SR271425 (BioDeep_00000271360)

   


代谢物信息卡片


Formamide, N-((1-((2-(diethylamino)ethyl)amino)-7-methoxy-9-oxo-9H-thioxanthen-4-yl)methyl)-

化学式: C22H27N3O3S (413.1773)
中文名称:
谱图信息: 最多检出来源 Viridiplantae(plant) 100%

分子结构信息

SMILES: CCN(CC)CCNC1=C2C(=C(C=C1)CNC=O)SC3=C(C2=O)C=C(C=C3)OC
InChI: InChI=1S/C22H27N3O3S/c1-4-25(5-2)11-10-24-18-8-6-15(13-23-14-26)22-20(18)21(27)17-12-16(28-3)7-9-19(17)29-22/h6-9,12,14,24H,4-5,10-11,13H2,1-3H3,(H,23,26)

描述信息

CONFIDENCE standard compound; INTERNAL_ID 716; DATASET 20200303_ENTACT_RP_MIX506; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 7383; ORIGINAL_PRECURSOR_SCAN_NO 7381
CONFIDENCE standard compound; INTERNAL_ID 716; DATASET 20200303_ENTACT_RP_MIX506; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 7419; ORIGINAL_PRECURSOR_SCAN_NO 7418
CONFIDENCE standard compound; INTERNAL_ID 716; DATASET 20200303_ENTACT_RP_MIX506; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 7419; ORIGINAL_PRECURSOR_SCAN_NO 7417
CONFIDENCE standard compound; INTERNAL_ID 716; DATASET 20200303_ENTACT_RP_MIX506; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 7456; ORIGINAL_PRECURSOR_SCAN_NO 7453
CONFIDENCE standard compound; INTERNAL_ID 716; DATASET 20200303_ENTACT_RP_MIX506; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 7467; ORIGINAL_PRECURSOR_SCAN_NO 7466
CONFIDENCE standard compound; INTERNAL_ID 716; DATASET 20200303_ENTACT_RP_MIX506; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 7462; ORIGINAL_PRECURSOR_SCAN_NO 7460

同义名列表

2 个代谢物同义名

Formamide, N-((1-((2-(diethylamino)ethyl)amino)-7-methoxy-9-oxo-9H-thioxanthen-4-yl)methyl)-; SR271425



数据库引用编号

10 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表


文献列表

  • A Craig Lockhart, Emiliano Calvo, Anthony W Tolcher, Eric K Rowinsky, Gareth Shackleton, J Gilmour Morrison, Rezvan Rafi, Wendy VerMeulen, Mace L Rothenberg. A phase I dose-escalation study of SR271425, an intravenously dosed thioxanthone analog, administered weekly in patients with refractory solid tumors. American journal of clinical oncology. 2009 Feb; 32(1):9-14. doi: 10.1097/coc.0b013e318178331b. [PMID: 19194116]
  • Priscila H Goncalves, Francine High, Paul Juniewicz, Gareth Shackleton, Jing Li, Scott Boerner, Patricia M LoRusso. Phase I dose-escalation study of the thioxanthone SR271425 administered intravenously once every 3 weeks in patients with advanced malignancies. Investigational new drugs. 2008 Aug; 26(4):347-54. doi: 10.1007/s10637-008-9135-2. [PMID: 18449472]
  • M Campone, N Isambert, E Bourbouloux, S Maury, P Monin-Baroille, J Berille, P Fumoleau. Phase I dose-escalation study of a novel antitumor agent, SR271425, administered intravenously in split doses (d1-d2-d3) in patients with refractory solid tumors. Cancer chemotherapy and pharmacology. 2007 Apr; 59(5):689-95. doi: 10.1007/s00280-006-0349-8. [PMID: 17031647]
  • S Poondru, S Zhou, J Rake, G Shackleton, T H Corbett, R E Parchment, B R Jasti. High-performance liquid chromatographic method for the estimation of the novel investigational anti-cancer agent SR271425 and its metabolites in mouse plasma. Journal of chromatography. B, Biomedical sciences and applications. 2001 Aug; 759(1):175-8. doi: 10.1016/s0378-4347(01)00217-1. [PMID: 11499623]