Lacosamide (racemate) (BioDeep_00000271150)
代谢物信息卡片
Lacosamide (racemate)
化学式: C13H18N2O3 (250.1317)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC(=O)NC(COC)C(=O)NCC1=CC=CC=C1
InChI: InChI=1S/C13H18N2O3/c1-10(16)15-12(9-18-2)13(17)14-8-11-6-4-3-5-7-11/h3-7,12H,8-9H2,1-2H3,(H,14,17)(H,15,16)
描述信息
D002317 - Cardiovascular Agents > D026941 - Sodium Channel Blockers > D061567 - Voltage-Gated Sodium Channel Blockers
D002491 - Central Nervous System Agents > D000927 - Anticonvulsants
D049990 - Membrane Transport Modulators
同义名列表
1 个代谢物同义名
数据库引用编号
5 个数据库交叉引用编号
- PubChem: 21634109
- ChEMBL: CHEMBL57293
- MeSH: Lacosamide
- CAS: 175481-26-2
- PMhub: MS000001663
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
| 亚细胞结构定位 | 关联基因列表 |
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文献列表
- Yuichi Tateishi, Nobutsune Ishikawa, Yoshiyuki Kobayashi, Hiroki Izumo, Yuta Eguchi, Satoshi Okada. Effect of Lacosamide therapy on blood cells and IgA levels in children and adolescents with epilepsy in a clinical setting.
Epilepsy research.
2022 11; 187(?):107030. doi:
10.1016/j.eplepsyres.2022.107030. [PMID: 36308995] - Arzu Temizyürek, Canan Uğur Yılmaz, Serkan Emik, Uğur Akcan, Müge Atış, Nurcan Orhan, Nadir Arıcan, Bulent Ahishali, Erdem Tüzün, Mutlu Küçük, Candan Gürses, Mehmet Kaya. Blood-brain barrier targeted delivery of lacosamide-conjugated gold nanoparticles: Improving outcomes in absence seizures.
Epilepsy research.
2022 Aug; 184(?):106939. doi:
10.1016/j.eplepsyres.2022.106939. [PMID: 35785634] - Ting Zhao, Hong-Jian Li, Jie Feng, Hui-Lan Zhang, Wang Ting-Ting, Long Ma, Jing Yu, Wen-Bo Zhao, Li Sun, Lu-Hai Yu, Yan Sun. Impact of ABCB1 Polymorphisms on Lacosamide Serum Concentrations in Uygur Pediatric Patients With Epilepsy in China.
Therapeutic drug monitoring.
2022 06; 44(3):455-464. doi:
10.1097/ftd.0000000000000927. [PMID: 34610620] - Shamir N Kalaria, Michael Armahizer, Paul McCarthy, Neeraj Badjatia, Jogarao V Gobburu, Mathangi Gopalakrishnan. Development and Use of an Ex-Vivo In-Vivo Correlation to Predict Antiepileptic Drug Clearance in Patients Undergoing Continuous Renal Replacement Therapy.
Pharmaceutical research.
2022 May; 39(5):827-836. doi:
10.1007/s11095-022-03287-x. [PMID: 35552966] - Page B Pennell, Ashwin Karanam, Kimford J Meador, Elizabeth Gerard, Laura Kalayjian, Patricia Penovich, Abigail Matthews, Thomas M McElrath, Angela K Birnbaum. Antiseizure Medication Concentrations During Pregnancy: Results From the Maternal Outcomes and Neurodevelopmental Effects of Antiepileptic Drugs (MONEAD) Study.
JAMA neurology.
2022 04; 79(4):370-379. doi:
10.1001/jamaneurol.2021.5487. [PMID: 35157004] - Mirosław Zagaja, Anna Zagaja, Joanna Szala-Rycaj, Aleksandra Szewczyk, Marta Kinga Lemieszek, Grzegorz Raszewski, Marta Andres-Mach. Influence of Umbelliferone on the Anticonvulsant and Neuroprotective Activity of Selected Antiepileptic Drugs: An In Vivo and In Vitro Study.
International journal of molecular sciences.
2022 Mar; 23(7):. doi:
10.3390/ijms23073492. [PMID: 35408852] - Marco Pozzi, Nicoletta Zanotta, Roberta Epifanio, Sara Baldelli, Dario Cattaneo, Emilio Clementi, Claudio Zucca. Lacosamide effectiveness and tolerability in patients with drug-resistant epilepsy and severe disability under polytherapy: Therapy optimization as emerging from an observational study.
Epilepsy & behavior : E&B.
2022 03; 128(?):108598. doi:
10.1016/j.yebeh.2022.108598. [PMID: 35151192] - Alexander Walker, Arashdeep Rupal, Chinmay Jani, Omar Al Omari, Harpreet Singh, Dipesh Patel, Carmen Perrino, Jessica McCannon. Longstanding Phenytoin Use as a Cause of Progressive Dyspnea.
Chest.
