nipecotic acid (BioDeep_00000271216)

   


代谢物信息卡片


(±)-Nipecotic acid

化学式: C6H11NO2 (129.0789746)
中文名称: 诱导型一氧化氮合酶, 3-哌啶甲酸
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1CC(CNC1)C(=O)O
InChI: InChI=1S/C6H11NO2/c8-6(9)5-2-1-3-7-4-5/h5,7H,1-4H2,(H,8,9)

描述信息

Nipecotic acid ((±)-β-Homoproline) is a potent inhibitor of neuronal and glial-aminobutyric acid (GABA) uptake in vitro. Nipecotic acid can also directly activate GABAA-like chloride channels, with an EC50 of approximately 300?μM[1][2].

同义名列表

5 个代谢物同义名

(±)-Nipecotic acid; nipecotic acid; (±)-β-Homoproline; Hexahydronicotinic acid; 3-Carboxypiperidine



数据库引用编号

8 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。



文献列表

  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
  • Giorgia Fattorini, Myriam Catalano, Marcello Melone, Carmela Serpe, Silvia Bassi, Cristina Limatola, Fiorenzo Conti. Microglial expression of GAT-1 in the cerebral cortex. Glia. 2020 03; 68(3):646-655. doi: 10.1002/glia.23745. [PMID: 31692106]
  • Felix Kern, Klaus T Wanner. Screening oxime libraries by means of mass spectrometry (MS) binding assays: Identification of new highly potent inhibitors to optimized inhibitors γ-aminobutyric acid transporter 1. Bioorganic & medicinal chemistry. 2019 04; 27(7):1232-1245. doi: 10.1016/j.bmc.2019.02.015. [PMID: 30777661]
  • Michael Moldavan, Olga Cravetchi, Charles N Allen. GABA transporters regulate tonic and synaptic GABAA receptor-mediated currents in the suprachiasmatic nucleus neurons. Journal of neurophysiology. 2017 12; 118(6):3092-3106. doi: 10.1152/jn.00194.2017. [PMID: 28855287]
  • Thomas Wein, Marilena Petrera, Lars Allmendinger, Georg Höfner, Jörg Pabel, Klaus T Wanner. Different Binding Modes of Small and Large Binders of GAT1. ChemMedChem. 2016 Mar; 11(5):509-18. doi: 10.1002/cmdc.201500534. [PMID: 26804464]
  • Marilena Petrera, Thomas Wein, Lars Allmendinger, Miriam Sindelar, Jörg Pabel, Georg Höfner, Klaus T Wanner. Development of Highly Potent GAT1 Inhibitors: Synthesis of Nipecotic Acid Derivatives by Suzuki-Miyaura Cross-Coupling Reactions. ChemMedChem. 2016 Mar; 11(5):519-38. doi: 10.1002/cmdc.201500490. [PMID: 26683881]
  • Rune Nørgaard Rasmussen, Candela Lagunas, Jakob Plum, René Holm, Carsten Uhd Nielsen. Interaction of GABA-mimetics with the taurine transporter (TauT, Slc6a6) in hyperosmotic treated Caco-2, LLC-PK1 and rat renal SKPT cells. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. 2016 Jan; 82(?):138-46. doi: 10.1016/j.ejps.2015.11.020. [PMID: 26631583]
  • Michela Semeraro, Maurizio Muraca, Giulio Catesini, Rita Inglese, Francesca Iacovone, Gloria Maria Barraco, Melania Manco, Sara Boenzi, Carlo Dionisi-Vici, Cristiano Rizzo. Determination of plasma pipecolic acid by an easy and rapid liquid chromatography-tandem mass spectrometry method. Clinica chimica acta; international journal of clinical chemistry. 2015 Feb; 440(?):108-12. doi: 10.1016/j.cca.2014.11.014. [PMID: 25447702]
