Methoxetamine (BioDeep_00000271169)
Main id: BioDeep_00000180805
natural product
代谢物信息卡片
Methoxetamine
化学式: C15H21NO2 (247.15722060000002)
中文名称: 2-(乙氨基)-2-(3-甲氧基苯基)环己酮
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CCNC1(c2cccc(OC)c2)CCCCC1=O
InChI: InChI=1S/C15H21NO2/c1-3-16-15(10-5-4-9-14(15)17)12-7-6-8-13(11-12)18-2/h6-8,11,16H,3-5,9-10H2,1-2H3
描述信息
D002491 - Central Nervous System Agents > D002492 - Central Nervous System Depressants > D000777 - Anesthetics
同义名列表
1 个代谢物同义名
数据库引用编号
5 个数据库交叉引用编号
- PubChem: 52911279
- CAS: 1239943-76-0
- MoNA: CCMSLIB00004679321
- PMhub: MS000001727
- KEGG: C22711
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Isabel Gomila, Maria Ángeles Leciñena, Miguel Ángel Elorza, Yolanda Pastor, Laura Sahuquillo, Miguel Servera, Jordi Puiguriguer, Bernardino Barcelo. Detectability of Dissociative Psychoactive Substances in Urine by Five Commercial Phencyclidine Immunoassays.
Journal of analytical toxicology.
2019 Jul; 43(6):497-503. doi:
10.1093/jat/bkz026. [PMID: 31329888] - Anne Zwartsen, Carlijn H C Litjens, Laura Hondebrink, Jeroen J M W van den Heuvel, Rick Greupink, Frans G M Russel, Dylan W de Lange, Juliette Legler, Jan B Koenderink, Remco H S Westerink. Differential effects of psychoactive substances on human wildtype and polymorphic T356M dopamine transporters (DAT).
Toxicology.
2019 06; 422(?):69-75. doi:
10.1016/j.tox.2019.04.012. [PMID: 31009648] - Giulia Costa, Marcello Serra, Nicholas Pintori, Maria Antonietta Casu, Mary Tresa Zanda, Daniela Murtas, Maria Antonietta De Luca, Nicola Simola, Liana Fattore. The novel psychoactive substance methoxetamine induces persistent behavioral abnormalities and neurotoxicity in rats.
Neuropharmacology.
2019 01; 144(?):219-232. doi:
10.1016/j.neuropharm.2018.10.031. [PMID: 30366005] - Anne Zwartsen, Anouk H A Verboven, Regina G D M van Kleef, Fiona M J Wijnolts, Remco H S Westerink, Laura Hondebrink. Measuring inhibition of monoamine reuptake transporters by new psychoactive substances (NPS) in real-time using a high-throughput, fluorescence-based assay.
Toxicology in vitro : an international journal published in association with BIBRA.
2017 Dec; 45(Pt 1):60-71. doi:
10.1016/j.tiv.2017.05.010. [PMID: 28506818] - Stephen Thornton, David Lisbon, Thomas Lin, Roy Gerona. Beyond Ketamine and Phencyclidine: Analytically Confirmed Use of Multiple Novel Arylcyclohexylamines.
Journal of psychoactive drugs.
2017 Sep; 49(4):289-293. doi:
10.1080/02791072.2017.1333660. [PMID: 28590798] - Laura Hondebrink, Emma E J Kasteel, Anke M Tukker, Fiona M J Wijnolts, Anouk H A Verboven, Remco H S Westerink. Neuropharmacological characterization of the new psychoactive substance methoxetamine.
Neuropharmacology.
2017 Sep; 123(?):1-9. doi:
10.1016/j.neuropharm.2017.04.035. [PMID: 28454981] - Alberto Salomone, Joseph J Palamar, Enrico Gerace, Daniele Di Corcia, Marco Vincenti. Hair Testing for Drugs of Abuse and New Psychoactive Substances in a High-Risk Population.
Journal of analytical toxicology.
2017 Jun; 41(5):376-381. doi:
10.1093/jat/bkx020. [PMID: 28334805] - Rachel R Horsley, Eva Lhotkova, Katerina Hajkova, Bronislav Jurasek, Martin Kuchar, Tomas Palenicek. Detailed pharmacological evaluation of methoxetamine (MXE), a novel psychoactive ketamine analogue-Behavioural, pharmacokinetic and metabolic studies in the Wistar rat.
Brain research bulletin.
2016 09; 126(Pt 1):102-110. doi:
10.1016/j.brainresbull.2016.05.002. [PMID: 27155360] - Akiko Akashi, Masahiro Kashiura, Manabu Mikami, Yuichi Hamabe. [The current situation of aggravated intoxication with 'kiken' drugs (law-evading drugs)].
Chudoku kenkyu : Chudoku Kenkyukai jun kikanshi = The Japanese journal of toxicology.
2016 Mar; 29(1):21-5. doi:
NULL. [PMID: 27255020] - Piotr Adamowicz, Dariusz Zuba. Fatal intoxication with methoxetamine.
Journal of forensic sciences.
2015 Jan; 60 Suppl 1(?):S264-8. doi:
10.1111/1556-4029.12594. [PMID: 25413263] - Cassandra L Craig, George H Loeffler. The ketamine analog methoxetamine: a new designer drug to threaten military readiness.
Military medicine.
