zaprinast (BioDeep_00000271609)
代谢物信息卡片
3,6-dihydro-5-(2-propoxyphenyl)-7H-1,2,3-triazolo[4,5-d]pyrimidin-7-one
化学式: C13H13N5O2 (271.1069198)
中文名称: 扎普司特
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CCCOC1=CC=CC=C1C2=NC3=NNN=C3C(=O)N2
InChI: InChI=1S/C13H13N5O2/c1-2-7-20-9-6-4-3-5-8(9)11-14-12-10(13(19)15-11)16-18-17-12/h3-6H,2,7H2,1H3,(H2,14,15,16,17,18,19)
描述信息
C471 - Enzyme Inhibitor > C744 - Phosphodiesterase Inhibitor > C2127 - cGMP Phosphodiesterase Inhibitor
D004791 - Enzyme Inhibitors > D010726 - Phosphodiesterase Inhibitors
同义名列表
数据库引用编号
7 个数据库交叉引用编号
- ChEBI: CHEBI:92215
- PubChem: 135399235
- Metlin: METLIN44292
- ChEMBL: CHEMBL28079
- CAS: 1110670-37-5
- CAS: 37762-06-4
- PMhub: MS000002837
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Veronika Wetzl, Elisabeth Schinner, Frieder Kees, Lothar Faerber, Jens Schlossmann. Differences in the renal antifibrotic cGMP/cGKI-dependent signaling of serelaxin, zaprinast, and their combination.
Naunyn-Schmiedeberg's archives of pharmacology.
2017 Sep; 390(9):939-948. doi:
10.1007/s00210-017-1394-z. [PMID: 28660304] - Kevin M Brown, Sebastian Lourido, L David Sibley. Serum Albumin Stimulates Protein Kinase G-dependent Microneme Secretion in Toxoplasma gondii.
The Journal of biological chemistry.
2016 Apr; 291(18):9554-65. doi:
10.1074/jbc.m115.700518. [PMID: 26933037] - Juan Liu, Zhengju Chen, Liping Ye, Huixia Liu, Dou Dou, Limei Liu, Xiaoxing Yu, Yuansheng Gao. Preservation of nitric oxide-induced relaxation of porcine coronary artery: roles of the dimers of soluble guanylyl cyclase, phosphodiesterase type 5, and cGMP-dependent protein kinase.
Pflugers Archiv : European journal of physiology.
2014 Oct; 466(10):1999-2008. doi:
10.1007/s00424-014-1441-2. [PMID: 24413911] - Cátia Fernandes-Cerqueira, Benedita Sampaio-Maia, Janete Quelhas-Santos, Mónica Moreira-Rodrigues, Liliana Simões-Silva, Ana M Blazquez-Medela, C Martinez-Salgado, Jose M Lopez-Novoa, Manuel Pestana. Concerted action of ANP and dopamine D1-receptor to regulate sodium homeostasis in nephrotic syndrome.
BioMed research international.
2013; 2013(?):397391. doi:
10.1155/2013/397391. [PMID: 23956981] - Thiago R L Romero, Giovane S Galdino, Grazielle C Silva, Lívia C Resende, Andréa C Perez, Steyner F Cortes, Igor D G Duarte. Involvement of the L-arginine/nitric oxide/cyclic guanosine monophosphate pathway in peripheral antinociception induced by N-palmitoyl-ethanolamine in rats.
Journal of neuroscience research.
2012 Jul; 90(7):1474-9. doi:
10.1002/jnr.22797. [PMID: 22411529] - Patrick Oeckl, Boris Ferger. Simultaneous LC-MS/MS analysis of the biomarkers cAMP and cGMP in plasma, CSF and brain tissue.
Journal of neuroscience methods.
2012 Jan; 203(2):338-43. doi:
10.1016/j.jneumeth.2011.09.032. [PMID: 22001223] - Chung-Hung Shih, Ling-Hung Lin, Hsin-Te Hsu, Kuo-Hsien Wang, Chi-Yin Lai, Chien-Ming Chen, Wun-Chang Ko. Hesperetin, a Selective Phosphodiesterase 4 Inhibitor, Effectively Suppresses Ovalbumin-Induced Airway Hyperresponsiveness without Influencing Xylazine/Ketamine-Induced Anesthesia.
Evidence-based complementary and alternative medicine : eCAM.
