(R)-methanandamide (BioDeep_00000271827)
代谢物信息卡片
(R)-methanandamide
化学式: C23H39NO2 (361.2980634)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CCCCCC=CCC=CCC=CCC=CCCCC(=O)NC(C)CO
InChI:
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Stewart Christie, Vladimir Zagorodnyuk. CB2 cannabinoid receptor agonist selectively inhibits the mechanosensitivity of mucosal afferents in the guinea pig bladder.
American journal of physiology. Renal physiology.
2021 05; 320(5):F859-F865. doi:
10.1152/ajprenal.00065.2021. [PMID: 33749323] - Katharina Bublitz, Sabine Böckmann, Kirsten Peters, Burkhard Hinz. Cannabinoid-Induced Autophagy and Heme Oxygenase-1 Determine the Fate of Adipose Tissue-Derived Mesenchymal Stem Cells under Stressful Conditions.
Cells.
2020 10; 9(10):. doi:
10.3390/cells9102298. [PMID: 33076330] - Sophia Karouzaki, Charoula Peta, Emmanouella Tsirimonaki, Dimitra Mangoura. PKCε-dependent H-Ras activation encompasses the recruitment of the RasGEF SOS1 and of the RasGAP neurofibromin in the lipid rafts of embryonic neurons.
Neurochemistry international.
2019 12; 131(?):104582. doi:
10.1016/j.neuint.2019.104582. [PMID: 31629778] - Rachel Ribeiro, Jie Wen, Shihe Li, Yumin Zhang. Involvement of ERK1/2, cPLA2 and NF-κB in microglia suppression by cannabinoid receptor agonists and antagonists.
Prostaglandins & other lipid mediators.
2013 Jan; 100-101(?):1-14. doi:
10.1016/j.prostaglandins.2012.11.003. [PMID: 23219970] - Claudia Osycka-Salut, María Gracia Gervasi, Elba Pereyra, Maximiliano Cella, María Laura Ribeiro, Ana María Franchi, Silvina Perez-Martinez. Anandamide induces sperm release from oviductal epithelia through nitric oxide pathway in bovines.
PloS one.
2012; 7(2):e30671. doi:
10.1371/journal.pone.0030671. [PMID: 22363468] - K Weller, P W Reeh, S K Sauer. TRPV1, TRPA1, and CB1 in the isolated vagus nerve--axonal chemosensitivity and control of neuropeptide release.
Neuropeptides.
2011 Dec; 45(6):391-400. doi:
10.1016/j.npep.2011.07.011. [PMID: 21868092] - Sebastian Dresen, Stefan Kneisel, Wolfgang Weinmann, Ralf Zimmermann, Volker Auwärter. Development and validation of a liquid chromatography-tandem mass spectrometry method for the quantitation of synthetic cannabinoids of the aminoalkylindole type and methanandamide in serum and its application to forensic samples.
Journal of mass spectrometry : JMS.
2011 Feb; 46(2):163-71. doi:
10.1002/jms.1877. [PMID: 21259394] - Nicole M Tsutahara, Yoshie S Weems, J Alejandro Arreguin-Arevalo, Torrance M Nett, Magen E LaPorte, Janelle Uchida, Janelle Pang, Tonya McBride, Ronald D Randel, Charles W Weems. Effects of endocannabinoid 1 and 2 (CB1; CB2) receptor agonists on luteal weight, circulating progesterone, luteal mRNA for luteinizing hormone (LH) receptors, and luteal unoccupied and occupied receptors for LH in vivo in ewes.
Prostaglandins & other lipid mediators.
2011 Feb; 94(1-2):17-24. doi:
10.1016/j.prostaglandins.2010.11.002. [PMID: 21109016] - Bruce A Rasmussen, Ellen M Unterwald, Jae K Kim, Scott M Rawls. Methanandamide blocks amphetamine-induced behavioral sensitization in rats.
