PENFLURIDOL (BioDeep_00000271189)

   


代谢物信息卡片


PENFLURIDOL

化学式: C28H27ClF5NO (523.1701222)
中文名称: 五氟利多
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1CN(CCC1(C2=CC(=C(C=C2)Cl)C(F)(F)F)O)CCCC(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F
InChI: InChI=1S/C28H27ClF5NO/c29-26-12-7-21(18-25(26)28(32,33)34)27(36)13-16-35(17-14-27)15-1-2-24(19-3-8-22(30)9-4-19)20-5-10-23(31)11-6-20/h3-12,18,24,36H,1-2,13-17H2

描述信息

D002492 - Central Nervous System Depressants > D014149 - Tranquilizing Agents > D014150 - Antipsychotic Agents
N - Nervous system > N05 - Psycholeptics > N05A - Antipsychotics > N05AG - Diphenylbutylpiperidine derivatives
D002491 - Central Nervous System Agents > D011619 - Psychotropic Drugs > D014149 - Tranquilizing Agents
D018377 - Neurotransmitter Agents > D015259 - Dopamine Agents > D018492 - Dopamine Antagonists
D002491 - Central Nervous System Agents > D002492 - Central Nervous System Depressants
C78272 - Agent Affecting Nervous System > C66883 - Dopamine Antagonist
Penfluridol (R-16341) is a potent, long-acting, first-generation, oral diphenylbutylpiperidine antipsychotic agent by targeting D2-like dopamine receptor. Penfluridol effectively inhibits TNFα-induced NF-κB activation and alleviates the severity of arthritis and colitis in vivo. Penfluridol is a Ca2+-calmodulin inhibitor. Penfluridol induces apoptosis and autophagy. Penfluridol is used for chronic schizophrenia, acute psychosis, Tourette syndrome and autoimmune diseases. Penfluridol inhibites the growth of E. faecalis planktonic cells with the MIC of 7.81 μg/ml[1][2][3][4].

