Morissette, C Regan, K Fitzgerald, P Gerenser, J Travis, S Wang, P Fanelli, F Sannajust. Shortening of the electromechanical window in the ketamine/xylazine-anesthetized guinea pig model to assess pro-arrhythmic risk in early drug development.
Journal of pharmacological and toxicological methods.
2016 Sep; 81(?):171-82. doi:
10.1016/j.vascn.2016.06.003. [PMID: 27377419] - G Daş, A Vernunft, S Görs, E Kanitz, J M Weitzel, K-P Brüssow, C C Metges. Effects of general anesthesia with ketamine in combination with the neuroleptic sedatives xylazine or azaperone on plasma metabolites and hormones in pigs.
Journal of animal science.
2016 Aug; 94(8):3229-3239. doi:
10.2527/jas.2016-0365. [PMID: 27695801] - Nicolai J Wewer Albrechtsen, Rune E Kuhre, Johanne A Windeløv, Anne Ørgaard, Carolyn F Deacon, Hannelouise Kissow, Bolette Hartmann, Jens J Holst. Dynamics of glucagon secretion in mice and rats revealed using a validated sandwich ELISA for small sample volumes.
American journal of physiology. Endocrinology and metabolism.
2016 08; 311(2):E302-9. doi:
10.1152/ajpendo.00119.2016. [PMID: 27245336] - James L Carmalt, Tanya Duke-Novakovski, Harold C Schott, Johannes H van der Kolk. Effects of anesthesia with isoflurane on plasma concentrations of adrenocorticotropic hormone in samples obtained from the cavernous sinus and jugular vein of horses.
American journal of veterinary research.
2016 Jul; 77(7):730-7. doi:
10.2460/ajvr.77.7.730. [PMID: 27347826] - Johanne A Windeløv, Jens Pedersen, Jens J Holst. Use of anesthesia dramatically alters the oral glucose tolerance and insulin secretion in C57Bl/6 mice.
Physiological reports.
2016 Jun; 4(11):. doi:
10.14814/phy2.12824. [PMID: 27255361] - Douglas L Miller, Xiaofang Lu, Mario Fabiilli, Chunyan Dou. Do Anesthetic Techniques Influence the Threshold for Glomerular Capillary Hemorrhage Induced in Rats by Contrast-Enhanced Diagnostic Ultrasound?.
Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine.
2016 Feb; 35(2):373-80. doi:
10.7863/ultra.15.05015. [PMID: 26764276] - Marie-Chantal Giroux, Raphael Santamaria, Pierre Hélie, Patrick Burns, Francis Beaudry, Pascal Vachon. Physiological, pharmacokinetic and liver metabolism comparisons between 3-, 6-, 12- and 18-month-old male Sprague Dawley rats under ketamine-xylazine anesthesia.
Experimental animals.
2016; 65(1):63-75. doi:
10.1538/expanim.15-0039. [PMID: 26489361] - Wendy R Williams, Matthew S Johnston, Sarah Higgins, Angelo A Izzo, Lon V Kendall. Blood profiles in unanesthetized and anesthetized guinea pigs (Cavia porcellus).
Lab animal.
2016 Jan; 45(1):35-41. doi:
10.1038/laban.911. [PMID: 26684957] - Gregory S Doran, Leah A Bradbury. Quantitation of the anaesthetic xylazine in ovine plasma by LC-MS/MS.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2015 Aug; 997(?):81-4. doi:
10.1016/j.jchromb.2015.06.005. [PMID: 26094209] - Xue Gao, Hao Guo, Yaoyu Du, Chaokang Gu. Simultaneous Determination of Xylazine and 2,6-Xylidine in Blood and Urine by Auto Solid-Phase Extraction and Ultra High Performance Liquid Chromatography Coupled with Quadrupole-Time of Flight Mass Spectrometry.
Journal of analytical toxicology.
2015 Jul; 39(6):444-50. doi:
10.1093/jat/bkv040. [PMID: 25907168] - Klaus Hopster, Tamas D Ambrisko, Jessica Stahl, Johannes P Schramel, Sabine B R Kästner. Influence of xylazine on the function of the LiDCO sensor in isoflurane anaesthetized horses.
Veterinary anaesthesia and analgesia.
2015 Mar; 42(2):142-9. doi:
10.1111/vaa.12181. [PMID: 24890704] - Marcelo Augusto de Araújo, Carolina Aparecida Carlin Beloti, Maurício Deschk, André Moreira Martins Arruda, Lu Shi Cheng, Verônica Batista de Albuquerque, Paulo Sergio Patto dos Santos. Bispectral index in calves anesthetized with xylazine, midazolam, ketamine, isoflurane and subjected to continuous rate infusion of lidocaine.
