Romifidine (BioDeep_00000271163)
代谢物信息卡片
Romifidine
化学式: C9H9BrFN3 (256.9964)
中文名称: 罗米非定
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1CN=C(N1)NC2=C(C=CC=C2Br)F
InChI: InChI=1S/C9H9BrFN3/c10-6-2-1-3-7(11)8(6)14-9-12-4-5-13-9/h1-3H,4-5H2,(H2,12,13,14)
描述信息
D002491 - Central Nervous System Agents > D002492 - Central Nervous System Depressants > D000777 - Anesthetics
D018377 - Neurotransmitter Agents > D018663 - Adrenergic Agents > D000322 - Adrenergic Agonists
C78272 - Agent Affecting Nervous System > C47794 - Serotonin Agonist
Romifidine is an α2 adrenergic receptor agonist. Romifidine shows sedation effects in vivo[1][2].
同义名列表
1 个代谢物同义名
数据库引用编号
7 个数据库交叉引用编号
- KEGGdrug: D08487
- PubChem: 71969
- DrugBank: DB11543
- ChEMBL: CHEMBL2105424
- CAS: 65896-16-4
- PMhub: MS000001701
- medchemexpress: HY-119456
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
| 亚细胞结构定位 | 关联基因列表 |
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文献列表
- Nicole Studer, Sabina Diez Bernal, Wolfgang Thormann, Olivier Levionnois, Claudia Spadavecchia. Antinociceptive effects of levomethadone in standing horses sedated with romifidine.
Veterinary anaesthesia and analgesia.
2021 May; 48(3):451-460. doi:
10.1016/j.vaa.2020.08.011. [PMID: 33685821] - Sabina Diez Bernal, Nicole Studer, Wolfgang Thormann, Claudia Spadavecchia, Olivier Levionnois. Pharmacokinetic-pharmacodynamic modelling of the antinociceptive effect of a romifidine infusion in standing horses.
Veterinary anaesthesia and analgesia.
2020 Jan; 47(1):129-136. doi:
10.1016/j.vaa.2019.06.010. [PMID: 31810766] - Soile Anja Eliisa Pakkanen, Annemarie de Vries, Marja Riitta Raekallio, Anna Kristina Mykkänen, Mari Johanna Palviainen, Satu Marja Sankari, Outi Maritta Vainio. Changes in energy metabolism, and levels of stress-related hormones and electrolytes in horses after intravenous administration of romifidine and the peripheral α-2 adrenoceptor antagonist vatinoxan.
Acta veterinaria Scandinavica.
2018 May; 60(1):27. doi:
10.1186/s13028-018-0380-x. [PMID: 29743097] - H K Knych, S D Stanley, D S McKemie, S J Steinmetz. Pharmacokinetics and selected pharmacodynamics of romifidine following low-dose intravenous administration in combination with exercise to quarter horses.
Journal of veterinary pharmacology and therapeutics.
2017 Oct; 40(5):569-574. doi:
10.1111/jvp.12395. [PMID: 28097665] - M C Niimura Del Barrio, Rachel C Bennett, J M Lynne Hughes. Effect of detomidine or romifidine constant rate infusion on plasma lactate concentration and inhalant requirements during isoflurane anaesthesia in horses.
Veterinary anaesthesia and analgesia.
2017 May; 44(3):473-482. doi:
10.1016/j.vaa.2016.01.002. [PMID: 28462846] - Alessia Cenani, Robert J Brosnan, Shara Madigan, Heather K Knych, John E Madigan. Pharmacokinetics and pharmacodynamics of intravenous romifidine and propranolol administered alone or in combination for equine sedation.
Veterinary anaesthesia and analgesia.
2017 Jan; 44(1):86-97. doi:
10.1111/vaa.12410. [PMID: 27426730] - Annemarie de Vries, Soile Ae Pakkanen, Marja R Raekallio, Abel Ekiri, Mika Scheinin, Polly M Taylor, Outi M Vainio. Clinical effects and pharmacokinetic variables of romifidine and the peripheral α2 -adrenoceptor antagonist MK-467 in horses.
Veterinary anaesthesia and analgesia.