European journal of pharmacology.
2010 Feb; 627(1-3):150-5. doi:
10.1016/j.ejphar.2009.10.059. [PMID: 19879869] - Nuria Olea-Herrero, Diana Vara, Sophie Malagarie-Cazenave, Inés Díaz-Laviada. The cannabinoid R+ methanandamide induces IL-6 secretion by prostate cancer PC3 cells.
Journal of immunotoxicology.
2009 Dec; 6(4):249-56. doi:
10.3109/15476910903241696. [PMID: 19908944] - C A Vercelli, J Aisemberg, S Billi, M L Wolfson, A M Franchi. Endocannabinoid system and nitric oxide are involved in the deleterious effects of lipopolysaccharide on murine decidua.
Placenta.
2009 Jul; 30(7):579-84. doi:
10.1016/j.placenta.2009.04.003. [PMID: 19428101] - Miriam Melis, Giuliano Pillolla, Antonio Luchicchi, Anna Lisa Muntoni, Sevil Yasar, Steven R Goldberg, Marco Pistis. Endogenous fatty acid ethanolamides suppress nicotine-induced activation of mesolimbic dopamine neurons through nuclear receptors.
The Journal of neuroscience : the official journal of the Society for Neuroscience.
2008 Dec; 28(51):13985-94. doi:
10.1523/jneurosci.3221-08.2008. [PMID: 19091987] - Kristin Gustafsson, Xiao Wang, Denise Severa, Maeve Eriksson, Eva Kimby, Mats Merup, Birger Christensson, Jenny Flygare, Birgitta Sander. Expression of cannabinoid receptors type 1 and type 2 in non-Hodgkin lymphoma: growth inhibition by receptor activation.
International journal of cancer.
2008 Sep; 123(5):1025-33. doi:
10.1002/ijc.23584. [PMID: 18546271] - Garth Terry, Jeih-San Liow, Eyassu Chernet, Sami S Zoghbi, Lee Phebus, Christian C Felder, Johannes Tauscher, John M Schaus, Victor W Pike, Christer Halldin, Robert B Innis. Positron emission tomography imaging using an inverse agonist radioligand to assess cannabinoid CB1 receptors in rodents.
NeuroImage.
2008 Jul; 41(3):690-8. doi:
10.1016/j.neuroimage.2008.03.004. [PMID: 18456516] - E L Veale, R Buswell, C E Clarke, A Mathie. Identification of a region in the TASK3 two pore domain potassium channel that is critical for its blockade by methanandamide.
British journal of pharmacology.
2007 Nov; 152(5):778-86. doi:
10.1038/sj.bjp.0707436. [PMID: 17828294] - M G Pistilli, N Bernabò, A Gloria, M Mattioli, B Barboni. Effect of CB1 receptors on boar sperm plasma membrane.
Veterinary research communications.
2007 Aug; 31 Suppl 1(?):189-91. doi:
10.1007/s11259-007-0093-5. [PMID: 17682872] - Youping Wang, Norbert E Kaminski, Donna H Wang. Endocannabinoid regulates blood pressure via activation of the transient receptor potential vanilloid type 1 in Wistar rats fed a high-salt diet.
The Journal of pharmacology and experimental therapeutics.
2007 May; 321(2):763-9. doi:
10.1124/jpet.106.112904. [PMID: 17308041] - David A Price, William A Owens, Georgianna G Gould, Alan Frazer, James L Roberts, Lynette C Daws, Andrea Giuffrida. CB1-independent inhibition of dopamine transporter activity by cannabinoids in mouse dorsal striatum.
Journal of neurochemistry.
2007 Apr; 101(2):389-96. doi:
10.1111/j.1471-4159.2006.04383.x. [PMID: 17250681] - W-S V Ho, M D Randall. Endothelium-dependent metabolism by endocannabinoid hydrolases and cyclooxygenases limits vasorelaxation to anandamide and 2-arachidonoylglycerol.