Acta cirurgica brasileira.
2015 Jan; 30(1):67-72. doi:
10.1590/s0102-86502015001000009. [PMID: 25627273] - Ryohei Kuroda, Kaori Shintani-Ishida, Kana Unuma, Ken-ichi Yoshida. Immobilization Stress With α2-Adrenergic Stimulation Induces Regional and Transient Reduction of Cardiac Contraction Through Gi Coupling in Rats.
International heart journal.
2015; 56(5):537-43. doi:
10.1536/ihj.15-034. [PMID: 26346517] - Yusuke Murahata, Yuya Miki, Yoshiaki Hikasa. Antagonistic effects of atipamezole, yohimbine, and prazosin on xylazine-induced diuresis in clinically normal cats.
Canadian journal of veterinary research = Revue canadienne de recherche veterinaire.
2014 Oct; 78(4):304-15. doi:
. [PMID: 25356000] - Annie Kullmann, Macarena Sanz, Geoffrey T Fosgate, Montague N Saulez, Patrick C Page, Eva Rioja. Effects of xylazine, romifidine, or detomidine on hematology, biochemistry, and splenic thickness in healthy horses.
The Canadian veterinary journal = La revue veterinaire canadienne.
2014 Apr; 55(4):334-40. doi:
NULL. [PMID: 24688132] - Marcelo A Araújo, Bianca P Dias, Fernanda Bovino, Maurício Deschk, Caio Jx Abimussi, Valéria Nls Oliva, Celso A Rodrigues, Paulo Sp Santos. Cardiovascular effects of a continuous rate infusion of lidocaine in calves anesthetized with xylazine, midazolam, ketamine and isoflurane.
Veterinary anaesthesia and analgesia.
2014 Mar; 41(2):145-52. doi:
10.1111/vaa.12102. [PMID: 24344783] - Klaus Hopster, Christina Müller, Charlotte Hopster-Iversen, Jessica Stahl, Karl Rohn, Sabine Kästner. Effects of dexmedetomidine and xylazine on cardiovascular function during total intravenous anaesthesia with midazolam and ketamine and recovery quality and duration in horses.
Veterinary anaesthesia and analgesia.
2014 Jan; 41(1):25-35. doi:
10.1111/vaa.12095. [PMID: 24127757] - Il-Woo Shin, Young-Sool Hah, Cheol Kim, Jungchul Park, Heewon Shin, Kyeong-Eon Park, Seong-Ho Ok, Heon-Keun Lee, Young-Kyun Chung, Haeng Seon Shim, Dong Hoon Lim, Ju-Tae Sohn. Systemic blockage of nitric oxide synthase by L-NAME increases left ventricular systolic pressure, which is not augmented further by Intralipid®.
International journal of biological sciences.
2014; 10(4):367-76. doi:
10.7150/ijbs.8048. [PMID: 24719554] - Golo M J Meyer, Hans H Maurer. Qualitative metabolism assessment and toxicological detection of xylazine, a veterinary tranquilizer and drug of abuse, in rat and human urine using GC-MS, LC-MSn, and LC-HR-MSn.
Analytical and bioanalytical chemistry.
2013 Dec; 405(30):9779-89. doi:
10.1007/s00216-013-7419-7. [PMID: 24141317] - J C De Oliveira, R Ludemann Camargo, L F Barella, R Chaves Souto Branco, C Gravena, S Grassiolli, R Torrezan, P Cezar De Freitas Mathias. Anesthetic-induced transient hyperglycemia and insulin resistance do not depend on the sympathoadrenal axis.
Minerva endocrinologica.
2013 Dec; 38(4):379-88. doi:
. [PMID: 24285105] - Pedro I Nóbrega Neto, Stelio P L Luna, Patricia Queiroz-Williams, Khursheed R Mama, Eugene P Steffey, Adriano B Carregaro. Cardiorespiratory and antinociceptive effects of two different doses of lidocaine administered to horses during a constant intravenous infusion of xylazine and ketamine.
BMC veterinary research.
2013 Oct; 9(?):199. doi:
10.1186/1746-6148-9-199. [PMID: 24103634] - Kimberly L Rainwater, Marc T Valitutto, Penny Kalk, Robert P Moore, John M Sykes. Comparison of two injectable immobilization combinations in Himalayan tahr (Hemitragus jemlahicus): medetomidine, ketamine, and atipamezole versus carfentanil, xylazine, naltrexone, and atipamezole.
Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians.
2013 Sep; 44(3):596-604. doi:
10.1638/2012-0140r1.1. [PMID: 24063087] - Golo M J Meyer, Markus R Meyer, Bernhard Mischo, Otto Schofer, Hans H Maurer. Case report of accidental poisoning with the tranquilizer xylazine and the anesthetic ketamine confirmed by qualitative and quantitative toxicological analysis using GC-MS and LC-MS(n.).
Drug testing and analysis.
2013 Sep; 5(9-10):785-9. doi:
10.1002/dta.1475. [PMID: 23554358] - Daphnée Veilleux-Lemieux, Aude Castel, Denise Carrier, Francis Beaudry, Pascal Vachon. Pharmacokinetics of ketamine and xylazine in young and old Sprague-Dawley rats.
Journal of the American Association for Laboratory Animal Science : JAALAS.
2013 Sep; 52(5):567-70. doi:
NULL. [PMID: 24041212] - David Wellington, Igor Mikaelian, Laura Singer. Comparison of ketamine-xylazine and ketamine-dexmedetomidine anesthesia and intraperitoneal tolerance in rats.
Journal of the American Association for Laboratory Animal Science : JAALAS.
2013 Jul; 52(4):481-7. doi:
NULL. [PMID: 23849447] - Xiaochun Zheng, Xiaoxia Mi, Sicong Li, Gang Chen. Determination of xylazine and 2,6-xylidine in animal tissues by liquid chromatography-tandem mass spectrometry.
Journal of food science.
2013 Jun; 78(6):T955-9. doi:
10.1111/1750-3841.12144. [PMID: 23647632] - Jin Won Park, Hyun Woo Chung, Eun Jeong Lee, Kyung-Ho Jung, Jin-Young Paik, Kyung-Han Lee. α2-Adrenergic agonists including xylazine and dexmedetomidine inhibit norepinephrine transporter function in SK-N-SH cells.
Neuroscience letters.
2013 Apr; 541(?):184-9. doi:
10.1016/j.neulet.2013.02.022. [PMID: 23485735] - Maria Pedro Guarino, Ana Isabel Santos, Miguel Mota-Carmo, Pedro Freire Costa. Effects of anaesthesia on insulin sensitivity and metabolic parameters in Wistar rats.
In vivo (Athens, Greece).
2013 Jan; 27(1):127-32. doi:
. [PMID: 23239861] - Yusuke Murahata, Yoshiaki Hikasa. Comparison of the diuretic effects of medetomidine hydrochloride and xylazine hydrochloride in healthy cats.
American journal of veterinary research.
2012 Dec; 73(12):1871-80. doi:
10.2460/ajvr.73.12.1871. [PMID: 23176412] - Daniel J Warner, Hongming Chen, Louis-David Cantin, J Gerry Kenna, Simone Stahl, Clare L Walker, Tobias Noeske. Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
Drug metabolism and disposition: the biological fate of chemicals.
2012 Dec; 40(12):2332-41. doi:
10.1124/dmd.112.047068. [PMID: 22961681] - Mohammad Ashrafzadeh Takhtfooladi, Amirali Jahanshahi, Gholamreza Jahanshahi, Amir Sotoudeh, Hamed Ashrafzadeh Takhtfooladi, Mohammadreza Khansari. Protective effect of N-acetylcysteine on kidney as a remote organ after skeletal muscle ischemia-reperfusion.
Acta cirurgica brasileira.
2012 Sep; 27(9):611-5. doi:
10.1590/s0102-86502012000900004. [PMID: 22936085] - Angela Hefti, Inka Schlemmer, Carola Sauter-Louis, Moritz Metzner. [Comparison of three different anesthesia procedures in calves with respect to possible pain-associated reactions].
Berliner und Munchener tierarztliche Wochenschrift.
2012 Jul; 125(7-8):315-25. doi:
NULL. [PMID: 22919925] - Sheila R Ernest, Michael G Wade, Claudia Lalancette, Yi-Qian Ma, Robert G Berger, Bernard Robaire, Barbara F Hales. Effects of chronic exposure to an environmentally relevant mixture of brominated flame retardants on the reproductive and thyroid system in adult male rats.
Toxicological sciences : an official journal of the Society of Toxicology.
2012 Jun; 127(2):496-507. doi:
10.1093/toxsci/kfs098. [PMID: 22387749] - Awad Rizk, Sarah Herdtweck, Henning Meyer, Jennifer Offinger, Adel Zaghloul, Juergen Rehage. Effects of xylazine hydrochloride on hormonal, metabolic, and cardiorespiratory stress responses to lateral recumbency and claw trimming in dairy cows.
