benserazide (BioDeep_00000271467)

   

Volatile Flavor Compounds


代谢物信息卡片


2-Amino-3-hydroxy-2-(2,3,4-trihydroxybenzyl)propionohydrazide

化学式: C10H15N3O5 (257.101166)
中文名称: 苄丝肼
谱图信息: 最多检出来源 Viridiplantae(plant) 96.15%

分子结构信息

SMILES: C1=CC(=C(C(=C1CNNC(=O)C(CO)N)O)O)O
InChI: InChI=1S/C10H15N3O5/c11-6(4-14)10(18)13-12-3-5-1-2-7(15)9(17)8(5)16/h1-2,6,12,14-17H,3-4,11H2,(H,13,18)

描述信息

D002491 - Central Nervous System Agents > D018726 - Anti-Dyskinesia Agents > D000978 - Antiparkinson Agents
C78272 - Agent Affecting Nervous System > C38149 - Antiparkinsonian Agent
D018377 - Neurotransmitter Agents > D015259 - Dopamine Agents
D004791 - Enzyme Inhibitors
C471 - Enzyme Inhibitor
CONFIDENCE standard compound; EAWAG_UCHEM_ID 2853

同义名列表

3 个代谢物同义名

2-Amino-3-hydroxy-2-(2,3,4-trihydroxybenzyl)propionohydrazide; benserazide; Benserazide