2012; 2012(?):472897. doi:
10.1155/2012/472897. [PMID: 22454667] - You-Lan Yang, Hsin-Te Hsu, Kuo-Hsien Wang, Cheng-Ying Han, Chien-Ming Chen, Chi-Ming Chen, Wun-Chang Ko. Hesperetin-7,3'-O-dimethylether selectively inhibits phosphodiesterase 4 and effectively suppresses ovalbumin-induced airway hyperresponsiveness with a high therapeutic ratio.
Journal of biomedical science.
2011 Nov; 18(?):84. doi:
10.1186/1423-0127-18-84. [PMID: 22074248] - Cristina Cosi, Guido Mannaioni, Andrea Cozzi, Vincenzo Carlà, Maria Sili, Leonardo Cavone, Dario Maratea, Flavio Moroni. G-protein coupled receptor 35 (GPR35) activation and inflammatory pain: Studies on the antinociceptive effects of kynurenic acid and zaprinast.
Neuropharmacology.
2011 Jun; 60(7-8):1227-31. doi:
10.1016/j.neuropharm.2010.11.014. [PMID: 21110987] - Yongping Chai, Dai-Min Zhang, Yu-Fung Lin. Activation of cGMP-dependent protein kinase stimulates cardiac ATP-sensitive potassium channels via a ROS/calmodulin/CaMKII signaling cascade.
PloS one.
2011 Mar; 6(3):e18191. doi:
10.1371/journal.pone.0018191. [PMID: 21479273] - Chung-Hung Shih, Tzu-Jung Huang, Chien-Ming Chen, Yun-Lian Lin, Wun-Chang Ko. S-Petasin, the Main Sesquiterpene of Petasites formosanus, Inhibits Phosphodiesterase Activity and Suppresses Ovalbumin-Induced Airway Hyperresponsiveness.
Evidence-based complementary and alternative medicine : eCAM.
2011; 2011(?):132374. doi:
10.1093/ecam/nep088. [PMID: 19641087] - Johan Sällström, Boye L Jensen, Ole Skøtt, Xiang Gao, A Erik G Persson. Neuronal nitric oxide synthase supports Renin release during sodium restriction through inhibition of phosphodiesterase 3.
American journal of hypertension.
2010 Nov; 23(11):1241-6. doi:
10.1038/ajh.2010.153. [PMID: 20651700] - Karl Toischer, Nils Teucher, Bernhard Unsöld, Michaela Kuhn, Harald Kögler, Gerd Hasenfuss. BNP controls early load-dependent regulation of SERCA through calcineurin.
Basic research in cardiology.
2010 Nov; 105(6):795-804. doi:
10.1007/s00395-010-0115-2. [PMID: 20711735] - Silvia Fallarini, Laura Magliulo, Tiziana Paoletti, Claudia de Lalla, Grazia Lombardi. Expression of functional GPR35 in human iNKT cells.
Biochemical and biophysical research communications.
2010 Jul; 398(3):420-5. doi:
10.1016/j.bbrc.2010.06.091. [PMID: 20599711] - Carmina Montoliu, Regina Rodrigo, Pilar Monfort, Marta Llansola, Omar Cauli, Jordi Boix, Nisrin Elmlili, Ana Agusti, Vicente Felipo. Cyclic GMP pathways in hepatic encephalopathy. Neurological and therapeutic implications.
Metabolic brain disease.
2010 Mar; 25(1):39-48. doi:
10.1007/s11011-010-9184-z. [PMID: 20195723] - Jerzy Bełtowski. Leptin and the Regulation of Renal Sodium Handling and Renal Na-Transporting ATPases: Role in the Pathogenesis of Arterial Hypertension.
Current cardiology reviews.
2010 Feb; 6(1):31-40. doi:
10.2174/157340310790231644. [PMID: 21286276] - Ichiro Kishimoto, Takeshi Tokudome, Takeshi Horio, David L Garbers, Kazuwa Nakao, Kenji Kangawa. Natriuretic Peptide Signaling via Guanylyl Cyclase (GC)-A: An Endogenous Protective Mechanism of the Heart.
Current cardiology reviews.
2009 Jan; 5(1):45-51. doi:
10.2174/157340309787048068. [PMID: 20066148] - Yongping Chai, Yu-Fung Lin. Dual regulation of the ATP-sensitive potassium channel by activation of cGMP-dependent protein kinase.
Pflugers Archiv : European journal of physiology.
2008 Aug; 456(5):897-915. doi:
10.1007/s00424-008-0447-z. [PMID: 18231807] - Yasuhito Taniguchi, Hiroko Tonai-Kachi, Katsuhiro Shinjo. 5-Nitro-2-(3-phenylpropylamino)benzoic acid is a GPR35 agonist.
