SULFISOMIDINE (BioDeep_00000271140)

   


代谢物信息卡片


SULFISOMIDINE

化学式: C12H14N4O2S (278.0837424)
中文名称: 磺胺索嘧啶
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC1=CC(=NC(=N1)C)NS(=O)(=O)C2=CC=C(C=C2)N
InChI: InChI=1S/C12H14N4O2S/c1-8-7-12(15-9(2)14-8)16-19(17,18)11-5-3-10(13)4-6-11/h3-7H,13H2,1-2H3,(H,14,15,16)

描述信息

J - Antiinfectives for systemic use > J01 - Antibacterials for systemic use > J01E - Sulfonamides and trimethoprim > J01EB - Short-acting sulfonamides
C254 - Anti-Infective Agent > C29739 - Sulfonamide Anti-Infective Agent
D000890 - Anti-Infective Agents > D013424 - Sulfanilamides

同义名列表

1 个代谢物同义名

SULFISOMIDINE



数据库引用编号

8 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
  • Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology. 2019 11; 96(5):629-640. doi: 10.1124/mol.119.115964. [PMID: 31515284]
  • Zuhal Alim, Deryanur Kilic, Zeynep Koksal, Sukru Beydemir, Hasan Ozdemir. Assessment of the inhibitory effects and molecular docking of some sulfonamides on human serum paraoxonase 1. Journal of biochemical and molecular toxicology. 2017 Oct; 31(10):. doi: 10.1002/jbt.21950. [PMID: 28665493]
  • Jadwiga Prokopczyk, Ewa Kaminska. [Drugs and breastfeeding]. Medycyna wieku rozwojowego. 2002 Apr; 6(2):135-44. doi: NULL. [PMID: 12426458]
  • T Sakane, M Akizuki, S Yamashita, H Sezaki, T Nadai. Direct drug transport from the rat nasal cavity to the cerebrospinal fluid: the relation to the dissociation of the drug. The Journal of pharmacy and pharmacology. 1994 May; 46(5):378-9. doi: 10.1111/j.2042-7158.1994.tb03817.x. [PMID: 8083811]
  • S P Boom, A C Wouterse, T B Vree, C A Van Ginneken, F G Russel. Renal tubular excretion of the N4-acetyl metabolites of sulphasomidine and sulphadimethoxine in the dog. The Journal of pharmacy and pharmacology. 1993 Jul; 45(7):614-7. doi: 10.1111/j.2042-7158.1993.tb05663.x. [PMID: 8105055]
  • H Van Gogh, J M Van Deurzen, C T Van Duin, A S Van Miert. Influence of gestation on the pharmacokinetics of four sulphonamides in goats. Research in veterinary science. 1990 Mar; 48(2):152-7. doi: . [PMID: 2333421]
  • J N Bruun, J E Bredesen, P Kierulf, P K Lunde. Pharmacokinetic studies of antibacterial agents using the suction blister method. Scandinavian journal of infectious diseases. Supplementum. 1990; 74(?):49-53. doi: NULL. [PMID: 2097719]
  • A D Watson, H van Gogh, E J van Deurzen, C T van Duin, A S van Miert. Pharmacokinetics of three sulphonamides in ruminant and preruminant kids. Research in veterinary science. 1987 Sep; 43(2):208-16. doi: 10.1016/s0034-5288(18)30775-6. [PMID: 3685634]
  • I von Zabern, R Nolte, H Przyklenk, W Vogt. Effect of different sulfonamides on the human serum complement system. International archives of allergy and applied immunology. 1985; 76(3):205-13. doi: 10.1159/000233693. [PMID: 3918940]
  • T B Vree, Y A Hekster, M W Tijhuis, M Baakman, M J Oosterbaan, E F Termond. Effects of methoxy groups in the NI-substituent of sulfonamides on the pathways of elimination in man. The acetylation-deacetylation equilibrium and mechanisms of renal excretion of sulfisomidine, sulfamethomidine and sulfadimethoxine. Pharmaceutisch weekblad. Scientific edition. 1984 Aug; 6(4):150-6. doi: 10.1007/bf01954042. [PMID: 6483571]
  • A Melander, P O Bitzén, S Olsson. Therapeutic equivalence of sulfaisodimidine 2 g twice daily and 1 g four times daily in lower urinary tract infections. Acta medica Scandinavica. 1982; 211(5):361-4. doi: 10.1111/j.0954-6820.1982.tb01962.x. [PMID: 7051761]