2022 02; 161(2):e91-e96. doi:
10.1016/j.chest.2021.08.079. [PMID: 35131079] - Katsuyuki Tanabe, Natsumi Matsuoka-Uchiyama, Tomoyo Mifune, Chieko Kawakita, Hitoshi Sugiyama, Jun Wada. Management of corticosteroid-dependent eosinophilic interstitial nephritis: A case report.
Medicine.
2021 Dec; 100(50):e28252. doi:
10.1097/md.0000000000028252. [PMID: 34918693] - Shamir N Kalaria, Michael Armahizer, Paul McCarthy, Neeraj Badjatia, Jogarao V Gobburu, Mathangi Gopalakrishnan. A prospective, real-world, clinical pharmacokinetic study to inform lacosamide dosing in critically ill patients undergoing continuous venovenous haemofiltration (PADRE-02).
British journal of clinical pharmacology.
2021 11; 87(11):4375-4385. doi:
10.1111/bcp.14858. [PMID: 33855736] - Deepti Zutshi, Scott R Millis, Maysaa M Basha, Maha A Daimee, Meghana Srinivas. Lacosamide serum concentrations during pregnancy.
Epilepsy & behavior : E&B.
2021 10; 123(?):108253. doi:
10.1016/j.yebeh.2021.108253. [PMID: 34399392] - Dennis Klimpel, Anne Hagemann, Christian G Bien, Bertin Dufaux, Theodor W May, Christian Brandt. Therapeutic Drug Monitoring of Lamotrigine, Lacosamide, and Levetiracetam in Dried Capillary Blood-Determination of Conversion Factors for Serum-Based Reference Ranges.
Therapeutic drug monitoring.
2021 06; 43(3):394-400. doi:
10.1097/ftd.0000000000000890. [PMID: 33851939] - Michaela Shishmanova-Doseva, Dimitrinka Atanasova, Yordanka Uzunova, Lyubka Yoanidu, Lyudmil Peychev, Pencho Marinov, Jana Tchekalarova. Effects of Lacosamide Treatment on Epileptogenesis, Neuronal Damage and Behavioral Comorbidities in a Rat Model of Temporal Lobe Epilepsy.
International journal of molecular sciences.
2021 Apr; 22(9):. doi:
10.3390/ijms22094667. [PMID: 33925082] - Ting Zhao, Lu-Hai Yu, Ting-Ting Wang, Jie Feng, Long Ma, Jing Yu, Li Sun, Hong-Jian Li, Yan Sun. Development and validation of an innovative UPLC method to quantify lacosamide, oxcarbazepine, and lamotrigine in the serum of children with epilepsy in China.
Biomedical chromatography : BMC.
2021 Apr; 35(4):e5022. doi:
10.1002/bmc.5022. [PMID: 33169403] - Cecilie Johannessen Landmark, Lene Rektorli, Margrete Larsen Burns, Eline Revdal, Svein I Johannessen, Eylert Brodtkorb. Pharmacokinetic data on brivaracetam, lacosamide and perampanel during pregnancy and lactation.
Epileptic disorders : international epilepsy journal with videotape.
2021 Apr; 23(2):426-431. doi:
10.1684/epd.2021.1273. [PMID: 33935028] - Prateek Kumar Panda, Indar Kumar Sharawat. Impact of carbamazepine and lacosamide on serum lipid levels.
Epilepsia.
2021 04; 62(4):1034-1035. doi:
10.1111/epi.16859. [PMID: 33651399] - Yong-Won Shin, Jangsup Moon, Yong Won Cho, Dong Wook Kim, Sang Bin Hong, Do-Yong Kim, Hyeyeon Chang, Seo Hyun Yoon, Kyung-Sang Yu, In-Jin Jang, Soon-Tae Lee, Keun-Hwa Jung, Kyung-Il Park, Ki-Young Jung, Manho Kim, Kon Chu, SeungHwan Lee, Sang Kun Lee. Tolerability of lacosamide rapid dose titration: A randomized, multicenter, prospective, open-label study.
Epilepsy & behavior : E&B.
2021 02; 115(?):107663. doi:
10.1016/j.yebeh.2020.107663. [PMID: 33342710] - Joana Gonçalves, Gilberto Alves, Carla Fonseca, Andreia Carona, Joana Bicker, Amílcar Falcão, Ana Fortuna. Is intranasal administration an opportunity for direct brain delivery of lacosamide?.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.
2021 Feb; 157(?):105632. doi:
10.1016/j.ejps.2020.105632. [PMID: 33152466] - Reem Odi, Valentina Franco, Emilio Perucca, Meir Bialer. Bioequivalence and switchability of generic antiseizure medications (ASMs): A re-appraisal based on analysis of generic ASM products approved in Europe.
Epilepsia.
2021 02; 62(2):285-302. doi:
10.1111/epi.16802. [PMID: 33426641] - Anil K Chimakurthy, R Eugene Ramsay, Vivek Sabharwal, Uma Menon. Safety, tolerability, and pharmacokinetics of weight-based IV loading dose of lacosamide in the ICU.