Pharmacology.
2008; 82(4):245-9. doi:
10.1159/000157625. [PMID: 18818509] - Tobias Schulz, Udo Schumacher, Peter Prehm. Hyaluronan export by the ABC transporter MRP5 and its modulation by intracellular cGMP.
The Journal of biological chemistry.
2007 Jul; 282(29):20999-1004. doi:
10.1074/jbc.m700915200. [PMID: 17540771] - Xia Mao, Yongping Chai, Yu-Fung Lin. Dual regulation of the ATP-sensitive potassium channel by caffeine.
American journal of physiology. Cell physiology.
2007 Jun; 292(6):C2239-58. doi:
10.1152/ajpcell.00326.2006. [PMID: 17303650] - K Rutten, C Lieben, L Smits, A Blokland. The PDE4 inhibitor rolipram reverses object memory impairment induced by acute tryptophan depletion in the rat.
Psychopharmacology.
2007 Jun; 192(2):275-82. doi:
10.1007/s00213-006-0697-4. [PMID: 17265077] - Yasuhito Taniguchi, Hiroko Tonai-Kachi, Katsuhiro Shinjo. Zaprinast, a well-known cyclic guanosine monophosphate-specific phosphodiesterase inhibitor, is an agonist for GPR35.
FEBS letters.
2006 Sep; 580(21):5003-8. doi:
10.1016/j.febslet.2006.08.015. [PMID: 16934253] - William H Beierwaltes. cGMP stimulates renin secretion in vivo by inhibiting phosphodiesterase-3.
American journal of physiology. Renal physiology.
2006 Jun; 290(6):F1376-81. doi:
10.1152/ajprenal.00209.2005. [PMID: 16449359] - Jerzy Beltowski, Anna Jamroz-Wisniewska, Ewelina Borkowska, Andrzej Marciniak. Phosphodiesterase 5 inhibitor ameliorates renal resistance to atrial natriuretic peptide associated with obesity and hyperleptinemia.
Archives of medical research.
2006 Apr; 37(3):307-15. doi:
10.1016/j.arcmed.2005.06.008. [PMID: 16513477] - Jonathan P Day, Miles D Houslay, Shireen-A Davies. A novel role for a Drosophila homologue of cGMP-specific phosphodiesterase in the active transport of cGMP.
The Biochemical journal.
2006 Jan; 393(Pt 2):481-8. doi:
10.1042/bj20051505. [PMID: 16232123] - Shengjun Zhang, Roberto Rodriguez, Peter M Scholz, Harvey R Weiss. Functional interaction of a beta-adrenergic agonist and cyclic GMP phosphodiesterase inhibitor in control and hypertrophic cardiomyocytes.
Pharmacology.
2006; 76(2):53-60. doi:
10.1159/000089550. [PMID: 16276122] - Susan Pratt, Robert L Shepard, Ramani A Kandasamy, Paul A Johnston, William Perry, Anne H Dantzig. The multidrug resistance protein 5 (ABCC5) confers resistance to 5-fluorouracil and transports its monophosphorylated metabolites.
Molecular cancer therapeutics.
2005 May; 4(5):855-63. doi:
10.1158/1535-7163.mct-04-0291. [PMID: 15897250] - S K Kulkarni, C S Patil. Phosphodiesterase 5 enzyme and its inhibitors: update on pharmacological and therapeutical aspects.
Methods and findings in experimental and clinical pharmacology.
2004 Dec; 26(10):789-99. doi:
10.1358/mf.2004.26.10.872561. [PMID: 15672122] - Ekaterina M Fock, Elena A Lavrova, Vera T Bachteeva, Elena V Chernigovskaya, Rimma G Parnova. Nitric oxide inhibits arginine-vasotocin-induced increase of water osmotic permeability in frog urinary bladder.
Pflugers Archiv : European journal of physiology.
2004 May; 448(2):197-203. doi:
10.1007/s00424-003-1233-6. [PMID: 14722776] - Maximiliano A D'Angelo, Santiago Sanguineti, Jeffrey M Reece, Lutz Birnbaumer, Héctor N Torres, Mirtha M Flawiá. Identification, characterization and subcellular localization of TcPDE1, a novel cAMP-specific phosphodiesterase from Trypanosoma cruzi.
The Biochemical journal.