  • Murray B Herd, Adam R Brown, Jeremy J Lambert, Delia Belelli. Extrasynaptic GABA(A) receptors couple presynaptic activity to postsynaptic inhibition in the somatosensory thalamus. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2013 Sep; 33(37):14850-68. doi: 10.1523/jneurosci.1174-13.2013. [PMID: 24027285]
  • Ingolf Sitka, Lars Allmendinger, Günther Fülep, Georg Höfner, Klaus T Wanner. Synthesis of N-substituted acyclic β-amino acids and their investigation as GABA uptake inhibitors. European journal of medicinal chemistry. 2013 Jul; 65(?):487-99. doi: 10.1016/j.ejmech.2013.04.063. [PMID: 23770450]
  • Jessica L Bell, Andrew J Haak, Susan M Wade, Paul D Kirchhoff, Richard R Neubig, Scott D Larsen. Optimization of novel nipecotic bis(amide) inhibitors of the Rho/MKL1/SRF transcriptional pathway as potential anti-metastasis agents. Bioorganic & medicinal chemistry letters. 2013 Jul; 23(13):3826-32. doi: 10.1016/j.bmcl.2013.04.080. [PMID: 23707258]
  • Gabriele Quandt, Georg Höfner, Klaus T Wanner. Synthesis and evaluation of N-substituted nipecotic acid derivatives with an unsymmetrical bis-aromatic residue attached to a vinyl ether spacer as potential GABA uptake inhibitors. Bioorganic & medicinal chemistry. 2013 Jun; 21(11):3363-78. doi: 10.1016/j.bmc.2013.02.056. [PMID: 23598250]
  • Miriam Sindelar, Toni A Lutz, Marilena Petrera, Klaus T Wanner. Focused pseudostatic hydrazone libraries screened by mass spectrometry binding assay: optimizing affinities toward γ-aminobutyric acid transporter 1. Journal of medicinal chemistry. 2013 Feb; 56(3):1323-40. doi: 10.1021/jm301800j. [PMID: 23336362]
  • Miriam Sindelar, Klaus T Wanner. Library screening by means of mass spectrometry (MS) binding assays-exemplarily demonstrated for a pseudostatic library addressing γ-aminobutyric acid (GABA) transporter 1 (GAT1). ChemMedChem. 2012 Sep; 7(9):1678-90. doi: 10.1002/cmdc.201200201. [PMID: 22689508]
  • Saori Ikeda, Masanori Tachikawa, Shin-ichi Akanuma, Jun Fujinawa, Ken-ichi Hosoya. Involvement of γ-aminobutyric acid transporter 2 in the hepatic uptake of taurine in rats. American journal of physiology. Gastrointestinal and liver physiology. 2012 Aug; 303(3):G291-7. doi: 10.1152/ajpgi.00388.2011. [PMID: 22678999]
  • Masanori Tachikawa, Saori Ikeda, Jun Fujinawa, Shirou Hirose, Shin-ichi Akanuma, Ken-ichi Hosoya. γ-Aminobutyric acid transporter 2 mediates the hepatic uptake of guanidinoacetate, the creatine biosynthetic precursor, in rats. PloS one. 2012; 7(2):e32557. doi: 10.1371/journal.pone.0032557. [PMID: 22384273]
  • Søren Skovstrup, Laurent David, Olivier Taboureau, Flemming Steen Jørgensen. A steered molecular dynamics study of binding and translocation processes in the GABA transporter. PloS one. 2012; 7(6):e39360. doi: 10.1371/journal.pone.0039360. [PMID: 22737235]
  • Eiji Shigetomi, Xiaoping Tong, Kelvin Y Kwan, David P Corey, Baljit S Khakh. TRPA1 channels regulate astrocyte resting calcium and inhibitory synapse efficacy through GAT-3. Nature neuroscience. 2011 Dec; 15(1):70-80. doi: 10.1038/nn.3000. [PMID: 22158513]