2014 Oct; 179(10):1149-57. doi:
10.7205/milmed-d-13-00470. [PMID: 25269134] - Laurent Imbert, Alexandra Boucher, Gilles Delhome, Thierry Cueto, Michel Boudinaud, Julie Maublanc, Sylvain Dulaurent, Jacques Descotes, Gérard Lachâtre, Jean-Michel Gaulier. Analytical findings of an acute intoxication after inhalation of methoxetamine.
Journal of analytical toxicology.
2014 Sep; 38(7):410-5. doi:
10.1093/jat/bku052. [PMID: 24904014] - Marek Wiergowski, Jacek Sein Anand, Maciej Krzyżanowski, Zbigniew Jankowski. Acute methoxetamine and amphetamine poisoning with fatal outcome: a case report.
International journal of occupational medicine and environmental health.
2014 Aug; 27(4):683-90. doi:
10.2478/s13382-014-0290-8. [PMID: 25060403] - E L Menzies, S C Hudson, P I Dargan, M C Parkin, D M Wood, A T Kicman. Characterizing metabolites and potential metabolic pathways for the novel psychoactive substance methoxetamine.
Drug testing and analysis.
2014 Jun; 6(6):506-15. doi:
10.1002/dta.1541. [PMID: 24574323] - P I Dargan, H C Tang, W Liang, D M Wood, D T Yew. Three months of methoxetamine administration is associated with significant bladder and renal toxicity in mice.
Clinical toxicology (Philadelphia, Pa.).
2014 Mar; 52(3):176-80. doi:
10.3109/15563650.2014.892605. [PMID: 24580056] - J R H Archer, P I Dargan, H M D Lee, S Hudson, D M Wood. Trend analysis of anonymised pooled urine from portable street urinals in central London identifies variation in the use of novel psychoactive substances.
Clinical toxicology (Philadelphia, Pa.).
2014 Mar; 52(3):160-5. doi:
10.3109/15563650.2014.885982. [PMID: 24506433] - Markus R Meyer, Martina Bach, Jessica Welter, Michael Bovens, Alain Turcant, Hans H Maurer. Ketamine-derived designer drug methoxetamine: metabolism including isoenzyme kinetics and toxicological detectability using GC-MS and LC-(HR-)MSn.
Analytical and bioanalytical chemistry.
2013 Jul; 405(19):6307-21. doi:
10.1007/s00216-013-7051-6. [PMID: 23774830] - Giorgia De Paoli, Simon D Brandt, Jason Wallach, Roland P Archer, Derrick J Pounder. From the street to the laboratory: analytical profiles of methoxetamine, 3-methoxyeticyclidine and 3-methoxyphencyclidine and their determination in three biological matrices.
Journal of analytical toxicology.
2013 Jun; 37(5):277-83. doi:
10.1093/jat/bkt023. [PMID: 23552616] - Bryan L Roth, Simon Gibbons, Warunya Arunotayanun, Xi-Ping Huang, Vincent Setola, Ric Treble, Les Iversen. The ketamine analogue methoxetamine and 3- and 4-methoxy analogues of phencyclidine are high affinity and selective ligands for the glutamate NMDA receptor.
PloS one.
2013; 8(3):e59334. doi:
10.1371/journal.pone.0059334. [PMID: 23527166] - Emuri Abe, Florian Ricard, François Darrouzain, Jean Claude Alvarez. An automated method for measurement of methoxetamine in human plasma by use of turbulent flow on-line extraction coupled with liquid chromatography and mass spectrometric detection.
Analytical and bioanalytical chemistry.
2013 Jan; 405(1):239-45. doi:
10.1007/s00216-012-6470-0. [PMID: 23079952] - Magdalena Łukasik-Głebocka, Karina Sommerfeld, Artur Tezyk, Barbara Zielińska-Psuja, Artur Druzdz. [Acute methoxetamine intoxication--a case report with serum and urine concentrations].
Przeglad lekarski.
2013; 70(8):671-3. doi:
NULL. [PMID: 24466717] - Jennifer E Shields, Paul I Dargan, David M Wood, Malgorzata Puchnarewicz, Susannah Davies, W Stephen Waring. Methoxetamine associated reversible cerebellar toxicity: three cases with analytical confirmation.
Clinical toxicology (Philadelphia, Pa.).
2012 Jun; 50(5):438-40. doi:
10.3109/15563650.2012.683437. [PMID: 22578175] - David M Wood, Susannah Davies, Malgorzata Puchnarewicz, Atholl Johnston, Paul I Dargan. Acute toxicity associated with the recreational use of the ketamine derivative methoxetamine.
European journal of clinical pharmacology.
2012 May; 68(5):853-6. doi:
10.1007/s00228-011-1199-9. [PMID: 22205276] - Christopher D Rosenbaum, Stephanie P Carreiro, Kavita M Babu. Here today, gone tomorrow…and back again? A review of herbal marijuana alternatives (K2, Spice), synthetic cathinones (bath salts), kratom, Salvia divinorum, methoxetamine, and piperazines.
Journal of medical toxicology : official journal of the American College of Medical Toxicology.
2012 Mar; 8(1):15-32. doi:
10.1007/s13181-011-0202-2. [PMID: 22271566] - Simon Gibbons. 'Legal highs'--novel and emerging psychoactive drugs: a chemical overview for the toxicologist.
Clinical toxicology (Philadelphia, Pa.).
2012 Jan; 50(1):15-24. doi:
10.3109/15563650.2011.645952. [PMID: 22248120]