British journal of pharmacology.
2007 Mar; 150(5):641-51. doi:
10.1038/sj.bjp.0707141. [PMID: 17245358] - Jianping Li, Donna H Wang. Differential mechanisms mediating depressor and diuretic effects of anandamide.
Journal of hypertension.
2006 Nov; 24(11):2271-6. doi:
10.1097/01.hjh.0000249706.42230.a8. [PMID: 17053550] - Aaron M D'Antona, Kwang H Ahn, Debra A Kendall. Mutations of CB1 T210 produce active and inactive receptor forms: correlations with ligand affinity, receptor stability, and cellular localization.
Biochemistry.
2006 May; 45(17):5606-17. doi:
10.1021/bi060067k. [PMID: 16634642] - Hiroko Sade, Katsuhiko Muraki, Susumu Ohya, Noriyuki Hatano, Yuji Imaizumi. Activation of large-conductance, Ca2+-activated K+ channels by cannabinoids.
American journal of physiology. Cell physiology.
2006 Jan; 290(1):C77-86. doi:
10.1152/ajpcell.00482.2004. [PMID: 16107501] - Jane E Lauckner, Bertil Hille, Ken Mackie. The cannabinoid agonist WIN55,212-2 increases intracellular calcium via CB1 receptor coupling to Gq/11 G proteins.
Proceedings of the National Academy of Sciences of the United States of America.
2005 Dec; 102(52):19144-9. doi:
10.1073/pnas.0509588102. [PMID: 16365309] - Birgit Kraft, Hans G Kress. Indirect CB2 receptor and mediator-dependent stimulation of human whole-blood neutrophils by exogenous and endogenous cannabinoids.
The Journal of pharmacology and experimental therapeutics.
2005 Nov; 315(2):641-7. doi:
10.1124/jpet.105.084269. [PMID: 16055676] - Burkhard Hinz, Robert Ramer, Karin Eichele, Ulrike Weinzierl, Kay Brune. R(+)-methanandamide-induced cyclooxygenase-2 expression in H4 human neuroglioma cells: possible involvement of membrane lipid rafts.
Biochemical and biophysical research communications.
2004 Nov; 324(2):621-6. doi:
10.1016/j.bbrc.2004.09.095. [PMID: 15474472] - Maria M Winnicka, Robert Ł Zbucki R, Jacek Dadan, Bogusław Sawicki, Anna Hryniewicz, Piotr Kosiorek, Izabela Bialuk, Zbigniew Puchalski. An immunohistochemical study of the thyroid parafollicular (C) cells in rats treated with cannabinoids - preliminary investigations.
Folia morphologica.
2003 Nov; 62(4):419-21. doi:
NULL. [PMID: 14655131] - Fushan Wang, Brandy Daugherty, Lisa L Keise, Zhangyong Wei, Joseph P Foley, Rashmin C Savani, Michael Koval. Heterogeneity of claudin expression by alveolar epithelial cells.
American journal of respiratory cell and molecular biology.
2003 Jul; 29(1):62-70. doi:
10.1165/rcmb.2002-0180oc. [PMID: 12600828] - Jianping Li, Norbert E Kaminski, Donna H Wang. Anandamide-induced depressor effect in spontaneously hypertensive rats: role of the vanilloid receptor.
Hypertension (Dallas, Tex. : 1979).
2003 Mar; 41(3 Pt 2):757-62. doi:
10.1161/01.hyp.0000051641.58674.f7. [PMID: 12623992] - Rhonda Jo Pearlman, Karin R Aubrey, Robert J Vandenberg. Arachidonic acid and anandamide have opposite modulatory actions at the glycine transporter, GLYT1a.
Journal of neurochemistry.
