4,4-Bipyridine (BioDeep_00000271433)

代谢物信息卡片

4,4-Bipyridine

化学式: C10H8N2 (156.0687448)
中文名称: 4,4-联吡啶, 4,4'-联吡啶
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1=CC(=CC=N1)C1=CC=NC=C1
InChI: InChI=1S/C10H8N2/c1-5-11-6-2-9(1)10-3-7-12-8-4-10/h1-8H

描述信息

CONFIDENCE standard compound; INTERNAL_ID 524; DATASET 20200303_ENTACT_RP_MIX506; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 1413; ORIGINAL_PRECURSOR_SCAN_NO 1412
CONFIDENCE standard compound; INTERNAL_ID 524; DATASET 20200303_ENTACT_RP_MIX506; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 1401; ORIGINAL_PRECURSOR_SCAN_NO 1400
CONFIDENCE standard compound; INTERNAL_ID 524; DATASET 20200303_ENTACT_RP_MIX506; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 1408; ORIGINAL_PRECURSOR_SCAN_NO 1407
CONFIDENCE standard compound; INTERNAL_ID 524; DATASET 20200303_ENTACT_RP_MIX506; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 1402; ORIGINAL_PRECURSOR_SCAN_NO 1401
CONFIDENCE standard compound; INTERNAL_ID 524; DATASET 20200303_ENTACT_RP_MIX506; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 1420; ORIGINAL_PRECURSOR_SCAN_NO 1418
CONFIDENCE standard compound; INTERNAL_ID 524; DATASET 20200303_ENTACT_RP_MIX506; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 1403; ORIGINAL_PRECURSOR_SCAN_NO 1401

同义名列表

2 个代谢物同义名

4,4-Bipyridine; 4,4'-Bipyridine

数据库引用编号

12 个数据库交叉引用编号

ChEBI: CHEBI:30985
PubChem: 11107
ChEMBL: CHEMBL1374568
CAS: 37275-48-2
CAS: 553-26-4
MoNA: LU052406
MoNA: LU052405
MoNA: LU052404
MoNA: LU052403
MoNA: LU052402
MoNA: LU052401
PMhub: MS000002437

