Bortezomib (BioDeep_00000027145)
human metabolite blood metabolite
代谢物信息卡片
[(1R)-3-methyl-1-[(2S)-3-phenyl-2-(pyrazin-2-ylformamido)propanamido]butyl]boronic acid
化学式: C19H25BN4O4 (384.19687600000003)
中文名称: 硼替佐米
谱图信息:
最多检出来源 Homo sapiens(blood) 38.31%
分子结构信息
SMILES: B(C(CC(C)C)NC(=O)C(CC1=CC=CC=C1)NC(=O)C2=NC=CN=C2)(O)O
InChI: InChI=1S/C19H25BN4O4/c1-13(2)10-17(20(27)28)24-18(25)15(11-14-6-4-3-5-7-14)23-19(26)16-12-21-8-9-22-16/h3-9,12-13,15,17,27-28H,10-11H2,1-2H3,(H,23,26)(H,24,25)/t15-,17-/m0/s1
描述信息
Bortezomib (originally PS-341 and marketed as Velcade by Millennium Pharmaceuticals) is the first therapeutic proteasome inhibitor to be tested in humans. It is approved in the U.S. for treating relapsed multiple myeloma and mantle cell lymphoma. In multiple myeloma, complete clinical responses have been obtained in patients with otherwise refractory or rapidly advancing disease.
L - Antineoplastic and immunomodulating agents > L01 - Antineoplastic agents > L01X - Other antineoplastic agents > L01XG - Proteasome inhibitors
C274 - Antineoplastic Agent > C163758 - Targeted Therapy Agent > C2160 - Proteasome Inhibitor
D000970 - Antineoplastic Agents
C471 - Enzyme Inhibitor
同义名列表
11 个代谢物同义名
[(1R)-3-methyl-1-[(2S)-3-phenyl-2-(pyrazin-2-ylformamido)propanamido]butyl]boronic acid; N-[(1R)-1-(DIHYDROXYBORYL)-3-methylbutyl]-N-(pyrazin-2-ylcarbonyl)-L-phenylalaninamide; Bortezomib Impurity (R,S-Isomer); Bortezomib (PS-341); Bortezomib; Velcade; LDP 341; 341, PS; LDP-341; PS-341; PS 341
数据库引用编号
12 个数据库交叉引用编号
- ChEBI: CHEBI:52717
- PubChem: 5213527
- PubChem: 387447
- HMDB: HMDB0014334
- DrugBank: DB00188
- ChEMBL: CHEMBL325041
- Wikipedia: Bortezomib
- MeSH: Bortezomib
- chemspider: 343402
- CAS: 1610526-91-4
- CAS: 179324-69-7
- PMhub: MS000244000
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Yang Yang, Bing Zhao, Hongli Lan, Jinbing Sun, Guoli Wei. Bortezomib-induced peripheral neuropathy: Clinical features, molecular basis, and therapeutic approach.
Critical reviews in oncology/hematology.
2024 May; 197(?):104353. doi:
10.1016/j.critrevonc.2024.104353. [PMID: 38615869] - Javier Avilés-Prieto, Manuel Caro-Magdaleno, Enrique Rodríguez-de-la-Rúa-Franch. Peripheral Ulcerative Keratopathy following Systemic Treatment with Bortezomib: A Case Report.
Ocular immunology and inflammation.
2024 May; 32(4):470-472. doi:
10.1080/09273948.2023.2173241. [PMID: 36780594] - Qianshuang Geng, Jie Li, Xi Li, Wenjie Zhang, Guoxiang Zhang, Li Ge, Li Liang. A case report: Nonsecretory multiple myeloma presenting with bone pain.
Medicine.
2024 Feb; 103(5):e36951. doi:
10.1097/md.0000000000036951. [PMID: 38306571] - Farid Mostafaei, Salar Hemmati, Hadi Valizadeh, Mohammad Mahmoudian, Muhammad Sarfraz, Mahdieh Abdi, Shukoofeh Torabi, Behzad Baradaran, Massoud Vosough, Parvin Zakeri-Milani. Enhanced intracellular accumulation and cytotoxicity of bortezomib against liver cancer cells using N-stearyl lactobionamide surface modified solid lipid nanoparticles.
International journal of pharmaceutics.
2024 Jan; 649(?):123635. doi:
10.1016/j.ijpharm.2023.123635. [PMID: 38000649] - Haimin Chen, Haiqi Chen, Yan Zhou, Weiwei Xu, Jingjing Yu, Yao Xu, Fan Zhou. Comparative efficacy of novel-drugs combined therapeutic regimens on relapsed/refractory multiple myeloma: a network meta-analysis.
Hematology (Amsterdam, Netherlands).
2023 Dec; 28(1):2225342. doi:
10.1080/16078454.2023.2225342. [PMID: 37343159] - Yunlong Tang, Weiying Gu, Lingling Cheng. Evodiamine attenuates oxidative stress and ferroptosis by inhibiting the MAPK signaling to improve bortezomib-induced peripheral neurotoxicity.
Environmental toxicology.
2023 Nov; ?(?):. doi:
10.1002/tox.24035. [PMID: 38010754] - Shuhan Jin, Bo Li, Bibo Zhang, Xuejie Gao, Xinyan Jia, Li Xu, Shuaikang Chang, Ke Hu, Guanli Wang, Zhijian Xu, Ting Zhang, Dongliang Song, Guang Yang, Xiaosong Wu, Huabin Zhu, Cheng Huang, Yumeng Lu, Jumei Shi, Weiliang Zhu, Gege Chen. Dihydrocelastrol induces antitumor activity and enhances the sensitivity of bortezomib in resistant multiple myeloma by inhibiting STAT3-dependent PSMB5 regulation.
Acta biochimica et biophysica Sinica.
2023 Nov; 55(12):1884-1891. doi:
10.3724/abbs.2023260. [PMID: 38009004] - Zeyuan Cao, Peiyi Li, Yuzhen Li, Manjin Zhang, Meng Hao, Wenwen Li, Xueli Mao, Lijie Mo, Chuan Yang, Xin Ding, Yi Yan Yang, Peiyan Yuan, Songtao Shi, Xiaoxing Kou. Encapsulation of Nano-Bortezomib in Apoptotic Stem Cell-Derived Vesicles for the Treatment of Multiple Myeloma.
Small (Weinheim an der Bergstrasse, Germany).
