indoprofen (BioDeep_00000271142)
代谢物信息卡片
indoprofen
化学式: C17H15NO3 (281.105188)
中文名称: 吲哚洛芬
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC(C(=O)O)c1ccc(N2Cc3ccccc3C2=O)cc1
InChI: InChI=1S/C17H15NO3/c1-11(17(20)21)12-6-8-14(9-7-12)18-10-13-4-2-3-5-15(13)16(18)19/h2-9,11H,10H2,1H3,(H,20,21)
描述信息
M - Musculo-skeletal system > M01 - Antiinflammatory and antirheumatic products > M01A - Antiinflammatory and antirheumatic products, non-steroids > M01AE - Propionic acid derivatives
D018501 - Antirheumatic Agents > D000894 - Anti-Inflammatory Agents, Non-Steroidal > D016861 - Cyclooxygenase Inhibitors
C78272 - Agent Affecting Nervous System > C241 - Analgesic Agent > C2198 - Nonnarcotic Analgesic
D018373 - Peripheral Nervous System Agents > D018689 - Sensory System Agents
D002491 - Central Nervous System Agents > D000700 - Analgesics
D000893 - Anti-Inflammatory Agents
D004791 - Enzyme Inhibitors
同义名列表
1 个代谢物同义名
数据库引用编号
11 个数据库交叉引用编号
- ChEBI: CHEBI:76162
- KEGGdrug: D04530
- KEGGdrug: D81783
- PubChem: 3718
- Metlin: METLIN44065
- DrugBank: DB08951
- ChEMBL: CHEMBL15870
- MeSH: Indoprofen
- CAS: 53022-60-9
- CAS: 31842-01-0
- PMhub: MS000001640
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
Molecular pharmacology.
2019 11; 96(5):629-640. doi:
10.1124/mol.119.115964. [PMID: 31515284] - S Menon, N Kadam, G Patil, P Mhatre. A randomized, crossover study to determine bioequivalence of two brands of dexibuprofen 400 mg tablets in healthy Asian adult male subjects of Indian origin.
International journal of clinical pharmacology and therapeutics.
2008 Jan; 46(1):48-54. doi:
10.5414/cpp46048. [PMID: 18218298] - B J Gómez, A Caunedo, L Redondo, J Esteban, M Sáenz-Dana, M Blasco, P Hergueta, M Rodríguez-Téllez, R Romero, F J Pellicer, J M Herrerías. Modification of pepsinogen I levels and their correlation with gastrointestinal injury after administration of dexibuprofen, ibuprofen or diclofenac: a randomized, open-label, controlled clinical trial.
International journal of clinical pharmacology and therapeutics.
2006 Apr; 44(4):154-62. doi:
10.5414/cpp44154. [PMID: 16625984] - Nikhil K Basu, Shigeki Kubota, Meselhy R Meselhy, Marco Ciotti, Bhabadeb Chowdhury, Masao Hartori, Ida S Owens. Gastrointestinally distributed UDP-glucuronosyltransferase 1A10, which metabolizes estrogens and nonsteroidal anti-inflammatory drugs, depends upon phosphorylation.
The Journal of biological chemistry.
2004 Jul; 279(27):28320-9. doi:
10.1074/jbc.m401396200. [PMID: 15117964] - Yi-Fen Pai, Chun-Chi Lin, Chuen-Ying Liu. Optimization of sample stacking for the simultaneous determination of nonsteroidal anti-inflammatory drugs with a wall-coated histidine capillary column.
Electrophoresis.
2004 Feb; 25(4-5):569-77. doi:
10.1002/elps.200305780. [PMID: 14981683] - A S Bourinbaiar, S Lee-Huang. The non-steroidal anti-inflammatory drug, indomethacin, as an inhibitor of HIV replication.
FEBS letters.
1995 Feb; 360(1):85-8. doi:
10.1016/0014-5793(95)00057-g. [PMID: 7875307] - D Siebler, A Kinawi. [Binding of racemic indoprofen and its enantiomers to human serum albumin].
Arzneimittel-Forschung.
1989 Jun; 39(6):659-60. doi:
NULL. [PMID: 2775332] - R García-Ortiz, G Campos, G Silva, M Gómez, C Uribe, O Herrera. [Indoprofen in chronic intermittent peritoneal dialysis: effects in the clearance of small molecules and protein loss].