分类词条

有机杂环化合物

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

文献列表

Guiping Gao, Jiayi Li, Yin Cao, Xudan Li, Yuqing Qian, Xiumei Wang, Mengyu Li, Yingkun Qiu, Tong Wu, Liqiang Wang, Meijuan Fang. Design, synthesis, and biological evaluation of novel 4,4'-bipyridine derivatives acting as CDK9-Cyclin T1 protein-protein interaction inhibitors against triple-negative breast cancer. European journal of medicinal chemistry. 2023 Oct; 261(?):115858. doi: 10.1016/j.ejmech.2023.115858. [PMID: 37837671]
Hadi Savaloni, Shokoofe Goli-Haghighi, Reza Babaei. Application of Mn-Cu Helical Star-Shaped (Pine-Tree-Like) Sculpted Thin Films with Different Symmetries Using Surface-Enhanced Raman Spectroscopy (SERS). Applied spectroscopy. 2019 Aug; 73(8):879-892. doi: 10.1177/0003702819841913. [PMID: 30990064]
Qiong Wu, Wenjie Mei, Kangdi Zheng, Yang Ding. Self-assembly of c-myc DNA promoted by a single enantiomer ruthenium complex as a potential nuclear targeting gene carrier. Scientific reports. 2016 07; 6(?):28582. doi: 10.1038/srep28582. [PMID: 27381008]
Narcisa Marangoci, Stelian S Maier, Rodinel Ardeleanu, Adina Arvinte, Adrian Fifere, Anca Roxana Petrovici, Alina Nicolescu, Valentin Nastasa, Mihai Mares, Sorin A Pasca, Ramona F Moraru, Mariana Pinteala, Anca Chiriac. Low toxicity β-cyclodextrin-caged 4,4'-bipyridinium-bis(siloxane): synthesis and evaluation. Chemical research in toxicology. 2014 Apr; 27(4):546-57. doi: 10.1021/tx400407e. [PMID: 24564239]
B Chihoho, A B Sage, R T Smolenski, A Vazir, M L Rose, N R Banner, N V Leaver. A clinical assay for the measurement of milrinone in plasma by HPLC mass spectrometry. Biomedical chromatography : BMC. 2012 May; 26(5):566-70. doi: 10.1002/bmc.1675. [PMID: 21905056]
Yingwei Zhang, Yonglan Luo, Jingqi Tian, Abdullah M Asiri, Abdulrahman O Al-Youbi, Xuping Sun. Rectangular coordination polymer nanoplates: large-scale, rapid synthesis and their application as a fluorescent sensing platform for DNA detection. PloS one. 2012; 7(1):e30426. doi: 10.1371/journal.pone.0030426. [PMID: 22279589]
Amr Amin, Christeena Abraham, Alaaeldin A Hamza, Zeinab A Abdalla, Shaikha B Al-Shamsi, Saina S Harethi, Sayel Daoud. A standardized extract of Ginkgo biloba neutralizes cisplatin-mediated reproductive toxicity in rats. Journal of biomedicine & biotechnology. 2012; 2012(?):362049. doi: 10.1155/2012/362049. [PMID: 22675250]
Bernice Lo, Austin D E Swafford, Kimberly A Shafer-Weaver, Lawrence F Jerome, Luba Rakhlin, Douglas R Mathern, Conor A Callahan, Ping Jiang, Lucy J Davison, Helen E Stevens, Carrie L Lucas, Jill White, Reid von Borstel, John A Todd, Michael J Lenardo. Antibodies against insulin measured by electrochemiluminescence predicts insulitis severity and disease onset in non-obese diabetic mice and can distinguish human type 1 diabetes status. Journal of translational medicine. 2011 Nov; 9(?):203. doi: 10.1186/1479-5876-9-203. [PMID: 22123298]
Guichi Zhu, Yongjun Hu, Jiao Gao, Liang Zhong. Highly sensitive detection of clenbuterol using competitive surface-enhanced Raman scattering immunoassay. Analytica chimica acta. 2011 Jul; 697(1-2):61-6. doi: 10.1016/j.aca.2011.04.031. [PMID: 21641419]
Min Sun, Juanjuan Feng, Shujuan Liu, Chunming Xiong, Xia Liu, Shengxiang Jiang. Dipyridine modified silica--a novel multi-interaction stationary phase for high performance liquid chromatography. Journal of chromatography. A. 2011 Jun; 1218(24):3743-9. doi: 10.1016/j.chroma.2011.04.036. [PMID: 21549383]
R Francik, M Krośniak, M Barlik, A Kudła, R Gryboś, T Librowski. Impact of vanadium complexes treatment on the oxidative stress factors in wistar rats plasma. Bioinorganic chemistry and applications. 2011; 2011(?):206316. doi: 10.1155/2011/206316. [PMID: 22007153]
John T Connelly, Ajay Mishra, Julien E Gautrot, Fiona M Watt. Shape-induced terminal differentiation of human epidermal stem cells requires p38 and is regulated by histone acetylation. PloS one. 2011; 6(11):e27259. doi: 10.1371/journal.pone.0027259. [PMID: 22073300]
Liang Xu, Li-Yan Gu, Yan-Yun Yang, Bing Wang, Ting-Guo Kang. {2-[2-(Carb-oxy-meth-oxy)-phen-oxy]acetato}[2,2'-(o-phenyl-enedi-oxy)diacetic acid]sodium 4,4'-bipyridine hemisolvate monohydrate. Acta crystallographica. Section E, Structure reports online. 2010 Jul; 66(Pt 8):m867. doi: 10.1107/s1600536810024797. [PMID: 21588116]
Ming-Yi Ho, Min-Lun Chiou, Ruei-Chi Chang, Yau-Hung Chen, Chien-Chung Cheng. Outer membrane protein OmpF involved in the transportation of polypyridyl ruthenium complexes into Escherichia coli. Journal of inorganic biochemistry. 2010 May; 104(5):614-7. doi: 10.1016/j.jinorgbio.2010.01.013. [PMID: 20176402]