2023 10; 19(40):e2301748. doi:
10.1002/smll.202301748. [PMID: 37282762] - Jianhao Liu, Xiaoman Xu, Yanying Li, Jingxia Xu, Ruogang Zhao, Siwei Liu, Jingliang Wu, Li Zhang, Bo Zhang. Bortezomib-loaded mixed micelles realize a "three-in-one" effect for enhanced breast cancer treatment.
Biomaterials science.
2023 Jun; ?(?):. doi:
10.1039/d3bm00254c. [PMID: 37306225] - Camilla Valente Pires, Jenna Oberstaller, Chengqi Wang, Debora Casandra, Min Zhang, Jyotsna Chawla, Swamy Rakesh Adapa, Thomas D Otto, Michael T Ferdig, Julian C Rayner, Rays H Y Jiang, John H Adams. Chemogenomic Profiling of a Plasmodium falciparum Transposon Mutant Library Reveals Shared Effects of Dihydroartemisinin and Bortezomib on Lipid Metabolism and Exported Proteins.
Microbiology spectrum.
2023 Apr; ?(?):e0501422. doi:
10.1128/spectrum.05014-22. [PMID: 37067430] - Yuxun Ding, Xiaowen Hu, Yinzi Piao, Rong Huang, Lingping Xie, Xiaojian Yan, Hui Sun, Yuanfeng Li, Linqi Shi, Yong Liu. Lipid Prodrug Nanoassemblies via Dynamic Covalent Boronates.
ACS nano.
2023 04; 17(7):6601-6614. doi:
10.1021/acsnano.2c12233. [PMID: 36999933] - Mina Maksimos, Barbara Muz, John L Magnani, Abdel Kareem Azab. E-selectin-targeting lipid nanoparticles improve therapeutic efficacy and reduce side effects of bortezomib in multiple myeloma.
Blood cancer journal.
2023 04; 13(1):48. doi:
10.1038/s41408-023-00828-4. [PMID: 37029121] - Shurong Hou, Zhenzhen Li, Xiaoling Chen, Wenxin Wang, Ting Duan, Louis Scampavia, Yaxia Yuan, Timothy P Spicer, Xiabin Chen, Tian Xie. Elemene sensitizes pancreatic cancer cells to bortezomib by enhancing proteasome inhibition via molecular patch mechanism.
Signal transduction and targeted therapy.
2023 02; 8(1):87. doi:
10.1038/s41392-023-01373-z. [PMID: 36849489] - Shangjin Yin, Kuangguo Zhou, Zhiqiong Wang, Duanhao Gong, Wei Huang. Coexistence of primary mediastinal MALT lymphoma and multiple myeloma like POEMS syndrome: A case report and literature review.
Medicine.
2023 Jan; 102(4):e32801. doi:
10.1097/md.0000000000032801. [PMID: 36705370] - Meng Chen, Lei Zhao, Fang Yao, Xiang Dong Yang. Severe lung injury induced by CD38 monoclonal antibody Daratumumab and bortezomib-containing regimen in a patient with preexisting interstitial lung disease: a case report and literature review.
Journal of clinical pharmacy and therapeutics.
2022 Dec; 47(12):2387-2392. doi:
10.1111/jcpt.13819. [PMID: 36478570] - Fangfang Zhou, Liyin Guo. Lncrna ANGPTL1-3 and its target microRNA-30a exhibit potency as biomarkers for bortezomib response and prognosis in multiple myeloma patients.
Hematology (Amsterdam, Netherlands).
2022 Dec; 27(1):596-602. doi:
10.1080/16078454.2022.2072062. [PMID: 35617291] - Kaixi Ding, Wei Jiang, Huanan Jia, Ming Lei. Synergistically Anti-Multiple Myeloma Effects: Flavonoid, Non-Flavonoid Polyphenols, and Bortezomib.
Biomolecules.
2022 11; 12(11):. doi:
10.3390/biom12111647. [PMID: 36358997] - S A Kardanova, Yu Yu Kirichenko, O V Bochkarnikova, O N Antyufeeva, Yu B Kochkareva, O Yu Vinogradova, E V Privalova, I S Ilgisonis, Yu N Belenkov. Relationship Between Markers of the Acute Phase of Inflammation, Parameters of Blood Lipid Composition and Intracardiac Hemodynamics During Chemotherapy in Patients With Multiple Myeloma.
Kardiologiia.
2022 Sep; 62(9):18-26. doi:
10.18087/cardio.2022.9.n2183. [PMID: 36206134] - Rintu Sharma, Arihant Jain, Aditya Jandial, Deepesh Lad, Alka Khadwal, Gaurav Prakash, Ritambhra Nada, Ritu Aggarwal, Raja Ramachandran, Neelam Varma, Pankaj Malhotra. Lack of Renal Recovery Predicts Poor Survival in Patients of Multiple Myeloma With Renal Impairment.
Clinical lymphoma, myeloma & leukemia.
2022 Aug; 22(8):626-634. doi:
10.1016/j.clml.2022.04.013. [PMID: 35610119] - S Vincent Rajkumar. Multiple myeloma: 2022 update on diagnosis, risk stratification, and management.
American journal of hematology.
2022 Aug; 97(8):1086-1107. doi:
10.1002/ajh.26590. [PMID: 35560063] - G Mele, N Cascavilla, N Di Renzo, A Guarini, P Mazza, L Melillo, V Pavone, G Tarantini, P Curci, A P Falcone, C Germano, A Mele, G Palazzo, G Palumbo, G Reddiconto, B Rossini, G Specchia, P Musto, D Pastore. Daratumumab plus bortezomib or daratumumab plus lenalidomide as salvage therapy for patients with myeloma: initial follow-up of an Italian multicentre retrospective clinical experience by 'Rete Ematologica Pugliese'.
Annals of hematology.
2022 Aug; 101(8):1727-1739. doi:
10.1007/s00277-022-04857-0. [PMID: 35587825] - Francesca Conti, Francesca Gottardi, Mattia Moratti, Tamara Belotti, Simona Ferrari, Paola Selva, Mirna Bassi, Daniele Zama, Andrea Pession. Refractory immune thrombocytopenia successfully treated with bortezomib in a child with 22q11.2 deletion syndrome, complicated by Evans syndrome and hypogammaglobulinemia.
Platelets.