2004 Feb; 378(Pt 1):63-72. doi:
10.1042/bj20031147. [PMID: 14556647] - Anna-Louise M Cook, John M Haynes. Protein kinase G II-mediated proliferative effects in human cultured prostatic stromal cells.
Cellular signalling.
2004 Feb; 16(2):253-61. doi:
10.1016/s0898-6568(03)00134-7. [PMID: 14636895] - M A Ibrahim, H Asai, S Satoh, N Satoh, S Ueda. Effect of zaprinast on nitric oxide levels in serum and aortic tissue.
Methods and findings in experimental and clinical pharmacology.
2004 Jan; 26(1):19-24. doi:
10.1358/mf.2004.26.1.793468. [PMID: 14988737] - Mohamed A Ibrahim, Nobunori Satoh, Shiro Ueda. Possible impact of nitric oxide on the antihypertensive effect of captopril and zaprinast.
Advances in therapy.
2003 May; 20(3):143-8. doi:
10.1007/bf02850201. [PMID: 12956256] - Hakan Kilicarslan, Sahin Yildirim, Ihsan Bagcivan, Gokhan Gokce, Bulent Sarac, Yusuf Sarioglu. The effect of chronic renal failure on phosphodiesterase inhibitor-induced relaxation responses in rabbit cavernosal strips.
European journal of pharmacology.
2003 Feb; 462(1-3):155-60. doi:
10.1016/s0014-2999(03)01296-2. [PMID: 12591108] - Kenjiro Noyama, Shohei Maekawa. Localization of cyclic nucleotide phosphodiesterase 2 in the brain-derived Triton-insoluble low-density fraction (raft).
Neuroscience research.
2003 Feb; 45(2):141-8. doi:
10.1016/s0168-0102(02)00208-0. [PMID: 12573460] - Zhe-Sheng Chen, Elizabeth Hopper-Borge, Martin G Belinsky, Irina Shchaveleva, Elena Kotova, Gary D Kruh. Characterization of the transport properties of human multidrug resistance protein 7 (MRP7, ABCC10).
Molecular pharmacology.
2003 Feb; 63(2):351-8. doi:
10.1124/mol.63.2.351. [PMID: 12527806] - J D Corbin, S H Francis. Pharmacology of phosphodiesterase-5 inhibitors.
International journal of clinical practice.
2002 Jul; 56(6):453-9. doi:
NULL. [PMID: 12166544] - Wen-Fei Chiou, Chieh-Fu Chen. Pharmacological profile of evodiamine in isolated rabbit corpus cavernosum.
European journal of pharmacology.
2002 Jun; 446(1-3):151-9. doi:
10.1016/s0014-2999(02)01762-4. [PMID: 12098597] - Per I Adolfsson, Christer Ahlstrand, Eberhard Varenhorst, Samuel P S Svensson. Lysophosphatidic acid stimulates proliferation of cultured smooth muscle cells from human BPH tissue: sildenafil and papaverin generate inhibition.
The Prostate.
2002 Apr; 51(1):50-8. doi:
10.1002/pros.10077. [PMID: 11920958] - Hanna Kotikoski, Päivi Alajuuma, Eeva Moilanen, Pertteli Salmenperä, Olli Oksala, Pekka Laippala, Heikki Vapaatalo. Comparison of nitric oxide donors in lowering intraocular pressure in rabbits: role of cyclic GMP.
Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics.
2002 Feb; 18(1):11-23. doi:
10.1089/108076802317233171. [PMID: 11858611] - A Robichaud, C Savoie, P B Stamatiou, N Lachance, P Jolicoeur, R Rasori, C C Chan. Assessing the emetic potential of PDE4 inhibitors in rats.
British journal of pharmacology.
2002 Jan; 135(1):113-8. doi:
10.1038/sj.bjp.0704457. [PMID: 11786486] - F Martel, E Keating, C Calhau, D Gründemann, E Schömig, I Azevedo. Regulation of human extraneuronal monoamine transporter (hEMT) expressed in HEK293 cells by intracellular second messenger systems.
Naunyn-Schmiedeberg's archives of pharmacology.
2001 Dec; 364(6):487-95. doi:
10.1007/s002100100476. [PMID: 11770002] - A M Hamad, A J Knox. Mechanisms mediating the antiproliferative effects of nitric oxide in cultured human airway smooth muscle cells.
FEBS letters.
2001 Oct; 506(2):91-6. doi:
10.1016/s0014-5793(01)02883-6. [PMID: 11591378] - G M Tiboni, D Lamonaca. Transplacental exposure to methylene blue initiates teratogenesis in the mouse: preliminary evidence for a mechanistic implication of cyclic GMP pathway disruption.