数据库引用编号

24 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。



文献列表

  • De-Qi Jiang, Qing-Min Zang, Li-Lin Jiang, Yan Wang, Ming-Xing Li, Jing-Yi Qiao. Comparison of pramipexole and levodopa/benserazide combination therapy versus levodopa/benserazide monotherapy in the treatment of Parkinson's disease: a systematic review and meta-analysis. Naunyn-Schmiedeberg's archives of pharmacology. 2021 09; 394(9):1893-1905. doi: 10.1007/s00210-021-02089-z. [PMID: 33959780]
  • Betty S Pace, Susan Perrine, Biaoru Li, Levi Makala, Hongyan Xu, Mayuko Takezaki, Roman F Wolf, Amy Wang, Xin Xu, Junfeng Huang, Asaf Alimardanov, Gregory J Tawa, Jose Sangerman, Aidan Faller, Wei Zheng, London Toney, Sharie J Haugabook. Benserazide racemate and enantiomers induce fetal globin gene expression in vivo: Studies to guide clinical development for beta thalassemia and sickle cell disease. Blood cells, molecules & diseases. 2021 07; 89(?):102561. doi: 10.1016/j.bcmd.2021.102561. [PMID: 33744514]
  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
  • Gregory Oxenkrug, Paul Summergrad. Benserazide, an Inhibitor of Peripheral Kynurenine Metabolism, Attenuates Olanzapine-Induced Weight Gain, Insulin Resistance, and Dyslipidemia in C57Bl/6j Mice. Molecular neurobiology. 2020 Jan; 57(1):135-138. doi: 10.1007/s12035-019-01763-x. [PMID: 31515691]
  • Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology. 2019 11; 96(5):629-640. doi: 10.1124/mol.119.115964. [PMID: 31515284]
  • Tajalli Ilm Chandel, Nida Zaidi, Masihuz Zaman, Ishrat Jahan, Aiman Masroor, Ibrar Ahmad Siddique, Shahid M Nayeem, Maroof Ali, Vladimir N Uversky, Rizwan Hasan Khan. A multiparametric analysis of the synergistic impact of anti-Parkinson's drugs on the fibrillation of human serum albumin. Biochimica et biophysica acta. Proteins and proteomics. 2019 03; 1867(3):275-285. doi: 10.1016/j.bbapap.2018.10.003. [PMID: 30312771]
  • Hiroko Tsunekawa, Kazue Takahata, Motoki Okano, Toshiko Ishikawa, Hiroshi Satoyoshi, Tetsuya Nishimura, Naoya Hoshino, Shizuko Muraoka. Selegiline increases on time without exacerbation of dyskinesia in 6-hydroxydopamine-lesioned rats displaying l-Dopa-induced wearing-off and abnormal involuntary movements. Behavioural brain research. 2018 07; 347(?):350-359. doi: 10.1016/j.bbr.2018.03.002. [PMID: 29526790]
  • Hongjie Liu, Lingxiu Chen, Zhe Zhang, Guozhu Geng, Wenjun Chen, Hanqiu Dong, Liang Chen, Sha Zhan, Tianhao Li. Effectiveness and safety of acupuncture combined with Madopar for Parkinson's disease: a systematic review with meta-analysis. Acupuncture in medicine : journal of the British Medical Acupuncture Society. 2017 Dec; 35(6):404-412. doi: 10.1136/acupmed-2016-011342. [PMID: 29180347]
  • Liping Huang, Minzhen Deng, Sheng Zhang, Shiyao Lu, Xuehong Gui, Yongqi Fang. β-asarone and levodopa coadministration increases striatal levels of dopamine and levodopa and improves behavioral competence in Parkinson's rat by enhancing dopa decarboxylase activity. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2017 Oct; 94(?):666-678. doi: 10.1016/j.biopha.2017.07.125. [PMID: 28787702]
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  • José-Francisco Rocha, Joaquim J Ferreira, Amílcar Falcão, Ana Santos, Roberto Pinto, Teresa Nunes, Luis Almeida, Patrício Soares-da-Silva. Effect of 3 Single-Dose Regimens of Opicapone on Levodopa Pharmacokinetics, Catechol-O-Methyltransferase Activity and Motor Response in Patients With Parkinson Disease. Clinical pharmacology in drug development. 2016 May; 5(3):232-40. doi: 10.1002/cpdd.217. [PMID: 27163503]