Revista medica de Chile.
1989 May; 117(5):528-33. doi:
NULL. [PMID: 2519164] - M Kurowski, A Schiemann, D Siebler. Transsynovial kinetics of indoprofen in patients with rheumatoid arthritis and cyclooxygenase-inhibition in vitro.
International journal of clinical pharmacology research.
1988; 8(4):287-93. doi:
NULL. [PMID: 3141302] - D Royston, J S Fleming, T Krausz. The non-steroidal anti-inflammatory agent, indoprofen, does not protect against hydrochloric acid induced lung injury in the rat.
Acta anaesthesiologica Scandinavica.
1986 Oct; 30(7):533-7. doi:
10.1111/j.1399-6576.1986.tb02470.x. [PMID: 3544643] - E Vinge, S Björkman. Compared effects of the two antiinflammatory drugs indoprofen and lonazolac on thromboxane generation and on platelet aggregation, related to plasma concentrations after single oral doses.
Acta pharmacologica et toxicologica.
1986 Sep; 59(3):165-74. doi:
10.1111/j.1600-0773.1986.tb00150.x. [PMID: 3799197] - C Zona, G Roscetti, F Venturelli, L G Roda. Effect of different parameters on the binding of two anti-inflammatory drugs to human serum albumin.
Pharmacology, biochemistry, and behavior.
1986 Apr; 24(4):1031-7. doi:
10.1016/0091-3057(86)90452-1. [PMID: 3714761] - S Björkman. Determination of the enantiomers of indoprofen in blood plasma by high-performance liquid chromatography after rapid derivatization by means of ethyl chloroformate.
Journal of chromatography.
1985 May; 339(2):339-46. doi:
10.1016/s0378-4347(00)84661-7. [PMID: 4008573] - G Micieli, D Piazza, E Sinforiani, A Cavallini, M Trucco, S Gabellini, A Mancuso, C Pacchetti. Antimigraine drugs in the management of daily chronic headaches: clinical profiles of responsive patients.
Cephalalgia : an international journal of headache.
1985 May; 5 Suppl 2(?):219-24. doi:
10.1177/03331024850050s243. [PMID: 4016938] - M Kurowski. Pharmacokinetics of indoprofen in elderly patients following repeated oral administration.
International journal of clinical pharmacology research.
1985; 5(4):255-63. doi:
NULL. [PMID: 4055168] - N H Persson, D Bergqvist, A Melander, B Zederfelt. Comparison of a narcotic (oxicone) and a non-narcotic anti-inflammatory analgesic (indoprofen) in the treatment of renal colic.
Acta chirurgica Scandinavica.
1985; 151(2):105-8. doi:
. [PMID: 3890435] - V Tamassia, M G Jannuzzo, E Moro, S Stegnjaich, W Groppi, F B Nicolis. Pharmacokinetics of the enantiomers of indoprofen in man.
International journal of clinical pharmacology research.
1984; 4(3):223-30. doi:
NULL. [PMID: 6490241] - A Pellegrini, B Massidda, P Pellegrini, E Defraia, A Usai, L Parrinello, G Bruni, G Rigamonti, G Sacchetti. Effect of i.v. indoprofen on cancer pain and serum prolactin and growth hormone levels--a controlled pharmacologic study vs i. m. morphine and placebo.
International journal of clinical pharmacology, therapy, and toxicology.
1983 Sep; 21(9):483-6. doi:
NULL. [PMID: 6354944] - K Juni, E A Nieves, J H Perrin. Some novel observations of a drug (indoprofen)--albumin interaction.
Biopharmaceutics & drug disposition.
1983 Jan; 4(1):1-7. doi:
10.1002/bdd.2510040103. [PMID: 6838999] - B Torchi, U Villani, G Bruni, M Lavezzari, V Mandelli. Intravenous indoprofen in the management of renal colic.
International journal of clinical pharmacology research.
1983; 3(3):167-73. doi:
NULL. [PMID: 6384073] - K F Benitz, R F Mankes. Renal effects of indoprofen in rhesus monkeys.
Arzneimittel-Forschung.
