N-Propylnorapomorphine (BioDeep_00000271173)
代谢物信息卡片
N-Propylnorapomorphine
化学式: C19H21NO2 (295.1572206)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CCCN1CCC2=C3C1CC4=C(C3=CC=C2)C(=C(C=C4)O)O
InChI: InChI=1S/C19H21NO2/c1-2-9-20-10-8-12-4-3-5-14-17(12)15(20)11-13-6-7-16(21)19(22)18(13)14/h3-7,15,21-22H,2,8-11H2,1H3/t15-/m1/s1
描述信息
D002491 - Central Nervous System Agents > D018726 - Anti-Dyskinesia Agents > D000978 - Antiparkinson Agents
D018377 - Neurotransmitter Agents > D015259 - Dopamine Agents > D018491 - Dopamine Agonists
同义名列表
1 个代谢物同义名
数据库引用编号
6 个数据库交叉引用编号
- ChEBI: CHEBI:92234
- PubChem: 167715
- ChEMBL: CHEMBL538542
- ChEMBL: CHEMBL225230
- CAS: 18426-20-5
- PMhub: MS000001755
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Fumitoshi Kodaka, Hiroshi Ito, Harumasa Takano, Hidehiko Takahashi, Ryosuke Arakawa, Michie Miyoshi, Masaki Okumura, Tatsui Otsuka, Kazuhiko Nakayama, Christer Halldin, Lars Farde, Tetsuya Suhara. Effect of risperidone on high-affinity state of dopamine D2 receptors: a PET study with agonist ligand [11C](R)-2-CH3O-N-n-propylnorapomorphine.
The international journal of neuropsychopharmacology.
2011 Feb; 14(1):83-9. doi:
10.1017/s1461145710001148. [PMID: 20860881] - Rajesh Narendran, N Scott Mason, Charles M Laymon, Brian J Lopresti, Natalie D Velasquez, Maureen A May, Steve Kendro, Diana Martinez, Chester A Mathis, W Gordon Frankle. A comparative evaluation of the dopamine D(2/3) agonist radiotracer [11C](-)-N-propyl-norapomorphine and antagonist [11C]raclopride to measure amphetamine-induced dopamine release in the human striatum.
The Journal of pharmacology and experimental therapeutics.
2010 May; 333(2):533-9. doi:
10.1124/jpet.109.163501. [PMID: 20103586] - Ju-Heon Kim, Eun-Young Cho, Chengchun Min, Jae H Park, Kyeong-Man Kim. Characterization of functional roles of DRY motif in the 2nd intracellular loop of dopamine D2 and D3 receptors.
Archives of pharmacal research.
2008 Apr; 31(4):474-81. doi:
10.1007/s12272-001-1181-x. [PMID: 18449505] - Dah-Ren Hwang, Rajesh Narendran, Yiyun Huang, Mark Slifstein, Peter S Talbot, Yasuhiko Sudo, Bart N Van Berckel, Lawrence S Kegeles, Diana Martinez, Marc Laruelle. Quantitative analysis of (-)-N-(11)C-propyl-norapomorphine in vivo binding in nonhuman primates.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine.
2004 Feb; 45(2):338-46. doi:
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Neuroscience letters.
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Molecular pharmacology.
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The Journal of pharmacology and experimental therapeutics.
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10.1007/bf00165296. [PMID: 1360151] - A W Essink, C P Lohuis, J T Klein Elhorst, W J Rutten. Selective and quantitative isolation and determination of apomorphine in human plasma.
Journal of chromatography.
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Proceedings of the National Academy of Sciences of the United States of America.
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1990 Oct; 531(1-2):253-62. doi:
10.1016/0006-8993(90)90781-6. [PMID: 1981163] - T M Trainor, P Vouros, P Lampen, J L Neumeyer, R J Baldessarini, N S Kula. Determination of N-n-propylnorapomorphine in serum and brain tissue by gas chromatography-negative ion chemical ionization mass spectrometry.
Journal of chromatography.
1988 Dec; 457(?):257-66. doi:
10.1016/s0021-9673(01)82073-2. [PMID: 3243885] - P Lampen, J L Neumeyer, R J Baldessarini. High-performance liquid chromatographic separation and electrochemical or spectrophotometric determination of R(-)N-n-propylnorapomorphine and R(-)10,11-methylenedioxy-N-n-propylnoraporphine in primate plasma.
Journal of chromatography.
1988 Apr; 426(2):283-94. doi:
10.1016/s0378-4347(00)81956-8. [PMID: 3392141] - R W Fuller, H D Snoddy, S K Hemrick-Luecke. Increase in serum corticosterone concentration and decrease in hypothalamic epinephrine concentration by N-propylnorapomorphine in rats.
Biochemical pharmacology.
1984 Apr; 33(8):1372-4. doi:
10.1016/0006-2952(84)90196-5. [PMID: 6712742] - M Mikuni, G A Gudelsky, M Simonovic, H Y Meltzer. Interaction of (+)- and (-)-3-PPP with the dopamine receptor in the anterior pituitary gland.
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10.1016/0024-3205(84)90595-2. [PMID: 6694521] - H M Maksoud, S H Kuttab, J L Neumeyer, P Vouros. Analysis of N-n-propylnorapomorphine in plasma and tissue by capillary gas chromatography--electron-capture detection.
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1983 May; 274(?):149-59. doi:
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10.1056/nejm197603112941101. [PMID: 1107835] - H J Crumly, R M Pinder, W B Hinshaw, L I Goldberg. Dopamine-like renal and mesenteric vasodilation caused by apomorphine 6-propylnorapomorphine and 2-amino-6, 7-dihydroxy-1,2,3,4-tetrahydronaphthalene.
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