ronidazole (BioDeep_00000271162)

代谢物信息卡片

ronidazole

化学式: C6H8N4O4 (200.05455279999998)
中文名称: 罗硝唑
谱图信息: 最多检出来源 Viridiplantae(plant) 66.67%

分子结构信息

SMILES: CN1C(=CN=C1COC(=O)N)[N+](=O)[O-]
InChI: InChI=1S/C6H8N4O4/c1-9-4(3-14-6(7)11)8-2-5(9)10(12)13/h2H,3H2,1H3,(H2,7,11)

描述信息

D000890 - Anti-Infective Agents > D000977 - Antiparasitic Agents > D000981 - Antiprotozoal Agents
C254 - Anti-Infective Agent > C276 - Antiparasitic Agent > C277 - Antiprotozoal Agent
ORIGINAL_ACQUISITION_NO 7869; CONFIDENCE standard compound; INTERNAL_ID 892; DATASET 20200303_ENTACT_RP_MIX506; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_PRECURSOR_SCAN_NO 7868
CONFIDENCE standard compound; INTERNAL_ID 892; DATASET 20200303_ENTACT_RP_MIX506; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 7869; ORIGINAL_PRECURSOR_SCAN_NO 7868
CONFIDENCE standard compound; INTERNAL_ID 892; DATASET 20200303_ENTACT_RP_MIX508; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 4231; ORIGINAL_PRECURSOR_SCAN_NO 4227
CONFIDENCE standard compound; INTERNAL_ID 892; DATASET 20200303_ENTACT_RP_MIX506; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 4244; ORIGINAL_PRECURSOR_SCAN_NO 4242
CONFIDENCE standard compound; INTERNAL_ID 892; DATASET 20200303_ENTACT_RP_MIX508; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 4251; ORIGINAL_PRECURSOR_SCAN_NO 4249
CONFIDENCE standard compound; INTERNAL_ID 892; DATASET 20200303_ENTACT_RP_MIX508; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 4259; ORIGINAL_PRECURSOR_SCAN_NO 4256
CONFIDENCE standard compound; INTERNAL_ID 892; DATASET 20200303_ENTACT_RP_MIX508; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 4251; ORIGINAL_PRECURSOR_SCAN_NO 4248
CONFIDENCE standard compound; EAWAG_UCHEM_ID 3695
CONFIDENCE standard compound; INTERNAL_ID 1071

同义名列表

1 个代谢物同义名

ronidazole

数据库引用编号

25 个数据库交叉引用编号

ChEBI: CHEBI:141154
ChEBI: CHEBI:94804
KEGGdrug: D05752
PubChem: 5094
Metlin: METLIN43485
ChEMBL: CHEMBL290299
MeSH: Ronidazole
CAS: 7681-76-7
MoNA: LU089206
MoNA: LU089205
MoNA: LU089204
MoNA: LU089203
MoNA: LU089202
MoNA: LU089201
MoNA: EQ369509
MoNA: EQ369508
MoNA: EQ369507
MoNA: EQ369506
MoNA: EQ369505
MoNA: EQ369504
MoNA: EQ369503
MoNA: EQ369502
MoNA: EQ369501
MoNA: AU107101
PMhub: MS000001699