Teratology.
2001 Oct; 64(4):213-20. doi:
10.1002/tera.1066. [PMID: 11598927] - C M Sayago, W H Beierwaltes. Nitric oxide synthase and cGMP-mediated stimulation of renin secretion.
American journal of physiology. Regulatory, integrative and comparative physiology.
2001 Oct; 281(4):R1146-51. doi:
10.1152/ajpregu.2001.281.4.r1146. [PMID: 11557622] - M C McGuinness, H P Zhang, K D Smith. Evaluation of pharmacological induction of fatty acid beta-oxidation in X-linked adrenoleukodystrophy.
Molecular genetics and metabolism.
2001 Sep; 74(1-2):256-63. doi:
10.1006/mgme.2001.3239. [PMID: 11592822] - J Keeble, O A Al-Swayeh, P K Moore. Vasorelaxant effect of nitric oxide releasing steroidal and nonsteroidal anti-inflammatory drugs.
British journal of pharmacology.
2001 Aug; 133(7):1023-8. doi:
10.1038/sj.bjp.0704161. [PMID: 11487511] - A C Eklöf, U Holtbäck, J Svennilson, A Fienberg, P Greengard, A Aperia. Increased blood pressure and loss of anp-induced natriuresis in mice lacking DARPP-32 gene.
Clinical and experimental hypertension (New York, N.Y. : 1993).
2001 Aug; 23(6):449-60. doi:
10.1081/ceh-100104236. [PMID: 11478427] - L Kalinowski, M Szczepańska-Konkel, M Jankowski, S Angielski. Studies on potential involvement of protein kinase C in glomerular insensitivity to atrial natriuretic factor on low sodium intake.
Medical science monitor : international medical journal of experimental and clinical research.
2001 Jul; 7(4):628-34. doi:
NULL. [PMID: 11433187] - D Giordano, M E De Stefano, G Citro, A Modica, M Giorgi. Expression of cGMP-binding cGMP-specific phosphodiesterase (PDE5) in mouse tissues and cell lines using an antibody against the enzyme amino-terminal domain.
Biochimica et biophysica acta.
2001 May; 1539(1-2):16-27. doi:
10.1016/s0167-4889(01)00086-6. [PMID: 11389965] - K Irie, E Fujii, H Ishida, K Wada, T Suganuma, T Nishikori, T Yoshioka, T Muraki. Inhibitory effects of cyclic AMP elevating agents on lipopolysaccharide (LPS)-induced microvascular permeability change in mouse skin.
British journal of pharmacology.
2001 May; 133(2):237-42. doi:
10.1038/sj.bjp.0704073. [PMID: 11350859] - G Anfossi, I Russo, P Massucco, L Mattiello, F Cavalot, M Trovati. N-acetyl-L-cysteine exerts direct anti-aggregating effect on human platelets.
European journal of clinical investigation.
2001 May; 31(5):452-61. doi:
10.1046/j.1365-2362.2001.00815.x. [PMID: 11380598] - X P Ni, M Safai, D G Gardner, M H Humphreys. Increased cGMP phosphodiesterase activity mediates renal resistance to ANP in rats with bile duct ligation.
Kidney international.
2001 Apr; 59(4):1264-73. doi:
10.1046/j.1523-1755.2001.0590041264.x. [PMID: 11260387] - J A Cherry, B E Thompson, V Pho. Diazepam and rolipram differentially inhibit cyclic AMP-specific phosphodiesterases PDE4A1 and PDE4B3 in the mouse.
Biochimica et biophysica acta.
2001 Mar; 1518(1-2):27-35. doi:
10.1016/s0167-4781(01)00164-6. [PMID: 11267656] - L Fawcett, R Baxendale, P Stacey, C McGrouther, I Harrow, S Soderling, J Hetman, J A Beavo, S C Phillips. Molecular cloning and characterization of a distinct human phosphodiesterase gene family: PDE11A.
Proceedings of the National Academy of Sciences of the United States of America.
2000 Mar; 97(7):3702-7. doi:
10.1073/pnas.97.7.3702. [PMID: 10725373] - P Angeli, W Jiménez, R Veggian, S Fasolato, R Volpin, H S MacHenzie, R Craighero, V D Libera, A Sticca, V Arroyo, A Gatta. Increased activity of guanosine 3'-5'-cyclic monophosphate phosphodiesterase in the renal tissue of cirrhotic rats with ascites.
