piracetam (BioDeep_00000271178)
Volatile Flavor Compounds
代谢物信息卡片
化学式: C6H10N2O2 (142.07422400000002)
中文名称: 吡拉西坦
谱图信息:
最多检出来源 Viridiplantae(plant) 92.31%
分子结构信息
SMILES: C1CC(=O)N(C1)CC(=O)N
InChI: InChI=1S/C6H10N2O2/c7-5(9)4-8-3-1-2-6(8)10/h1-4H2,(H2,7,9)
描述信息
N - Nervous system > N06 - Psychoanaleptics > N06B - Psychostimulants, agents used for adhd and nootropics
D002491 - Central Nervous System Agents > D018696 - Neuroprotective Agents
D002491 - Central Nervous System Agents > D018697 - Nootropic Agents
C26170 - Protective Agent > C1509 - Neuroprotective Agent
D020011 - Protective Agents
CONFIDENCE standard compound; EAWAG_UCHEM_ID 3076
Piracetam (UCB-6215) is a cyclic derivative of the neurotransmitter gamma-aminobutyric acid (GABA), used in treatment of a wide range of cognitive disorders.
同义名列表
数据库引用编号
21 个数据库交叉引用编号
- ChEBI: CHEBI:32010
- KEGGdrug: D01914
- PubChem: 4843
- Metlin: METLIN44173
- DrugBank: DB09210
- ChEMBL: CHEMBL36715
- MeSH: Piracetam
- CAS: 7491-74-9
- MoNA: WA002326
- MoNA: WA002325
- MoNA: WA002324
- MoNA: WA002323
- MoNA: EQ307606
- MoNA: EQ307605
- MoNA: EQ307604
- MoNA: EQ307603
- MoNA: EQ307602
- MoNA: EQ307601
- PMhub: MS000001775
- RefMet: Piracetam
- medchemexpress: HY-B0585
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:
- PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。
文献列表
- Mohamed Abomosallam, Basma M Hendam, Amr A Abdallah, Rasha Refaat, Ahmed Elshatory, Heba Nageh Gad El Hak. Neuroprotective effect of piracetam-loaded magnetic chitosan nanoparticles against thiacloprid-induced neurotoxicity in albino rats.
Inflammopharmacology.
2023 Feb; ?(?):. doi:
10.1007/s10787-023-01151-x
. [PMID: 36745244] - Antoine Kavaye Kandeda, Saleh Nodeina, Symphorien Talom Mabou. An aqueous extract of Syzygium cumini protects against kainate-induced status epilepticus and amnesia: evidence for antioxidant and anti-inflammatory intervention.
Metabolic brain disease.
2022 10; 37(7):2581-2602. doi:
10.1007/s11011-022-01052-y
. [PMID: 35916986] - Rasha E Mostafa, Azza Hassan Morsi, Gihan F Asaad. Piracetam attenuates cyclophosphamide-induced hepatotoxicity in rats: Amelioration of necroptosis, pyroptosis and caspase-dependent apoptosis.
Life sciences.
2022 Aug; 303(?):120671. doi:
10.1016/j.lfs.2022.120671
. [PMID: 35636581] - Elias Konrath, Franz Marhold, Wolfgang Kindler, Florian Scheichel, Branko Popadic, Katrin Blauensteiner, Bernadette Calabek, Elisabeth Freydl, Michael Weber, Robin Ristl, Katharina Hainz, Camillo Sherif, Stefan Oberndorfer. Perioperative levetiracetam for seizure prophylaxis in seizure-naive brain tumor patients with focus on neurocognitive functioning.
BMC neurology.
2022 Jul; 22(1):250. doi:
10.1186/s12883-022-02762-7
. [PMID: 35804291] - Ozkan Ates, Ibrahim Yilmaz, Numan Karaarslan, Emel Ersoz, Fatma Bahar Hacioglu Kasim, Mustafa Dogan, Hanefi Ozbek. Coexistence of SARS-CoV-2 and cerebrovascular diseases: does COVID-19 positivity trigger cerebrovascular pathologies?.
Journal of infection in developing countries.