1982; 32(7):742-5. doi:
NULL. [PMID: 6889875] - N Christophidis, E C Huskisson. Intra-articular drug therapy in rheumatoid arthritis. A study with indoprofen.
Rheumatology international.
1982; 2(3):129-32. doi:
10.1007/bf00541165. [PMID: 7163733] - E C Huskisson, J Scott, N Christophidis. How frequently should anti-inflammatory drugs be given? A study with indoprofen.
Rheumatology and rehabilitation.
1981 Aug; 20(3):174-6. doi:
10.1093/rheumatology/20.3.174. [PMID: 7025175] - E Wåhlin-Boll, B Brantmark, A Hanson, A Melander, C Nilsson. High-pressure liquid chromatographic determination of acetylsalicylic acid, salicylic acid, diflunisal, indomethacin, indoprofen and indobufen.
European journal of clinical pharmacology.
1981; 20(5):375-8. doi:
10.1007/bf00615408. [PMID: 7286048] - V Tamassia. Human pharmacokinetics of indoprofen.
European journal of rheumatology and inflammation.
1981; 4(1):11-5. doi:
NULL. [PMID: 7341274] - A Melander, E Wåhlin-Boll. Interaction of glipizide and indoprofen.
European journal of rheumatology and inflammation.
1981; 4(1):22-5. doi:
NULL. [PMID: 7341277] - L Wibell, P Nilsson, B Lindström. Kinetics of indoprofen in patients with renal insufficiency (a preliminary report).
European journal of rheumatology and inflammation.
1981; 4(1):16-21. doi:
NULL. [PMID: 7341276] - M Passeri, G Ferretti, C Monica, A Fanfani, N Bergamini. Study of the possible interactions of indoprofen on the diuretic effect of furosemide.
European journal of rheumatology and inflammation.
1981; 4(1):36-40. doi:
NULL. [PMID: 7042360] - M A Cagianelli, V Mioni, N Bergamini. Evaluation of the long-term efficacy and safety of indoprofen in rheumatoid arthritis and osteoarthritis patients.
European journal of rheumatology and inflammation.
1981; 4(1):144-50. doi:
NULL. [PMID: 7341275] - K Lanbeck, B Lindström, L Wibell. High-performance liquid chromatographic determination of indoprofen in plasma and urine.
Journal of chromatography.
1980 May; 182(2):262-6. doi:
10.1016/s0378-4347(00)81634-5. [PMID: 7380920] - I Caruso, E Moro, C Patrono, G Sacchetti, V Tamassia, G P Tosolini. Plasma and synovial fluid pharmacokinetics and prostaglandin inhibitory effect of indoprofen in patients with rheumatoid arthritis.
Scandinavian journal of rheumatology.
1980; 9(2):123-6. doi:
10.3109/03009748009098141. [PMID: 7433927] - G C Goldaniga, L Montesanti, E Moro, E Pianezzola, G Valzelli. Pharmacokinetics and metabolism of indoprofen in the hamster.
Arzneimittel-Forschung.
1980; 30(10):1654-8. doi:
NULL. [PMID: 7192105] - A Melander, E Wåhlin-Boll. Kinetic interaction of glipizide and indoprofen in healthy volunteers.
Acta endocrinologica. Supplementum.
1980; 239(?):9-10. doi:
NULL. [PMID: 6933822] - D B Lakings, C Lizarraga, W J Haggerty, M J Williamson. High-performance liquid chromatographic microdetermination of indoprofen in human milk.
Journal of pharmaceutical sciences.
1979 Sep; 68(9):1113-6. doi:
10.1002/jps.2600680914. [PMID: 501531] - V G Stygles, R A Commassaris, R H Rech, J B Hook. The effect of indoprofen on phenylquinone-writhing and prostaglandin synthesis.
Archives internationales de pharmacodynamie et de therapie.
1978 Sep; 235(1):43-50. doi:
NULL. [PMID: 736691] - G Sacchetti, G C Ferrati, L Parrinello, A Salami. Kinetics of analgesic response in man; an example with two non-steroidal anti-inflammatory analgesic drugs.
The Journal of international medical research.
1978; 6(4):312-6. doi:
10.1177/030006057800600409. [PMID: 357233]