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  • Giovanna Calandra-Buonaura, Andrea Doria, Giovanna Lopane, Pietro Guaraldi, Sabina Capellari, Paolo Martinelli, Pietro Cortelli, Manuela Contin. Pharmacodynamics of a low subacute levodopa dose helps distinguish between multiple system atrophy with predominant Parkinsonism and Parkinson's disease. Journal of neurology. 2016 Feb; 263(2):250-256. doi: 10.1007/s00415-015-7961-7. [PMID: 26566913]
  • Yasushi Ishida, Kosuke Ebihara, Masahiro Tabuchi, Sachiko Imamura, Kyoji Sekiguchi, Kazushige Mizoguchi, Yoshio Kase, Go Koganemaru, Hiroshi Abe, Yasushi Ikarashi. Yokukansan, a Traditional Japanese Medicine, Enhances the L-DOPA-Induced Rotational Response in 6-Hydroxydopamine-Lesioned Rats: Possible Inhibition of COMT. Biological & pharmaceutical bulletin. 2016; 39(1):104-13. doi: 10.1248/bpb.b15-00691. [PMID: 26725433]
  • Manuela Contin, Giovanna Lopane, Andrea Passini, Ferruccio Poli, Carmelina Iannello, Maria Guarino. Mucuna pruriens in Parkinson Disease: A Kinetic-Dynamic Comparison With Levodopa Standard Formulations. Clinical neuropharmacology. 2015 Sep; 38(5):201-3. doi: 10.1097/wnf.0000000000000098. [PMID: 26366963]
  • Xiaorong Pan, Chunxia Chen, Jianping Huang, Haiming Wei, Qiuping Fan. Neuroprotective effect of combined therapy with hyperbaric oxygen and madopar on 6-hydroxydopamine-induced Parkinson's disease in rats. Neuroscience letters. 2015 Jul; 600(?):220-5. doi: 10.1016/j.neulet.2015.06.030. [PMID: 26101828]
  • Masoud Alirezaei, Zeynab Khoshdel, Omid Dezfoulian, Marzyeh Rashidipour, Vahideh Taghadosi. Beneficial antioxidant properties of betaine against oxidative stress mediated by levodopa/benserazide in the brain of rats. The journal of physiological sciences : JPS. 2015 May; 65(3):243-52. doi: 10.1007/s12576-015-0360-0. [PMID: 25665954]
  • Michael S Boosalis, Jose I Sangerman, Gary L White, Roman F Wolf, Ling Shen, Yan Dai, Emily White, Levi H Makala, Biaoru Li, Betty S Pace, Mehdi Nouraie, Douglas V Faller, Susan P Perrine. Novel Inducers of Fetal Globin Identified through High Throughput Screening (HTS) Are Active In Vivo in Anemic Baboons and Transgenic Mice. PloS one. 2015; 10(12):e0144660. doi: 10.1371/journal.pone.0144660. [PMID: 26713848]
  • Cheng-long Xie, Wen-Wen Wang, Su-fang Zhang, Ming-Lu Yuan, Jun-Yi Che, Jing Gan, Lu Song, Wei-En Yuan, Zhen-Guo Liu. Levodopa/benserazide microsphere (LBM) prevents L-dopa induced dyskinesia by inactivation of the DR1/PKA/P-tau pathway in 6-OHDA-lesioned Parkinson's rats. Scientific reports. 2014 Dec; 4(?):7506. doi: 10.1038/srep07506. [PMID: 25511986]
  • Liping Huang, Minzhen Deng, Sheng Zhang, Yongqi Fang, Ling Li. Coadministration of β-asarone and levodopa increases dopamine in rat brain by accelerating transformation of levodopa: a different mechanism from Madopar. Clinical and experimental pharmacology & physiology. 2014 Sep; 41(9):685-90. doi: 10.1111/1440-1681.12270. [PMID: 24910244]
  • Ewa Narożańska, Monika Białecka, Urszula Adamiak-Giera, Barbara Gawrońska-Szklarz, Witold Sołtan, Michał Schinwelski, Piotr Robowski, Mariusz H Madaliński, Jarosław Sławek. Pharmacokinetics of levodopa in patients with Parkinson disease and motor fluctuations depending on the presence of Helicobacter pylori infection. Clinical neuropharmacology. 2014 Jul; 37(4):96-9. doi: 10.1097/wnf.0000000000000037. [PMID: 24992088]
  • Jie Zhang, Yun-zhi Ma, Xiao-ming Shen. Evaluation on the efficacy and safety of Chinese herbal medication Xifeng Dingchan Pill in treating Parkinson's disease: study protocol of a multicenter, open-label, randomized active-controlled trial. Journal of integrative medicine. 2013 Jul; 11(4):285-90. doi: 10.3736/jintegrmed2013035. [PMID: 23867247]