2022 Jun; 16(6):981-992. doi:
10.3855/jidc.15800
. [PMID: 35797292] - Rajpushpa Labh, Rachna Gupta, Manish Narang, Sumita Halder, Rajarshi Kar. Effect of valproate and add-on levetiracetam on inflammatory biomarkers in children with epilepsy.
Epilepsy & behavior : E&B.
2021 12; 125(?):108358. doi:
10.1016/j.yebeh.2021.108358
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Cell reports.
2021 04; 35(4):109040. doi:
10.1016/j.celrep.2021.109040
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TheScientificWorldJournal.
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Inflammopharmacology.
2020 Oct; 28(5):1283-1292. doi:
10.1007/s10787-020-00705-7
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International journal of clinical pharmacology and therapeutics.
2020 Sep; 58(9):482-490. doi:
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Journal of pharmaceutical sciences.
2020 06; 109(6):2070-2078. doi:
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Molecular pharmacology.
2019 11; 96(5):629-640. doi:
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. [PMID: 31515284] - Ankit Uniyal, Raghunath Singh, Ansab Akhtar, Yashika Bansal, Anurag Kuhad, Sangeeta Pilkhwal Sah. Co-treatment of piracetam with risperidone rescued extinction deficits in experimental paradigms of post-traumatic stress disorder by restoring the physiological alterations in cortex and hippocampus.
Pharmacology, biochemistry, and behavior.
2019 10; 185(?):172763. doi:
10.1016/j.pbb.2019.172763
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The Journal of pharmacy and pharmacology.
2019 Jul; 71(7):1055-1064. doi:
10.1111/jphp.13086
. [PMID: 30864160] - Maha Nasr, Sara A Wahdan. Neuroprotective effects of novel nanosystems simultaneously loaded with vinpocetine and piracetam after intranasal administration.
Life sciences.
2019 Jun; 226(?):117-129. doi:
10.1016/j.lfs.2019.04.014
. [PMID: 30981765] - Agnieszka Szkudlarek, Jadwiga Pożycka, Małgorzata Maciążek-Jurczyk. Influence of Piracetam on Gliclazide-Glycated Human Serum Albumin Interaction. A Spectrofluorometric Study.
Molecules (Basel, Switzerland).
2018 Dec; 24(1):. doi:
10.3390/molecules24010111
. [PMID: 30597970] - Mariana Grigoruţă, Alejandra Vargas-Caraveo, Emmanuel Vázquez-Mayorga, Hiram A Castillo-Michel, Ángel G Díaz-Sánchez, Juan Reyes-Herrera, Alejandro Martínez-Martínez. Blood mononuclear cells as speculum of emotional stress analyzed by synchrotron infrared spectroscopy and a nootropic drug.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy.
2018 Nov; 204(?):475-483. doi:
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Rinsho shinkeigaku = Clinical neurology.
2018 Oct; 58(10):636-641. doi:
10.5692/clinicalneurol.cn-001194
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Basic & clinical pharmacology & toxicology.
2018 Sep; 123(3):271-276. doi:
10.1111/bcpt.12996
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Journal of neurosurgical sciences.
2018 Aug; 62(4):418-422. doi:
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. [PMID: 27854111] - Meng Wang, Mengmeng Wang, Quanying Zhang, Shunlin Zong, Chengzhe Lv. Pharmacokinetics and Safety of Levetiracetam Extended-Release Tablets and Relative Bioavailability Compared with Immediate-Release Tablets in Healthy Chinese Subjects.
European journal of drug metabolism and pharmacokinetics.
2018 Aug; 43(4):405-413. doi:
10.1007/s13318-018-0461-2
. [PMID: 29383569] - Shamir N Kalaria, Elyes Dahmane, Michael Armahizer, Paul McCarthy, Mathangi Gopalakrishnan. Development and validation of a HPLC-UV assay for quantification of levetiracetam concentrations in critically ill patients undergoing continuous renal replacement therapy.
Biomedical chromatography : BMC.
2018 Aug; 32(8):e4257. doi:
10.1002/bmc.4257
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Equine veterinary journal.