2016 Nov; 43(6):599-610. doi:
10.1111/vaa.12354. [PMID: 26918855] - Annie Kullmann, Macarena Sanz, Geoffrey T Fosgate, Montague N Saulez, Patrick C Page, Eva Rioja. Effects of xylazine, romifidine, or detomidine on hematology, biochemistry, and splenic thickness in healthy horses.
The Canadian veterinary journal = La revue veterinaire canadienne.
2014 Apr; 55(4):334-40. doi:
NULL. [PMID: 24688132] - M Wojtasiak-Wypart, L R Soma, J A Rudy, C E Uboh, R C Boston, B Driessen. Pharmacokinetic profile and pharmacodynamic effects of romifidine hydrochloride in the horse.
Journal of veterinary pharmacology and therapeutics.
2012 Oct; 35(5):478-88. doi:
10.1111/j.1365-2885.2011.01347.x. [PMID: 22233529] - Simone K Ringer, Karine G Portier, Isabelle Fourel, Regula Bettschart-Wolfensberger. Development of a romifidine constant rate infusion with or without butorphanol for standing sedation of horses.
Veterinary anaesthesia and analgesia.
2012 Jan; 39(1):12-20. doi:
10.1111/j.1467-2995.2011.00681.x. [PMID: 22151873] - Mohamed Marzok, Sabry El-Khodery. Sedative and analgesic effects of romifidine in camels (Camelus dromedarius).
Veterinary anaesthesia and analgesia.
2009 Jul; 36(4):352-60. doi:
10.1111/j.1467-2995.2009.00473.x. [PMID: 19538572] - Gonzalo Marañón, William Manley, Patricia Cayado, Cruz García, Mercedes Sánchez de la Muela, Elena Vara. Alterations in the glutathione metabolism could be implicated in the ischemia-induced small intestinal cell damage in horses.
BMC veterinary research.
2009 Mar; 5(?):10. doi:
10.1186/1746-6148-5-10. [PMID: 19296836] - Lorenzo Novello, Federico Corletto, Roberto Rabozzi, Simon R Platt. Sparing effect of a low dose of intrathecal morphine on fentanyl requirements during spinal surgery: a preliminary clinical investigation in dogs.
Veterinary surgery : VS.
2008 Feb; 37(2):153-60. doi:
10.1111/j.1532-950x.2007.00358.x. [PMID: 18251809] - Anna H Edner, Görel C Nyman, Birgitta Essén-Gustavsson. Metabolism before, during and after anaesthesia in colic and healthy horses.
Acta veterinaria Scandinavica.
2007 Nov; 49(?):34. doi:
10.1186/1751-0147-49-34. [PMID: 18001483] - Regula Theurillat, Monika Knobloch, Olivier Levionnois, Paula Larenza, Meike Mevissen, Wolfgang Thormann. Characterization of the stereoselective biotransformation of ketamine to norketamine via determination of their enantiomers in equine plasma by capillary electrophoresis.
Electrophoresis.
2005 Oct; 26(20):3942-51. doi:
10.1002/elps.200500059. [PMID: 16167314] - Amarpal, P Kinjavdekar, H P Aithal, A M Pawde, K Pratap. Analgesic, sedative and haemodynamic effects of spinally administered romifidine in female goats.
Journal of veterinary medicine. A, Physiology, pathology, clinical medicine.
2002 Feb; 49(1):3-8. doi:
10.1046/j.1439-0442.2002.00385.x. [PMID: 11913823] - H P Aithal, Amarpal, P Kinjavdekar, A M Pawde, K Pratap. Analgesic and cardiopulmonary effects of intrathecally administered romifidine or romifidine and ketamine in goats (Capra hircus).
Journal of the South African Veterinary Association.
2001 Jun; 72(2):84-91. doi:
10.4102/jsava.v72i2.623. [PMID: 11513266] - C L Kerr, W N McDonell, S S Young. A comparison of romifidine and xylazine when used with diazepam/ketamine for short duration anesthesia in the horse.
The Canadian veterinary journal = La revue veterinaire canadienne.
1996 Oct; 37(10):601-9. doi:
NULL. [PMID: 8896874]