2022 Jul; 33(5):801-806. doi:
10.1080/09537104.2021.2002835. [PMID: 35132908] - Haiqin Wang, Xiaojuan Xiao, Zhenzhen Li, Saiqun Luo, Lei Hu, Hui Yi, Ruohong Xiang, Yu Zhu, Yanpeng Wang, Lin Zhu, Ling Xiao, Chongwen Dai, Abdul Aziz, Lingli Yuan, Yajuan Cui, Ruijuan Li, Fanjie Gong, Xifeng Liu, Long Liang, Hongling Peng, Hui Zhou, Jing Liu. Polyphyllin VII, a novel moesin inhibitor, suppresses cell growth and overcomes bortezomib resistance in multiple myeloma.
Cancer letters.
2022 07; 537(?):215647. doi:
10.1016/j.canlet.2022.215647. [PMID: 35306105] - Mengmeng Dong, Jinna Zhang, Xiaoyan Han, Jingsong He, Gaofeng Zheng, Zhen Cai. Baseline peripheral neuropathy was associated with age and a prognostic factor in newly diagnosed multiple myeloma patients.
Scientific reports.
2022 Jun; 12(1):10061. doi:
10.1038/s41598-022-13935-2. [PMID: 35710565] - Virginia Abello, William Armando Mantilla, Henry Idrobo, Claudia Lucia Sossa, Luis Antonio Salazar, Angela Pena, Juan Manuel Herrera, Paola Guerrero, Daniel Espinosa, Guillermo Enrique Quintero-Vega, Isabel Munevar, Kenny Galvez, Alicia Henao, Rigoberto Gómez, Jose Domingo Saavedra, Lina María Gaviria, Mónica Osuna, María Victoria Mateos. Real-World Evidence of Epidemiology and Clinical Outcomes in Multiple Myeloma, Findings from the Registry of Hemato-Oncologic Malignancies in Colombia, Observational Study.
Clinical lymphoma, myeloma & leukemia.
2022 06; 22(6):e405-e413. doi:
10.1016/j.clml.2021.12.009. [PMID: 35042679] - Morie A Gertz. Immunoglobulin light chain amyloidosis: 2022 update on diagnosis, prognosis, and treatment.
American journal of hematology.
2022 06; 97(6):818-829. doi:
10.1002/ajh.26569. [PMID: 35429180] - Saman Hewamana, Prasanna Gunasena, Chathuri Jayasinghe, Thurairajah Skandarajah, Mahesh Harischandra, Sobitha Abeyaratne, Lalith Ekanayake, Gnani Somasundaram, Surjit Somiah, Vadivelu Srinivasan, Gehan Arseculeratne, Neomal Perera, Jayaindra Fernando, Mazhar Faiz, Nihal Munasinghe, Ashfaq Mowlana, Samadhi Deshapriya, Supun Mawathakubura, Chandana Wickramarathna, Ananda Wijewickrama, Priyankara Jayawardena, Eranga Perera, Natasha Peiris, Sarath Paranawithane, Chitranganie Perera, Chitranga Kariyawasam, Sanjeewa Munasinghe, Chandu De Silva, Rohini Wadanamby, Geethani Galagoda, Thet Thet Lin, Bandula Wijesiriwardena, Jayantha Balawardena. Response and Survival Estimates of Patients With Plasma Cell Myeloma in a Resource-Constrained Setting Using Protocols From High-Income Countries: A Single-Center Experience From Sri Lanka.
JCO global oncology.
2022 Jun; 8(?):e2100352. doi:
10.1200/go.21.00352. [PMID: 35772042] - Qiaoyan Han, Hua Bai, Yong Xu, Min Zhou, He Zhou, Xiaoqing Dong, Bing Chen. Solamargine induces autophagy-mediated apoptosis and enhances bortezomib activity in multiple myeloma.
Clinical and experimental pharmacology & physiology.
2022 06; 49(6):674-685. doi:
10.1111/1440-1681.13643. [PMID: 35294057] - L T Liu, X J Wei, L X Gong, Z Yu, L G Qiu, M Hao. [Establishment and comparison of three human multiple myeloma cell line transplantation models in mice].
Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi.
2022 May; 43(5):414-419. doi:
10.3760/cma.j.issn.0253-2727.2022.05.011. [PMID: 35680600] - Masoud Farshbaf, Solmaz Mojarad-Jabali, Salar Hemmati, Ahmad Yari Khosroushahi, Hamidreza Motasadizadeh, Amir Zarebkohan, Hadi Valizadeh. Enhanced BBB and BBTB penetration and improved anti-glioma behavior of Bortezomib through dual-targeting nanostructured lipid carriers.
Journal of controlled release : official journal of the Controlled Release Society.
2022 05; 345(?):371-384. doi:
10.1016/j.jconrel.2022.03.019. [PMID: 35301054] - Makoto Hara, Hideto Nakajima. [Anti-NMDAR Encephalitis with Poor Recovery on Steroid Pulse and IVIg: Practical Approach to Intensive Immunotherapy].
Brain and nerve = Shinkei kenkyu no shinpo.
2022 May; 74(5):433-442. doi:
10.11477/mf.1416202061. [PMID: 35589628] - Floriane Lignet, Andreas D Becker, Claude Gimmi, Felix Rohdich, Samer El Bawab. Using thrombocytopenia modeling to investigate the mechanisms underlying platelet depletion induced by pan-proteasome inhibitors.
CPT: pharmacometrics & systems pharmacology.
2022 05; 11(5):594-603. doi:
10.1002/psp4.12743. [PMID: 34845847] - Rikako Oki, Kohei Unagami, Sekiko Taneda, Toshio Takagi, Hideki Ishida. Treatment with bortezomib for recurrent proliferative glomerulonephritis with monoclonal IgG deposits in kidney allograft. Case report and review of the literature.
Journal of nephrology.
2022 05; 35(4):1289-1293. doi:
10.1007/s40620-022-01332-x. [PMID: 35522429] - Hongyan Ma, Liyun Shen, Hua Yang, Hongtao Gong, Xingjun Du. Circular RNA circPSAP functions as an efficient miR-331-3p sponge to regulate proliferation, apoptosis and bortezomib sensitivity of human multiple myeloma cells by upregulating HDAC4.
Journal of pharmacological sciences.
2022 May; 149(1):27-36. doi:
10.1016/j.jphs.2022.01.013. [PMID: 35369902] - Rahul Lakhotia, Christopher Melani, Kieron Dunleavy, Stefania Pittaluga, Nakhle Saba, Liza Lindenberg, Esther Mena, Ethan Bergvall, Andrea Nicole Lucas, Allison Jacob, Erik Yusko, Seth M Steinberg, Elaine S Jaffe, Adrian Wiestner, Wyndham H Wilson, Mark Roschewski. Circulating tumor DNA predicts therapeutic outcome in mantle cell lymphoma.