Hepatology (Baltimore, Md.).
2000 Feb; 31(2):304-10. doi:
10.1002/hep.510310207. [PMID: 10655250] - A M Hamad, S R Johnson, A J Knox. Antiproliferative effects of NO and ANP in cultured human airway smooth muscle.
The American journal of physiology.
1999 11; 277(5):L910-8. doi:
10.1152/ajplung.1999.277.5.l910. [PMID: 10564175] - M Straznicka, G Gong, L Yan, P M Scholz, H R Weiss. Cyclic GMP protein kinase mediates negative metabolic and functional effects of cyclic GMP in control and hypertrophied rabbit cardiac myocytes.
Journal of cardiovascular pharmacology.
1999 Aug; 34(2):229-36. doi:
10.1097/00005344-199908000-00008. [PMID: 10445674] - H Adachi, K Kodama, H Ishihara. Evaluation of erectile response by continuous measurement of penile diameter in rats.
Journal of pharmacological and toxicological methods.
1999 Aug; 41(4):147-52. doi:
10.1016/s1056-8719(99)00034-9. [PMID: 10691019] - T Sekizawa, Y Shima, K Yoshida, M Tanahashi, M Yoshida, M Suzuki-Kusaba, H Hisa, S Satoh. Effects of zaprinast on renal nerve stimulation-induced anti-natriuresis in anaesthetized dogs.
Clinical and experimental pharmacology & physiology.
1998 Dec; 25(12):1008-12. doi:
10.1111/j.1440-1681.1998.tb02175.x. [PMID: 9887998] - J N Keller, K B Hanni, M P Mattson, W R Markesbery. Cyclic nucleotides attenuate lipid peroxidation-mediated neuron toxicity.
Neuroreport.
1998 Nov; 9(16):3731-4. doi:
10.1097/00001756-199811160-00029. [PMID: 9858387] - P Rabindranauth, P M Scholz, J Tse, K L Naim, H R Weiss. Altered relationship between cyclic GMP and myocardial O2 consumption in renal hypertension-induced cardiac hypertrophy.
Research in experimental medicine. Zeitschrift fur die gesamte experimentelle Medizin einschliesslich experimenteller Chirurgie.
1998 Jul; 198(1):11-21. doi:
10.1007/s004330050085. [PMID: 9706666] - P J Silver, E D Pagani, R L Dundore, L de Garavilla, D C Bode, E R Bacon. Cardiovascular activity of WIN 65579, a novel inhibitor of cyclic GMP phosphodiesterase 5.
European journal of pharmacology.
1998 May; 349(2-3):263-8. doi:
10.1016/s0014-2999(98)00209-x. [PMID: 9671106] - I K Anderson, G M Drew. Investigation of the inhibitory effect of N(G)-nitro-L-arginine methyl ester on the antihypertensive effect of the angiotensin AT1 receptor antagonist, GR138950.
British journal of pharmacology.
1997 Dec; 122(7):1385-94. doi:
10.1038/sj.bjp.0701531. [PMID: 9421286] - M K Sly, R C Eberhart, M D Prager. Anti-platelet action of nitric oxide and selective phosphodiesterase inhibitors.
Shock (Augusta, Ga.).
1997 Aug; 8(2):115-8. doi:
10.1097/00024382-199708000-00009. [PMID: 9261901] - C F Wu, N H Bishopric, R E Pratt. Atrial natriuretic peptide induces apoptosis in neonatal rat cardiac myocytes.
The Journal of biological chemistry.
1997 Jun; 272(23):14860-6. doi:
10.1074/jbc.272.23.14860. [PMID: 9169455] - J B Cheng, J W Watson, C J Pazoles, J D Eskra, R J Griffiths, V L Cohan, C R Turner, H J Showell, E R Pettipher. The phosphodiesterase type 4 (PDE4) inhibitor CP-80,633 elevates plasma cyclic AMP levels and decreases tumor necrosis factor-alpha (TNFalpha) production in mice: effect of adrenalectomy.
The Journal of pharmacology and experimental therapeutics.
1997 Feb; 280(2):621-6. doi:
NULL. [PMID: 9023272] - X Ni, Y Cheng, L Cao, D G Gardner, M H Humphreys. Mechanisms contributing to renal resistance to atrial natriuretic peptide in rats with common bile-duct ligation.
Journal of the American Society of Nephrology : JASN.