分类词条

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

文献列表

Junjun Feng, Haiyun Jiang, Jing Wang, Zhengyi Jing, Fan Zhang, Tianyu Tan, Feng He, Lihua Jiang, Haiqin Li, Shimin Chang, Tengfei Li. [Simultaneous determination of 40 plant growth regulators, fungicides, insecticides, and antibiotics in bean sprouts by QuEChERS-high performance liquid chromatography-tandem mass spectrometry]. Se pu = Chinese journal of chromatography. 2022 Sep; 40(9):843-853. doi: 10.3724/sp.j.1123.2021.12028. [PMID: 36156631]
Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
Barry A Hedgespeth, Stephen H Stauffer, James B Robertson, Jody L Gookin. Association of fecal sample collection technique and treatment history with Tritrichomonas foetus polymerase chain reaction test results in 1717 cats. Journal of veterinary internal medicine. 2020 Mar; 34(2):734-741. doi: 10.1111/jvim.15727. [PMID: 32039505]
Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology. 2019 11; 96(5):629-640. doi: 10.1124/mol.119.115964. [PMID: 31515284]
Tomasz Tuzimski, Tomasz Rejczak. A QuEChERS-Based Sample Preparation Method for the Analysis of 5-Nitroimidazoles in Bovine Milk by HPLC-DAD. Journal of AOAC International. 2017 Nov; 100(6):1671-1680. doi: 10.5740/jaoacint.17-0213. [PMID: 28707620]
Aurélien Grellet, Seyf Eddine Makhlouf, Loic Desquilbet, Fani Hovhannessian, Cassandre Boogaerts, Vanessa Dore, Myriam Anthony, Bernadette Espana, Caroline Prouillac, Plamen Kirilov, Bruno Polack, Sébastien Perrot. Efficacy of guar gum-based ronidazole capsules as a treatment for Tritrichomonas foetus infection in cats. Journal of feline medicine and surgery. 2017 02; 19(2):177-184. doi: 10.1177/1098612x15621353. [PMID: 26662037]
Jörg M Steiner, Sabine Schwamberger, Nikola Pantchev, Hans-Jörg Balzer, Majda Globokar Vrhovec, Marina Lesina, Hana Algül. Use of Ronidazole and Limited Culling To Eliminate Tritrichomonas muris from Laboratory Mice. Journal of the American Association for Laboratory Animal Science : JAALAS. 2016; 55(4):480-3. doi: . [PMID: 27423157]
Panagiotis G Xenoulis, Danielle J Lopinski, Sarah A Read, Jan S Suchodolski, Jörg M Steiner. Intestinal Tritrichomonas foetus infection in cats: a retrospective study of 104 cases. Journal of feline medicine and surgery. 2013 Dec; 15(12):1098-103. doi: 10.1177/1098612x13495024. [PMID: 23838083]
M G Papich, D N Levine, J L Gookin, G S Davidson, W C Stagner, R B Hayes. Ronidazole pharmacokinetics in cats following delivery of a delayed-release guar gum formulation. Journal of veterinary pharmacology and therapeutics. 2013 Aug; 36(4):399-407. doi: 10.1111/jvp.12019. [PMID: 23106427]
Ruth Fiechter, Peter Deplazes, Manuela Schnyder. Control of Giardia infections with ronidazole and intensive hygiene management in a dog kennel. Veterinary parasitology. 2012 Jun; 187(1-2):93-8. doi: 10.1016/j.vetpar.2011.12.023. [PMID: 22240238]
Sun Lim, Sang-Ik Park, Kyu-Sung Ahn, Dae-Sung Oh, Sung-Shik Shin. Efficacy of ronidazole for treatment of cats experimentally infected with a Korean isolate of Tritrichomonas foetus. The Korean journal of parasitology. 2012 Jun; 50(2):161-4. doi: 10.3347/kjp.2012.50.2.161. [PMID: 22711930]