2018 Jul; 50(4):532-536. doi:
10.1111/evj.12790
. [PMID: 29194744] - Sahar Mohamed El-Haggar, Tarek Mohamed Mostafa, Horeya Mohamed Sad Allah, Ghada Hassan Akef. Levetiracetam and lamotrigine effects as mono- and polytherapy on bone mineral density in epileptic patients.
Arquivos de neuro-psiquiatria.
2018 Jul; 76(7):452-458. doi:
10.1590/0004-282x20180068
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BMC veterinary research.
2018 Jun; 14(1):189. doi:
10.1186/s12917-018-1522-0
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Biochimica et biophysica acta. Molecular basis of disease.
2018 06; 1864(6 Pt A):2078-2096. doi:
10.1016/j.bbadis.2018.03.014
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Journal of clinical pharmacy and therapeutics.
2018 Jun; 43(3):422-429. doi:
10.1111/jcpt.12658
. [PMID: 29265480] - Yusuf Hussain, Sairam Krishnamurthy. Piracetam attenuates binge eating disorder related symptoms in rats.
Pharmacology, biochemistry, and behavior.
2018 06; 169(?):35-47. doi:
10.1016/j.pbb.2018.04.003
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Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2018 May; 1085(?):13-20. doi:
10.1016/j.jchromb.2018.03.037
. [PMID: 29626789] - Heidi Barnes Heller, Martin Granick, Mathew Van Hesteren, Dawn M Boothe. Serum levetiracetam concentrations and adverse events after multiple dose extended release levetiracetam administration to healthy cats.
Journal of veterinary internal medicine.
2018 May; 32(3):1145-1148. doi:
10.1111/jvim.15129
. [PMID: 29671898] - Pankaj Paliwal, Debabrata Dash, Sairam Krishnamurthy. Pharmacokinetic Study of Piracetam in Focal Cerebral Ischemic Rats.
European journal of drug metabolism and pharmacokinetics.
2018 Apr; 43(2):205-213. doi:
10.1007/s13318-017-0435-9
. [PMID: 28916907] - Joana Gonçalves, Gilberto Alves, Joana Bicker, Amílcar Falcão, Ana Fortuna. Development and full validation of an innovative HPLC-diode array detection technique to simultaneously quantify lacosamide, levetiracetam and zonisamide in human plasma.
Bioanalysis.
2018 Apr; 10(8):541-557. doi:
10.4155/bio-2017-0199
. [PMID: 29561632] - Cameron S Metcalf, Brian D Klein, Misty D Smith, Marc Ceusters, Hilde Lavreysen, Stefan Pype, Nancy Van Osselaer, Roy Twyman, H Steve White. Potent and selective pharmacodynamic synergy between the metabotropic glutamate receptor subtype 2-positive allosteric modulator JNJ-46356479 and levetiracetam in the mouse 6-Hz (44-mA) model.
Epilepsia.
2018 03; 59(3):724-735. doi:
10.1111/epi.14005
. [PMID: 29360159] - F B Cesar, A J Stewart, D M Boothe, W R Ravis, S H Duran, A A Wooldridge. Disposition of levetiracetam in healthy adult horses.
Journal of veterinary pharmacology and therapeutics.
2018 Feb; 41(1):92-97. doi:
10.1111/jvp.12417
. [PMID: 28503770] - Azucena Aldaz, Natalia Alzueta, César Viteri. Influence of Comedication on Levetiracetam Pharmacokinetics.
Therapeutic drug monitoring.
2018 02; 40(1):130-134. doi:
10.1097/ftd.0000000000000470
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Journal of veterinary internal medicine.
2018 Jan; 32(1):348-351. doi:
10.1111/jvim.14863
. [PMID: 29114943] - Camilla Linder, Anna Hansson, Sara Sadek, Lars L Gustafsson, Anton Pohanka. Carbamazepine, lamotrigine, levetiracetam and valproic acid in dried blood spots with liquid chromatography tandem mass spectrometry; method development and validation.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2018 Jan; 1072(?):116-122. doi:
10.1016/j.jchromb.2017.11.005
. [PMID: 29149735] - Bing Chun Yan, Hui Shen, Yuanyuan Zhang, Xiaolu Zhu, Jie Wang, Pei Xu, Dan Jiang, Xing Yu. The antiepileptic drug levetiracetam promotes neuroblast differentiation and expression of superoxide dismutase in the mouse hippocampal dentate gyrus via PI3K/Akt signalling.