Blood advances.
2022 04; 6(8):2667-2680. doi:
10.1182/bloodadvances.2021006397. [PMID: 35143622] - Michael Cass, Andrew B McDonald, Osnat Ben-Shahar, Yosef Landesman, Trinayan Kashyap. A Case Report of a 58-Year-Old Woman with a Diagnosis of High-Risk Myeloma Refractory to Multiple Line of Therapy and Treated with Selinexor, Bortezomib, and Dexamethasone Prior to Allogeneic Stem Cell Transplantation.
The American journal of case reports.
2022 Apr; 23(?):e935353. doi:
10.12659/ajcr.935353. [PMID: 35444159] - Yu-Bo Zhou, Yang-Ming Zhang, Hong-Hui Huang, Li-Jing Shen, Xiao-Feng Han, Xiao-Bei Hu, Song-da Yu, An-Hui Gao, Li Sheng, Ming-Bo Su, Xiao-Li Wei, Yue Zhang, Yi-Fan Zhang, Zhi-Wei Gao, Xiao-Yan Chen, Fa-Jun Nan, Jia Li, Jian Hou. Pharmacodynamic, pharmacokinetic, and phase 1a study of bisthianostat, a novel histone deacetylase inhibitor, for the treatment of relapsed or refractory multiple myeloma.
Acta pharmacologica Sinica.
2022 Apr; 43(4):1091-1099. doi:
10.1038/s41401-021-00728-y. [PMID: 34341512] - Zhen Yu, Xiaojing Wei, Lanting Liu, Hao Sun, Teng Fang, Lu Wang, Ying Li, Weiwei Sui, Kefei Wang, Yi He, Yaozhong Zhao, Wenyang Huang, Gang An, Fancui Meng, Changjiang Huang, Tengteng Yu, Kenneth C Anderson, Tao Cheng, Lugui Qiu, Mu Hao. Indirubin-3'-monoxime acts as proteasome inhibitor: Therapeutic application in multiple myeloma.
EBioMedicine.
2022 Apr; 78(?):103950. doi:
10.1016/j.ebiom.2022.103950. [PMID: 35344764] - Guy Pratt, Dima El-Sharkawi, Jaimal Kothari, Shirley D'Sa, Rebecca Auer, Helen McCarthy, Rajesh Krishna, Oliver Miles, Charalampia Kyriakou, Roger Owen. Diagnosis and management of Waldenström macroglobulinaemia-A British Society for Haematology guideline.
British journal of haematology.
2022 04; 197(2):171-187. doi:
10.1111/bjh.18036. [PMID: 35020191] - Hannah A Blair. Daratumumab: A Review in Newly Diagnosed Systemic Light Chain Amyloidosis.
Drugs.
2022 Apr; 82(6):683-690. doi:
10.1007/s40265-022-01705-3. [PMID: 35416593] - Di Wu, Zongyi Wang, Jun Li, Yan Song, Manuel Everardo Mondragon Perez, Zixuan Wang, Xia Cao, Changliang Cao, Sushila Maharjan, Kenneth C Anderson, Dharminder Chauhan, Yu Shrike Zhang. A 3D-Bioprinted Multiple Myeloma Model.
Advanced healthcare materials.
2022 04; 11(7):e2100884. doi:
10.1002/adhm.202100884. [PMID: 34558232] - Maya Abdallah, Vaishali Sanchorawala. Update on the Contemporary Treatment of Light Chain Amyloidosis Including Stem Cell Transplantation.
The American journal of medicine.
2022 04; 135 Suppl 1(?):S30-S37. doi:
10.1016/j.amjmed.2022.01.011. [PMID: 35081382] - Xi Huang, Wen Cao, Shunnan Yao, Jing Chen, Yang Liu, Jianwei Qu, Yi Li, Xiaoyan Han, Jingsong He, He Huang, Enfan Zhang, Zhen Cai. NEDD4L binds the proteasome and promotes autophagy and bortezomib sensitivity in multiple myeloma.
Cell death & disease.
2022 03; 13(3):197. doi:
10.1038/s41419-022-04629-8. [PMID: 35236820] - Qingqing Rao, Ricong Xu, Qijun Wan. Immunoglobulin heavy chain gene rearrangement in heavy chain deposition disease suggests it is a plasma cell disease: a case report.
The Journal of international medical research.
2022 Mar; 50(3):3000605221086428. doi:
10.1177/03000605221086428. [PMID: 35301906] - Sosana Delimpasi, Maria Victoria Mateos, Holger W Auner, Maria Gavriatopoulou, Meletios A Dimopoulos, Hang Quach, Halyna Pylypenko, Roman Hájek, Xavier Leleu, Tuphan Kanti Dolai, Dinesh Kumar Sinha, Christopher P Venner, Reuben Benjamin, Mamta Krishnan Garg, Vadim Doronin, Yair Levy, Philippe Moreau, Yi Chai, Melina Arazy, Jatin Shah, Sharon Shacham, Michael G Kauffman, Paul G Richardson, Sebastian Grosicki. Efficacy and tolerability of once-weekly selinexor, bortezomib, and dexamethasone in comparison with standard twice-weekly bortezomib and dexamethasone in previously treated multiple myeloma with renal impairment: Subgroup analysis from the BOSTON study.
American journal of hematology.
2022 03; 97(3):E83-E86. doi:
10.1002/ajh.26434. [PMID: 34882831] - Jin Ho Lee, Heeryong Lee, Kipyo Kim, Seoung Woo Lee, Joon Ho Song, Seun Deuk Hwang. Acute Anti-A/B Antibody-Mediated Rejection After ABO-Incompatible Kidney Transplantation Treated With Bortezomib and Plasmapheresis: A Case Report.
Transplantation proceedings.
2022 Mar; 54(2):540-543. doi:
10.1016/j.transproceed.2021.10.027. [PMID: 35067375] - Aneta Szudy-Szczyrek, Radosław Mlak, Michał Mielnik, Marcin Mazurek, Sylwia Chocholska, Martyna Podgajna, Michał Szczyrek, Iwona Homa-Mlak, Teresa Małecka-Massalska, Marek Hus. Circulating Serum MiRNA-8074 as a Novel Prognostic Biomarker for Multiple Myeloma.