Epilepsy & behavior : E&B.
2021 01; 114(Pt A):107449. doi:
10.1016/j.yebeh.2020.107449. [PMID: 32943331] - Scott Mintzer, Svetlana Dimova, Ying Zhang, Björn Steiniger-Brach, Marc De Backer, Daya Chellun, Robert Roebling. Effects of lacosamide and carbamazepine on lipids in a randomized trial.
Epilepsia.
2020 12; 61(12):2696-2704. doi:
10.1111/epi.16745. [PMID: 33200428] - Kirtikumar D Bharwad, Priyanka A Shah, Pranav S Shrivastav, Vinay S Sharma. Selective quantification of lacosamide in human plasma using UPLC-MS/MS: Application to pharmacokinetic study in healthy subjects with different doses.
Biomedical chromatography : BMC.
2020 Nov; 34(11):e4928. doi:
10.1002/bmc.4928. [PMID: 32567713] - Yoshiaki Yamamoto, Kiyohito Terada, Yasukiyo Araki, Yutaro Fukushima, Katsumi Imai, Yoshiyuki Kagawa, Yukitoshi Takahashi. Therapeutic Monitoring of Lacosamide in Japanese Patients With Epilepsy: Clinical Response, Tolerability, and Optimal Therapeutic Range.
Therapeutic drug monitoring.
2020 10; 42(5):754-759. doi:
10.1097/ftd.0000000000000764. [PMID: 32941398] - Lynnea Schultz, Sherif Hanafy Mahmoud. Is Therapeutic Drug Monitoring of Lacosamide Needed in Patients with Seizures and Epilepsy?.
European journal of drug metabolism and pharmacokinetics.
2020 Jun; 45(3):315-349. doi:
10.1007/s13318-019-00601-8. [PMID: 31950342] - Patrick M Wieruszewski, Arnaldo Lopez-Ruiz, Robert C Albright, Jennifer E Fugate, Erin Frazee Barreto. Lacosamide Pharmacokinetics in a Critically Ill Patient During Continuous Renal Replacement Therapy.
Journal of pharmacy practice.
2020 Jun; 33(3):395-398. doi:
10.1177/0897190018803765. [PMID: 30336720] - Deepti Zutshi, Kalyan Yarraguntla, Advait Mahulikar, Navid Seraji-Bozorgzad, Aashit K Shah, Maysaa M Basha. Racial variations in lacosamide serum concentrations in adult patients with epilepsy.
Journal of the neurological sciences.
2020 May; 412(?):116742. doi:
10.1016/j.jns.2020.116742. [PMID: 32126366] - Torleiv Svendsen, Eylert Brodtkorb, Arton Baftiu, Morten I Lossius, Karl O Nakken, Svein I Johannessen, Cecilie Johannessen Landmark. Clinical experience combined with therapeutic drug monitoring of lacosamide.
Acta neurologica Scandinavica.
2020 Apr; 141(4):279-286. doi:
10.1111/ane.13206. [PMID: 31853958] - Katarzyna Socała, Elżbieta Wyska, Małgorzata Szafarz, Dorota Nieoczym, Piotr Wlaź. Acute effect of cannabidiol on the activity of various novel antiepileptic drugs in the maximal electroshock- and 6 Hz-induced seizures in mice: Pharmacodynamic and pharmacokinetic studies.
Neuropharmacology.
2019 11; 158(?):107733. doi:
10.1016/j.neuropharm.2019.107733. [PMID: 31377197] - Michaela Shishmanova-Doseva, Katerina Georgieva, Yvetta Koeva, Dora Terzieva, Lyudmil Peychev. Enhancing effect of aerobic training on learning and memory performance in rats after long-term treatment with Lacosamide via BDNF-TrkB signaling pathway.
Behavioural brain research.
2019 09; 370(?):111963. doi:
10.1016/j.bbr.2019.111963. [PMID: 31116960] - Fardous A Mohamed, Marwa F B Ali, Azza H Rageh, Aya M Mostafa. Highly sensitive UHPLC-DAD method for simultaneous determination of two synergistically acting antiepileptic drugs; levetiracetam and lacosamide: Application to pharmaceutical tablets and human urine.
Biomedical chromatography : BMC.
2019 Sep; 33(9):e4554. doi:
10.1002/bmc.4554. [PMID: 30985932] - Margrete Larsen Burns, Marina Nikanorova, Arton Baftiu, Jan Borg Rasmussen, Svein I Johannessen, Cecilie Johannessen Landmark. Pharmacokinetic Variability and Clinical Use of Lacosamide in Children and Adolescents in Denmark and Norway.
Therapeutic drug monitoring.
2019 06; 41(3):340-347. doi:
10.1097/ftd.0000000000000599. [PMID: 30688870] - Julia Winkler, Rik Schoemaker, Armel Stockis. Population Pharmacokinetics of Adjunctive Lacosamide in Pediatric Patients With Epilepsy.
