Trifluperidol (BioDeep_00000271124)

   


代谢物信息卡片


Trifluperidol

化学式: C22H23F4NO2 (409.1664826)
中文名称: 三氟哌利多
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1CN(CCC1(C2=CC(=CC=C2)C(F)(F)F)O)CCCC(=O)C3=CC=C(C=C3)F
InChI: InChI=1S/C22H23F4NO2/c23-19-8-6-16(7-9-19)20(28)5-2-12-27-13-10-21(29,11-14-27)17-3-1-4-18(15-17)22(24,25)26/h1,3-4,6-9,15,29H,2,5,10-14H2

描述信息

D002492 - Central Nervous System Depressants > D014149 - Tranquilizing Agents > D014150 - Antipsychotic Agents
D002491 - Central Nervous System Agents > D011619 - Psychotropic Drugs > D014149 - Tranquilizing Agents
N - Nervous system > N05 - Psycholeptics > N05A - Antipsychotics > N05AD - Butyrophenone derivatives
D018377 - Neurotransmitter Agents > D015259 - Dopamine Agents > D018492 - Dopamine Antagonists
D002491 - Central Nervous System Agents > D002492 - Central Nervous System Depressants
C78272 - Agent Affecting Nervous System > C29710 - Antipsychotic Agent

同义名列表

1 个代谢物同义名

Trifluperidol



数据库引用编号

8 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Souradeep Basu, Tiffany Mak, Rachel Ulferts, Mary Wu, Tom Deegan, Ryo Fujisawa, Kang Wei Tan, Chew Theng Lim, Clovis Basier, Berta Canal, Joseph F Curran, Lucy S Drury, Allison W McClure, Emma L Roberts, Florian Weissmann, Theresa U Zeisner, Rupert Beale, Victoria H Cowling, Michael Howell, Karim Labib, John F X Diffley. Identifying SARS-CoV-2 antiviral compounds by screening for small molecule inhibitors of Nsp14 RNA cap methyltransferase. The Biochemical journal. 2021 07; 478(13):2481-2497. doi: 10.1042/bcj20210219. [PMID: 34198328]
  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
  • Daniel J Warner, Hongming Chen, Louis-David Cantin, J Gerry Kenna, Simone Stahl, Clare L Walker, Tobias Noeske. Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification. Drug metabolism and disposition: the biological fate of chemicals. 2012 Dec; 40(12):2332-41. doi: 10.1124/dmd.112.047068. [PMID: 22961681]
  • F Bischof, A Melms, M Fetter. Persistent cerebellar deterioration in a patient with lobar pneumonia under lithium, carbamazepine, and trifluperidol treatment. European psychiatry : the journal of the Association of European Psychiatrists. 1999 Jun; 14(3):175-6. doi: 10.1016/s0924-9338(99)80738-x. [PMID: 10572345]
  • L Przyborowski, G Misztal. [HPLC-determination of trifluperidol in blood plasma]. Die Pharmazie. 1991 Nov; 46(11):813-4. doi: NULL. [PMID: 1811235]
  • K Tárnoky, J Szenohradszky, G Petri. Plasma catecholamine levels in the postoperative period in complication-free and 'paralytic' ileus patients. Acta chirurgica Hungarica. 1987; 28(4):287-98. doi: NULL. [PMID: 3434085]
  • R Krüger, I Mengel, H J Kuss. Determination of benperidol in human plasma by high-performance liquid chromatography. Journal of chromatography. 1984 Nov; 311(1):109-16. doi: 10.1016/s0378-4347(00)84696-4. [PMID: 6520151]
  • H Maurer, K Pfleger. Screening procedure for detecting butyrophenone and bisfluorophenyl neuroleptics in urine using a computerized gas chromatographic-mass spectrometric technique. Journal of chromatography. 1983 Jan; 272(1):75-85. doi: 10.1016/s0378-4347(00)86104-6. [PMID: 6132926]
  • T Aimoto, M Kaida, K Numazaki, Y Masuda, T Murata. Development of tolerance to the stimulatory effect of neuroleptic butyrophenones on pituitary-adrenal activity in rats. Journal of pharmacobio-dynamics. 1981 Nov; 4(11):827-32. doi: 10.1248/bpb1978.4.827. [PMID: 6120222]
  • R Testa, E Dolfini, C Reschiotto, C Secchi, P A Biondi. GLC determination of nifedipine, a light sensitive drug, in plasma. Il Farmaco; edizione pratica. 1979 Nov; 34(11):463-73. doi: NULL. [PMID: 510525]
  • C L Hornbeck, J C Griffiths, R J Neborsky, M A Faulkner. A gas chromatographic mass spectrometric chemical ionization assay for haloperidol with selected ion monitoring. Biomedical mass spectrometry. 1979 Oct; 6(10):427-30. doi: 10.1002/bms.1200061004. [PMID: 526559]
  • M T Sobus, C E Holmlund, N F Whittaker. Effects of the hypocholesteremic agent trifluperidol on the sterol, steryl ester, and fatty acid metabolism of Saccharomyces cerevisiae. Journal of bacteriology. 1977 Jun; 130(3):1310-6. doi: 10.1128/jb.130.3.1310-1316.1977. [PMID: 324983]
  • V Máthé, G Kassay, M Tüske. [Results of glucose tolerance tests and changes in inorganic serum phosphate and potassium levels in schizophrenic patients responding to treatment with psychotropic drugs]. International pharmacopsychiatry. 1971; 6(2):111-30. doi: NULL. [PMID: 4147757]
  • P J Lewi, J J Heykants, P A Janssen. On the distribution and metabolism of neuroleptic drugs. 3. Pharmacokinetics of trifluperidol. Arzneimittel-Forschung. 1970 Nov; 20(11):1701-5. doi: NULL. [PMID: 5536974]
  • P A Janssen, F T Allewijn. The distribution of the butyrophenones haloperidol, trifluperidol, moperone, and clofluperol in rats, and its relationship with their neuroleptic activity. Arzneimittel-Forschung. 1969 Feb; 19(2):199-208. doi: NULL. [PMID: 5818759]
  • E M Acebal, H Spatz. Effect of trifluperidol (R 2498) on the urinary elimination of bufotenin in schizophrenia. International journal of neuropsychiatry. 1967 Dec; 3(6):472-6. doi: NULL. [PMID: 5583441]