  • Domenica A Pizzi, Colin P Leslie, Romano Di Fabio, Catia Seri, Giovanni Bernasconi, Michela Squaglia, Gennaro Carnevale, Alessandro Falchi, Elisabetta Greco, Laura Mangiarini, Michele Negri. Stereospecific synthesis and structure-activity relationships of unsymmetrical 4,4-diphenylbut-3-enyl derivatives of nipecotic acid as GAT-1 inhibitors. Bioorganic & medicinal chemistry letters. 2011 Jan; 21(1):602-5. doi: 10.1016/j.bmcl.2010.09.025. [PMID: 21134748]
  • C Suñol, Z Babot, R Cristòfol, U Sonnewald, H S Waagepetersen, A Schousboe. A possible role of the non-GAT1 GABA transporters in transfer of GABA from GABAergic to glutamatergic neurons in mouse cerebellar neuronal cultures. Neurochemical research. 2010 Sep; 35(9):1384-90. doi: 10.1007/s11064-010-0196-1. [PMID: 20512624]
  • Søren Skovstrup, Olivier Taboureau, Hans Bräuner-Osborne, Flemming Steen Jørgensen. Homology modelling of the GABA transporter and analysis of tiagabine binding. ChemMedChem. 2010 Jul; 5(7):986-1000. doi: 10.1002/cmdc.201000100. [PMID: 20491137]
  • Mark R Faust, Georg Höfner, Jörg Pabel, Klaus T Wanner. Azetidine derivatives as novel gamma-aminobutyric acid uptake inhibitors: synthesis, biological evaluation, and structure-activity relationship. European journal of medicinal chemistry. 2010 Jun; 45(6):2453-66. doi: 10.1016/j.ejmech.2010.02.029. [PMID: 20219271]
  • Jin Bong Park, Ji Yoon Jo, Hong Zheng, Kaushik P Patel, Javier E Stern. Regulation of tonic GABA inhibitory function, presympathetic neuronal activity and sympathetic outflow from the paraventricular nucleus by astroglial GABA transporters. The Journal of physiology. 2009 Oct; 587(Pt 19):4645-60. doi: 10.1113/jphysiol.2009.173435. [PMID: 19703969]
  • Haijun Zhang, Wenjun Xin, Patrick M Dougherty. Synaptically evoked glutamate transporter currents in Spinal Dorsal Horn Astrocytes. Molecular pain. 2009 Jul; 5(?):36. doi: 10.1186/1744-8069-5-36. [PMID: 19570219]
  • Andrea Kragler, Georg Höfner, Klaus T Wanner. Synthesis and biological evaluation of aminomethylphenol derivatives as inhibitors of the murine GABA transporters mGAT1-mGAT4. European journal of medicinal chemistry. 2008 Nov; 43(11):2404-11. doi: 10.1016/j.ejmech.2008.01.005. [PMID: 18395300]
  • C M Tartaglione, M N Ritta. On the presence of 3H-GABA uptake mechanism in bovine spermatozoa. Animal reproduction science. 2008 Oct; 108(1-2):247-58. doi: 10.1016/j.anireprosci.2007.08.010. [PMID: 17954017]
  • Naoki Masuda, Qi Peng, Qing Li, Mali Jiang, Yideng Liang, Xiaofang Wang, Ming Zhao, Wenfei Wang, Christopher A Ross, Wenzhen Duan. Tiagabine is neuroprotective in the N171-82Q and R6/2 mouse models of Huntington's disease. Neurobiology of disease. 2008 Jun; 30(3):293-302. doi: 10.1016/j.nbd.2008.01.014. [PMID: 18395459]
  • Moslem Mohammadi, Esmaeel Ghani, Asghar Ghasemi, Ali Khoshbaten, Alireza Asgari. Synaptosomal GABA uptake decreases in paraoxon-treated rat brain. Toxicology. 2008 Feb; 244(1):42-8. doi: 10.1016/j.tox.2007.10.024. [PMID: 18055092]
  • Jiange Zhang, Pei Zhang, Xianbo Liu, Kai Fang, Guoqiang Lin. Synthesis and biological evaluation of (R)-N-(diarylmethylthio/sulfinyl)ethyl/propyl-piperidine-3-carboxylic acid hydrochlorides as novel GABA uptake inhibitors. Bioorganic & medicinal chemistry letters. 2007 Jul; 17(13):3769-73. doi: 10.1016/j.bmcl.2007.04.010. [PMID: 17517506]