Journal of clinical pharmacology.
2019 04; 59(4):541-547. doi:
10.1002/jcph.1340. [PMID: 30427550] - He Sarina Yang, Leslie Edinboro. Therapeutic Drug Monitoring of Lacosamide by LC-MS/MS.
Methods in molecular biology (Clifton, N.J.).
2019; 1872(?):67-73. doi:
10.1007/978-1-4939-8823-5_7. [PMID: 30350280] - Serdar Demiroz, Koray Ur, Aykut Ulucan, Aydin Sukru Bengu, Feyza Demiralin Ur, Ozlem Oz Gergin, Sevki Erdem. Neuroprotective Effects of Lacosamide in Experimental Traumatic Spinal Cord Injury in Rats.
Turkish neurosurgery.
2019; 29(5):718-723. doi:
10.5137/1019-5149.jtn.25891-19.2. [PMID: 31124574] - Julia Winkler, Rik Schoemaker, Armel Stockis. Modeling and simulation for the evaluation of dose adaptation rules of intravenous lacosamide in children.
Epilepsy research.
2019 01; 149(?):13-16. doi:
10.1016/j.eplepsyres.2018.10.011. [PMID: 30415109] - Theodor W May, Renate Helmer, Christian G Bien, Christian Brandt. Influence of Dose and Antiepileptic Comedication on Lacosamide Serum Concentrations in Patients With Epilepsy of Different Ages.
Therapeutic drug monitoring.
2018 10; 40(5):620-627. doi:
10.1097/ftd.0000000000000538. [PMID: 30086089] - Nikita Nirwan, Fouzia Siraj, Divya Vohora. Inverted-U response of lacosamide on pilocarpine-induced status epilepticus and oxidative stress in C57BL/6 mice is independent of hippocampal collapsin response mediator protein-2.
Epilepsy research.
2018 09; 145(?):93-101. doi:
10.1016/j.eplepsyres.2018.06.009. [PMID: 29935443] - Julius Höhne, Karl-Michael Schebesch, Christian Ott, Alexander Brawanski, Max Lange. The risk of hypotension and seizures in patients receiving prophylactic anti-epileptic drugs for supratentorial craniotomy.
Journal of neurosurgical sciences.
2018 Aug; 62(4):418-422. doi:
10.23736/s0390-5616.16.03826-1. [PMID: 27854111] - Michaela Shishmanova-Doseva, Lyudmil Peychev, Yvetta Koeva, Dora Terzieva, Katerina Georgieva, Zhivko Peychev. Chronic treatment with the new anticonvulsant drug lacosamide impairs learning and memory processes in rats: A possible role of BDNF/TrkB ligand receptor system.
Pharmacology, biochemistry, and behavior.
2018 06; 169(?):1-9. doi:
10.1016/j.pbb.2018.03.009. [PMID: 29605232] - Mohamed A Korany, Hoda Mahgoub, Rim S Haggag, Marwa A A Ragab, Osama A Elmallah. Green gas chromatographic stability-indicating method for the determination of Lacosamide in tablets. Application to in-vivo human urine profiling.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2018 Apr; 1083(?):75-85. doi:
10.1016/j.jchromb.2018.02.033. [PMID: 29524696] - Joana Gonçalves, Gilberto Alves, Joana Bicker, Amílcar Falcão, Ana Fortuna. Development and full validation of an innovative HPLC-diode array detection technique to simultaneously quantify lacosamide, levetiracetam and zonisamide in human plasma.
Bioanalysis.
2018 Apr; 10(8):541-557. doi:
10.4155/bio-2017-0199. [PMID: 29561632] - Christian Brandt, Christian G Bien, Renate Helmer, Theodor W May. Assessment of the correlations of lacosamide concentrations in saliva and serum in patients with epilepsy.
Epilepsia.
2018 04; 59(4):e34-e39. doi:
10.1111/epi.14023. [PMID: 29450894] - Miguel J Franquiz, Shamir N Kalaria, Michael J Armahizer, Mathangi Gopalakrishnan, Paul J McCarthy, Neeraj Badjatia. Lacosamide Pharmacokinetics in a Critically Ill Patient Receiving Continuous Venovenous Hemofiltration.
Pharmacotherapy.
2018 02; 38(2):e17-e21. doi:
10.1002/phar.2063. [PMID: 29160945] - Zsolt Gáll, Szende Vancea. Distribution of lacosamide in the rat brain assessed by in vitro slice technique.
Archives of pharmacal research.
2018 Jan; 41(1):79-86. doi:
10.1007/s12272-017-0966-2. [PMID: 29019022] - Annachiara DʼUrso, Tiziano Ricotta, Ugo de Grazia. Evaluation of a Novel Immunoassay for Lacosamide Therapeutic Drug Monitoring: Comparison With a Liquid Chromatography-Mass Spectrometry Assay.
Therapeutic drug monitoring.
