BENZENESULFONAMIDE (BioDeep_00000271468)
代谢物信息卡片
BENZENESULFONAMIDE
化学式: C6H7NO2S (157.0197)
中文名称: 苯磺酰胺
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1=CC=C(C=C1)S(=O)(=O)N
InChI: InChI=1S/C6H7NO2S/c7-10(8,9)6-4-2-1-3-5-6/h1-5H,(H2,7,8,9)
描述信息
D004791 - Enzyme Inhibitors > D002257 - Carbonic Anhydrase Inhibitors
CONFIDENCE standard compound; EAWAG_UCHEM_ID 3595
同义名列表
1 个代谢物同义名
数据库引用编号
23 个数据库交叉引用编号
- ChEBI: CHEBI:191017
- PubChem: 7370
- ChEMBL: CHEMBL27601
- CAS: 98-10-2
- MoNA: EQ359559
- MoNA: EQ359558
- MoNA: EQ359557
- MoNA: EQ359556
- MoNA: EQ359555
- MoNA: EQ359554
- MoNA: EQ359553
- MoNA: EQ359552
- MoNA: EQ359551
- MoNA: EQ359509
- MoNA: EQ359508
- MoNA: EQ359507
- MoNA: EQ359506
- MoNA: EQ359505
- MoNA: EQ359504
- MoNA: EQ359503
- MoNA: EQ359502
- MoNA: EQ359501
- PMhub: MS000002517
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
| 亚细胞结构定位 | 关联基因列表 |
|---|
文献列表
- Ahmed M El-Saghier, Souhaila S Enaili, Aly Abdou, Abdullah Y A Alzahrani, Sana Ben Moussa, Mohamed A Gad, Asmaa M Kadry. Thiadiazole/Thiadiazine Derivatives as Insecticidal Agent: Design, Synthesis, and Biological Assessment of 1,3,4-(Thiadiazine/Thiadiazole)-Benzenesulfonamide Derivatives as IGRs Analogues against Spodoptera littoralis.
Journal of agricultural and food chemistry.
2024 May; 72(20):11369-11380. doi:
10.1021/acs.jafc.3c09703. [PMID: 38727083] - Ye-Rang Yun, Ji-Eun Lee. Kimchi attenuates endoplasmic reticulum stress-induced hepatic steatosis in HepG2 cells and C57BL/6N mice.
Nutrition research (New York, N.Y.).
2024 Apr; 124(?):43-54. doi:
10.1016/j.nutres.2024.01.013. [PMID: 38367426] - Monika, Chander, Deepansh Sharma, Pawan K Sharma, Sita Ram. Synthesis and biological evaluation of novel benzenesulfonamide incorporated thiazole-triazole hybrids as antimicrobial and antioxidant agents.
Archiv der Pharmazie.
2024 Mar; 357(3):e2300650. doi:
10.1002/ardp.202300650. [PMID: 38154111] - Dong-Ping Wang, Meng Zhang, Ming Li, Xiao-Na Yang, Changzhu Li, Peng Cao, Michael X Zhu, Yun Tian, Ye Yu, Yun-Tao Lei. Druggable site near the upper vestibule determines the high affinity and P2X3 homotrimer selectivity of Sivopixant/S-600918 and its analogue DDTPA.
British journal of pharmacology.
2023 Nov; ?(?):. doi:
10.1111/bph.16273. [PMID: 37921202] - Agnieszka Zajda, Joanna Sikora, Mira Hynninen, Janne Tampio, Kristiina M Huttunen, Magdalena Markowicz-Piasecka. Substituent effects of sulfonamide derivatives of metformin that can dually improve cellular glucose utilization and anti-coagulation.
Chemico-biological interactions.
2023 Mar; 373(?):110381. doi:
10.1016/j.cbi.2023.110381. [PMID: 36746201] - Óscar Castro, Sílvia Borrull, Eva Pocurull, Francesc Borrull. Determination of benzothiazoles, benzotriazoles and benzenesulfonamides in seafood using quick, easy, cheap, effective, rugged and safe extraction followed by gas chromatography - tandem mass spectrometry: Method development and risk assessment.
Journal of chromatography. A.
2023 Feb; 1691(?):463841. doi:
10.1016/j.chroma.2023.463841. [PMID: 36739837] - Xiaofeng Gao, Rui Li, Lijun Luo, Can Liao, Huiyuan Yang, Shengjun Mao. Alpha-Asarone Ameliorates Neurological Dysfunction of Subarachnoid Hemorrhagic Rats in Both Acute and Recovery Phases via Regulating the CaMKII-Dependent Pathways.
Translational stroke research.