  • G Heimann, J Mensah-Kordieh, B Roth, E Gladtke. [Enteral absorption of sulfasomidine depending on age (author's transl)]. Arzneimittel-Forschung. 1978; 28(5):861-4. doi: NULL. [PMID: 581965]
  • C Simon, V Malerczyk, B Tenschert, F Möhlenbeck. [The geriatric pharmacology of cefazolin, cefradin and sulfisomidine]. Arzneimittel-Forschung. 1976; 26(7):1377-82. doi: . [PMID: 1036929]
  • K J Freundt, P Kuttner, W Dreher. Specifity and sensitivity of the inhibition of drug metabolism following inhalation of carbon disulphide-air mixtures. Arzneimittel-Forschung. 1976; 26(5):793-9. doi: NULL. [PMID: 989352]
  • A Melander, E Wåhlin, K Danielson, C Rerup. On the influence of concomitant food intake on sulfonamide bioavailability. Acta medica Scandinavica. 1976; 200(6):497-500. doi: 10.1111/j.0954-6820.1976.tb08272.x. [PMID: 1015360]
  • B Hellman. Potentiating effects of drugs on the binding of glibenclamide to pancreatic beta cells. Metabolism: clinical and experimental. 1974 Sep; 23(9):839-46. doi: 10.1016/0026-0495(74)90117-6. [PMID: 4212254]
  • E A Jackson, D C McLeod. Pharmacokinetics and dosing of antimicrobial agents in renal impairment, Part II. American journal of hospital pharmacy. 1974 Feb; 31(2):137-48. doi: NULL. [PMID: 4815846]
  • H Bräunlich, F K Splinter. [Age-related differences in the pharmacokinetic behavior of short-time sulfonamides in rats with special reference to the protein binding rate]. Acta biologica et medica Germanica. 1973; 31(3):435-47. doi: NULL. [PMID: 4801264]
  • T Fujita. Hydrophobic bonding of sulfonamide drugs with serum albumin. Journal of medicinal chemistry. 1972 Oct; 15(10):1049-56. doi: 10.1021/jm00280a014. [PMID: 4672194]
  • K A McMahon, W J O'Reilly. Pharmacokinetics of three sulfonamides in the rabbit. Journal of pharmaceutical sciences. 1972 Apr; 61(4):518-23. doi: 10.1002/jps.2600610404. [PMID: 5014307]
  • T Urban. Transferable multiple drug resistance of shigella strains isolated in Sweden. Scandinavian journal of infectious diseases. 1972; 4(3):221-7. doi: 10.3109/inf.1972.4.issue-3.08. [PMID: 4565771]
  • M Jonsson, L Rutberg, G Tunevall. Transferable resistance to antibiotics in gram-negative bacteria isolated in a hospital for infectious diseases. II. Frequency of R factors and their transmission between patients and personnel in a salmonella-shigella ward. Scandinavian journal of infectious diseases. 1972; 4(3):209-19. doi: 10.3109/inf.1972.4.issue-3.07. [PMID: 4485602]
  • F P Meyer. [Problem of interaction between proteins and sulfanilamides]. Acta biologica et medica Germanica. 1972; 28(1):21-5. doi: NULL. [PMID: 5048185]
  • B Krauer. [Elimination kinetics of two sulfonamides in children with and without phenobarbital medication; a comparative study]. Schweizerische medizinische Wochenschrift. 1971 May; 101(19):668-71. doi: NULL. [PMID: 5142850]
  • T Arita, R Hori, M Takada, S Akuzu, A Misawa. Transformation and excretion of drugs in biological systems. VI. Correlation between renal excretion and biotransformation of sulfisomidine and sulfamethizole. Chemical & pharmaceutical bulletin. 1971 May; 19(5):937-43. doi: 10.1248/cpb.19.937. [PMID: 5557930]
  • K F Funk. [Tubular reabsorption of sulfanilamides in rats]. Acta biologica et medica Germanica. 1971; 26(6):1259-60. doi: NULL. [PMID: 5153316]
  • K F Funk. [Effect of protein binding on the pharmacokinetics of sulfanilamides in rats]. Acta biologica et medica Germanica. 1971; 27(3):611-7. doi: NULL. [PMID: 5147704]
  • K F Funk, W Oelssner, F P Meyer. [Resorption and elimination of N4-substituted sulfanilamides in rats]. Die Pharmazie. 1970 Sep; 25(9):554-6. doi: NULL. [PMID: 5486684]
