DIAZOXON (BioDeep_00000271277)

   


代谢物信息卡片


DIAZINON-O-ANALOG

化学式: C12H21N2O4P (288.12388760000005)
中文名称: 二嗪磷氧同系物
谱图信息: 最多检出来源 Ailuropoda melanoleuca(viridiplantae) 66.67%

分子结构信息

SMILES: CCOP(=O)(OCC)OC1=NC(=NC(=C1)C)C(C)C
InChI: InChI=1S/C12H21N2O4P/c1-6-16-19(15,17-7-2)18-11-8-10(5)13-12(14-11)9(3)4/h8-9H,6-7H2,1-5H3

描述信息

An organic phosphate that is diethyl hydrogen phosphate in which the hydrogen of the hydroxy group has been replaced by a 6-methyl-2-(propan-2-yl)pyrimidin-4-yl group. It is a metabolite of the pesticide diazinon.
CONFIDENCE standard compound; EAWAG_UCHEM_ID 2705

同义名列表

2 个代谢物同义名

DIAZINON-O-ANALOG; DIAZOXON



数据库引用编号

20 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Shensheng Zhao, Sebastiaan Wesseling, Bert Spenkelink, Ivonne M C M Rietjens. Physiologically based kinetic modelling based prediction of in vivo rat and human acetylcholinesterase (AChE) inhibition upon exposure to diazinon. Archives of toxicology. 2021 05; 95(5):1573-1593. doi: 10.1007/s00204-021-03015-1. [PMID: 33715020]
  • Bharti Mackness, Mike Mackness. Unexpectedly higher diazoxon hydrolysis by serum paraoxonase-1 in coronary heart disease. Clinical biochemistry. 2019 Mar; 65(?):21-23. doi: 10.1016/j.clinbiochem.2019.01.003. [PMID: 30659791]
  • Mirjana B Čolović, Vesna M Vasić, Nataša S Avramović, Milan M Gajić, Dragan M Djurić, Danijela Z Krstić. In vitro evaluation of neurotoxicity potential and oxidative stress responses of diazinon and its degradation products in rat brain synaptosomes. Toxicology letters. 2015 Feb; 233(1):29-37. doi: 10.1016/j.toxlet.2015.01.003. [PMID: 25562544]
  • Feng Jiang, Yixi Zhang, Huahua Sun, Xiangkun Meng, Haibo Bao, Jichao Fang, Zewen Liu. Identification of polymorphisms in Cyrtorhinus lividipennis RDL subunit contributing to fipronil sensitivity. Pesticide biochemistry and physiology. 2015 Jan; 117(?):62-7. doi: 10.1016/j.pestbp.2014.10.010. [PMID: 25619913]
  • Junho Jeon, Andreas Kretschmann, Beate I Escher, Juliane Hollender. Characterization of acetylcholinesterase inhibition and energy allocation in Daphnia magna exposed to carbaryl. Ecotoxicology and environmental safety. 2013 Dec; 98(?):28-35. doi: 10.1016/j.ecoenv.2013.09.033. [PMID: 24139064]
  • Andreas Kretschmann, Roman Ashauer, Thomas G Preuss, Piet Spaak, Beate I Escher, Juliane Hollender. Toxicokinetic model describing bioconcentration and biotransformation of diazinon in Daphnia magna. Environmental science & technology. 2011 Jun; 45(11):4995-5002. doi: 10.1021/es104324v. [PMID: 21561125]
  • Miguel A Sogorb, Eugenio Vilanova. Serum albumins and detoxication of anti-cholinesterase agents. Chemico-biological interactions. 2010 Sep; 187(1-3):325-9. doi: 10.1016/j.cbi.2010.03.001. [PMID: 20211614]
  • I López-Flores, M Lacasaña, J Blanco-Muñoz, C Aguilar-Garduño, P Sanchez-Villegas, O A Pérez-Méndez, R Gamboa-Avila. Relationship between human paraoxonase-1 activity and PON1 polymorphisms in Mexican workers exposed to organophosphate pesticides. Toxicology letters. 2009 Jul; 188(2):84-90. doi: 10.1016/j.toxlet.2009.03.010. [PMID: 19446239]
  • Karen Huen, Rebecca Richter, Clement Furlong, Brenda Eskenazi, Nina Holland. Validation of PON1 enzyme activity assays for longitudinal studies. Clinica chimica acta; international journal of clinical chemistry. 2009 Apr; 402(1-2):67-74. doi: 10.1016/j.cca.2008.12.019. [PMID: 19146843]
  • Rebecca J Richter, Gail P Jarvik, Clement E Furlong. Paraoxonase 1 (PON1) status and substrate hydrolysis. Toxicology and applied pharmacology. 2009 Feb; 235(1):1-9. doi: 10.1016/j.taap.2008.11.001. [PMID: 19071155]
  • Miguel A Sogorb, Sara García-Argüelles, Victoria Carrera, Eugenio Vilanova. Serum albumin is as efficient as paraxonase in the detoxication of paraoxon at toxicologically relevant concentrations. Chemical research in toxicology. 2008 Aug; 21(8):1524-9. doi: 10.1021/tx800075x. [PMID: 18597495]
  • Daniel K Nomura, Kathleen A Durkin, Kyle P Chiang, Gary B Quistad, Benjamin F Cravatt, John E Casida. Serine hydrolase KIAA1363: toxicological and structural features with emphasis on organophosphate interactions. Chemical research in toxicology. 2006 Sep; 19(9):1142-50. doi: 10.1021/tx060117m. [PMID: 16978018]
  • Gary B Quistad, Shannon N Liang, Karl J Fisher, Daniel K Nomura, John E Casida. Each lipase has a unique sensitivity profile for organophosphorus inhibitors. Toxicological sciences : an official journal of the Society of Toxicology. 2006 May; 91(1):166-72. doi: 10.1093/toxsci/kfj124. [PMID: 16449251]