Journal of the American Veterinary Medical Association.
2012 May; 240(10):1223-30. doi:
10.2460/javma.240.10.1223. [PMID: 22559113] - Urmila M Aswar, V Mohan, Subhash L Bodhankar. Antiosteoporotic activity of phytoestrogen-rich fraction separated from ethanol extract of aerial parts of Cissus quadrangularis in ovariectomized rats.
Indian journal of pharmacology.
2012 May; 44(3):345-50. doi:
10.4103/0253-7613.96310. [PMID: 22701244] - Awad Rizk, Sarah Herdtweck, Jennifer Offinger, Henning Meyer, Adel Zaghloul, Juergen Rehage. The use of xylazine hydrochloride in an analgesic protocol for claw treatment of lame dairy cows in lateral recumbency on a surgical tipping table.
Veterinary journal (London, England : 1997).
2012 May; 192(2):193-8. doi:
10.1016/j.tvjl.2011.05.022. [PMID: 22503720] - D C Williams, M Aleman, B Tharp, D J Fletcher, P H Kass, E P Steffey, R A LeCouteur, T A Holliday. Qualitative and quantitative characteristics of the electroencephalogram in normal horses after sedation.
Journal of veterinary internal medicine.
2012 May; 26(3):645-53. doi:
10.1111/j.1939-1676.2012.00921.x. [PMID: 22489924] - Pinelopi P Kapitsinou, Jonathan Jaffe, Mark Michael, Christina E Swan, Kevin J Duffy, Connie L Erickson-Miller, Volker H Haase. Preischemic targeting of HIF prolyl hydroxylation inhibits fibrosis associated with acute kidney injury.
American journal of physiology. Renal physiology.
2012 May; 302(9):F1172-9. doi:
10.1152/ajprenal.00667.2011. [PMID: 22262480] - Kristina Nordéus, Renée Båge, Hans Gustafsson, Patrice Humblot, Lennart Söderquist. The influence of oestrous substances on cyclicity and oestrous behaviour in dairy heifers.
Acta veterinaria Scandinavica.
2012 Apr; 54(?):26. doi:
10.1186/1751-0147-54-26. [PMID: 22510614] - Catherine M Creighton, Kip A Lemke, Leigh A Lamont, Barbara S Horney, Aimie J Doyle. Comparison of the effects of xylazine bolus versus medetomidine constant rate infusion on the stress response, urine production, and anesthetic recovery characteristics in horses anesthetized with isoflurane.
Journal of the American Veterinary Medical Association.
2012 Apr; 240(8):998-1002. doi:
10.2460/javma.240.8.998. [PMID: 22471830] - Amany K Elshorbagy, Chris Church, Maria Valdivia-Garcia, A David Smith, Helga Refsum, Roger Cox. Dietary cystine level affects metabolic rate and glycaemic control in adult mice.
The Journal of nutritional biochemistry.
2012 Apr; 23(4):332-40. doi:
10.1016/j.jnutbio.2010.12.009. [PMID: 21543215] - Eun Young Kim, Joon Seok Choi, Ko Eun Lee, Chang Seong Kim, Eun Hui Bae, Seong Kwon Ma, Suhn Hee Kim, Jong Un Lee, Soo Wan Kim. Altered regulation of renal Acid base transporters in response to ammonium chloride loading in rats.
The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology.
2012 Apr; 16(2):91-5. doi:
10.4196/kjpp.2012.16.2.91. [PMID: 22563253] - Qing Fang, Alicia M Giordimaina, David F Dolan, Sally A Camper, Mirna Mustapha. Genetic background of Prop1(df) mutants provides remarkable protection against hypothyroidism-induced hearing impairment.
Journal of the Association for Research in Otolaryngology : JARO.
2012 Apr; 13(2):173-184. doi:
10.1007/s10162-011-0302-3. [PMID: 22143287] - Mujalin Prasannarong, Vitoon Saengsirisuwan, Pawinee Piyachaturawat, Apichart Suksamrarn. Improvements of insulin resistance in ovariectomized rats by a novel phytoestrogen from Curcuma comosa Roxb.
BMC complementary and alternative medicine.
2012 Mar; 12(?):28. doi:
10.1186/1472-6882-12-28. [PMID: 22463706] - László Héja, Gabriella Nyitrai, Orsolya Kékesi, Arpád Dobolyi, Pál Szabó, Richárd Fiáth, István Ulbert, Borbála Pál-Szenthe, Miklós Palkovits, Julianna Kardos. Astrocytes convert network excitation to tonic inhibition of neurons.