1996 Oct; 7(10):2110-8. doi:
10.1681/asn.v7102110. [PMID: 8915970] - V M Reddy, J Wong, J R Liddicoat, M Johengen, R Chang, J R Fineman. Altered endothelium-dependent responses in lambs with pulmonary hypertension and increased pulmonary blood flow.
The American journal of physiology.
1996 Aug; 271(2 Pt 2):H562-70. doi:
10.1152/ajpheart.1996.271.2.h562. [PMID: 8770097] - J P Valentin, W Z Ying, L A Sechi, K T Ling, C Qiu, W G Couser, M H Humphreys. Phosphodiesterase inhibitors correct resistance to natriuretic peptides in rats with Heymann Nephritis.
Journal of the American Society of Nephrology : JASN.
1996 Apr; 7(4):582-93. doi:
10.1681/asn.v74582. [PMID: 8724892] - Z Guan, S B Miller, J E Greenwald. Zaprinast accelerates recovery from established acute renal failure in the rat.
Kidney international.
1995 Jun; 47(6):1569-75. doi:
10.1038/ki.1995.220. [PMID: 7643525] - F Ichinose, C Adrie, W E Hurford, W M Zapol. Prolonged pulmonary vasodilator action of inhaled nitric oxide by Zaprinast in awake lambs.
Journal of applied physiology (Bethesda, Md. : 1985).
1995 Apr; 78(4):1288-95. doi:
10.1152/jappl.1995.78.4.1288. [PMID: 7615435] - L Sekut, D Yarnall, S A Stimpson, L S Noel, R Bateman-Fite, R L Clark, M F Brackeen, J A Menius, K M Connolly. Anti-inflammatory activity of phosphodiesterase (PDE)-IV inhibitors in acute and chronic models of inflammation.
Clinical and experimental immunology.
1995 Apr; 100(1):126-32. doi:
10.1111/j.1365-2249.1995.tb03613.x. [PMID: 7697910] - A R Noble, R A Abu-Kishk, M A D'Aloia, B C Williams, D J Lush. Cyclic GMP-linked pathway for renin secretion.
Kidney international.
1994 Dec; 46(6):1588-90. doi:
10.1038/ki.1994.454. [PMID: 7700014] - M S Chintala, V Bernardino, P J Chiu. Cyclic GMP but not cyclic AMP prevents renal platelet accumulation after ischemia-reperfusion in anesthetized rats.
The Journal of pharmacology and experimental therapeutics.
1994 Dec; 271(3):1203-8. doi:
NULL. [PMID: 7996427] - C García-Escribano, M L Díez-Marqués, J Medina-Alonso, M Rodríguez-Puyol, D Rodríguez-Puyol. Somatostatin activates particulate guanylate cyclase in cultured rat mesangial cells.
Kidney international.
1994 Dec; 46(6):1611-5. doi:
10.1038/ki.1994.459. [PMID: 7700018] - M M Teixeira, A G Rossi, T J Williams, P G Hellewell. Effects of phosphodiesterase isoenzyme inhibitors on cutaneous inflammation in the guinea-pig.
British journal of pharmacology.
1994 May; 112(1):332-40. doi:
10.1111/j.1476-5381.1994.tb13073.x. [PMID: 8032659] - R L Dundore, D M Clas, L T Wheeler, P G Habeeb, D C Bode, R A Buchholz, P J Silver, E D Pagani. Zaprinast increases cyclic GMP levels in plasma and in aortic tissue of rats.
European journal of pharmacology.
1993 Nov; 249(3):293-7. doi:
10.1016/0014-2999(93)90525-m. [PMID: 8287916] - P Ruiz-Torres, F J Lucio, M González-Rubio, M Rodríguez-Puyol, D Rodríguez-Puyol. A dual effect of somatostatin on the proliferation of cultured rat mesangial cells.
Biochemical and biophysical research communications.
1993 Sep; 195(2):1057-62. doi:
10.1006/bbrc.1993.2151. [PMID: 8103984] - J P Valentin, M H Humphreys. [Modulating effects of atrial natriuretic peptide on vascular permeability and blood pressure by inhibition of cyclic phosphodiesterase GMP in the rat].
Archives des maladies du coeur et des vaisseaux.
1992 Aug; 85(8):1219-22. doi:
NULL. [PMID: 1336359] - E Doyle, R Huber, V S Picot. Direct injection/h.p.l.c. methods for the analysis of drugs in biological samples.
Xenobiotica; the fate of foreign compounds in biological systems.