同义名列表

2 个代谢物同义名

PENFLURIDOL; R-16341



数据库引用编号

14 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Wenlong Xu, Yuqi Wang, Na Zhang, Xiaofeng Lin, Di Zhu, Cheng Shen, Xiaobo Wang, Haiyang Li, Jinjiang Xue, Qian Yu, Xinyi Lu, Lu Zhou, Qingli He, Zhijun Tang, Shaodan He, Jianjun Fan, Jianbo Pan, Jiangjiang Tang, Wei Jiang, Mingliang Ye, Fanghui Lu, Zengxia Li, Yongjun Dang. The Antipsychotic Drug Penfluridol Inhibits N-Linked Glycoprotein Processing and Enhances T-cell-Mediated Tumor Immunity. Molecular cancer therapeutics. 2024 May; 23(5):648-661. doi: 10.1158/1535-7163.mct-23-0449. [PMID: 37963566]
  • Min-Che Tung, Yung-Wei Lin, Wei-Jiunn Lee, Yu-Ching Wen, Yu-Cheng Liu, Ji-Qing Chen, Michael Hsiao, Yi-Chieh Yang, Ming-Hsien Chien. Targeting DRD2 by the antipsychotic drug, penfluridol, retards growth of renal cell carcinoma via inducing stemness inhibition and autophagy-mediated apoptosis. Cell death & disease. 2022 Apr; 13(4):400. doi: 10.1038/s41419-022-04828-3. [PMID: 35461314]
  • Ning-Ning Wang, Peng-Zhen Zhang, Jing Zhang, Hai-Ning Wang, Ling Li, Feng Ren, Peng-Fei Dai, Hui Li, Xiao-Feng Lv. Penfluridol triggers mitochondrial-mediated apoptosis and suppresses glycolysis in colorectal cancer cells through down-regulating hexokinase-2. Anatomical record (Hoboken, N.J. : 2007). 2021 03; 304(3):520-530. doi: 10.1002/ar.24464. [PMID: 32470200]
  • Prasad Dandawate, Gaurav Kaushik, Chandrayee Ghosh, David Standing, Afreen Asif Ali Sayed, Sonali Choudhury, Dharmalingam Subramaniam, Ann Manzardo, Tuhina Banerjee, Santimukul Santra, Prabhu Ramamoorthy, Merlin Butler, Subhash B Padhye, Joaquina Baranda, Anup Kasi, Weijing Sun, Ossama Tawfik, Domenico Coppola, Mokenge Malafa, Shahid Umar, Michael J Soares, Subhrajit Saha, Scott J Weir, Animesh Dhar, Roy A Jensen, Sufi Mary Thomas, Shrikant Anant. Diphenylbutylpiperidine Antipsychotic Drugs Inhibit Prolactin Receptor Signaling to Reduce Growth of Pancreatic Ductal Adenocarcinoma in Mice. Gastroenterology. 2020 04; 158(5):1433-1449.e27. doi: 10.1053/j.gastro.2019.11.279. [PMID: 31786131]
  • Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology. 2019 11; 96(5):629-640. doi: 10.1124/mol.119.115964. [PMID: 31515284]
  • Lu Wu, Yan-Yang Liu, Zhi-Xi Li, Qian Zhao, Xia Wang, Yang Yu, Yu-Yi Wang, Yi-Qin Wang, Feng Luo. Anti-tumor effects of penfluridol through dysregulation of cholesterol homeostasis. Asian Pacific journal of cancer prevention : APJCP. 2014; 15(1):489-94. doi: 10.7314/apjcp.2014.15.1.489. [PMID: 24528079]
  • Patrice Njomnang Soh, Benoît Witkowski, David Olagnier, Marie-Laure Nicolau, Maria-Concepcion Garcia-Alvarez, Antoine Berry, Françoise Benoit-Vical. In vitro and in vivo properties of ellagic acid in malaria treatment. Antimicrobial agents and chemotherapy. 2009 Mar; 53(3):1100-6. doi: 10.1128/aac.01175-08. [PMID: 19015354]
  • John J Enyeart, Lin Xu, Sanjay Danthi, Judith A Enyeart. An ACTH- and ATP-regulated background K+ channel in adrenocortical cells is TREK-1. The Journal of biological chemistry. 2002 Dec; 277(51):49186-99. doi: 10.1074/jbc.m207233200. [PMID: 12368289]
  • Celia M Santi, Francisco S Cayabyab, Kathy G Sutton, John E McRory, Janette Mezeyova, Kevin S Hamming, David Parker, Anthony Stea, Terrance P Snutch. Differential inhibition of T-type calcium channels by neuroleptics. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2002 Jan; 22(2):396-403. doi: 10.1523/jneurosci.22-02-00396.2002. [PMID: 11784784]
  • E Tani, E Rekka, P N Kourounakis. Modification of lipid peroxidation by some known substituted imidazole derivatives. An attempt to correlate their antioxidant activity with lipophilicity. Die Pharmazie. 1991 Feb; 46(2):118-9. doi: ". [PMID: 1677199]
  • D Naber, N Nedopil, E Eben. No correlation between neuroleptic-induced increase of beta-endorphin serum level and therapeutic efficacy in schizophrenia. The British journal of psychiatry : the journal of mental science. 1984 Jun; 144(?):651-3. doi: 10.1192/bjp.144.6.651. [PMID: 6146374]
