medazepam (BioDeep_00000271161)

   


代谢物信息卡片


medazepam

化学式: C16H15ClN2 (270.09237)
中文名称: 美达西泮
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: Clc(c3)cc(c(c3)2)C(=NCCN(C)2)c(c1)cccc1
InChI: InChI=1S/C16H15ClN2/c1-19-10-9-18-16(12-5-3-2-4-6-12)14-11-13(17)7-8-15(14)19/h2-8,11H,9-10H2,1H3

描述信息

D002491 - Central Nervous System Agents > D002492 - Central Nervous System Depressants > D006993 - Hypnotics and Sedatives
D002492 - Central Nervous System Depressants > D014149 - Tranquilizing Agents > D014151 - Anti-Anxiety Agents
D002491 - Central Nervous System Agents > D011619 - Psychotropic Drugs > D014149 - Tranquilizing Agents
N - Nervous system > N05 - Psycholeptics > N05B - Anxiolytics > N05BA - Benzodiazepine derivatives
C78272 - Agent Affecting Nervous System > C29756 - Sedative and Hypnotic > C1012 - Benzodiazepine
D018377 - Neurotransmitter Agents > D018682 - GABA Agents > D018757 - GABA Modulators
D018373 - Peripheral Nervous System Agents > D009465 - Neuromuscular Agents
C78272 - Agent Affecting Nervous System > C28197 - Antianxiety Agent
D002491 - Central Nervous System Agents > D000927 - Anticonvulsants
CONFIDENCE standard compound; EAWAG_UCHEM_ID 3022