Adám Tölgyesi, Virender K Sharma, Szabolcs Fekete, Jenő Fekete, Andrea Simon, Szilvia Farkas. Development of a rapid method for the determination and confirmation of nitroimidazoles in six matrices by fast liquid chromatography-tandem mass spectrometry. Journal of pharmaceutical and biomedical analysis. 2012 May; 64-65(?):40-8. doi: 10.1016/j.jpba.2012.02.013. [PMID: 22417613]
Dana N LeVine, Mark G Papich, Jody L Gookin, Gigi S Davidson, Jennifer L Davis, Rebecca B Hayes. Ronidazole pharmacokinetics after intravenous and oral immediate-release capsule administration in healthy cats. Journal of feline medicine and surgery. 2011 Apr; 13(4):244-50. doi: 10.1016/j.jfms.2010.12.001. [PMID: 21239199]
Danielle Gunn-Moore, Stephanie Lalor. Treatment of diarrhoea in cats caused by Tritrichomonas foetus. The Veterinary record. 2011 Jan; 168(2):56-7. doi: 10.1136/vr.d189. [PMID: 21257565]
J L Gookin, S H Stauffer, D Dybas, D H Cannon. Documentation of in vivo and in vitro aerobic resistance of feline Tritrichomonas foetus isolates to ronidazole. Journal of veterinary internal medicine. 2010 Jul; 24(4):1003-7. doi: 10.1111/j.1939-1676.2010.0534.x. [PMID: 20492492]
Sara G Gray, Stuart A Hunter, Maria R Stone, Jody L Gookin. Assessment of reproductive tract disease in cats at risk for Tritrichomonas foetus infection. American journal of veterinary research. 2010 Jan; 71(1):76-81. doi: 10.2460/ajvr.71.1.76. [PMID: 20043785]
Malcolm Holliday, Dario Deni, Danièlle A Gunn-Moore. Tritrichomonas foetus infection in cats with diarrhoea in a rescue colony in Italy. Journal of feline medicine and surgery. 2009 Feb; 11(2):131-4. doi: 10.1016/j.jfms.2008.06.004. [PMID: 18774326]
Stéphanie Fraselle, Veerle Derop, Jean-Marie Degroodt, Joris Van Loco. Validation of a method for the detection and confirmation of nitroimidazoles and the corresponding hydroxy metabolites in pig plasma by high performance liquid chromatography-tandem mass spectrometry. Analytica chimica acta. 2007 Mar; 586(1-2):383-93. doi: 10.1016/j.aca.2007.01.009. [PMID: 17386738]
Tao Ding, Jinzhong Xu, Chongyu Shen, Yuan Jiang, Huilan Chen, Bin Wu, Zengyun Zhao, Gonghai Li, Jing Zhang, Fei Liu. [Determination of three nitroimidazole residues in royal jelly by high performance liquid chromatography-tandem mass spectrometry]. Se pu = Chinese journal of chromatography. 2006 Jul; 24(4):331-4. doi: ". [PMID: 17017153]
Jody L Gookin, Christina N Copple, Mark G Papich, Matthew F Poore, Stephen H Stauffer, Adam J Birkenheuer, David C Twedt, Michael G Levy. Efficacy of ronidazole for treatment of feline Tritrichomonas foetus infection. Journal of veterinary internal medicine. 2006 May; 20(3):536-43. doi: 10.1892/0891-6640(2006)20[536:eorfto]2.0.co;2. [PMID: 16734086]
M Vanrobaeys, P De Herdt, R Ducatelle, L A Devriese, G Charlier, F Haesebrouck. Typhlitis caused by intestinal Serpulina-like bacteria in domestic guinea pigs (Cavia porcellus). Journal of clinical microbiology. 1998 Mar; 36(3):690-4. doi: 10.1128/jcm.36.3.690-694.1998. [PMID: 9508297]
L J Filippich, P J O'Donoghue. Cochlosoma infections in finches. Australian veterinary journal. 1997 Aug; 75(8):561-3. doi: 10.1111/j.1751-0813.1997.tb14193.x. [PMID: 9293335]
F F Franssen, J T Lumeij, F van Knapen. Susceptibility of Encephalitozoon cuniculi to several drugs in vitro. Antimicrobial agents and chemotherapy. 1995 Jun; 39(6):1265-8. doi: 10.1128/aac.39.6.1265. [PMID: 7574513]