Claudia S Pilz, Claudia Steinem. Modulation of the conductance of a 2,2'-bipyridine-functionalized peptidic ion channel by Ni2+. European biophysics journal : EBJ. 2008 Jul; 37(6):1065-71. doi: 10.1007/s00249-008-0298-8. [PMID: 18347789]
Raj Kumar Koiri, Surendra Kumar Trigun, Santosh Kumar Dubey, Santosh Singh, Lallan Mishra. Metal Cu(II) and Zn(II) bipyridyls as inhibitors of lactate dehydrogenase. Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine. 2008 Apr; 21(2):117-26. doi: 10.1007/s10534-007-9098-3. [PMID: 17541766]
Georgi Momekov, Dilyan Ferdinandov, Spiro Konstantinov, Sonja Arpadjan, Daniela Tsekova, Galina Gencheva, Panayot R Bontchev, Margarita Karaivanova. In vitro evaluation of a stable monomeric gold(II) complex with hematoporphyrin IX: cytotoxicity against tumor and kidney cells, cellular accumulation, and induction of apoptosis. Bioinorganic chemistry and applications. 2008; ?(?):367471. doi: 10.1155/2008/367471. [PMID: 18497870]
Ahmad H Malkawi, Abeer M Al-Ghananeem, Shama Nasim, Jose de Leon, Peter A Crooks. An HPLC method for the simultaneous determination of neurotoxic dipyridyl isomers in human plasma. Journal of pharmaceutical and biomedical analysis. 2007 Sep; 45(1):120-124. doi: 10.1016/j.jpba.2007.06.024. [PMID: 17706392]
Michael Devereux, Malachy McCann, Denis O'shea, Mark O'connor, Eileen Kiely, Vickie McKee, Declan Naughton, Anna Fisher, Andrew Kellett, Maureen Walsh, Denise Egan, Carol Deegan. Synthesis, Superoxide Dismutase Mimetic and Anticancer Activities of Metal Complexes of 2,2-Dimethylpentanedioic Acid(2dmepdaH(2)) and 3,3-Dimethylpentanedioic acid(3dmepdaH(2)): X-Ray Crystal Structures of [Cu(3dmepda)(bipy)](2). 6H(2)O and [Cu(2dmepda)(bipy)(EtOH)](2). 4EtOH (bipy = 2,2'Bipyridine). Bioinorganic chemistry and applications. 2006; ?(?):80283. doi: 10.1155/bca/2006/80283. [PMID: 17497019]
Miranda Bartels-Stringer, Jack F M Wetzels, Alfons C Wouterse, Eric Steenbergen, Frans G M Russel, Cornelis Kramers. Iron chelators do not reduce cold-induced cell injury in the isolated perfused rat kidney model. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association. 2005 Dec; 20(12):2646-53. doi: 10.1093/ndt/gfi127. [PMID: 16204299]
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Alberta Bergamo, Gabriele Stocco, Claudia Casarsa, Moreno Cocchietto, Enzo Alessio, Barbara Serli, Sonia Zorzet, Gianni Sava. Reduction of in vivo lung metastases by dinuclear ruthenium complexes is coupled to inhibition of in vitro tumour invasion. International journal of oncology. 2004 Feb; 24(2):373-9. doi: 10.3892/ijo.24.2.373. [PMID: 14719114]
Judah L Rosner, Bindi Dangi, Angela M Gronenborn, Robert G Martin. Posttranscriptional activation of the transcriptional activator Rob by dipyridyl in Escherichia coli. Journal of bacteriology. 2002 Mar; 184(5):1407-16. doi: 10.1128/jb.184.5.1407-1416.2002. [PMID: 11844771]
N Stadler, M Höfer, K Sigler. Mechanisms of Saccharomyces cerevisiae PMA1 H+-ATPase inactivation by Fe2+, H2O2 and Fenton reagents. Free radical research. 2001 Dec; 35(6):643-53. doi: 10.1080/10715760100301171. [PMID: 11811518]
V Simeon-Rudolf, Z Kovarik, Z Radić, E Reiner. Reversible inhibition of acetylcholinesterase and butyrylcholinesterase by 4,4'-bipyridine and by a coumarin derivative. Chemico-biological interactions. 1999 May; 119-120(?):119-28. doi: 10.1016/s0009-2797(99)00020-4. [PMID: 10421445]
M Michel-Buono, J P Buono, G Serre, D Dumont, P Bernard. In vitro cytotoxic effects of 4,4'-bipyridyl on normal human keratinocytes. Cell biology and toxicology. 1997 Mar; 13(3):193-204. doi: 10.1023/a:1007314430645. [PMID: 9088629]
G M Paddle, A J Osborn, G D Parker. Mortality of employees in plants manufacturing 4,4'-bipyridyl. Scandinavian journal of work, environment & health. 1991 Jun; 17(3):175-8. doi: 10.5271/sjweh.1714. [PMID: 2068555]
C S Godin, P A Crooks. N-methylation as a toxication route for xenobiotics. II. In vivo formation of N,N'-dimethyl-4,4'-bipyridyl ion (paraquat) from 4,4'-bipyridyl in the guinea pig. Drug metabolism and disposition: the biological fate of chemicals. 1989 Mar; 17(2):180-5. doi: NULL. [PMID: 2565208]
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D F Groce, R D Kimbrough. Acute and subacute toxicity in Sherman strain rats exposed to 4,4'- and 2,2'-dipyridyl. Journal of toxicology and environmental health. 1982 Sep; 10(3):363-72. doi: 10.1080/15287398209530259. [PMID: 7175967]