  • R S Nathan, E J Sachar, L Ostrow, G M Asnis, U Halbreich, F Halpern, N L Renzi, V Slotnick. A preliminary study of sex-related differences in prolactin responses to dopamine blockade and insulin hypoglycemia and in penfluridol plasma levels in schizophrenic patients. Psychopharmacology. 1983; 80(1):46-9. doi: 10.1007/bf00427494. [PMID: 6408670]
  • R T Rubin. Plasma prolactin and testosterone during penfluridol treatment. Lancet (London, England). 1980 Aug; 2(8190):370. doi: 10.1016/s0140-6736(80)90369-4. [PMID: 6105505]
  • R S Nathan, G M Asnis, I Dyrenfurth, F S Halpern, U Halbreich, L C Ostrow, E J Sachar. Plasma prolactin and testosterone during penfluridol treatment. Lancet (London, England). 1980 Jul; 2(8185):94. doi: 10.1016/s0140-6736(80)92977-3. [PMID: 6105283]
  • J M Grindel, B H Migdalof, J F Hills. Characterization of a new urinary metabolite of penfluridol in the rat, rabbit, dog, and man. Drug metabolism and disposition: the biological fate of chemicals. 1979 Nov; 7(6):448. doi: NULL. [PMID: 43238]
  • J M Grindel, B H Migdalof, W A Cressman. The comparative metabolism and disposition of penfluridol-3H in the rat, rabbit, dog, and man. Drug metabolism and disposition: the biological fate of chemicals. 1979 Sep; 7(5):325-9. doi: NULL. [PMID: 40775]
  • A Quattrone, G Schettini, G F Di Renzo, P Preziosi. Pharmacological evidence of an interaction between serotonergic and dopaminergic neurons in the control of prolactin secretion in male rats. Archives internationales de pharmacodynamie et de therapie. 1979 Mar; 238(1):42-9. doi: NULL. [PMID: 485703]
  • B H Migdalof, J M Grindel, J J Heykants, P A Janssen. Penfluridol: a neuroleptic drug designed for long duration of action. Drug metabolism reviews. 1979; 9(2):281-99. doi: 10.3109/03602537908993895. [PMID: 385274]
  • L A Annunziato, S M Wuerthele, K E Moore. Comparative effects of penfluridol on circling behavior and striatal DOPAC and serum prolactin concentrations in the rat. European journal of pharmacology. 1978 Aug; 50(3):187-92. doi: 10.1016/0014-2999(78)90350-3. [PMID: 567584]
  • T B Cooper. Plasma level monitoring of antipsychotic drugs. Clinical pharmacokinetics. 1978 Jan; 3(1):14-38. doi: 10.2165/00003088-197803010-00002. [PMID: 25154]
  • J P Davy, M Moulin, J C Andersson, J J Halbecq, P Morel, E Poilpre. [Relations between the levels of neuroleptics and the doses, the therapeutic effects and the side effects]. L'Encephale. 1978; 4(4):293-321. doi: NULL. [PMID: 33791]
  • G d'Elia, L Jacobsson, L von Knorring, B Mattsson, T Mjörndal, L Oreland, C Perris, W Rapp. Changes in psychopathology in relation to EEG variables and visual averaged evoked responses (V.AER) in schizophrenic patients treated with penfluridol or thiothixene. Acta psychiatrica Scandinavica. 1977 Apr; 55(4):309-18. doi: 10.1111/j.1600-0447.1977.tb00175.x. [PMID: 855677]
  • G Chouinard, L Annable, S Cooper. Antiparkinsonian drug administration and plasma levels of penfluridol, a new long-acting neuroleptic. Communications in psychopharmacology. 1977; 1(4):325-31. doi: NULL. [PMID: 615695]
  • K Ito, S Nurimoto, T Ochiai, M Horiuchi, S Suzuki. [Pharmacological studies of antipsychotic drug, penfluridol. 2. General pharmacological properties]. Nihon yakurigaku zasshi. Folia pharmacologica Japonica. 1976 Jul; 72(5):501-17. doi: 10.1254/fpj.72.501. [PMID: 1033105]
  • L Jacobsson, L von Knorring, B Mattsson, T Mjörndal, L Oreland, C Perris, W Rapp, B Edenius, B Kettner, K E Magnusson, P Villemoes. Penfluridol and thiothixene. Dosage, plasma levels and changes in psychopathology. International pharmacopsychiatry. 1976; 11(4):206-14. doi: NULL. [PMID: 795779]
  • S F Cooper, R Dugal, J M Albert, M Bertrand. Penfluridol steady-state kinetics in psychiatric patients. Clinical pharmacology and therapeutics. 1975 Sep; 18(3):325-9. doi: 10.1002/cpt1975183325. [PMID: 1100301]
  • S F Cooper, J M Albert, R Dugal. Gas-liquid chromatographic determination of penfluridol in plasma. A new specific technique. International pharmacopsychiatry. 1975; 10(2):78-88. doi: 10.1159/000468174. [PMID: 1140908]
  • T Mjörndal, L Oreland, C Perris, W Rapp. Concentration in plasma of an orally long-acting new neuroleptic, penfluridol. Acta psychiatrica Scandinavica. Supplementum. 1974; 255(?):85-7. doi: 10.1111/j.1600-0447.1974.tb08897.x. [PMID: 4533718]