2017 12; 39(6):663-668. doi:
10.1097/ftd.0000000000000450. [PMID: 29135908] - Andreas Lindauer, Christian Laveille, Armel Stockis. Time-to-Seizure Modeling of Lacosamide Used in Monotherapy in Patients with Newly Diagnosed Epilepsy.
Clinical pharmacokinetics.
2017 11; 56(11):1403-1413. doi:
10.1007/s40262-017-0530-8. [PMID: 28290119] - Stefano de Biase, Mariarosaria Valente, Gian Luigi Gigli, Giovanni Merlino. Pharmacokinetic drug evaluation of lacosamide for the treatment of partial-onset seizures.
Expert opinion on drug metabolism & toxicology.
2017 Sep; 13(9):997-1005. doi:
10.1080/17425255.2017.1360278. [PMID: 28750560] - Matthieu Perrenoud, Pascal André, Vincent Alvarez, Christine Stähli, Laurent A Decosterd, Andrea O Rossetti, Jan Novy. Intravenous lacosamide in status epilepticus: Correlation between loading dose, serum levels, and clinical response.
Epilepsy research.
2017 09; 135(?):38-42. doi:
10.1016/j.eplepsyres.2017.05.007. [PMID: 28622537] - Baldeep Kumar, Manish Modi, Biman Saikia, Bikash Medhi. Evaluation of Brain Pharmacokinetic and Neuropharmacodynamic Attributes of an Antiepileptic Drug, Lacosamide, in Hepatic and Renal Impairment: Preclinical Evidence.
ACS chemical neuroscience.
2017 07; 8(7):1589-1597. doi:
10.1021/acschemneuro.7b00084. [PMID: 28324653] - Torleiv Svendsen, Eylert Brodtkorb, Arton Baftiu, Margrete Larsen Burns, Svein I Johannessen, Cecilie Johannessen Landmark. Therapeutic Drug Monitoring of Lacosamide in Norway: Focus on Pharmacokinetic Variability, Efficacy and Tolerability.
Neurochemical research.
2017 Jul; 42(7):2077-2083. doi:
10.1007/s11064-017-2234-8. [PMID: 28349359] - Jarogniew J Luszczki, Pawel Patrzylas, Miroslaw Zagaja, Marta Andres-Mach, Katarzyna Zaluska, Maria W Kondrat-Wrobel, Monika Szpringer, Jaroslaw Chmielewski, Magdalena Florek-Luszczki. Effects of arachidonyl-2'-chloroethylamide (ACEA) on the protective action of various antiepileptic drugs in the 6-Hz corneal stimulation model in mice.
PloS one.
2017; 12(8):e0183873. doi:
10.1371/journal.pone.0183873. [PMID: 28859122] - Mirosław Zagaja, Marta Andres-Mach, Paweł Patrzylas, Daniel Pyrka, Monika Szpringer, Magdalena Florek-Łuszczki, Dorota Żółkowska, Krystyna Skalicka-Woźniak, Jarogniew J Łuszczki. Influence of xanthotoxin (8-methoxypsoralen) on the anticonvulsant activity of various novel antiepileptic drugs against maximal electroshock-induced seizures in mice.
Fitoterapia.
2016 Dec; 115(?):86-91. doi:
10.1016/j.fitote.2016.09.020. [PMID: 27702668] - Keaton S Smetana, Aaron M Cook, Melissa L Thompson Bastin, Douglas R Oyler. Antiepileptic dosing for critically ill adult patients receiving renal replacement therapy.
Journal of critical care.
2016 12; 36(?):116-124. doi:
10.1016/j.jcrc.2016.06.023. [PMID: 27546759] - Christian E Elger, Michael Rademacher, Christian Brandt, Sami Elmoufti, Peter Dedeken, Klaus Eckhardt, Frank Tennigkeit, Marc De Backer. Changes in hormone and lipid levels in male patients with focal seizures when switched from carbamazepine to lacosamide as adjunctive treatment to levetiracetam: A small phase IIIb, prospective, multicenter, open-label trial.
Epilepsy & behavior : E&B.
2016 09; 62(?):1-5. doi:
10.1016/j.yebeh.2016.05.023. [PMID: 27423106] - Sharon K Michelhaugh, Maysaa Basha, Denise H Rhoney, Aashit K Shah, Sandeep Mittal. Acute or chronic use of lacosamide does not alter its distribution between serum and cerebrospinal fluid.
Epilepsia.
2015 Nov; 56(11):1732-7. doi:
10.1111/epi.13111. [PMID: 26249845] - Volkan Solmaz, Dürdane Aksoy, Mustafa Yılmaz, Enes Eser, Oytun Erbas. Demonstration of ameliorative effect of lacosamide: in a rat model of sepsis-induced critical illness polyneuropathy.
Neurological research.
2015 Sep; 37(9):797-802. doi:
10.1179/1743132815y.0000000040. [PMID: 25916937] - Willi Cawello. Clinical pharmacokinetic and pharmacodynamic profile of lacosamide.
Clinical pharmacokinetics.