BMC biology.
2012 Mar; 10(?):26. doi:
10.1186/1741-7007-10-26. [PMID: 22420899] - Eduardo G Victor, Paulo C L Silveira, Jonathann C Possato, Guilherme L da Rosa, Uillian B Munari, Claudio T de Souza, Ricardo A Pinho, Luciano da Silva, Emilio L Streck, Marcos M S Paula. Pulsed ultrasound associated with gold nanoparticle gel reduces oxidative stress parameters and expression of pro-inflammatory molecules in an animal model of muscle injury.
Journal of nanobiotechnology.
2012 Mar; 10(?):11. doi:
10.1186/1477-3155-10-11. [PMID: 22410000] - Wouter Bult, Hendrik de Leeuw, Olav M Steinebach, Martijn J van der Bom, Hubert Th Wolterbeek, Ron M A Heeren, Chris J G Bakker, Alfred D van Het Schip, Wim E Hennink, J Frank W Nijsen. Radioactive holmium acetylacetonate microspheres for interstitial microbrachytherapy: an in vitro and in vivo stability study.
Pharmaceutical research.
2012 Mar; 29(3):827-36. doi:
10.1007/s11095-011-0610-7. [PMID: 22068276] - Firoz N Momin, Bharatesh R Kalai, Tabassum S Shikalgar, Nilofar S Naikwade. Cardioprotective effect of methanolic extract of Ixora coccinea Linn. leaves on doxorubicin-induced cardiac toxicity in rats.
Indian journal of pharmacology.
2012 Mar; 44(2):178-83. doi:
10.4103/0253-7613.93844. [PMID: 22529471] - M J Mirzayan, C Probst, M Samii, C Krettek, A Gharabaghi, H C Pape, M van Griensven, A Samii. Histopathological features of the brain, liver, kidney and spleen following an innovative polytrauma model of the mouse.
Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie.
2012 Mar; 64(3):133-9. doi:
10.1016/j.etp.2010.07.007. [PMID: 20688496] - Ibrahim Abdel Aziz Ibrahim, Yusof Kamisah, Mohd Ismail Nafeeza, Mohd Fahami Nur Azlina. The effects of palm vitamin E on stress hormone levels and gastric lesions in stress-induced rats.
Archives of medical science : AMS.
2012 Feb; 8(1):22-9. doi:
10.5114/aoms.2012.27276. [PMID: 22457670] - Kathrin Hermeyer, Inka Buchenau, Anne Thomasmeyer, Berit Baum, Joachim Spergser, Renate Rosengarten, Marion Hewicker-Trautwein. Chronic pneumonia in calves after experimental infection with Mycoplasma bovis strain 1067: characterization of lung pathology, persistence of variable surface protein antigens and local immune response.
Acta veterinaria Scandinavica.
2012 Feb; 54(?):9. doi:
10.1186/1751-0147-54-9. [PMID: 22305416] - Peide Li, Hangru Han, Xiaohu Zhai, Weihua He, Liying Sun, Jiafa Hou. Simultaneous HPLC-UV determination of ketamine, xylazine, and midazolam in canine plasma.
Journal of chromatographic science.
2012 Feb; 50(2):108-13. doi:
10.1093/chromsci/bmr036. [PMID: 22298759] - Shuyu Zhang, Chuanjun Song, Jundong Zhou, Ling Xie, Xingjun Meng, Pengfei Liu, Jianping Cao, Xueguang Zhang, Wei-Qun Ding, Jinchang Wu. Amelioration of radiation-induced skin injury by adenovirus-mediated heme oxygenase-1 (HO-1) overexpression in rats.
Radiation oncology (London, England).
2012 Jan; 7(?):4. doi:
10.1186/1748-717x-7-4. [PMID: 22247972] - Marcel Binnebösel, Klaus T von Trotha, Christina Ricken, Christian D Klink, Karsten Junge, Joachim Conze, Marc Jansen, Ulf P Neumann, Petra Lynen Jansen. Gentamicin supplemented polyvinylidenfluoride mesh materials enhance tissue integration due to a transcriptionally reduced MMP-2 protein expression.
BMC surgery.
2012 Jan; 12(?):1. doi:
10.1186/1471-2482-12-1. [PMID: 22244356] - Susana S Caetano, Tatiana Teixeira, Carlos E Tadokoro. Intravital imaging of the mouse thymus using 2-photon Microscopy.
Journal of visualized experiments : JoVE.
2012 Jan; ?(59):e3504. doi:
10.3791/3504. [PMID: 22258059]
