1,5-isoquinolinediol (BioDeep_00000271212)

   


代谢物信息卡片


1,5-isoquinolinediol

化学式: C9H7NO2 (161.0476762)
中文名称: 1,5-二羟基异喹啉
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1=CC2=C(C=CNC2=O)C(=C1)O
InChI: InChI=1S/C9H7NO2/c11-8-3-1-2-7-6(8)4-5-10-9(7)12/h1-5,11H,(H,10,12)

描述信息

D000970 - Antineoplastic Agents > D000067856 - Poly(ADP-ribose) Polymerase Inhibitors
D004791 - Enzyme Inhibitors

同义名列表

1 个代谢物同义名

1,5-isoquinolinediol



数据库引用编号

5 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

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文献列表

  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
  • Thomas D Walko, Valentina Di Caro, Jon Piganelli, Timothy R Billiar, Robert S B Clark, Rajesh K Aneja. Poly(ADP-ribose) polymerase 1-sirtuin 1 functional interplay regulates LPS-mediated high mobility group box 1 secretion. Molecular medicine (Cambridge, Mass.). 2015 Mar; 20(?):612-24. doi: 10.2119/molmed.2014.00156. [PMID: 25517228]
  • Ashok Jangra, Ashok Kumar Datusalia, Shyam Sunder Sharma. Reversal of neurobehavioral and neurochemical alterations in STZ-induced diabetic rats by FeTMPyP, a peroxynitrite decomposition catalyst and 1,5-Isoquinolinediol a poly(ADP-ribose) polymerase inhibitor. Neurological research. 2014 Jul; 36(7):619-26. doi: 10.1179/1743132813y.0000000301. [PMID: 24620961]
  • M M Huzyk, K O Diakun, L V Ianits'ka, T M Kuchmerovs'ka. [Influence of poly(ADP-ribose) polymerase inhibitors on some parameters of oxidative stress in blood leukocytes of rats with experimental diabetes]. Ukrains'kyi biokhimichnyi zhurnal (1999 ). 2013 Jan; 85(1):62-70. doi: NULL. [PMID: 23534291]
  • Selvinaz Dalaklioglu, Pinar Sahin, Ece Gungor Ordueri, Ciler Celik-Ozenci, Arda Tasatargil. Potential role of poly(ADP-ribose) polymerase (PARP) activation in methotrexate-induced nephrotoxicity and tubular apoptosis. International journal of toxicology. 2012 Sep; 31(5):430-40. doi: 10.1177/1091581812457430. [PMID: 22914891]
  • Selvinaz Dalaklioglu, Merih Tekcan, Nazli Ece Gungor, Ciler Celik-Ozenci, Nazif Hikmet Aksoy, Asli Baykal, Arda Tasatargil. Role of the poly(ADP-ribose)polymerase activity in vancomycin-induced renal injury. Toxicology letters. 2010 Feb; 192(2):91-6. doi: 10.1016/j.toxlet.2009.10.002. [PMID: 19833176]
  • Viktor R Drel, Weizheng Xu, Jie Zhang, Ivan A Pavlov, Hanna Shevalye, Barbara Slusher, Irina G Obrosova. Poly(Adenosine 5'-diphosphate-ribose) polymerase inhibition counteracts multiple manifestations of experimental type 1 diabetic nephropathy. Endocrinology. 2009 Dec; 150(12):5273-83. doi: 10.1210/en.2009-0628. [PMID: 19854869]
  • Irina G Obrosova, Alexander G Minchenko, Robert N Frank, Gail M Seigel, Zsuzsanna Zsengeller, Pál Pacher, Martin J Stevens, Csaba Szabó. Poly(ADP-ribose) polymerase inhibitors counteract diabetes- and hypoxia-induced retinal vascular endothelial growth factor overexpression. International journal of molecular medicine. 2004 Jul; 14(1):55-64. doi: 10.3892/ijmm.14.1.55. [PMID: 15202016]
  • Grzegorz A Czapski, Magdalena Cakala, Dorota Kopczuk, Joanna B Strosznajder. Effect of poly(ADP-ribose) polymerase inhibitors on oxidative stress evoked hydroxyl radical level and macromolecules oxidation in cell free system of rat brain cortex. Neuroscience letters. 2004 Feb; 356(1):45-8. doi: 10.1016/j.neulet.2003.11.022. [PMID: 14746898]
  • Alexander G Minchenko, Martin J Stevens, Lauren White, Omorodola I Abatan, Katalin Komjáti, Pal Pacher, Csaba Szabó, Irina G Obrosova. Diabetes-induced overexpression of endothelin-1 and endothelin receptors in the rat renal cortex is mediated via poly(ADP-ribose) polymerase activation. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2003 Aug; 17(11):1514-6. doi: 10.1096/fj.03-0013fje. [PMID: 12824290]
  • Basilia Zingarelli, Michael O'Connor, Paul W Hake. Inhibitors of poly (ADP-ribose) polymerase modulate signal transduction pathways in colitis. European journal of pharmacology. 2003 May; 469(1-3):183-94. doi: 10.1016/s0014-2999(03)01726-6. [PMID: 12782201]
  • Murat Bozlu, Gülçin Eskandari, Selahittin Cayan, Bülent Canpolat, Erdem Akbay, Uğur Atik. The effect of poly (adenosine diphosphate-ribose) polymerase inhibitors on biochemical changes in testicular ischemia-reperfusion injury. The Journal of urology. 2003 May; 169(5):1870-3. doi: 10.1097/01.ju.0000049228.37887.4d. [PMID: 12686864]
  • P K Chatterjee, K Zacharowski, S Cuzzocrea, M Otto, C Thiemermann. Inhibitors of poly (ADP-ribose) synthetase reduce renal ischemia-reperfusion injury in the anesthetized rat in vivo. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2000 Apr; 14(5):641-51. doi: 10.1096/fasebj.14.5.641. [PMID: 10744621]
  • M C McDonald, H M Filipe, C Thiemermann. Effects of inhibitors of the activity of poly (ADP-ribose) synthetase on the organ injury and dysfunction caused by haemorrhagic shock. British journal of pharmacology. 1999 Nov; 128(6):1339-45. doi: 10.1038/sj.bjp.0702928. [PMID: 10578150]
  • P K Chatterjee, S Cuzzocrea, C Thiemermann. Inhibitors of poly (ADP-ribose) synthetase protect rat proximal tubular cells against oxidant stress. Kidney international. 1999 Sep; 56(3):973-84. doi: 10.1046/j.1523-1755.1999.00644.x. [PMID: 10469365]
  • G M Wray, C J Hinds, C Thiemermann. Effects of inhibitors of poly(ADP-ribose) synthetase activity on hypotension and multiple organ dysfunction caused by endotoxin. Shock (Augusta, Ga.). 1998 Jul; 10(1):13-9. doi: 10.1097/00024382-199807000-00003. [PMID: 9688085]