  • Joanna R Dodd, David L Christie. Selective amino acid substitutions convert the creatine transporter to a gamma-aminobutyric acid transporter. The Journal of biological chemistry. 2007 May; 282(21):15528-33. doi: 10.1074/jbc.m611705200. [PMID: 17400549]
  • Sayumi Fujimori, Eiichi Hinoi, Takeshi Takarada, Mika Iemata, Yoshifumi Takahata, Yukio Yoneda. Possible expression of a particular gamma-aminobutyric acid transporter isoform responsive to upregulation by hyperosmolarity in rat calvarial osteoblasts. European journal of pharmacology. 2006 Nov; 550(1-3):24-32. doi: 10.1016/j.ejphar.2006.08.088. [PMID: 17022965]
  • Sotirios Keros, John J Hablitz. Subtype-specific GABA transporter antagonists synergistically modulate phasic and tonic GABAA conductances in rat neocortex. Journal of neurophysiology. 2005 Sep; 94(3):2073-85. doi: 10.1152/jn.00520.2005. [PMID: 15987761]
  • Wei Zhang, Heidi A Campbell, Steven C King, William Dowhan. Phospholipids as determinants of membrane protein topology. Phosphatidylethanolamine is required for the proper topological organization of the gamma-aminobutyric acid permease (GabP) of Escherichia coli. The Journal of biological chemistry. 2005 Jul; 280(28):26032-8. doi: 10.1074/jbc.m504929200. [PMID: 15890647]
  • Steven C King. The 'Transport Specificity Ratio': a structure-function tool to search the protein fold for loci that control transition state stability in membrane transport catalysis. BMC biochemistry. 2004 Nov; 5(?):16. doi: 10.1186/1471-2091-5-16. [PMID: 15548327]
  • Sandra M Leal, Nitin Kumar, Wendi S Neckameyer. GABAergic modulation of motor-driven behaviors in juvenile Drosophila and evidence for a nonbehavioral role for GABA transport. Journal of neurobiology. 2004 Nov; 61(2):189-208. doi: 10.1002/neu.20061. [PMID: 15389689]
  • M V Linetska, L G Storchak, A S Tarasenko, N H Himmelreich. Involvement of membrane GABA transporter in alpha-latrotoxin-stimulated [3H]GABA release. Neurochemistry international. 2004 Apr; 44(5):303-12. doi: 10.1016/j.neuint.2003.07.003. [PMID: 14643747]
  • Alessandro Dalpiaz, Barbara Pavan, Martina Scaglianti, Federica Vitali, Fabrizio Bortolotti, Carla Biondi, Angelo Scatturin, Sergio Tanganelli, Luca Ferraro, Puttur Prasad, Stefano Manfredini. Transporter-mediated effects of diclofenamic acid and its ascorbyl pro-drug in the in vivo neurotropic activity of ascorbyl nipecotic acid conjugate. Journal of pharmaceutical sciences. 2004 Jan; 93(1):78-85. doi: 10.1002/jps.10532. [PMID: 14648638]
  • Steven C King, Lisa Brown-Istvan. Use of the transport specificity ratio and cysteine-scanning mutagenesis to detect multiple substrate specificity determinants in the consensus amphipathic region of the Escherichia coli GABA (gamma-aminobutyric acid) transporter encoded by gabP. The Biochemical journal. 2003 Dec; 376(Pt 3):633-44. doi: 10.1042/bj20030594. [PMID: 12956624]