Cells.
2022 02; 11(4):. doi:
10.3390/cells11040752. [PMID: 35203396] - Keika Adachi, Hirobumi Tokuyama, Yoichi Oshima, Tomoaki Itoh, Akinori Hashiguchi, Hiroyuki Yamakawa, Tadayasu Togawa, Hitoshi Sakuraba, Shu Wakino, Hiroshi Itoh. Fabry disease associated with multiple myeloma: a case report.
CEN case reports.
2022 02; 11(1):146-153. doi:
10.1007/s13730-021-00613-x. [PMID: 34529243] - Wing-Kee Lee, Michelle Maaß, Amy Quach, Nataliya Poscic, Holly Prangley, Erin-Claire Pallott, Jiyoon L Kim, Jason S Pierce, Besim Ogretmen, Anthony H Futerman, Frank Thévenod. Dependence of ABCB1 transporter expression and function on distinct sphingolipids generated by ceramide synthases-2 and -6 in chemoresistant renal cancer.
The Journal of biological chemistry.
2022 02; 298(2):101492. doi:
10.1016/j.jbc.2021.101492. [PMID: 34915026] - Maria Gavriatopoulou, Panagiotis Malandrakis, Ioannis Ntanasis-Stathopoulos, Meletios Athanasios Dimopoulos. Nonselective proteasome inhibitors in multiple myeloma and future perspectives.
Expert opinion on pharmacotherapy.
2022 Feb; 23(3):335-347. doi:
10.1080/14656566.2021.1999411. [PMID: 34761710] - Chao Zhang, Xiaoxuan Xu, Timothy N Trotter, Pramod S Gowda, Yun Lu, Mark J Suto, Amjad Javed, Joanne E Murphy-Ullrich, Juan Li, Yang Yang. Runx2 Deficiency in Osteoblasts Promotes Myeloma Resistance to Bortezomib by Increasing TSP-1-Dependent TGFβ1 Activation and Suppressing Immunity in Bone Marrow.
Molecular cancer therapeutics.
2022 02; 21(2):347-358. doi:
10.1158/1535-7163.mct-21-0310. [PMID: 34907087] - Noémie Saraux, Deniza Imeri, Luis Quirós-Guerrero, Soumana Karimou, Philippe Christen, Muriel Cuendet. Phytochemical Investigation of the Roots of Ipomoea asarifolia and Antiproliferative Activity of the Isolated Compounds against Multiple Myeloma Cells.
Journal of natural products.
2022 01; 85(1):56-62. doi:
10.1021/acs.jnatprod.1c00649. [PMID: 34969245] - Silvia Baldo, Patrícia Antunes, João Falcão Felicidade, Fábio M F Santos, Jesús F Arteaga, Fábio Fernandes, Uwe Pischel, Sandra N Pinto, Pedro M P Gois. The BASHY Platform Enables the Assembly of a Fluorescent Bortezomib-GV1001 Conjugate.
ACS medicinal chemistry letters.
2022 Jan; 13(1):128-133. doi:
10.1021/acsmedchemlett.1c00615. [PMID: 35059132] - Giorgio Santoni, Consuelo Amantini, Federica Maggi, Oliviero Marinelli, Matteo Santoni, Maria Beatrice Morelli. The Mucolipin TRPML2 Channel Enhances the Sensitivity of Multiple Myeloma Cell Lines to Ibrutinib and/or Bortezomib Treatment.
Biomolecules.
2022 01; 12(1):. doi:
10.3390/biom12010107. [PMID: 35053255] - Yawara Kawano, Takayuki Sasano, Yuichiro Arima, Saki Kushima, Kenichi Tsujita, Masao Matsuoka, Hiroyuki Hata. A novel PDK1 inhibitor, JX06, inhibits glycolysis and induces apoptosis in multiple myeloma cells.
Biochemical and biophysical research communications.
2022 01; 587(?):153-159. doi:
10.1016/j.bbrc.2021.11.102. [PMID: 34875534] - Kai-Ni Shen, Wei-Jun Fu, Yu Wu, Yu-Jun Dong, Zhong-Xia Huang, Yong-Qiang Wei, Chun-Rui Li, Chun-Yan Sun, Ye Chen, Hui-Lei Miao, Yue-Lun Zhang, Xin-Xin Cao, Dao-Bin Zhou, Jian Li. Doxycycline Combined With Bortezomib-Cyclophosphamide-Dexamethasone Chemotherapy for Newly Diagnosed Cardiac Light-Chain Amyloidosis: A Multicenter Randomized Controlled Trial.
Circulation.
2022 01; 145(1):8-17. doi:
10.1161/circulationaha.121.055953. [PMID: 34503349] - Masahiko Komagome, Akira Maki, Rihito Nagata, Wataru Masuda, Ryota Kogure, Tetsuya Mitsui, Riki Ninomiya, Nobuhisa Akamatsu, Kiyoshi Hasegawa, Yoshifumi Beck. Refractory Acute Antibody Mediated Rejection in Liver Transplant After Desensitization of Preformed Donor Specific Antibody-Validity of Bortezomib and Everolimus: A Case Report.
Transplantation proceedings.
2022 Jan; 54(1):147-152. doi:
10.1016/j.transproceed.2021.11.022. [PMID: 34974892] - Runjie Sun, Jiang Liu, Manya Yu, Mengting Xia, Yanyu Zhang, Xiaoqi Sun, Yunsheng Xu, Xing Cui. Paeoniflorin Ameliorates BiPN by Reducing IL6 Levels and Regulating PARKIN-Mediated Mitochondrial Autophagy.
Drug design, development and therapy.
2022; 16(?):2241-2259. doi:
10.2147/dddt.s369111. [PMID: 35860525] - Kamron R Hamedi, Katrina A Harmon, Richard L Goodwin, Sergio Arce. Autophagy and the Bone Marrow Microenvironment: A Review of Protective Factors in the Development and Maintenance of Multiple Myeloma.
Frontiers in immunology.
2022; 13(?):889954. doi:
10.3389/fimmu.2022.889954. [PMID: 35663979] - Katrin Sak. Dietary Flavonoids with Catechol Moiety Inhibit Anticancer Action of Bortezomib: What about the other Boronic Acid-based Drugs?.
Current cancer drug targets.