2015 Sep; 54(9):901-14. doi:
10.1007/s40262-015-0276-0. [PMID: 25957198] - Jenny L Chua-Tuan, Dazhe Cao, Janetta L Iwanicki, Christopher O Hoyte. Cardiac sodium channel blockade after an intentional ingestion of lacosamide, cyclobenzaprine, and levetiracetam: Case report.
Clinical toxicology (Philadelphia, Pa.).
2015 Jul; 53(6):565-8. doi:
10.3109/15563650.2015.1040157. [PMID: 25951877] - Theodor W May, Christian Brandt, Renate Helmer, Christian G Bien, Willi Cawello. Comparison of lacosamide concentrations in cerebrospinal fluid and serum in patients with epilepsy.
Epilepsia.
2015 Jul; 56(7):1134-40. doi:
10.1111/epi.13022. [PMID: 25988882] - Carina Schaefer, Willi Cawello, Josef Waitzinger, Jan-Peer Elshoff. Effect of age and sex on lacosamide pharmacokinetics in healthy adult subjects and adults with focal epilepsy.
Clinical drug investigation.
2015 Apr; 35(4):255-65. doi:
10.1007/s40261-015-0277-7. [PMID: 25708532] - C-W Huang, T-Y Hung, S-N Wu. The inhibitory actions by lacosamide, a functionalized amino acid, on voltage-gated Na+ currents.
Neuroscience.
2015 Feb; 287(?):125-36. doi:
10.1016/j.neuroscience.2014.12.026. [PMID: 25534720] - Eric Korman, Loralie J Langman, Paul J Jannetto. High-throughput method for the quantification of lacosamide in serum using ultrafast SPE-MS/MS.
Therapeutic drug monitoring.
2015 Feb; 37(1):126-31. doi:
10.1097/ftd.0000000000000115. [PMID: 25029293] - Panagiota Nikolaou, Ioannis Papoutsis, Chara Spiliopoulou, Constantinos Voudris, Sotiris Athanaselis. A fully validated method for the determination of lacosamide in human plasma using gas chromatography with mass spectrometry: application for therapeutic drug monitoring.
Journal of separation science.
2015 Jan; 38(2):260-6. doi:
10.1002/jssc.201400858. [PMID: 25395063] - Willi Cawello, Armel Stockis, Jens-Otto Andreas, Svetlana Dimova. Advances in epilepsy treatment: lacosamide pharmacokinetic profile.
Annals of the New York Academy of Sciences.
2014 Nov; 1329(?):18-32. doi:
10.1111/nyas.12513. [PMID: 25167889] - Sofia Markoula, Rute Teotonio, Neville Ratnaraj, John S Duncan, Josemir W Sander, Philip N Patsalos. Lacosamide serum concentrations in adult patients with epilepsy: the influence of gender, age, dose, and concomitant antiepileptic drugs.
Therapeutic drug monitoring.
2014 Aug; 36(4):494-8. doi:
10.1097/ftd.0000000000000051. [PMID: 24562047] - Willi Cawello, Carina Schäfer. A system of equations to approximate the pharmacokinetic parameters of lacosamide at steady state from one plasma sample.
Epilepsy research.
2014 Aug; 108(6):1068-75. doi:
10.1016/j.eplepsyres.2014.05.001. [PMID: 24893832] - Willi Cawello, Christa Mueller-Voessing, Jens-Otto Andreas. Effect of lacosamide on the steady-state pharmacokinetics of digoxin: results from a phase I, multiple-dose, double-blind, randomised, placebo-controlled, crossover trial.
Clinical drug investigation.
2014 May; 34(5):327-34. doi:
10.1007/s40261-014-0180-7. [PMID: 24634110] - D Calderon Guzman, E Hernandez Garcia, G Barragan Mejia, H Juarez Olguin, J A Saldivar Gonzalez, N A Labra Ruiz. Effect of morphine and lacosamide on levels of dopamine and 5-HIAA in brain regions of rats with induced hypoglycemia.
Pakistan journal of biological sciences : PJBS.
2014 Jan; 17(2):292-6. doi:
10.3923/pjbs.2014.292.296. [PMID: 24783817] - Drew Payto, Nancy Foldvary-Schaefer, Norman So, Monica Bruton, Sihe Wang. A sensitive and rapid method for quantification of lacosamide and desmethyl lacosamide by LC-MS/MS.
Bioanalysis.
2014; 6(23):3161-8. doi:
10.4155/bio.14.158. [PMID: 25529884] - Manuela Contin, Fiorenzo Albani, Roberto Riva, Carmina Candela, Susan Mohamed, Agostino Baruzzi. Lacosamide therapeutic monitoring in patients with epilepsy: effect of concomitant antiepileptic drugs.
Therapeutic drug monitoring.