  • Alan Sarup, Orla Miller Larsson, Tina Bolvig, Bente Frølund, Povl Krogsgaard-Larsen, Arne Schousboe. Effects of 3-hydroxy-4-amino-4,5,6,7-tetrahydro-1,2-benzisoxazol (exo-THPO) and its N-substituted analogs on GABA transport in cultured neurons and astrocytes and by the four cloned mouse GABA transporters. Neurochemistry international. 2003 Sep; 43(4-5):445-51. doi: 10.1016/s0197-0186(03)00033-0. [PMID: 12742090]
  • Cosimo Altomare, Giuseppe Trapani, Andrea Latrofa, Mariangela Serra, Enrico Sanna, Giovanni Biggio, Gaetano Liso. Highly water-soluble derivatives of the anesthetic agent propofol: in vitro and in vivo evaluation of cyclic amino acid esters. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. 2003 Sep; 20(1):17-26. doi: 10.1016/s0928-0987(03)00161-1. [PMID: 13678789]
  • M V Linetska, L G Storchak, N H Himmelreich. Phenylarsine oxide inhibits alpha-latrotoxin-stimulated [3H]GABA release from rat brain synaptosomes. Neurochemistry international. 2003 Jun; 42(7):583-90. doi: 10.1016/s0197-0186(02)00158-4. [PMID: 12590941]
  • Modesto de Candia, Luciana Summo, Antonio Carrieri, Cosimo Altomare, Adele Nardecchia, Saverio Cellamare, Angelo Carotti. Investigation of platelet aggregation inhibitory activity by phenyl amides and esters of piperidinecarboxylic acids. Bioorganic & medicinal chemistry. 2003 Apr; 11(7):1439-50. doi: 10.1016/s0968-0896(02)00599-0. [PMID: 12628670]
  • Julieta Garduño, Sergio Elenes, Jorge Cebada, Elizabeth Becerra, Ubaldo García. Expression and functional characterization of GABA transporters in crayfish neurosecretory cells. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2002 Nov; 22(21):9176-84. doi: 10.1523/jneurosci.22-21-09176.2002. [PMID: 12417642]
  • L Barakat, A Bordey. GAT-1 and reversible GABA transport in Bergmann glia in slices. Journal of neurophysiology. 2002 Sep; 88(3):1407-19. doi: 10.1152/jn.2002.88.3.1407. [PMID: 12205162]
  • Marion Maus, Jacques Glowinski, Joel Premont. GABA is toxic for mouse striatal neurones through a transporter-mediated process. Journal of neurochemistry. 2002 Aug; 82(4):763-73. doi: 10.1046/j.1471-4159.2002.01011.x. [PMID: 12358781]
  • M-E Ruiz-Tachiquín, E Sánchez-Lemus, L-E Soria-Jasso, J-A Arias-Montaño, A Ortega. Gamma-aminobutyric acid transporter (BGT-1) expressed in human astrocytoma U373 MG cells: pharmacological and molecular characterization and phorbol ester-induced inhibition. Journal of neuroscience research. 2002 Jul; 69(1):125-32. doi: 10.1002/jnr.10258. [PMID: 12111824]
  • Sylvie Poluch, Norbert König. AMPA receptor activation induces GABA release from neurons migrating tangentially in the intermediate zone of embryonic rat neocortex. The European journal of neuroscience. 2002 Jul; 16(2):350-4. doi: 10.1046/j.1460-9568.2002.02068.x. [PMID: 12169116]
  • Michael W Quick. Substrates regulate gamma-aminobutyric acid transporters in a syntaxin 1A-dependent manner. Proceedings of the National Academy of Sciences of the United States of America. 2002 Apr; 99(8):5686-91. doi: 10.1073/pnas.082712899. [PMID: 11960023]
  • Chia-Mei Wang, Yuan-Yi Chang, Jon-Son Kuo, Synthia H Sun. Activation of P2X(7) receptors induced [(3)H]GABA release from the RBA-2 type-2 astrocyte cell line through a Cl(-)/HCO(3)(-)-dependent mechanism. Glia. 2002 Jan; 37(1):8-18. doi: 10.1002/glia.10004. [PMID: 11746779]