  • Ali A Ensafi, Hajar Bahrami, B Rezaei, Hassan Karimi-Maleh. Application of ionic liquid-TiO2 nanoparticle modified carbon paste electrode for the voltammetric determination of benserazide in biological samples. Materials science & engineering. C, Materials for biological applications. 2013 Mar; 33(2):831-5. doi: 10.1016/j.msec.2012.11.008. [PMID: 25427494]
  • Daniel J Warner, Hongming Chen, Louis-David Cantin, J Gerry Kenna, Simone Stahl, Clare L Walker, Tobias Noeske. Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification. Drug metabolism and disposition: the biological fate of chemicals. 2012 Dec; 40(12):2332-41. doi: 10.1124/dmd.112.047068. [PMID: 22961681]
  • Philippe Huot, Tom H Johnston, James B Koprich, Susan H Fox, Jonathan M Brotchie. L-DOPA pharmacokinetics in the MPTP-lesioned macaque model of Parkinson's disease. Neuropharmacology. 2012 Oct; 63(5):829-36. doi: 10.1016/j.neuropharm.2012.06.012. [PMID: 22722022]
  • Maryka Quik, Keon Min Park, Maya Hrachova, Archana Mallela, Luping Z Huang, J Michael McIntosh, Sharon R Grady. Role for α6 nicotinic receptors in l-dopa-induced dyskinesias in parkinsonian mice. Neuropharmacology. 2012 Sep; 63(3):450-9. doi: 10.1016/j.neuropharm.2012.04.029. [PMID: 22579614]
  • Na Wu, Lu Song, Xin-xin Yang, Jiang-lei Wei, Zhen-guo Liu. [Effects of Chinese herbal medicine Tianqi Pingchan Granule on G protein-coupled receptor kinase 6 involved in the prevention of levodopa-induced dyskinesia in rats with Parkinson disease]. Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine. 2012 Sep; 10(9):1018-24. doi: 10.3736/jcim20120911. [PMID: 22979934]
  • Dag Nyholm, Tommy Lewander, Cecilia Gomes-Trolin, Tobias Bäckström, Georgios Panagiotidis, Mats Ehrnebo, Christer Nyström, Sten-Magnus Aquilonius. Pharmacokinetics of levodopa/carbidopa microtablets versus levodopa/benserazide and levodopa/carbidopa in healthy volunteers. Clinical neuropharmacology. 2012 May; 35(3):111-7. doi: 10.1097/wnf.0b013e31825645d1. [PMID: 22549097]
  • Kayhan A Tayarani-Binazir, Michael J Jackson, Isobel Strang, Mark Jairaj, Sarah Rose, Peter Jenner. Benserazide dosing regimen affects the response to L-3,4-dihydroxyphenylalanine in the 6-hydroxydopamine-lesioned rat. Behavioural pharmacology. 2012 Apr; 23(2):126-33. doi: 10.1097/fbp.0b013e32834f9f82. [PMID: 22236652]
  • Min Li, Ming-Hui Yang, Yi Liu. [Effects of 'attenuation and synergia' for Bushenhuoxue Granules on Parkinson's patients]. Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials. 2012 Mar; 35(3):503-6. doi: ". [PMID: 22876692]
  • Paulien Gm Ravenstijn, Henk-Jan Drenth, Michael J O'Neill, Meindert Danhof, Elizabeth Cm de Lange. Evaluation of blood-brain barrier transport and CNS drug metabolism in diseased and control brain after intravenous L-DOPA in a unilateral rat model of Parkinson's disease. Fluids and barriers of the CNS. 2012 Feb; 9(?):4. doi: 10.1186/2045-8118-9-4. [PMID: 22316420]
  • Isabela da Costa César, Ricardo Martins Duarte Byrro, Fabiana Fernandes de Santana e Silva Cardoso, Iram Moreira Mundim, Leonardo de Souza Teixeira, Enikson Pontes da Silva, Sandro Antônio Gomes, Ricardo Rodrigues Bonfim, Gerson Antônio Pianetti. Simultaneous quantitation of levodopa and 3-O-methyldopa in human plasma by HPLC-ESI-MS/MS: application for a pharmacokinetic study with a levodopa/benserazide formulation. Journal of pharmaceutical and biomedical analysis. 2011 Dec; 56(5):1094-100. doi: 10.1016/j.jpba.2011.07.040. [PMID: 21856105]