2023 Feb; ?(?):. doi:
10.1007/s12975-023-01139-3. [PMID: 36781743] - Manoela Sacramento, Angélica S Reis, Carolina C Martins, Cristiane Luchese, Ethel A Wilhelm, Diego Alves. Synthesis and Evaluation of Antioxidant, Anti-Edematogenic and Antinociceptive Properties of Selenium-Sulfa Compounds.
ChemMedChem.
2022 02; 17(4):e202100507. doi:
10.1002/cmdc.202100507. [PMID: 34854233] - Jianzhang Yang, Marthandam Asokan Shibu, Lulu Kong, Jinfeng Luo, Farheen BadrealamKhan, Yanhui Huang, Zheng-Chao Tu, Cai-Hong Yun, Chih-Yang Huang, Ke Ding, Xiaoyun Lu. Design, Synthesis, and Structure-Activity Relationships of 1,2,3-Triazole Benzenesulfonamides as New Selective Leucine-Zipper and Sterile-α Motif Kinase (ZAK) Inhibitors.
Journal of medicinal chemistry.
2020 03; 63(5):2114-2130. doi:
10.1021/acs.jmedchem.9b00664. [PMID: 31244114] - Chul Soon Park, Kazuki Iwabata, Uma Sridhar, Michael Tsuei, Khushboo Singh, Young-Ki Kim, S Thayumanavan, Nicholas L Abbott. A New Strategy for Reporting Specific Protein Binding Events at Aqueous-Liquid Crystal Interfaces in the Presence of Non-Specific Proteins.
ACS applied materials & interfaces.
2020 Feb; 12(7):7869-7878. doi:
10.1021/acsami.9b16867. [PMID: 31825195] - Sun-Yee Cheung, Markus Werner, Lucia Esposito, Fabiana Troisi, Vincenza Cantone, Stefanie Liening, Stefanie König, Jana Gerstmeier, Andreas Koeberle, Rossella Bilancia, Roberta Rizza, Antonietta Rossi, Fiorentina Roviezzo, Veronika Temml, Daniela Schuster, Hermann Stuppner, Manfred Schubert-Zsilavecz, Oliver Werz, Thomas Hanke, Simona Pace. Discovery of a benzenesulfonamide-based dual inhibitor of microsomal prostaglandin E2 synthase-1 and 5-lipoxygenase that favorably modulates lipid mediator biosynthesis in inflammation.
European journal of medicinal chemistry.
2018 Aug; 156(?):815-830. doi:
10.1016/j.ejmech.2018.07.031. [PMID: 30053720] - Naohiro Narita, Akio Morohashi, Kimio Tohyama, Toshiyuki Takeuchi, Yoshihiko Tagawa, Takahiro Kondo, Satoru Asahi. Mechanism for Covalent Binding of MLN3126, an Oral Chemokine C-C Motif Receptor 9 Antagonist, to Serum Albumins.
Drug metabolism and disposition: the biological fate of chemicals.
2018 03; 46(3):204-213. doi:
10.1124/dmd.117.078782. [PMID: 29269409] - Yong Xie, Wei Peng, Fei Ding, Shu-Jie Liu, Hong-Juan Ma, Chang-Ling Liu. Quantitative structure-activity relationship (QSAR) directed the discovery of 3-(pyridin-2-yl)benzenesulfonamide derivatives as novel herbicidal agents.
Pest management science.
2018 Jan; 74(1):189-199. doi:
10.1002/ps.4693. [PMID: 28762622] - Souvik Banerjee, Derek D Norman, Sue Chin Lee, Abby L Parrill, Truc Chi T Pham, Daniel L Baker, Gabor J Tigyi, Duane D Miller. Highly Potent Non-Carboxylic Acid Autotaxin Inhibitors Reduce Melanoma Metastasis and Chemotherapeutic Resistance of Breast Cancer Stem Cells.
Journal of medicinal chemistry.
2017 02; 60(4):1309-1324. doi:
10.1021/acs.jmedchem.6b01270. [PMID: 28112925] - Md Abdul Hye Khan, Sung Hee Hwang, Amit Sharma, John A Corbett, Bruce D Hammock, John D Imig. A dual COX-2/sEH inhibitor improves the metabolic profile and reduces kidney injury in Zucker diabetic fatty rat.
Prostaglandins & other lipid mediators.
2016 09; 125(?):40-7. doi:
10.1016/j.prostaglandins.2016.07.003. [PMID: 27432695] - Akinranti Ajibola, Pablo Gago-Ferrero, Viola L Borova, Marilena E Dasenaki, Anna A Bletsou, Nikolaos S Thomaidis. Benzosulfonamides in wastewater: method development, occurrence and removal efficiencies.
Chemosphere.