2013 Dec; 35(6):849-52. doi:
10.1097/ftd.0b013e318290eacc. [PMID: 23942540] - Zsolt Gáll, Szende Vancea, Maria T Dogaru, Tibor Szilágyi. Liquid chromatography-mass spectrometric determination of rufinamide in low volume plasma samples.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2013 Dec; 940(?):42-6. doi:
10.1016/j.jchromb.2013.07.014. [PMID: 24140655] - Willi Cawello, Uwe Fuhr, Ursula Hering, Haidar Maatouk, Atef Halabi. Impact of impaired renal function on the pharmacokinetics of the antiepileptic drug lacosamide.
Clinical pharmacokinetics.
2013 Oct; 52(10):897-906. doi:
10.1007/s40262-013-0080-7. [PMID: 23737404] - Armel Stockis, Jan Jaap van Lier, Willi Cawello, Thomas Kumke, Klaus Eckhardt. Lack of effect of lacosamide on the pharmacokinetic and pharmacodynamic profiles of warfarin.
Epilepsia.
2013 Jul; 54(7):1161-6. doi:
10.1111/epi.12192. [PMID: 23614393] - Alexey Shandra, Pavel Shandra, Olga Kaschenko, Alain Matagne, Thomas Stöhr. Synergism of lacosamide with established antiepileptic drugs in the 6-Hz seizure model in mice.
Epilepsia.
2013 Jul; 54(7):1167-75. doi:
10.1111/epi.12237. [PMID: 23750855] - Willi Cawello, Bernd Rosenkranz, Bernhard Schmid, Werner Wierich. Pharmacodynamic and pharmacokinetic evaluation of coadministration of lacosamide and an oral contraceptive (levonorgestrel plus ethinylestradiol) in healthy female volunteers.
Epilepsia.
2013 Mar; 54(3):530-6. doi:
10.1111/epi.12085. [PMID: 23360419] - Nathan B Fountain, Gregory Krauss, Jouko Isojarvi, Deanne Dilley, Pamela Doty, G David Rudd. Safety and tolerability of adjunctive lacosamide intravenous loading dose in lacosamide-naive patients with partial-onset seizures.
Epilepsia.
2013 Jan; 54(1):58-65. doi:
10.1111/j.1528-1167.2012.03543.x. [PMID: 22708895] - Willi Cawello, Hilmar Bökens, Brunhild Nickel, Jens-Otto Andreas, Atef Halabi. Tolerability, pharmacokinetics, and bioequivalence of the tablet and syrup formulations of lacosamide in plasma, saliva, and urine: saliva as a surrogate of pharmacokinetics in the central compartment.
Epilepsia.
2013 Jan; 54(1):81-8. doi:
10.1111/j.1528-1167.2012.03725.x. [PMID: 23148731] - Willi Cawello, Hilmar Boekens, Rainer Bonn. Absorption, disposition, metabolic fate and elimination of the anti-epileptic drug lacosamide in humans: mass balance following intravenous and oral administration.
European journal of drug metabolism and pharmacokinetics.
2012 Dec; 37(4):241-8. doi:
10.1007/s13318-012-0093-x. [PMID: 22544644] - Willi Cawello, Rainer Bonn. No pharmacokinetic interaction between lacosamide and valproic acid in healthy volunteers.
Journal of clinical pharmacology.
2012 Nov; 52(11):1739-48. doi:
10.1177/0091270011426875. [PMID: 22162508] - Victor Biton. Lacosamide for the treatment of partial-onset seizures.
Expert review of neurotherapeutics.
2012 Jun; 12(6):645-55. doi:
10.1586/ern.12.50. [PMID: 22650166] - Stephanie E Martinez, Kurt A Bowen, Connie M Remsberg, Jody K Takemoto, Heather M Wright, Annie V Chen-Allen, Neal M Davies. High-performance liquid chromatographic analysis of lacosamide in canine serum using ultraviolet detection: application to pre-clinical pharmacokinetics in dogs.
Biomedical chromatography : BMC.
2012 May; 26(5):606-9. doi:
10.1002/bmc.1704. [PMID: 21898475] - S Shah, S G Vasantharaju, K Arumugam, B S Muddukrishna, N Desai. Development of a sensitive bioanalytical method for the quantification of lacosamide in rat plasma. Application to preclinical pharmacokinetics studies in rats.
Arzneimittel-Forschung.
2012 May; 62(5):243-6. doi:
10.1055/s-0032-1301911. [PMID: 22382788] - Soo-Jin Kim, Tae-Sung Koo, Dong-Jin Ha, Myoungki Baek, Sang-Kil Lee, Dong-Soo Shin, Hongsik Moon. Liquid chromatography-tandem mass spectrometry for quantification of lacosamide, an antiepileptic drug, in rat plasma and its application to pharmacokinetic study.
Biomedical chromatography : BMC.
2012 Mar; 26(3):371-6. doi:
10.1002/bmc.1668. [PMID: 21735462] - Danièle Bentué-Ferrer, Olivier Tribut, Marie-Clémence Verdier. [Therapeutic drug monitoring of lacosamide].
Therapie.