  • K F Funk, W Oelssner. [Mechanism of hydrolysis of N4-substituted sulfanilamides in vivo]. Die Pharmazie. 1970 Sep; 25(9):557-60. doi: NULL. [PMID: 4098821]
  • E Reimerdes, J H Thumim. [Behavior of sulfanilamides in the body]. Arzneimittel-Forschung. 1970 Sep; 20(9):1171-9. doi: NULL. [PMID: 4922318]
  • S R Walker. The influence of protein binding on the excretion of some sulphanilamidopyrimidines in man. The Journal of pharmacy and pharmacology. 1970 Aug; 22(8):574-7. doi: 10.1111/j.2042-7158.1970.tb10573.x. [PMID: 4394530]
  • B Krauer. [Daily fluctuations in the velocity of elimination of 2 sulfonamides in children beyond the 1st year of life]. Internationale Zeitschrift fur klinische Pharmakologie, Therapie, und Toxikologie. International journal of clinical pharmacology, therapy, and toxicology. 1970 May; 3(2):117-21. doi: NULL. [PMID: 5425953]
  • K F Funk. [Pharmacokinetic model studies on the rat. The single-chamber model of the organism]. Acta biologica et medica Germanica. 1970; 25(1):151-60. doi: NULL. [PMID: 5489670]
  • B Krauer. [Effect of posture on elimination of sulfisomidine]. Schweizerische medizinische Wochenschrift. 1969 Dec; 99(52):1896-8. doi: NULL. [PMID: 5385474]
  • J W Bridges, S R Walker, R T Williams. Species differences in the metabolism and excretion of sulphasomidine and sulphamethomidine. The Biochemical journal. 1969 Jan; 111(2):173-9. doi: 10.1042/bj1110173. [PMID: 4974221]
  • K J Freundt, P Kuttner. [Oxidative drug metabolism following low carbon disulphide concentrations]. Naunyn-Schmiedebergs Archiv fur Pharmakologie. 1969; 264(3):232-3. doi: 10.1007/bf02431429. [PMID: 4242384]
  • M J Mattila, H Tiitinen, E Alhava. Acetylation pattern of different sulphonamides in rapid and slow isoniazid inactivators. Annales medicinae experimentalis et biologiae Fenniae. 1969; 47(4):308-15. doi: NULL. [PMID: 5384058]
  • B Krauer, L Dettli. Diurnal variations in the elimination rate of sulfisomidine in children during the first year of life. Chemotherapy. 1969; 14(1):1-6. doi: 10.1159/000220606. [PMID: 5772660]
  • W Oelssner, K F Funk. [Experimental studies of some new halogenated sulfapyrimidines]. Arzneimittel-Forschung. 1966 Sep; 16(9):1134-40. doi: NULL. [PMID: 6014731]
  • F J DICARLO, L J HAYNES, N J SLIVER, C B COUTINHO, G E PHILLIPS. EFFECTS OF METHENAMINE ON THE METABOLISM OF N1-(2,6-DIMETHYL-4-PYRIMIDINYL) SULFANILAMIDE (SULFISOMIDINE) BY THE RAT AND THE RABBIT. Chemotherapia. 1964 ; 25(?):255-64. doi: 10.1159/000220320. [PMID: 14291465]
  • C M SMYTHE. MANAGEMENT ACUTE PYELONEPHRITIS. Modern treatment. 1964 Jan; 1(?):63-77. doi: NULL. [PMID: 14161717]
  • F J DiCarlo, N J Sliver, C B Coutinho, L J Haynes, G E Phillips. Effect of methenamine on the metabolism of N-1-(2,6-dimethyl-4-pyrimidinyl) sulfanilamide (sulfisomidine) by humans. Chemotherapia. 1964 196; 9(3):129-43. doi: 10.1159/000220354. [PMID: 5834967]
  • E NELSON. KINETICS OF THE ACETYLATION AND EXCRETION OF SULFONAMIDES AND A COMPARISON OF TWO MODELS. Antibiotica et chemotherapia. Fortschritte. Advances. Progres. 1964; 12(?):29-40. doi: 10.1159/000386727. [PMID: 14262397]
  • K FLEISCHER, E GLADTKE. [STUDIES ON SERUM CONCENTRATION AFTER INTRACONCHAL APPLICATION OF DRUGS]. Archiv fur Ohren-, Nasen- und Kehlkopfheilkunde. 1963 Dec; 182(?):485-8. doi: NULL. [PMID: 14116985]
  • E A ANDERSON, E G KNOUFF, A G BOWER. Sulfisomidine in the treatment of pertussis. California medicine. 1956 May; 84(5):329-30. doi: NULL. [PMID: 13316533]