同义名列表

1 个代谢物同义名

medazepam



数据库引用编号

21 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology. 2019 11; 96(5):629-640. doi: 10.1124/mol.119.115964. [PMID: 31515284]
  • Bılal Yılmaz, Alı Fuat Erdem. Simultaneous Determination of Tramadol and its Metabolite in Human Plasma by GC/MS. Journal of AOAC International. 2015 Jan; 98(1):56-61. doi: 10.5740/jaoacint.14-085. [PMID: 25857879]
  • Zeynel Abidin Sayiner, Zeynel Abidin Ozturk. Acute kidney injury with medazepam-hyoscine buthylbromide. Wiener klinische Wochenschrift. 2014 May; 126(9-10):291-3. doi: 10.1007/s00508-014-0523-7. [PMID: 24664310]
  • Eduardo Costa Figueiredo, Regina Sparrapan, Gustavo Braga Sanvido, Mariane Gonçalves Santos, Marco Aurélio Zezzi Arruda, Marcos Nogueira Eberlin. Quantitation of drugs via molecularly imprinted polymer solid phase extraction and electrospray ionization mass spectrometry: benzodiazepines in human plasma. The Analyst. 2011 Sep; 136(18):3753-7. doi: 10.1039/c1an15198c. [PMID: 21776492]
  • Fedor A Brovko, Victoria S Vasil'eva, Antonina L Lushnikova, Svetlana Yu Selivankina, Natalia N Karavaiko, Khanafy M Boziev, Anna O Shepelyakovskaya, Dmitry A Moshkov, Liubov L Pavlik, Victor V Kusnetsov, Olga N Kulaeva. Cytokinin-binding protein (70 kDa) from etioplasts and amyloplasts of etiolated maize seedlings and chloroplasts of green plants and its putative function. Journal of experimental botany. 2010 Jul; 61(12):3461-74. doi: 10.1093/jxb/erq170. [PMID: 20584787]
  • Radim Vrzal, Katerina Kubesova, Petr Pavek, Zdenek Dvorak. Benzodiazepines medazepam and midazolam are activators of pregnane X receptor and weak inducers of CYP3A4: investigation in primary cultures of human hepatocytes and hepatocarcinoma cell lines. Toxicology letters. 2010 Mar; 193(2):183-8. doi: 10.1016/j.toxlet.2010.01.004. [PMID: 20080160]
  • Fedor A Brovko, Victoria S Vasil'eva, Anna O Shepelyakovskaya, Svetlana Yu Selivankina, Guzel R Kudoyarova, Alexander V Nosov, Dmitry A Moshkov, Alexander G Laman, Khanafy M Boziev, Victor V Kusnetsov, Olga N Kulaeva. Cytokinin-binding protein (70 kDa): localization in tissues and cells of etiolated maize seedlings and its putative function. Journal of experimental botany. 2007; 58(10):2479-90. doi: 10.1093/jxb/erm108. [PMID: 17584953]
  • M Kh Kurdanova, I A Beslaneev, L M Batyrbekova, Z A Berkhamova, A Kh Sarbasheva, Kh A Kurdanov. [The nitric oxide system in patients with arterial hypertension living in high mountains]. Terapevticheskii arkhiv. 2007; 79(12):25-8. doi: NULL. [PMID: 18220026]
  • Carsten Kratzsch, Oliver Tenberken, Frank T Peters, Armin A Weber, Thomas Kraemer, Hans H Maurer. Screening, library-assisted identification and validated quantification of 23 benzodiazepines, flumazenil, zaleplone, zolpidem and zopiclone in plasma by liquid chromatography/mass spectrometry with atmospheric pressure chemical ionization. Journal of mass spectrometry : JMS. 2004 Aug; 39(8):856-72. doi: 10.1002/jms.599. [PMID: 15329838]
  • R H C Queiroz, R C Pereira, M A Gotardo, D S Cordeiro, E Melchior. Determination of clofazimine in leprosy patients by high-performance liquid chromatography. Journal of analytical toxicology. 2003 Sep; 27(6):377-80. doi: 10.1093/jat/27.6.377. [PMID: 14516492]
  • Karen S Scott, Yuji Nakahara. A study into the rate of incorporation of eight benzodiazepines into rat hair. Forensic science international. 2003 Apr; 133(1-2):47-56. doi: 10.1016/s0379-0738(03)00049-5. [PMID: 12742689]
  • Maria Elisa Capella-Peiró, Devasish Bose, Adrià Martinavarro-Domínguez, Mayte Gil-Agustí, Josep Esteve-Romero. Direct injection micellar liquid chromatographic determination of benzodiazepines in serum. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2002 Nov; 780(2):241-9. doi: 10.1016/s1570-0232(02)00523-8. [PMID: 12401349]
  • Andrejus Zevzikovas, Guoda Kiliuviene, Liudas Ivanauskas, Vidmantas Dirse. [Analysis of benzodiazepine derivative mixture by gas-liquid chromatography]. Medicina (Kaunas, Lithuania). 2002; 38(3):316-20. doi: NULL. [PMID: 12474705]
  • M Palmada, C Böhmer, J J Centelles, R K Kinne. Effect of benzodiazepines on the epithelial and neuronal high-affinity glutamate transporter EAAC1. Journal of neurochemistry. 1999 Dec; 73(6):2389-96. doi: 10.1046/j.1471-4159.1999.0732389.x. [PMID: 10582598]
  • R Herráez-Hernández, A J Louter, N C van de Merbel, U A Brinkman. Automated on-line dialysis for sample preparation for gas chromatography: determination of benzodiazepines in human plasma. Journal of pharmaceutical and biomedical analysis. 1996 Jun; 14(8-10):1077-87. doi: 10.1016/0731-7085(95)01703-8. [PMID: 8818018]
  • E Boisvieux-Ulrich, M C Laine, D Sandoz. In vitro effects of benzodiazepines on ciliogenesis in the quail oviduct. Cell motility and the cytoskeleton. 1987; 8(4):333-44. doi: 10.1002/cm.970080406. [PMID: 3690692]
  • N Boyadjieva, R Ovtcharov. Effect of some benzodiazepines on the secretion of thyrotropic hormone and prolactin under conditions of experimental stress. Acta physiologica et pharmacologica Bulgarica. 1987; 13(2):18-21. doi: NULL. [PMID: 2890258]
  • N Boyadjieva, R Ovcharov, N Visheva, S Milanov. Effect of diazepam and medazepam on prolactin secretion. Acta physiologica et pharmacologica Bulgarica. 1986; 12(2):3-6. doi: . [PMID: 2876582]
  • S G McKenzie. Introduction to the pharmacokinetics and pharmacodynamics of benzodiazepines. Progress in neuro-psychopharmacology & biological psychiatry. 1983; 7(4-6):623-7. doi: 10.1016/0278-5846(83)90035-0. [PMID: 6141605]
  • D M Hailey, E S Baird. Plasma concentrations of medazepam and its metabolites after oral administration. British journal of anaesthesia. 1979 Jun; 51(6):493-6. doi: 10.1093/bja/51.6.493. [PMID: 37864]
  • M Viukari, M Linnoila. Serum medazepam, diazepam, and N-desmethyldiazepam levels after single and multiple oral doses of medazepam. Annals of clinical research. 1977 Oct; 9(5):284-6. doi: NULL. [PMID: 28686]
  • B E Pape, M A Ribick. Analysis of medazepam, diazepam, and metabolites in plasma by gas-liquid chromatography with electrolytic conductivity detection. Journal of chromatography. 1977 Jun; 136(1):127-39. doi: 10.1016/s0021-9673(00)83001-0. [PMID: 18486]
  • A J Bond, D M Hailey, M H Lader. Plasma concentrations of benzodiazepines. British journal of clinical pharmacology. 1977 Feb; 4(1):51-6. doi: 10.1111/j.1365-2125.1977.tb00666.x. [PMID: 14659]
  • B Terhaag, A Bockisch. [Antihemolytic effect of various benzodiazepines on human erythrocytes]. Acta biologica et medica Germanica. 1976; 35(10):1415-7. doi: ". [PMID: 14466]
  • A Viala, J P Cano, A Durand. [Determination of chloroquine in biological material by gas-liquid chromatography (author's transl)]. Journal of chromatography. 1975 Sep; 111(2):299-303. doi: 10.1016/s0021-9673(00)99278-1. [PMID: 1159008]
  • . . . . doi: . [PMID: 19554302]