2015 Jan; 119 Suppl(?):S21-7. doi:
10.1016/j.chemosphere.2014.04.003. [PMID: 24784769] - Joseph Lau, Jinhe Pan, Zhengxing Zhang, Navjit Hundal-Jabal, Zhibo Liu, François Bénard, Kuo-Shyan Lin. Synthesis and evaluation of (18)F-labeled tertiary benzenesulfonamides for imaging carbonic anhydrase IX expression in tumours with positron emission tomography.
Bioorganic & medicinal chemistry letters.
2014 Jul; 24(14):3064-8. doi:
10.1016/j.bmcl.2014.05.021. [PMID: 24878197] - Ramazan Demirdağ, Veysel Çomaklı, Murat Şentürk, Deniz Ekinci, Ö İrfan Küfrevioğlu, Claudiu T Supuran. Purification and characterization of carbonic anhydrase from sheep kidney and effects of sulfonamides on enzyme activity.
Bioorganic & medicinal chemistry.
2013 Mar; 21(6):1522-5. doi:
10.1016/j.bmc.2012.08.018. [PMID: 22974493] - Christine Crumbley, Yongjun Wang, Subhashis Banerjee, Thomas P Burris. Regulation of expression of citrate synthase by the retinoic acid receptor-related orphan receptor α (RORα).
PloS one.
2012; 7(4):e33804. doi:
10.1371/journal.pone.0033804. [PMID: 22485150] - Lars Baltzer. Crossing borders to bind proteins--a new concept in protein recognition based on the conjugation of small organic molecules or short peptides to polypeptides from a designed set.
Analytical and bioanalytical chemistry.
2011 Jun; 400(6):1653-64. doi:
10.1007/s00216-011-4905-7. [PMID: 21461620] - Polyxeni Alexiou, Vassilis J Demopoulos. A diverse series of substituted benzenesulfonamides as aldose reductase inhibitors with antioxidant activity: design, synthesis, and in vitro activity.
Journal of medicinal chemistry.
2010 Nov; 53(21):7756-66. doi:
10.1021/jm101008m. [PMID: 20936791] - Jeffrey G Varnes, Janet M Forst, Tiffany N Hoerter, Christopher R Holmquist, Deidre E Wilkins, Gaochao Tian, Gerald Jonak, Xia Wang, William M Potts, Michael W Wood, Cristóbal Alhambra, Todd A Brugel, Jeffrey S Albert. Identification of N-(2-(azepan-1-yl)-2-phenylethyl)-benzenesulfonamides as novel inhibitors of GlyT1.
Bioorganic & medicinal chemistry letters.
2010 Aug; 20(16):4878-81. doi:
10.1016/j.bmcl.2010.06.085. [PMID: 20637614] - Naresh Kumar, Laura A Solt, Juliana J Conkright, Yongjun Wang, Monica A Istrate, Scott A Busby, Ruben D Garcia-Ordonez, Thomas P Burris, Patrick R Griffin. The benzenesulfoamide T0901317 [N-(2,2,2-trifluoroethyl)-N-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-benzenesulfonamide] is a novel retinoic acid receptor-related orphan receptor-alpha/gamma inverse agonist.
Molecular pharmacology.
2010 Feb; 77(2):228-36. doi:
10.1124/mol.109.060905. [PMID: 19887649] - Theres Ramenda, Torsten Kniess, Ralf Bergmann, Jörg Steinbach, Frank Wuest. Radiolabelling of proteins with fluorine-18 via click chemistry.
Chemical communications (Cambridge, England).
2009 Dec; ?(48):7521-3. doi:
10.1039/b916075b. [PMID: 20024266] - Doreen Richter, Gudrun Massmann, Thomas Taute, Uwe Duennbier. Investigation of the fate of sulfonamides downgradient of a decommissioned sewage farm near Berlin, Germany.
Journal of contaminant hydrology.
2009 May; 106(3-4):183-94. doi:
10.1016/j.jconhyd.2009.03.001. [PMID: 19371963] - Hui-Bin Zhang, Ya-An Zhang, Guan-Zhong Wu, Jin-Pei Zhou, Wen-Long Huang, Xiao-Wen Hu. Synthesis and biological evaluation of sulfonylurea and thiourea derivatives substituted with benzenesulfonamide groups as potential hypoglycemic agents.
Bioorganic & medicinal chemistry letters.
2009 Mar; 19(6):1740-4. doi:
10.1016/j.bmcl.2009.01.082. [PMID: 19216076] - Hermenegilda Moreno-Díaz, Rafael Villalobos-Molina, Rolffy Ortiz-Andrade, Daniel Díaz-Coutiño, Jose Luis Medina-Franco, Scott P Webster, Margaret Binnie, Samuel Estrada-Soto, Maximiliano Ibarra-Barajas, Ismael León-Rivera, Gabriel Navarrete-Vázquez. Antidiabetic activity of N-(6-substituted-1,3-benzothiazol-2-yl)benzenesulfonamides.