  • Nariaki Asada, Masayuki Takase, Jin Nakamura, Akiko Oguchi, Misako Asada, Norio Suzuki, Ken-ichi Yamamura, Narihito Nagoshi, Shinsuke Shibata, Tata Nageswara Rao, Hans Joerg Fehling, Atsushi Fukatsu, Naoko Minegishi, Toru Kita, Takeshi Kimura, Hideyuki Okano, Masayuki Yamamoto, Motoko Yanagita. Dysfunction of fibroblasts of extrarenal origin underlies renal fibrosis and renal anemia in mice. The Journal of clinical investigation. 2011 Oct; 121(10):3981-90. doi: 10.1172/jci57301. [PMID: 21911936]
  • Aiko Ishihara, Takafumi Miyachi, Takeshi Nakamura, Toshiho Ohtsuki, Yasuhiro Kimura, Kenji Kihira, Takemori Yamawaki, Masayasu Matsumoto. Relationship between 3-O-methyldopa and the clinical effects of entacapone in advanced Parkinson's disease. Hiroshima journal of medical sciences. 2011 Sep; 60(3):57-62. doi: . [PMID: 22053701]
  • Min Li, Ming-Hui Yang, Shao-Dan Li, Yi Liu. [Effects of bushenhuoxue granules on sleep quality in Parkinson's patients]. Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials. 2011 Sep; 34(9):1473-7. doi: ". [PMID: 22260015]
  • Sandra Pérez-Rial, María S García-Gutiérrez, José A Molina, Beatriz G Pérez-Nievas, Catherine Ledent, Carlos Leiva, Juan C Leza, Jorge Manzanares. Increased vulnerability to 6-hydroxydopamine lesion and reduced development of dyskinesias in mice lacking CB1 cannabinoid receptors. Neurobiology of aging. 2011 Apr; 32(4):631-45. doi: 10.1016/j.neurobiolaging.2009.03.017. [PMID: 19419794]
  • Guillermo A Keller, Paola Czerniuk, Roberto Bertuola, Juan G Spatz, Aria R Assefi, Guillermo Di Girolamo. Comparative bioavailability of 2 tablet formulations of levodopa/benserazide in healthy, fasting volunteers: a single-dose, randomized-sequence, open-label crossover study. Clinical therapeutics. 2011 Apr; 33(4):500-10. doi: 10.1016/j.clinthera.2011.04.012. [PMID: 21635995]
  • Ndidi C Ngwuluka, Viness Pillay, Yahya E Choonara, Girish Modi, Dinesh Naidoo, Lisa C du Toit, Pradeep Kumar, Valence M K Ndesendo, Riaz A Khan. Fabrication, modeling and characterization of multi-crosslinked methacrylate copolymeric nanoparticles for oral drug delivery. International journal of molecular sciences. 2011; 12(9):6194-225. doi: 10.3390/ijms12096194. [PMID: 22016653]
  • Yoshihiro Tani, Atsuto Ogata, Makoto Koyama, Teruyoshi Inoue. Effects of piclozotan (SUN N4057), a partial serotonin 1A receptor agonist, on motor complications induced by repeated administration of levodopa in parkinsonian rats. European journal of pharmacology. 2010 Dec; 649(1-3):218-23. doi: 10.1016/j.ejphar.2010.09.013. [PMID: 20858480]
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  • Bazoumana Ouattara, Samah Belkhir, Marc Morissette, Mehdi Dridi, Pershia Samadi, Laurent Grégoire, Leonard T Meltzer, Thérèse Di Paolo. Implication of NMDA receptors in the antidyskinetic activity of cabergoline, CI-1041, and Ro 61-8048 in MPTP monkeys with levodopa-induced dyskinesias. Journal of molecular neuroscience : MN. 2009 Jun; 38(2):128-42. doi: 10.1007/s12031-008-9137-8. [PMID: 18704766]
  • T T Zhang, M Song, T J Hang, X F Xu, A D Wen, L Yang, L Jia. Pharmacokinetic profile of talipexole in healthy volunteers is not altered when it is co-administered with Madopar (co-beneldopa). Journal of clinical pharmacy and therapeutics. 2009 Jun; 34(3):345-54. doi: 10.1111/j.1365-2710.2008.01008.x. [PMID: 19646081]
  • C Marin, E Aguilar, M C Rodríguez-Oroz, G D Bartoszyk, J A Obeso. Local administration of sarizotan into the subthalamic nucleus attenuates levodopa-induced dyskinesias in 6-OHDA-lesioned rats. Psychopharmacology. 2009 Jun; 204(2):241-50. doi: 10.1007/s00213-008-1452-9. [PMID: 19159919]
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