1992 Jul; 22(7):765-74. doi:
10.3109/00498259209053139. [PMID: 1333685] - P Soares-da-Silva, M H Fernandes. Effect of alpha-human atrial natriuretic peptide on the synthesis of dopamine in the rat kidney.
British journal of pharmacology.
1992 Apr; 105(4):869-74. doi:
10.1111/j.1476-5381.1992.tb09070.x. [PMID: 1324052] - P Soares-da-Silva, M H Fernandes. Inhibitory effects of guanosine 3':5'-cyclic monophosphate on the synthesis of dopamine in the rat kidney.
British journal of pharmacology.
1991 Aug; 103(4):1923-7. doi:
10.1111/j.1476-5381.1991.tb12353.x. [PMID: 1655148] - C E Lofton, W H Newman, M G Currie. Atrial natriuretic peptide regulation of endothelial permeability is mediated by cGMP.
Biochemical and biophysical research communications.
1990 Oct; 172(2):793-9. doi:
10.1016/0006-291x(90)90744-8. [PMID: 2173580] - M R Wilkins, S L Settle, P T Stockmann, P Needleman. Maximizing the natriuretic effect of endogenous atriopeptin in a rat model of heart failure.
Proceedings of the National Academy of Sciences of the United States of America.
1990 Aug; 87(16):6465-9. doi:
10.1073/pnas.87.16.6465. [PMID: 2166956] - V S Picot, E Doyle, J C Pearce. Analysis of zaprinast in rat and human plasma by automated solid-phase extraction and reversed-phase high-performance liquid chromatography.
Journal of chromatography.
1990 May; 527(2):454-60. doi:
10.1016/s0378-4347(00)82131-3. [PMID: 2167325] - R E Weishaar, D C Kobylarz-Singer, J Keiser, S J Haleen, T C Major, S Rapundalo, J T Peterson, R Panek. Subclasses of cyclic GMP-specific phosphodiesterase and their role in regulating the effects of atrial natriuretic factor.
Hypertension (Dallas, Tex. : 1979).
1990 May; 15(5):528-40. doi:
10.1161/01.hyp.15.5.528. [PMID: 2158939] - E Doyle, R D McDowall, G S Murkitt, V S Picot, S J Rogers. Two systems for the automated analysis of drugs in biological fluids using high-performance liquid chromatography.
Journal of chromatography.
1990 Apr; 527(1):67-77. doi:
10.1016/s0378-4347(00)82084-8. [PMID: 2164038] - M R Wilkins, S L Settle, P Needleman. Augmentation of the natriuretic activity of exogenous and endogenous atriopeptin in rats by inhibition of guanosine 3',5'-cyclic monophosphate degradation.
The Journal of clinical investigation.
1990 Apr; 85(4):1274-9. doi:
10.1172/jci114564. [PMID: 2156897] - E G McMahon, M A Palomo, P Mehta, G M Olins. Depressor and natriuretic effects of M&B 22,948, a guanosine cyclic 3',5'-monophosphate-selective phosphodiesterase inhibitor.
The Journal of pharmacology and experimental therapeutics.
1989 Dec; 251(3):1000-5. doi:
NULL. [PMID: 2557409] - E J Verspohl, H P Ammon. Atrial natriuretic peptide (ANP) acts via specific binding sites on cGMP system of rat pancreatic islets without affecting insulin release.
Naunyn-Schmiedeberg's archives of pharmacology.
1989 Mar; 339(3):348-53. doi:
10.1007/bf00173590. [PMID: 2542810] - M N Krupp, K W Hoover, J J Valentine. Effects of doxazosin and other antihypertensives on serum lipid levels and lipoprotein lipase in the C57BR/cdJ mouse.
Journal of cardiovascular pharmacology.
1989; 13 Suppl 2(?):S11-8; discussion S18. doi:
10.1097/00005344-198900132-00004. [PMID: 2471010] - K Ohishi, A Hishida, N Honda. Direct vasodilatory action of atrial natriuretic factor on canine glomerular afferent arterioles.
The American journal of physiology.
1988 Sep; 255(3 Pt 2):F415-20. doi:
10.1152/ajprenal.1988.255.3.f415. [PMID: 2970796] - R M Rudd, A R Gellert, P R Studdy, D M Geddes. Inhibition of exercise-induced asthma by an orally absorbed mast cell stabilizer (M & B 22,948).
British journal of diseases of the chest.
1983 Jan; 77(1):78-86. doi:
10.1016/0007-0971(83)90009-8. [PMID: 6344900]