Bioorganic & medicinal chemistry letters.
2008 May; 18(9):2871-7. doi:
10.1016/j.bmcl.2008.03.086. [PMID: 18424136] - Doreen Richter, Gudrun Massmann, Uwe Dünnbier. Behaviour and biodegradation of sulfonamides (p-TSA, o-TSA, BSA) during drinking water treatment.
Chemosphere.
2008 Apr; 71(8):1574-81. doi:
10.1016/j.chemosphere.2007.11.026. [PMID: 18179813] - Polyxeni Alexiou, Ioannis Nicolaou, Milan Stefek, Albin Kristl, Vassilis J Demopoulos. Design and synthesis of N-(3,5-difluoro-4-hydroxyphenyl)benzenesulfonamides as aldose reductase inhibitors.
Bioorganic & medicinal chemistry.
2008 Apr; 16(7):3926-32. doi:
10.1016/j.bmc.2008.01.042. [PMID: 18267362] - Nicolas Bousette, Fu Hu, Eliot H Ohlstein, Dashyant Dhanak, Stephen A Douglas, Adel Giaid. Urotensin-II blockade with SB-611812 attenuates cardiac dysfunction in a rat model of coronary artery ligation.
Journal of molecular and cellular cardiology.
2006 Aug; 41(2):285-95. doi:
10.1016/j.yjmcc.2006.05.008. [PMID: 16797584] - William C Koskinen, María Jesus Calderón, Pamela J Rice, Juan Cornejo. Sorption-desorption of flucarbazone and propoxycarbazone and their benzenesulfonamide and triazolinone metabolites in two soils.
Pest management science.
2006 Jul; 62(7):598-602. doi:
10.1002/ps.1196. [PMID: 16691543] - William C Koskinen, Jennifer A Anhalt, Ona Sakaliene, Pamela J Rice, Thomas B Moorman, Ellen L Arthur. Sorption-desorption of two 'aged' sulfonylaminocarbonyltriazolinone herbicide metabolites in soil.
Journal of agricultural and food chemistry.
2003 Jun; 51(12):3604-8. doi:
10.1021/jf021040k. [PMID: 12769532] - H J G Desirée van sen Bongard, Dick Pluim, Hilde Rosing, Lianda Nan-Offeringa, Margaret Schot, Miroslav Ravic, Jan H M Schellens, Jos H Beijnen. An excretion balance and pharmacokinetic study of the novel anticancer agent E7070 in cancer patients.
Anti-cancer drugs.
2002 Sep; 13(8):807-14. doi:
10.1097/00001813-200209000-00004. [PMID: 12394264] - Wei Tang, Ralph A Stearns, Randall R Miller, Jason S Ngui, Robert J Mathvink, Ann E Weber, Gloria Y Kwei, John R Strauss, Carol A Keohane, George A Doss, Shuet-Hing L Chiu, Thomas A Baillie. Metabolism of a thiazole benzenesulfonamide derivative, a potent and elective agonist of the human beta3-adrenergic receptor, in rats: identification of a novel isethionic acid conjugate.
Drug metabolism and disposition: the biological fate of chemicals.
2002 Jul; 30(7):778-87. doi:
10.1124/dmd.30.7.778. [PMID: 12065436] - H Tanaka, N Ohshima, H Hidaka. Isolation of cDNAs encoding cellular drug-binding proteins using a novel expression cloning procedure: drug-western.
Molecular pharmacology.
1999 Feb; 55(2):356-63. doi:
10.1124/mol.55.2.356. [PMID: 9927629] - K J Ullrich, G Fritzsch, G Rumrich, C David. Polysubstrates: substances that interact with renal contraluminal PAH, sulfate, and NMeN transport: sulfamoyl-, sulfonylurea-, thiazide- and benzeneamino-carboxylate (nicotinate) compounds.
The Journal of pharmacology and experimental therapeutics.
1994 May; 269(2):684-92. doi:
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Biomedical chromatography : BMC.
1992 Sep; 6(5):251-4. doi:
10.1002/bmc.1130060511. [PMID: 1463938] - H Kataoka, S Ohrui, Y Miyamoto, M Makita. Determination of urinary beta-phenylethylamine as its N-benzenesulphonamide derivative by gas chromatography with flame photometric detection.
Journal of chromatography.
1992 Jul; 578(1):120-3. doi:
10.1016/0378-4347(92)80233-g. [PMID: 1400777] - H P Hershey, T D Stoner. Isolation and characterization of cDNA clones for RNA species induced by substituted benzenesulfonamides in corn.
Plant molecular biology.
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