2012 Mar; 67(2):151-5. doi:
10.2515/therapie/2012012. [PMID: 22850102] - Willi Cawello, Rainer Bonn, Hilmar Boekens. Bioequivalence of intravenous and oral formulations of the antiepileptic drug lacosamide.
Pharmacology.
2012; 90(1-2):40-6. doi:
10.1159/000339077. [PMID: 22722651] - Tae-Sung Koo, Soo-Jin Kim, Dong-Jin Ha, Myoungki Baek, Hongsik Moon. Pharmacokinetics, brain distribution, and plasma protein binding of the antiepileptic drug lacosamide in rats.
Archives of pharmacal research.
2011 Dec; 34(12):2059-64. doi:
10.1007/s12272-011-1208-7. [PMID: 22210031] - C Kestelyn, M Lastelle, N Higuet, S Dell'Aiera, L Staelens, P Boulanger, H Boekens, S Smith. A simple HPLC-UV method for the determination of lacosamide in human plasma.
Bioanalysis.
2011 Nov; 3(22):2515-22. doi:
10.4155/bio.11.261. [PMID: 22122600] - Barbara Hillenbrand, Ilona Wisniewski, Uta Jürges, Bernhard J Steinhoff. Add-on lacosamide: a retrospective study on the relationship between serum concentration, dosage, and adverse events.
Epilepsy & behavior : E&B.
2011 Nov; 22(3):548-51. doi:
10.1016/j.yebeh.2011.08.032. [PMID: 21962950] - Christian Geis, Bettina K Beyreuther, Thomas Stöhr, Claudia Sommer. Lacosamide has protective disease modifying properties in experimental vincristine neuropathy.
Neuropharmacology.
2011 Sep; 61(4):600-7. doi:
10.1016/j.neuropharm.2011.05.001. [PMID: 21586299] - Annika Sattler, Marion Schaefer, Theodor W May, Bernhard Rambeck, Christian Brandt. Fluctuation of lacosamide serum concentrations during the day and occurrence of adverse drug reactions--first clinical experience.
Epilepsy research.
2011 Aug; 95(3):207-12. doi:
10.1016/j.eplepsyres.2011.03.019. [PMID: 21543186] - Clare Greenaway, Neville Ratnaraj, Josemir W Sander, Philip N Patsalos. Saliva and serum lacosamide concentrations in patients with epilepsy.
Epilepsia.
2011 Feb; 52(2):258-63. doi:
10.1111/j.1528-1167.2010.02751.x. [PMID: 20946125] - Clare Greenaway, Neville Ratnaraj, Josemir W Sander, Philip N Patsalos. A high-performance liquid chromatography assay to monitor the new antiepileptic drug lacosamide in patients with epilepsy.
Therapeutic drug monitoring.
2010 Aug; 32(4):448-52. doi:
10.1097/ftd.0b013e3181dcc5fb. [PMID: 20386357] - Gregory Krauss, Elinor Ben-Menachem, Ruta Mameniskiene, Nerija Vaiciene-Magistris, Melissa Brock, John G Whitesides, Martin E Johnson. Intravenous lacosamide as short-term replacement for oral lacosamide in partial-onset seizures.
Epilepsia.
2010 Jun; 51(6):951-7. doi:
10.1111/j.1528-1167.2009.02463.x. [PMID: 20041945] - Willi Cawello, Brunhild Nickel, Andrea Eggert-Formella. No pharmacokinetic interaction between lacosamide and carbamazepine in healthy volunteers.
Journal of clinical pharmacology.
2010 Apr; 50(4):459-71. doi:
10.1177/0091270009347675. [PMID: 19841161] - Péter Halász, Reetta Kälviäinen, Maria Mazurkiewicz-Beldzińska, Felix Rosenow, Pamela Doty, David Hebert, Timothy Sullivan. Adjunctive lacosamide for partial-onset seizures: Efficacy and safety results from a randomized controlled trial.
Epilepsia.
2009 Mar; 50(3):443-53. doi:
10.1111/j.1528-1167.2008.01951.x. [PMID: 19183227] - Ahmad Beydoun, Joseph D'Souza, David Hebert, Pamela Doty. Lacosamide: pharmacology, mechanisms of action and pooled efficacy and safety data in partial-onset seizures.
Expert review of neurotherapeutics.
2009 Jan; 9(1):33-42. doi:
10.1586/14737175.9.1.33. [PMID: 19102666] - Victor Biton. Lacosamide for the treatment of diabetic neuropathic pain.
Expert review of neurotherapeutics.
2008 Nov; 8(11):1649-60. doi:
10.1586/14737175.8.11.1649. [PMID: 18986235] - Elinor Ben-Menachem, Victor Biton, Dalius Jatuzis, Bassel Abou-Khalil, Pamela Doty, G David Rudd. Efficacy and safety of oral lacosamide as adjunctive therapy in adults with partial-onset seizures.
Epilepsia.
2007 Jul; 48(7):1308-17. doi:
10.1111/j.1528-1167.2007.01188.x. [PMID: 17635557]