  • Eric S Peeples, Lawrence M Schopfer, Ellen G Duysen, Reggie Spaulding, Troy Voelker, Charles M Thompson, Oksana Lockridge. Albumin, a new biomarker of organophosphorus toxicant exposure, identified by mass spectrometry. Toxicological sciences : an official journal of the Society of Toxicology. 2005 Feb; 83(2):303-12. doi: 10.1093/toxsci/kfi023. [PMID: 15525694]
  • Wimon Phuntuwate, Chuthamanee Suthisisang, Banhan Koanantakul, Michael I Mackness, Bharti Mackness. Paraoxonase 1 status in the Thai population. Journal of human genetics. 2005; 50(6):293-300. doi: 10.1007/s10038-005-0255-7. [PMID: 15924216]
  • S Padilla, H-J Sung, V C Moser. Further assessment of an in vitro screen that may help identify organophosphorus pesticides that are more acutely toxic to the young. Journal of toxicology and environmental health. Part A. 2004 Sep; 67(18):1477-89. doi: 10.1080/15287390490483836. [PMID: 15371233]
  • Bharti Mackness, Paul Durrington, Andrew Povey, Stuart Thomson, Martin Dippnall, Mike Mackness, Ted Smith, Nicola Cherry. Paraoxonase and susceptibility to organophosphorus poisoning in farmers dipping sheep. Pharmacogenetics. 2003 Feb; 13(2):81-8. doi: 10.1097/00008571-200302000-00004. [PMID: 12563177]
  • Gary B Quistad, Daniel K Nomura, Susan E Sparks, Yoffi Segall, John E Casida. Cannabinoid CB1 receptor as a target for chlorpyrifos oxon and other organophosphorus pesticides. Toxicology letters. 2002 Sep; 135(1-2):89-93. doi: 10.1016/s0378-4274(02)00251-5. [PMID: 12243867]
  • G P Jarvik, L S Rozek, V H Brophy, T S Hatsukami, R J Richter, G D Schellenberg, C E Furlong. Paraoxonase (PON1) phenotype is a better predictor of vascular disease than is PON1(192) or PON1(55) genotype. Arteriosclerosis, thrombosis, and vascular biology. 2000 Nov; 20(11):2441-7. doi: 10.1161/01.atv.20.11.2441. [PMID: 11073850]
  • B Mackness, P N Durrington, M I Mackness. Low paraoxonase in Persian Gulf War Veterans self-reporting Gulf War Syndrome. Biochemical and biophysical research communications. 2000 Sep; 276(2):729-33. doi: 10.1006/bbrc.2000.3526. [PMID: 11027539]
  • M L Parker, M I Goldstein. Differential toxicities of organophosphate and carbamate insecticides in the nestling European starling (Sturnus vulgaris). Archives of environmental contamination and toxicology. 2000 Aug; 39(2):233-42. doi: 10.1007/s002440010100. [PMID: 10871426]
  • C E Furlong, W F Li, V H Brophy, G P Jarvik, R J Richter, D M Shih, A J Lusis, L G Costa. The PON1 gene and detoxication. Neurotoxicology. 2000 Aug; 21(4):581-7. doi: NULL. [PMID: 11022865]
  • V H Brophy, G P Jarvik, R J Richter, L S Rozek, G D Schellenberg, C E Furlong. Analysis of paraoxonase (PON1) L55M status requires both genotype and phenotype. Pharmacogenetics. 2000 Jul; 10(5):453-60. doi: 10.1097/00008571-200007000-00008. [PMID: 10898114]
  • D Josse, W Xie, P Masson, L M Schopfer, O Lockridge. Tryptophan residue(s) as major components of the human serum paraoxonase active site. Chemico-biological interactions. 1999 May; 119-120(?):79-84. doi: 10.1016/s0009-2797(99)00016-2. [PMID: 10421441]
  • H G Davies, R J Richter, M Keifer, C A Broomfield, J Sowalla, C E Furlong. The effect of the human serum paraoxonase polymorphism is reversed with diazoxon, soman and sarin. Nature genetics. 1996 Nov; 14(3):334-6. doi: 10.1038/ng1196-334. [PMID: 8896566]
  • M I Mackness, C H Walker. Multiple forms of sheep serum A-esterase activity associated with the high-density lipoprotein. The Biochemical journal. 1988 Mar; 250(2):539-45. doi: 10.1042/bj2500539. [PMID: 2451511]
  • A Brock. Binding of digitoxin to human serum albumin: influence of ionic strength and ionic medium on the digitoxin-albumin complex formation. Acta pharmacologica et toxicologica. 1975 Nov; 37(5):361-8. doi: 10.1111/j.1600-0773.1975.tb00854.x. [PMID: 887]
  • M Nozaki. [Combined use of bucolome and pyrazolone derivatives (1). Pharmacological activities and blood concentration]. Nihon yakurigaku zasshi. Folia pharmacologica Japonica. 1975 Sep; 71(6):609-29. doi: NULL. [PMID: 281]
  • I N Golovistikov. [Ability of antilymphocyte sera to counteract the allogeneic inhibition of hematopoietic stem cells]. Doklady Akademii nauk SSSR. 1975 Aug; 223(5):1245-7. doi: NULL. [PMID: 222]