Neuroscience letters.
2018 Jan; 662(?):84-90. doi:
10.1016/j.neulet.2017.10.010
. [PMID: 29024726] - M J Company-Albir, J Ruíz-Ramos, A Solana Altabella, M R Marqués-Miñana, C Vicent, J L Poveda. Haemodialysis significantly reduces serum levetiracetam levels inducing epileptic seizures: Case report.
Journal of clinical pharmacy and therapeutics.
2017 Dec; 42(6):774-775. doi:
10.1111/jcpt.12568
. [PMID: 28555936] - Martina Fanella, Alessandra Morano, Jinane Fattouch, Mariarita Albini, Luca M Basili, Sara Casciato, Mario Manfredi, Anna T Giallonardo, Carlo Di Bonaventura. Switch From Originator to Equivalent Drug in the Era of Generic Antiepileptic Drugs: Study of Keppra Versus Epitiram Clinical Equivalence.
Clinical neuropharmacology.
2017 Nov; 40(6):239-242. doi:
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. [PMID: 28976412] - Jason Tan, Vanessa Paquette, Marc Levine, Mary H H Ensom. Levetiracetam Clinical Pharmacokinetic Monitoring in Pediatric Patients with Epilepsy.
Clinical pharmacokinetics.
2017 11; 56(11):1267-1285. doi:
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Cellular and molecular neurobiology.
2017 Nov; 37(8):1373-1386. doi:
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Current drug metabolism.
2017 Oct; 18(8):727-734. doi:
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The Annals of pharmacotherapy.
2017 Oct; 51(10):862-865. doi:
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Epilepsia.
2017 10; 58(10):1762-1770. doi:
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Biomedical chromatography : BMC.
2017 Oct; 31(10):. doi:
10.1002/bmc.3969
. [PMID: 28294369] - Olivier Gnankiné, Imaël Henri Nestor Bassolé. Essential Oils as an Alternative to Pyrethroids' Resistance against Anopheles Species Complex Giles (Diptera: Culicidae).
Molecules (Basel, Switzerland).
2017 Sep; 22(10):. doi:
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Pharmacology, biochemistry, and behavior.
2017 09; 160(?):21-29. doi:
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Epilepsy research.
2017 08; 134(?):54-61. doi:
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Cellular and molecular neurobiology.
2017 Jul; 37(5):791-802. doi:
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Experimental biology and medicine (Maywood, N.J.).
2017 07; 242(13):1335-1344. doi:
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BMJ case reports.
2017 Jun; 2017(?):. doi:
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Therapeutic drug monitoring.
2017 06; 39(3):263-268. doi:
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Journal of biochemical and molecular toxicology.
2017 Jun; 31(6):. doi:
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Journal of ethnopharmacology.
2017 May; 203(?):252-259. doi:
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. [PMID: 28363525] - Sofia Markoula, Dimitrios Chatzistefanidis, Stylianos Gatzonis, Anna Siatouni, Eleftheria Siarava, Anastasia Verentzioti, Athanassios P Kyritsis, Philip N Patsalos. Brand-to-generic levetiracetam switch in patients with epilepsy in a routine clinical setting.
Seizure.
2017 May; 48(?):1-6. doi:
10.1016/j.seizure.2017.03.012
. [PMID: 28363098] - Edward T Van Matre, Scott W Mueller, Douglas N Fish, Robert MacLaren, Luis F Cava, Robert T Neumann, Tyree H Kiser. Levetiracetam Pharmacokinetics in a Patient with Intracranial Hemorrhage Undergoing Continuous Veno-Venous Hemofiltration.
The American journal of case reports.
2017 Apr; 18(?):458-462. doi:
10.12659/ajcr.902709
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Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy.
2017 Apr; 177(?):41-48. doi:
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Epilepsia.
2017 03; 58(3):484-493. doi:
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The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians.
2017 Feb; 30(4):420-423. doi:
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PloS one.
2017; 12(4):e0175990. doi:
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PloS one.