L J Vynckier, M Debackere. Plasma ronidazole concentrations in sheep after intravenous, oral, intraruminal and intraabomasal administration. Journal of veterinary pharmacology and therapeutics. 1993 Mar; 16(1):70-8. doi: 10.1111/j.1365-2885.1993.tb00291.x. [PMID: 8479003]
R M Aerts, I M Egberink, C A Kan, H J Keukens, W M Beek. Liquid chromatographic multicomponent method for determination of residues of ipronidazole, ronidazole, and dimetridazole and some relevant metabolites in eggs, plasma, and feces and its use in depletion studies in laying hens. Journal - Association of Official Analytical Chemists. 1991 Jan; 74(1):46-55. doi: NULL. [PMID: 2026576]
J Herman, H Vermeersch, J P Remon, P De Backer. Pharmacokinetics and bioavailability of ronidazole from a prolonged release tablet in the homing pigeon (Columba livia). Journal of veterinary pharmacology and therapeutics. 1989 Mar; 12(1):46-9. doi: 10.1111/j.1365-2885.1989.tb00640.x. [PMID: 2704060]
G L Biagi, G Cantelli-Forti, A M Barbaro, M C Guerra, P Hrelia, P A Borea. The influence of physicochemical parameters on the biliary excretion of a series of nitroimidazoles. Journal of medicinal chemistry. 1987 Feb; 30(2):420-3. doi: 10.1021/jm00385a027. [PMID: 3806622]
L D Olson. Probable elimination of swine dysentery after feeding ronidazole, carbadox or lincomycin and verification by feeding sodium arsanilate. Canadian journal of veterinary research = Revue canadienne de recherche veterinaire. 1986 Jul; 50(3):365-8. doi: NULL. [PMID: 3742373]
F J Wolf, R F Alvaro, K Fiorentini, M Green, A Y Lu, G T Miwa, P G Wislocki, R T Koch, M A McLafferty, P Goldman. Drug residue formation from ronidazole, a 5-nitro-imidazole. IV. The role of the microflora. Chemico-biological interactions. 1983 Jul; 45(1):7-14. doi: 10.1016/0009-2797(83)90038-8. [PMID: 6872101]
J Siwecki, K Kotowski. [Effect of ronidazole on the growth of weaned piglets and the levels of urea nitrogen in plasma and blood glucose]. Polskie archiwum weterynaryjne. 1983; 23(4):37-49. doi: NULL. [PMID: 6634458]
G T Miwa, S B West, J S Walsh, F J Wolf, A Y Lu. Drug residue formation from ronidazole, a 5-nitroimidazole. III. Studies on the mechanism of protein alkylation in vitro. Chemico-biological interactions. 1982 Sep; 41(3):297-312. doi: 10.1016/0009-2797(82)90107-7. [PMID: 6809347]
S B West, P G Wislocki, F J Wolf, A Y Lu. Drug residue formation from ronidazole, a 5-nitroimidazole. II. Involvement of microsomal NADPH-cytochrome P-450 reductase in protein alkylation in vitro. Chemico-biological interactions. 1982 Sep; 41(3):281-96. doi: 10.1016/0009-2797(82)90106-5. [PMID: 6809346]
I Herzig, M Dvorák, M Toulová, B Vojísek, A Hera, K Plísek, J Skaloud. [Stimulatory and metabolic effects of Ridizol P in the fattening of pigs]. Veterinarni medicina. 1980 Jan; 25(1):1-9. doi: NULL. [PMID: 6766587]
C H Lee, L D Olson, D E Rodabaugh. Influence of medication on development of serum antibody to swine dysentery as detected with indirect fluorescent antibody method. American journal of veterinary research. 1976 Oct; 37(10):1159-63. doi: NULL. [PMID: 136221]
P C Cala, G V Downing, R F Michielli, J J Wittick. Determination of ronidazole in swine tissues by differential pulse polarography. Journal of agricultural and food chemistry. 1976 Jul; 24(4):764-7. doi: 10.1021/jf60206a002. [PMID: 956540]