2003 Feb; 84(3):592-601. doi:
10.1046/j.1471-4159.2003.01549.x. [PMID: 12558979] - Andrea Barbuti, Satoshi Ishii, Takao Shimizu, Richard B Robinson, Steven J Feinmark. Block of the background K(+) channel TASK-1 contributes to arrhythmogenic effects of platelet-activating factor.
American journal of physiology. Heart and circulatory physiology.
2002 Jun; 282(6):H2024-30. doi:
10.1152/ajpheart.00956.2001. [PMID: 12003807] - S O Jacobsson, T Wallin, C J Fowler. Inhibition of rat C6 glioma cell proliferation by endogenous and synthetic cannabinoids. Relative involvement of cannabinoid and vanilloid receptors.
The Journal of pharmacology and experimental therapeutics.
2001 Dec; 299(3):951-9. doi:
". [PMID: 11714882] - V Ralevic, D A Kendall, J C Jerman, D N Middlemiss, D Smart. Cannabinoid activation of recombinant and endogenous vanilloid receptors.
European journal of pharmacology.
2001 Jul; 424(3):211-9. doi:
10.1016/s0014-2999(01)01153-0. [PMID: 11672565] - D Smart, M J Gunthorpe, J C Jerman, S Nasir, J Gray, A I Muir, J K Chambers, A D Randall, J B Davis. The endogenous lipid anandamide is a full agonist at the human vanilloid receptor (hVR1).
British journal of pharmacology.
2000 Jan; 129(2):227-30. doi:
10.1038/sj.bjp.0703050. [PMID: 10694225] - J Romero, F Berrendero, L García-Gil, S Y Lin, A Makriyannis, J A Ramos, J J Fernández-Ruiz. Cannabinoid receptor and WIN-55,212-2-stimulated [35S]GTPgammaS binding and cannabinoid receptor mRNA levels in several brain structures of adult male rats chronically exposed to R-methanandamide.
Neurochemistry international.
1999 Jun; 34(6):473-82. doi:
10.1016/s0197-0186(99)00020-0. [PMID: 10402222] - B N Zenor, G D Weesner, P V Malven. Endocrine and other responses to acute administration of cannabinoid compounds to non-stressed male calves.
Life sciences.
1999; 65(2):125-33. doi:
10.1016/s0024-3205(99)00229-5. [PMID: 10416818] - R de Miguel, J Romero, R M Muñoz, L García-Gil, S González, M A Villanua, A Makriyannis, J A Ramos, J J Fernández-Ruiz. Effects of cannabinoids on prolactin and gonadotrophin secretion: involvement of changes in hypothalamic gamma-aminobutyric acid (GABA) inputs.
Biochemical pharmacology.
1998 Nov; 56(10):1331-8. doi:
10.1016/s0006-2952(98)00185-3. [PMID: 9825732] - J M Derocq, M Bouaboula, J Marchand, M Rinaldi-Carmona, M Ségui, P Casellas. The endogenous cannabinoid anandamide is a lipid messenger activating cell growth via a cannabinoid receptor-independent pathway in hematopoietic cell lines.
FEBS letters.
1998 Apr; 425(3):419-25. doi:
10.1016/s0014-5793(98)00275-0. [PMID: 9563506] - Jennelle Durnett Richardson, Sonja Kilo, Kenneth M Hargreaves. Cannabinoids reduce hyperalgesia and inflammation via interaction with peripheral CB1 receptors.
Pain.
1998 Mar; 75(1):111-119. doi:
10.1016/s0304-3959(97)00213-3. [PMID: 9539680] - J J Fernández-Ruiz, R M Muñoz, J Romero, M A Villanua, A Makriyannis, J A Ramos. Time course of the effects of different cannabimimetics on prolactin and gonadotrophin secretion: evidence for the presence of CB1 receptors in hypothalamic structures and their involvement in the effects of cannabimimetics.
Biochemical pharmacology.
1997 Jun; 53(12):1919-27. doi:
10.1016/s0006-2952(97)00168-8. [PMID: 9256167]