2022; 22(9):741-748. doi:
10.2174/1568009622666220516102235. [PMID: 35578889] - Miriam Fels, Anna Lena Fisse, Carolin Schwake, Jeremias Motte, Diamantis Athanasopoulos, Thomas Grüter, Marie Spenner, Thomas Breuer, Katharina Starz, David Heinrich, Martin Grond, Kathy Keyvani, Luise Appeltshauser, Kathrin Doppler, Claudia Sommer, Ilya Ayzenberg, Christiane Schneider-Gold, Ralf Gold, Kalliopi Pitarokoili, Adnan Labedi. Report of a fulminant anti-pan-neurofascin-associated neuropathy responsive to rituximab and bortezomib.
Journal of the peripheral nervous system : JPNS.
2021 12; 26(4):475-480. doi:
10.1111/jns.12465. [PMID: 34486194] - Liang Zhou, Xiangao Huang, Ruben Niesvizky, Zhongjian Pu, Guoqiang Xu. Caspase-8 Regulates the Antimyeloma Activity of Bortezomib and Lenalidomide.
The Journal of pharmacology and experimental therapeutics.
2021 12; 379(3):303-309. doi:
10.1124/jpet.121.000818. [PMID: 34588172] - Gaojie Xu, Sheng Huang, Jian Peng, Xiaofang Gao, Minhui Li, Sisi Yu, Zuofeng Liu, Pengfan Qie, Yu Wang, Siqi Yu, Siyuan Liu, Hu Wen, Lijuan Su, Ping Li, Bin Guang, Renhan Dong, Jin Liu, Tai Yang. Targeting lipid metabolism in multiple myeloma cells: Rational development of a synergistic strategy with proteasome inhibitors.
British journal of pharmacology.
2021 12; 178(23):4741-4757. doi:
10.1111/bph.15653. [PMID: 34378191] - Hong Cheng, Bin Xu, Lijie Zhang, Yi Wang, Ming Chen, Shuqiu Chen. Bortezomib alleviates antibody-mediated rejection in kidney transplantation by facilitating Atg5 expression.
Journal of cellular and molecular medicine.
2021 12; 25(23):10939-10949. doi:
10.1111/jcmm.16998. [PMID: 34734681] - Hayley Beer, David Routledge, Trish Joyce, Emma-Jane Furphy, Nella Combe, David Ritchie, Amit Khot, Seok Ming Lim, Michael Montalto, Simon J Harrison. The development of a home-based therapeutic platform for multiple myeloma.
Expert review of hematology.
2021 12; 14(12):1129-1135. doi:
10.1080/17474086.2021.2022471. [PMID: 34936527] - Efstathios Kastritis, Pantelis Rousakis, Ioannis V Kostopoulos, Maria Gavriatopoulou, Foteini Theodorakakou, Despina Fotiou, Ioanna Dialoupi, Magdalini Migkou, Maria Roussou, Nikolaos Kanellias, Maria-Irini Tselegkidi, Evangelos Eleutherakis-Papaiakovou, Asimina Papanikolaou, Charikleia Gakiopoulou, Erasmia Psimenou, Marylin Spyropoulou-Vlachou, Anastasia Gatou, Evangelos Terpos, Ourania Tsitsilonis, Meletios A Dimopoulos. Consolidation with a short course of daratumumab in patients with AL amyloidosis or light chain deposition disease.
Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis.
2021 Dec; 28(4):259-266. doi:
10.1080/13506129.2021.1971192. [PMID: 34468250] - Huiqi Yang, Can Liu, Fen Yuan, Fang Li. Clinical significance of SIRT3 and inflammatory factors in multiple myeloma patients with bortezomib-induced peripheral neuropathy: a cohort study.
Scandinavian journal of clinical and laboratory investigation.
2021 12; 81(8):615-621. doi:
10.1080/00365513.2021.1986857. [PMID: 34648407] - Alixandra Ryan, Karine Tawagi, Nathan VanderVeen, Marc Matrana, Robert Vasquez. Combination Therapy With Bortezomib in Renal Medullary Carcinoma: A Case Series.
Clinical genitourinary cancer.
2021 12; 19(6):e395-e400. doi:
10.1016/j.clgc.2021.08.004. [PMID: 34565708] - Qinhong Xu, Jieni Yu, Xiaoyan Lin, Youli Li, Kejie Zhang. CB-LPD, MGUS, T-LGLL, and PRCA: A rare case report of 4 concomitant hematological disorders.
Medicine.
2021 Nov; 100(47):e27874. doi:
10.1097/md.0000000000027874. [PMID: 34964755] - Hui Yi, Long Liang, Haiqin Wang, Saiqun Luo, Lei Hu, Yanpeng Wang, Xiaokai Shen, Ling Xiao, Yibin Zhang, Hongling Peng, Chongwen Dai, Lingli Yuan, Ruijuan Li, Fanjie Gong, Zhenzhen Li, Mao Ye, Jing Liu, Hui Zhou, Ji Zhang, Xiaojuan Xiao. Albendazole inhibits NF-κB signaling pathway to overcome tumor stemness and bortezomib resistance in multiple myeloma.
Cancer letters.
2021 11; 520(?):307-320. doi:
10.1016/j.canlet.2021.08.009. [PMID: 34390764] - Xue-Min Gao, Yan-Ying Yu, Hao Zhao, Hao Cai, Lu Zhang, Xin-Xin Cao, Dao-Bin Zhou, Jian Li. Bortezomib plus dexamethasone as first-line therapy for patients with POEMS syndrome.
Annals of hematology.
2021 Nov; 100(11):2755-2761. doi:
10.1007/s00277-021-04609-6. [PMID: 34331562] - Yi Ding, Yu Cui, Xi Yang, Xiaolu Wang, Guangzhao Tian, Jiang Peng, Bo Wu, Li Tang, Chun-Ping Cui, Lingqiang Zhang. Anti-RANKL monoclonal antibody and bortezomib prevent mechanical unloading-induced bone loss.
Journal of bone and mineral metabolism.
2021 Nov; 39(6):974-983. doi:
10.1007/s00774-021-01246-x. [PMID: 34212247] - Muhammad Uzair Ali, Shafaq Maqsood, Mahrukh Malik, Kausar Bano. Central nervous system involvement in Multiple Myeloma-Diagnosis, treatment and outcome: A case report.
JPMA. The Journal of the Pakistan Medical Association.
