ethyl loflazepate (BioDeep_00000271126)

   


代谢物信息卡片


ethyl 7-chloro-5-(2-fluorophenyl)-2-oxo-1,3-dihydro-1,4-benzodiazepine-3-carboxylate

化学式: C18H14ClFN2O3 (360.0676936)
中文名称: 来克伦
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CCOC(=O)C(C(=O)1)N=C(c(c3)c(F)ccc3)c(c2)c(ccc(Cl)2)N1
InChI: InChI=1S/C18H14ClFN2O3/c1-2-25-18(24)16-17(23)21-14-8-7-10(19)9-12(14)15(22-16)11-5-3-4-6-13(11)20/h3-9,16H,2H2,1H3,(H,21,23)

描述信息

D002492 - Central Nervous System Depressants > D014149 - Tranquilizing Agents > D014151 - Anti-Anxiety Agents
D002491 - Central Nervous System Agents > D011619 - Psychotropic Drugs > D014149 - Tranquilizing Agents
N - Nervous system > N05 - Psycholeptics > N05B - Anxiolytics > N05BA - Benzodiazepine derivatives
C78272 - Agent Affecting Nervous System > C29756 - Sedative and Hypnotic > C1012 - Benzodiazepine
D002491 - Central Nervous System Agents > D002492 - Central Nervous System Depressants
C78272 - Agent Affecting Nervous System > C28197 - Antianxiety Agent

同义名列表

2 个代谢物同义名

ethyl 7-chloro-5-(2-fluorophenyl)-2-oxo-1,3-dihydro-1,4-benzodiazepine-3-carboxylate; ethyl loflazepate



数据库引用编号

12 个数据库交叉引用编号

分类词条

相关代谢途径

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代谢反应

0 个相关的代谢反应过程信息。

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INOH(0)

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在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Hyung Seok Yoo, Francis Sahngun Nahm, Kyoung Hoon Yim, Jee Youn Moon, Yung Suk Kim, Pyung Bok Lee. Pregnancy in woman with spinal cord stimulator for complex regional pain syndrome: a case report and review of the literature. The Korean journal of pain. 2010 Dec; 23(4):266-9. doi: 10.3344/kjp.2010.23.4.266. [PMID: 21217892]
  • Guillaume Hoizey, Anne Goglin, Jean-Marc Malinovsky, Arnaud Robinet, Laurent Binet, Matthieu L Kaltenbach, Hervé Millart, Denis Lamiable. Specific and sensitive analysis of nefopam and its main metabolite desmethyl-nefopam in human plasma by liquid chromatography-ion trap tandem mass spectrometry. Journal of pharmaceutical and biomedical analysis. 2006 Nov; 42(5):593-600. doi: 10.1016/j.jpba.2006.05.024. [PMID: 16842961]
  • Yoshito Kamijo, Izumi Hayashi, Takashi Nishikawa, Kuniko Yoshimura, Kazui Soma. Pharmacokinetics of the active metabolites of ethyl loflazepate in elderly patients who died of asphyxia associated with benzodiazepine-related toxicity. Journal of analytical toxicology. 2005 Mar; 29(2):140-4. doi: 10.1093/jat/29.2.140. [PMID: 15902983]
  • H Sakaino. The biochemical study of intermaxillary fixation (IMF) stress in oral surgery inpatients. The Kurume medical journal. 2001; 48(1):71-7. doi: 10.2739/kurumemedj.48.71. [PMID: 11402624]
  • B B Ba, A Iliadis, J P Cano. Pharmacokinetic modeling of ethyl loflazepate (Victan) and its main active metabolites. Annals of biomedical engineering. 1989; 17(6):633-46. doi: 10.1007/bf02367467. [PMID: 2574017]
  • B B Ba, A Iliadis, A Durand, Y Berger, J Necciari, J P Cano. Effect of renal failure on the pharmacokinetics of ethyl loflazepate (Victan) in man. Fundamental & clinical pharmacology. 1989; 3(1):11-7. doi: 10.1111/j.1472-8206.1989.tb00025.x. [PMID: 2714728]
  • E J Fazackerley, N P Randall, B J Pleuvry, I Bradbrook, G E Mawer. The respiratory effects of oral ethyl loflazepate in volunteers. British journal of clinical pharmacology. 1987 Feb; 23(2):183-7. doi: 10.1111/j.1365-2125.1987.tb03027.x. [PMID: 2881572]
  • H Davi, J Guyonnet, J Necciari, W Cautreels. Determination of circulating ethyl loflazepate metabolites in the baboon by radio-high-performance liquid chromatography with injection of crude plasma samples: comparison with solvent extraction and thin-layer chromatography. Journal of chromatography. 1985 Jul; 342(1):159-65. doi: 10.1016/s0378-4347(00)84498-9. [PMID: 2864352]
  • H Davi, J Guyonnet, Y Sales, W Cautreels. Metabolism of ethyl loflazepate in the rat, the dog, the baboon and in man. Arzneimittel-Forschung. 1985; 35(7):1061-5. doi: NULL. [PMID: 2864933]
  • J P Chambon, A Perio, H Demarne, A Hallot, R Dantzer, R Roncucci, K Bizière. Ethyl loflazepate: a prodrug from the benzodiazepine series designed to dissociate anxiolytic and sedative activities. Arzneimittel-Forschung. 1985; 35(10):1573-7. doi: NULL. [PMID: 2866771]
  • J P Cano, Y C Sumirtapura, W Cautreels, Y Sales. Analysis of the metabolites of ethyl loflazepate by gas chromatography with electron-capture detection. Journal of chromatography. 1981 Dec; 226(2):413-22. doi: 10.1016/s0378-4347(00)86075-2. [PMID: 6119320]
  • W Cautreels, J P Jeanniot. Quantitative analysis of CM 6912 (ethyl loflazepate) and its metabolites in plasma and urine by chemical ionization gas chromatography mass spectrometry. Application to pharmacokinetic studies in man. Biomedical mass spectrometry. 1980 Nov; 7(11-12):565-71. doi: 10.1002/bms.1200071124. [PMID: 6112027]