2017; 12(8):e0183873. doi:
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European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.
2017 Jan; 96(?):449-455. doi:
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Chemico-biological interactions.
2016 Dec; 260(?):208-218. doi:
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Journal of critical care.
2016 12; 36(?):116-124. doi:
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Environmental toxicology.
2016 Dec; 31(12):1955-1963. doi:
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Pediatric neurology.
2016 11; 64(?):e5-e6. doi:
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Bioanalysis.
2016 Nov; 8(21):2219-2234. doi:
10.4155/bio-2016-0211
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The Journal of neuroscience nursing : journal of the American Association of Neuroscience Nurses.
2016 Oct; 48(5):270-3. doi:
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Analytica chimica acta.
2016 Sep; 938(?):82-9. doi:
10.1016/j.aca.2016.08.016
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Brain & development.
2016 Sep; 38(8):723-30. doi:
10.1016/j.braindev.2016.03.004
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Clinical neuropharmacology.
2016 Sep; 39(5):265-8. doi:
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Epilepsy & behavior : E&B.
2016 09; 62(?):1-5. doi:
10.1016/j.yebeh.2016.05.023
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Seizure.
2016 Aug; 40(?):7-9. doi:
10.1016/j.seizure.2016.05.011
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Journal of fluorescence.
2016 Jul; 26(4):1225-38. doi:
10.1007/s10895-016-1810-7
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Therapeutic drug monitoring.
2016 06; 38(3):371-8. doi:
10.1097/ftd.0000000000000291
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Drugs in R&D.
2016 Jun; 16(2):229-38. doi:
10.1007/s40268-016-0132-1
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Nuclear medicine and biology.
2016 06; 43(6):325-32. doi:
10.1016/j.nucmedbio.2016.03.004
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Phytomedicine : international journal of phytotherapy and phytopharmacology.
2016 May; 23(5):460-7. doi:
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CNS drugs.
2016 05; 30(5):455-60. doi:
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Epilepsy research.
2016 May; 122(?):79-83. doi:
10.1016/j.eplepsyres.2016.02.012
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Epilepsy & behavior : E&B.
2016 05; 58(?):127-32. doi:
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Diabetes research and clinical practice.
2016 Apr; 114(?):106-16. doi:
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Biomedical chromatography : BMC.
2016 Apr; 30(4):536-42. doi:
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The Indian journal of medical research.
2016 Mar; 143(3):323-30. doi:
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. [PMID: 27241646] - Oytun Erbaş, Mustafa Yılmaz, Dilek Taşkıran. Levetiracetam attenuates rotenone-induced toxicity: A rat model of Parkinson's disease.
Environmental toxicology and pharmacology.
2016 Mar; 42(?):226-30. doi:
10.1016/j.etap.2016.02.005
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Epilepsia.
2016 Feb; 57(2):201-9. doi:
10.1111/epi.13267
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Methods in molecular biology (Clifton, N.J.).
2016; 1383(?):29-37. doi:
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Turkish neurosurgery.
2016; 26(5):732-5. doi:
10.5137/1019-5149.jtn.8245-13.1
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Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova.
2016; 116(4):28-31. doi:
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European journal of drug metabolism and pharmacokinetics.
2015 Dec; 40(4):461-9. doi:
10.1007/s13318-014-0227-4
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Cell biochemistry and biophysics.
2015 Nov; 73(2):489-494. doi:
10.1007/s12013-015-0683-8
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Pharmacotherapy.
2015 Nov; 35(11):1063-75. doi:
10.1002/phar.1653
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Epilepsy & behavior : E&B.
2015 Oct; 51(?):221-4. doi:
10.1016/j.yebeh.2015.06.025
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Neuroscience.
2015 Sep; 303(?):595-603. doi:
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Journal of veterinary internal medicine.
2015 Sep; 29(5):1348-53. doi:
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American journal of veterinary research.
2015 Aug; 76(8):719-23. doi:
10.2460/ajvr.76.8.719
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Clinical drug investigation.
2015 Aug; 35(8):495-503. doi:
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Clinical toxicology (Philadelphia, Pa.).
2015 Jul; 53(6):565-8. doi:
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