2021 Nov; 71(11):2659-2661. doi:
10.47391/jpma.01825. [PMID: 34783755] - Shahira Ghobrial, Corina Elena Gonzalez, Stuart Kaufman, Nada Yazigi, Cal Matsumoto, Thomas Fishbein, Jason Hawksworth, Udeme D Ekong, Alexander Kroemer, Khalid Khan. Anti-plasma cell treatment in refractory autoimmune hemolytic anemia in a child with multivisceral transplant.
Pediatric transplantation.
2021 Nov; 25(7):e14045. doi:
10.1111/petr.14045. [PMID: 34092010] - Shinichi Mizuno, Chigusa Kitayama, Satoru Sanada, Toshinobu Sato. Bortezomib-induced glomerular microangiopathy complicated with monoclonal immunoglobulin deposition disease.
CEN case reports.
2021 11; 10(4):537-542. doi:
10.1007/s13730-021-00603-z. [PMID: 33909224] - Marta Krejci, Ludek Pour, Zdenek Adam, Viera Sandecka, Martin Stork, Sabina Sevcikova, Martin Krejci, Zdenka Knechtova, Zdenek Kral. Outcome of COVID-19 infection in 50 multiple myeloma patients treated with novel drugs: single-center experience.
Annals of hematology.
2021 Oct; 100(10):2541-2546. doi:
10.1007/s00277-021-04594-w. [PMID: 34309714] - Gonzalo Latorre, José Ignacio Vargas, Alberto Espino. Endoscopic features of gastrointestinal amyloid light-chain amyloidosis.
The lancet. Gastroenterology & hepatology.
2021 10; 6(10):874. doi:
10.1016/s2468-1253(21)00222-3. [PMID: 34509193] - Hideki Ishida, Kohei Unagami, Kazuya Omoto, Taichi Kanzawa, Kazunari Tanabe. Desensitization Regimen Consisting of High-Dose Intravenous Immunoglobulin, Plasmapheresis, and Rituximab (an Anti-CD20 Antibody), Without Eculizumab and/or Bortezomib, in 41 Highly Sensitized Kidney Transplant Recipients.
Experimental and clinical transplantation : official journal of the Middle East Society for Organ Transplantation.
2021 10; 19(10):1032-1040. doi:
10.6002/ect.2021.0234. [PMID: 34498551] - Nadia ElMenshawy, Nora A Farag, Doaa M Atia, Nashwa Abousamra, Doaa Shahin, Eman Fawzi, Hayam Ghazi, Attalla F El-Kott, Mohamed Eissa. Prognostic Relevance of Concordant Expression CD69 and CD56 in Response to Bortezomib Combination Therapy in Multiple Myeloma Patients.
Cancer investigation.
2021 Oct; 39(9):777-782. doi:
10.1080/07357907.2021.1964521. [PMID: 34344244] - Sofiane Salhi, David Ribes, Magali Colombat, Françoise Fortenfant, Stanislas Faguer. Bortezomib plus dexamethasone for rituximab-resistant PLA2R+ membranous nephropathy.
Kidney international.
2021 09; 100(3):708-709. doi:
10.1016/j.kint.2021.04.011. [PMID: 34420663] - Zi-Xuan Guo, Fan Yang, Johannes N van den Anker, Yi Zheng, Wei Zhao. A simplified method for bortezomib determination using dried blood spots in combination with liquid chromatography/tandem mass spectrometry.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2021 Sep; 1181(?):122905. doi:
10.1016/j.jchromb.2021.122905. [PMID: 34438277] - Lidia Usnarska-Zubkiewicz, Hanna Augustyniak-Bartosik, Agnieszka Zubkiewicz-Kucharska, Brygida Knysz. An asymptomatic course of SARS-CoV-2 infection in a patient with 3 different neoplasms and treated with bortezomib: a coincidence or new therapeutic possibility?.
Polish archives of internal medicine.
2021 08; 131(7-8):747-748. doi:
10.20452/pamw.16013. [PMID: 34048156] - Jiao Wu, Jing Liu. Research progress in proteasome inhibitor resistance to multiple myeloma.
Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences.
2021 Aug; 46(8):900-908. doi:
10.11817/j.issn.1672-7347.2021.200430. [PMID: 34565737] - Harriet Ghansah, Ildikó Beke Debreceni, Zsolt Fejes, Béla Nagy, János Kappelmayer. The Proteasome Inhibitor Bortezomib Induces Apoptosis and Activation in Gel-Filtered Human Platelets.
International journal of molecular sciences.
2021 Aug; 22(16):. doi:
10.3390/ijms22168955. [PMID: 34445660] - N Steiner, A Abdel Hamid, A Kronbichler, H Neuwirt, M Myslivecek, M Kollar, J Lachmanova, R Rysava, Z Hruskova, I Spicka, W Willenbacher, D Nachbaur, D Wolf, V Tesar, E Gunsilius. Real world analysis of high-cut-off (HCO) hemodialysis with bortezomib-based backbone therapy in patients with multiple myeloma and acute kidney injury.
Journal of nephrology.
2021 Aug; 34(4):1263-1270. doi:
10.1007/s40620-020-00939-2. [PMID: 33382447] - Marcela Hernández-Coronado, José Carlos Jaime-Pérez, Alejandra Villarreal-Martínez, Jorge Ocampo-Candiani, David Gómez-Almaguer. Successful second outpatient autologous hematopoietic cell transplant for relapsed POEMS syndrome in a patient with coexisting HIV, HBV and syphilis infections during the COVID-19 pandemic.
Transplant immunology.
2021 08; 67(?):101412. doi:
10.1016/j.trim.2021.101412. [PMID: 34020046] - Yong Liu, Yun Xu, Yan Xie, Guang-Hua Chen, Wei Liu, Wei-Qin Yao, Shuang Yan, Ling-Zhi Yan, De-Pei Wu, Cheng-Cheng Fu. [The Effects of Chidamide Combined with Anti-myeloma Drugs on the Proliferation and Apoptosis of Myeloma Cells].
Zhongguo shi yan xue ye xue za zhi.
2021 Aug; 29(4):1187-1194. doi:
10.19746/j.cnki.issn.1009-2137.2021.04.026. [PMID: 34362501] - Sun-Qiu Xu, Pan Zhao, Zhi-Hui Wang, Hong Deng, Liang Zhang, Jin Wei, Xing-Li Zou. [Predictive Value of Pre-treatment Serum Uric Acid Level for Prognosis in Newly Diagnosed Patients with Multiple Myeloma].