  • Harald H Sitte, Ernst A Singer, Petra Scholze. Bi-directional transport of GABA in human embryonic kidney (HEK-293) cells stably expressing the rat GABA transporter GAT-1. British journal of pharmacology. 2002 Jan; 135(1):93-102. doi: 10.1038/sj.bjp.0704446. [PMID: 11786484]
  • T L Whitworth, M W Quick. Substrate-induced regulation of gamma-aminobutyric acid transporter trafficking requires tyrosine phosphorylation. The Journal of biological chemistry. 2001 Nov; 276(46):42932-7. doi: 10.1074/jbc.m107638200. [PMID: 11555659]
  • B A Hirayama, A Díez-Sampedro, E M Wright. Common mechanisms of inhibition for the Na+/glucose (hSGLT1) and Na+/Cl-/GABA (hGAT1) cotransporters. British journal of pharmacology. 2001 Oct; 134(3):484-95. doi: 10.1038/sj.bjp.0704274. [PMID: 11588102]
  • H Takanaga, S Ohtsuki, Hosoya Ki, T Terasaki. GAT2/BGT-1 as a system responsible for the transport of gamma-aminobutyric acid at the mouse blood-brain barrier. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. 2001 Oct; 21(10):1232-9. doi: 10.1097/00004647-200110000-00012. [PMID: 11598501]
  • A Kakee, H Takanaga, T Terasaki, M Naito, T Tsuruo, Y Sugiyama. Efflux of a suppressive neurotransmitter, GABA, across the blood-brain barrier. Journal of neurochemistry. 2001 Oct; 79(1):110-8. doi: 10.1046/j.1471-4159.2001.00540.x. [PMID: 11595763]
  • Marta García-Delgado, María J Peral, Mercedes Cano, María L Calonge, Anunciación A Ilundáin. Creatine transport in brush-border membrane vesicles isolated from rat kidney cortex. Journal of the American Society of Nephrology : JASN. 2001 Sep; 12(9):1819-1825. doi: 10.1681/asn.v1291819. [PMID: 11518774]
  • L G Harsing, S Solyom, C Salamon. The role of glycineB binding site and glycine transporter (GlyT1) in the regulation of [3H]GABA and [3H]glycine release in the rat brain. Neurochemical research. 2001 Sep; 26(8-9):915-23. doi: 10.1023/a:1012328300037. [PMID: 11699943]
  • Y Wu, W Wang, G B Richerson. GABA transaminase inhibition induces spontaneous and enhances depolarization-evoked GABA efflux via reversal of the GABA transporter. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2001 Apr; 21(8):2630-9. doi: . [PMID: 11306616]
  • X D Li, A Villa, C Gownley, M J Kim, J Song, M Auer, D N Wang. Monomeric state and ligand binding of recombinant GABA transporter from Escherichia coli. FEBS letters. 2001 Apr; 494(3):165-9. doi: 10.1016/s0014-5793(01)02334-1. [PMID: 11311234]
  • A Wawrzeńczyk, A Sacher, M Mac, M J Nałecz, K A Nałecz. Transport of L-carnitine in isolated cerebral cortex neurons. European journal of biochemistry. 2001 Apr; 268(7):2091-8. doi: 10.1046/j.1432-1327.2001.02087.x. [PMID: 11277932]
  • P R Patrylo, D D Spencer, A Williamson. GABA uptake and heterotransport are impaired in the dentate gyrus of epileptic rats and humans with temporal lobe sclerosis. Journal of neurophysiology. 2001 Apr; 85(4):1533-42. doi: 10.1152/jn.2001.85.4.1533. [PMID: 11287477]
  • P Genton, R Guerrini, E Perucca. Tiagabine in clinical practice. Epilepsia. 2001; 42 Suppl 3(?):42-5. doi: 10.1046/j.1528-1157.2001.042suppl.3042.x. [PMID: 11520322]