Zhongguo shi yan xue ye xue za zhi.
2021 Aug; 29(4):1216-1223. doi:
10.19746/j.cnki.issn.1009-2137.2021.04.030. [PMID: 34362505] - Yousef Salama, Nidal Jaradat, Koichi Hattori, Beate Heissig. Aloysia Citrodora Essential Oil Inhibits Melanoma Cell Growth and Migration by Targeting HB-EGF-EGFR Signaling.
International journal of molecular sciences.
2021 Jul; 22(15):. doi:
10.3390/ijms22158151. [PMID: 34360915] - Efstathios Kastritis, Giovanni Palladini, Monique C Minnema, Ashutosh D Wechalekar, Arnaud Jaccard, Hans C Lee, Vaishali Sanchorawala, Simon Gibbs, Peter Mollee, Christopher P Venner, Jin Lu, Stefan Schönland, Moshe E Gatt, Kenshi Suzuki, Kihyun Kim, M Teresa Cibeira, Meral Beksac, Edward Libby, Jason Valent, Vania Hungria, Sandy W Wong, Michael Rosenzweig, Naresh Bumma, Antoine Huart, Meletios A Dimopoulos, Divaya Bhutani, Adam J Waxman, Stacey A Goodman, Jeffrey A Zonder, Selay Lam, Kevin Song, Timon Hansen, Salomon Manier, Wilfried Roeloffzen, Krzysztof Jamroziak, Fiona Kwok, Chihiro Shimazaki, Jin-Seok Kim, Edvan Crusoe, Tahamtan Ahmadi, NamPhuong Tran, Xiang Qin, Sandra Y Vasey, Brenda Tromp, Jordan M Schecter, Brendan M Weiss, Sen H Zhuang, Jessica Vermeulen, Giampaolo Merlini, Raymond L Comenzo. Daratumumab-Based Treatment for Immunoglobulin Light-Chain Amyloidosis.
The New England journal of medicine.
2021 07; 385(1):46-58. doi:
10.1056/nejmoa2028631. [PMID: 34192431] - María José Cejalvo, Gabriela Bustamante, Esther González, Judith Vázquez-Álvarez, Ricarda García, Ángel Ramírez-Payer, Ernesto Pérez-Persona, Eugenia Abella, Sebastián Garzón, Antoni García, Isidro Jarque, Marta Sonia González, Antonia Sampol, Cristina Motlló, Josep María Martí, Magdalena Alcalá, Rafael Duro, Yolanda González, José Luis Sastre, Josep Sarrà, Giselle Lostaunau, Rocío López, Javier de la Rubia. Treatment patterns and outcomes in real-world transplant-ineligible patients newly diagnosed with multiple myeloma.
Annals of hematology.
2021 Jul; 100(7):1769-1778. doi:
10.1007/s00277-021-04529-5. [PMID: 33885924] - Jaya Lakshmi Thangaraj, Seo-Yeon Ahn, Sung-Hoon Jung, Manh-Cuong Vo, Tan-Huy Chu, Minh-Trang Thi Phan, Minsuk Kwon, Kyung-Hwa Lee, Mihee Kim, Ga-Young Song, Deok-Hwan Yang, Jae-Sook Ahn, Hyeoung-Joon Kim, Duck Cho, Je-Jung Lee. Expanded natural killer cells augment the antimyeloma effect of daratumumab, bortezomib, and dexamethasone in a mouse model.
Cellular & molecular immunology.
2021 07; 18(7):1652-1661. doi:
10.1038/s41423-021-00686-9. [PMID: 33980993] - Danwen Yang, Nikhil Agrawal, Chelsea Marcus, Neil Roy, Katelyn R Richards, Myrna R Nahas, Francesca Cardarelli. Treatment of Multiple Myeloma With Daratumumab in a Kidney Transplant Patient.
American journal of therapeutics.
2021 Jul; 28(4):e488-e491. doi:
10.1097/mjt.0000000000001024. [PMID: 34228654] - Hadi E Berbari, Shaji K Kumar. Initial Therapeutic Approaches to Patients with Multiple Myeloma.
Advances in therapy.
2021 07; 38(7):3694-3711. doi:
10.1007/s12325-021-01824-5. [PMID: 34145483] - Li-Hui Yang, Peng Du, Wei Liu, Li-Kun An, Jian Li, Wen-Yi Zhu, Shuo Yuan, Lei Wang, Lei Zang. LncRNA ANRIL promotes multiple myeloma progression and bortezomib resistance by EZH2-mediated epigenetically silencing of PTEN.
Neoplasma.
2021 Jul; 68(4):788-797. doi:
10.4149/neo_2021_210205n184. [PMID: 34034498] - Srikanth R Polusani, Valerie Cortez, Javier Esparza, Huynh Nga Nguyen, Hongxin Fan, Gopalrao V N Velagaleti, Matthew J Butler, Marsha C Kinney, Babatunde O Oyajobi, Samy L Habib, Reto Asmis, Edward A Medina. Oxidatively modified low-density lipoproteins are potential mediators of proteasome inhibitor resistance in multiple myeloma.
International journal of cancer.
2021 06; 148(12):3032-3040. doi:
10.1002/ijc.33497. [PMID: 33521927] - Chengxing Liu, Jin Zhou, Boyuan Wang, Yuqi Zheng, Shangwei Liu, Wenling Yang, Dazhu Li, Shaolin He, Jibin Lin. Bortezomib alleviates myocardial ischemia reperfusion injury via enhancing of Nrf2/HO-1 signaling pathway.
Biochemical and biophysical research communications.
2021 06; 556(?):207-214. doi:
10.1016/j.bbrc.2021.03.154. [PMID: 33848935] - Philipp Klingler, Marius Niklaus, Juergen Koessler, Katja Weber, Angela Koessler, Markus Boeck, Anna Kobsar. Influence of long-term proteasome inhibition on platelet responsiveness mediated by bortezomib.
Vascular pharmacology.
2021 06; 138(?):106830. doi:
10.1016/j.vph.2021.106830. [PMID: 33422688] - Chase Wilson, Carrie L Phillips, Alison Klenk, Matthew Kuhar, Muhammad S Yaqub. Crystalglobulinemia causing cutaneous vasculopathy and acute nephropathy in a kidney transplant patient.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.
2021 06; 21(6):2285-2289. doi:
10.1111/ajt.16536. [PMID: 33565232]