  • A Köfalvi, B Sperlágh, T Zelles, E S Vizi. Long-lasting facilitation of 4-amino-n-[2,3-(3)H]butyric acid ([(3)H]GABA) release from rat hippocampal slices by nicotinic receptor activation. The Journal of pharmacology and experimental therapeutics. 2000 Nov; 295(2):453-62. doi: NULL. [PMID: 11046076]
  • L J Knutsen, K E Andersen, J Lau, B F Lundt, R F Henry, H E Morton, L Naerum, H Petersen, H Stephensen, P D Suzdak, M D Swedberg, C Thomsen, P O Sørensen. Synthesis of novel GABA uptake inhibitors. 3. Diaryloxime and diarylvinyl ether derivatives of nipecotic acid and guvacine as anticonvulsant agents. Journal of medicinal chemistry. 1999 Sep; 42(18):3447-62. doi: 10.1021/jm981027k. [PMID: 10479278]
  • V R Durgam, M Vitela, S W Mifflin. Enhanced gamma-aminobutyric acid-B receptor agonist responses and mRNA within the nucleus of the solitary tract in hypertension. Hypertension (Dallas, Tex. : 1979). 1999 Jan; 33(1 Pt 2):530-6. doi: 10.1161/01.hyp.33.1.530. [PMID: 9931160]
  • M D Simpson, P Slater, J F Deakin, C G Gottfries, I Karlsson, B Grenfeldt, T J Crow. Absence of basal ganglia amino acid neuron deficits in schizophrenia in three collections of brains. Schizophrenia research. 1998 May; 31(2-3):167-75. doi: 10.1016/s0920-9964(98)00020-6. [PMID: 9689721]
  • J M Yee, S Agulian, J D Kocsis. Vigabatrin enhances promoted release of GABA in neonatal rat optic nerve. Epilepsy research. 1998 Feb; 29(3):195-200. doi: 10.1016/s0920-1211(97)00086-7. [PMID: 9551781]
  • J Verweij, M Kamermans, K Negishi, H Spekreijse. GABA sensitivity of spectrally classified horizontal cells in goldfish retina. Visual neuroscience. 1998 Jan; 15(1):77-86. doi: 10.1017/s0952523898151039. [PMID: 9456507]
  • P Krogsgaard-Larsen, B F Frølund, E Falch. Inhibitors of gamma-aminobutyric acid transport as experimental tools and therapeutic agents. Methods in enzymology. 1998; 296(?):165-75. doi: 10.1016/s0076-6879(98)96013-x. [PMID: 9779447]
  • A Del Arco, T R Castañeda, F Mora. Amphetamine releases GABA in striatum of the freely moving rat: involvement of calcium and high affinity transporter mechanisms. Neuropharmacology. 1998; 37(2):199-205. doi: 10.1016/s0028-3908(98)00013-6. [PMID: 9680244]
  • G D Zeevalk, W J Nicklas. Activity at the GABA transporter contributes to acute cellular swelling produced by metabolic impairment in retina. Vision research. 1997 Dec; 37(24):3463-70. doi: 10.1016/s0042-6989(97)00184-3. [PMID: 9425523]
  • C Thomsen, P O Sørensen, J Egebjerg. 1-(3-(9H-carbazol-9-yl)-1-propyl)-4-(2-methoxyphenyl)-4-piperidinol, a novel subtype selective inhibitor of the mouse type II GABA-transporter. British journal of pharmacology. 1997 Mar; 120(6):983-5. doi: 10.1038/sj.bjp.0700957. [PMID: 9134205]
  • S C King, S R Fleming, C Brechtel. Pyridine carboxylic acids as inhibitors and substrates of the Escherichia coli gab permease encoded by gabP. Journal of bacteriology. 1995 Sep; 177(18):5381-2. doi: 10.1128/jb.177.18.5381-5382.1995. [PMID: 7665533]
  • D Mbungu, L S Ross, S S Gill. Cloning, functional expression, and pharmacology of a GABA transporter from Manduca sexta. Archives of biochemistry and biophysics. 1995 Apr; 318(2):489-97. doi: 10.1006/abbi.1995.1258. [PMID: 7733681]
  • K Takahashi, S Miyoshi, A Kaneko, D R Copenhagen. Actions of nipecotic acid and SKF89976A on GABA transporter in cone-driven horizontal cells dissociated from the catfish retina. The Japanese journal of physiology. 1995; 45(3):457-73. doi: 10.2170/jjphysiol.45.457. [PMID: 7474528]
  • T G Dhar, L A Borden, S Tyagarajan, K E Smith, T A Branchek, R L Weinshank, C Gluchowski. Design, synthesis and evaluation of substituted triarylnipecotic acid derivatives as GABA uptake inhibitors: identification of a ligand with moderate affinity and selectivity for the cloned human GABA transporter GAT-3. Journal of medicinal chemistry. 1994 Jul; 37(15):2334-42. doi: 10.1021/jm00041a012. [PMID: 8057281]
  • I Osawa, N Saito, T Koga, C Tanaka. Phorbol ester-induced inhibition of GABA uptake by synaptosomes and by Xenopus oocytes expressing GABA transporter (GAT1). Neuroscience research. 1994 May; 19(3):287-93. doi: 10.1016/0168-0102(94)90041-8. [PMID: 8058205]
  • Q R Liu, B López-Corcuera, S Mandiyan, H Nelson, N Nelson. Molecular characterization of four pharmacologically distinct gamma-aminobutyric acid transporters in mouse brain [corrected]. The Journal of biological chemistry. 1993 Jan; 268(3):2106-12. doi: . [PMID: 8420981]
  • G Bonanno, A Ruelle, G C Andrioli, M Raiteri. Cholinergic nerve terminals of human cerebral cortex possess a GABA transporter whose activation induces release of acetylcholine. Brain research. 1991 Jan; 539(2):191-5. doi: 10.1016/0006-8993(91)91620-g. [PMID: 2054596]
  • J Taylor, P R Gordon-Weeks. Calcium-independent gamma-aminobutyric acid release from growth cones: role of gamma-aminobutyric acid transport. Journal of neurochemistry. 1991 Jan; 56(1):273-80. doi: 10.1111/j.1471-4159.1991.tb02592.x. [PMID: 1987321]
  • V Gallo, M Patrizio, G Levi. GABA release triggered by the activation of neuron-like non-NMDA receptors in cultured type 2 astrocytes is carrier-mediated. Glia. 1991; 4(3):245-55. doi: 10.1002/glia.440040302. [PMID: 1680100]
  • T Segura, E M Hasser, R E Shade, J R Haywood. Evidence of an endogenous forebrain GABAergic system capable of inhibiting baroreceptor-mediated vasopressin release. Brain research. 1989 Oct; 499(1):53-62. doi: 10.1016/0006-8993(89)91134-7. [PMID: 2804669]
  • J M Catelli, W J Giakas, A F Sved. GABAergic mechanisms in nucleus tractus solitarius alter blood pressure and vasopressin release. Brain research. 1987 Feb; 403(2):279-89. doi: 10.1016/0006-8993(87)90065-5. [PMID: 3828822]
  • J R Haywood, T J Brennan, C Hinojosa. Neurohumoral mechanisms of sodium-dependent hypertension. Federation proceedings. 1985 May; 44(8):2393-9. doi: NULL. [PMID: 2859221]
  • B I Kanner, A Bendahan, R Radian. Efflux and exchange of gamma-aminobutyric acid and nipecotic acid catalysed by synaptic plasma membrane vesicles isolated from immature rat brain. Biochimica et biophysica acta. 1983 May; 731(1):54-62. doi: 10.1016/0005-2736(83)90397-8. [PMID: 6849911]