Cyamemazine (BioDeep_00000271113)

   


代谢物信息卡片


Cyamemazine

化学式: C19H21N3S (323.14561060000005)
中文名称: 氰美马嗪
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC(CN(C)C)CN1c2ccccc2Sc2ccc(C#N)cc21
InChI: InChI=1S/C19H21N3S/c1-14(12-21(2)3)13-22-16-6-4-5-7-18(16)23-19-9-8-15(11-20)10-17(19)22/h4-10,14H,12-13H2,1-3H3

描述信息

N - Nervous system > N05 - Psycholeptics > N05A - Antipsychotics > N05AA - Phenothiazines with aliphatic side-chain
C308 - Immunotherapeutic Agent > C29578 - Histamine-1 Receptor Antagonist
Cyamemazine is a neuroleptic agent that contains the phenothiazine chromophore. Cyamemazine is often used as an anxiolytic. Cyamemazine is a potent 5-HT3 (Ki of 12 nM), 5-HT2A (Ki = 1.5 nM) and 5-HT2C (Ki of 75 nM) receptors antagonist with antipsychotic activity[1][2].

同义名列表

1 个代谢物同义名

Cyamemazine



数据库引用编号

14 个数据库交叉引用编号

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相关代谢途径

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代谢反应

0 个相关的代谢反应过程信息。

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0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Tiago Rosado, David Oppolzer, Belinda Cruz, Mário Barroso, Samira Varela, Victor Oliveira, Carlos Leitão, Eugenia Gallardo. Development and validation of a gas chromatography/tandem mass spectrometry method for simultaneous quantitation of several antipsychotics in human plasma and oral fluid. Rapid communications in mass spectrometry : RCM. 2018 Dec; 32(23):2081-2095. doi: 10.1002/rcm.8087. [PMID: 29448305]
  • Kristal R Tucker, Ethan R Block, Edwin S Levitan. Action potentials and amphetamine release antipsychotic drug from dopamine neuron synaptic VMAT vesicles. Proceedings of the National Academy of Sciences of the United States of America. 2015 Aug; 112(32):E4485-94. doi: 10.1073/pnas.1503766112. [PMID: 26216995]
  • Fabien Bévalot, Charline Bottinelli, Nathalie Cartiser, Laurent Fanton, Jérôme Guitton. Quantification of five compounds with heterogeneous physicochemical properties (morphine, 6-monoacetylmorphine, cyamemazine, meprobamate and caffeine) in 11 fluids and tissues, using automated solid-phase extraction and gas chromatography-tandem mass spectrometry. Journal of analytical toxicology. 2014 Jun; 38(5):256-64. doi: 10.1093/jat/bku029. [PMID: 24790060]
  • Gurmit Singh, Terry B Koerner, Samuel Benrejeb Godefroy, Claude Armand. N-demethylation of cyamemazine via non-classical Polonovski reaction and its conjugation to bovine serum albumin. Bioorganic & medicinal chemistry letters. 2012 Mar; 22(6):2160-2. doi: 10.1016/j.bmcl.2012.01.131. [PMID: 22361131]
  • Yann Hodé, Amine Benyamina, Christophe Arbus, Matthias Reimold. Active cyamemazine metabolites in patients treated with cyamemazine (Tercian®): influence on cerebral dopamine D2 and serotonin 5-HT (2A) receptor occupancy as measured by positron emission tomography (PET). Psychopharmacology. 2011 Oct; 217(3):315-21. doi: 10.1007/s00213-011-2289-1. [PMID: 21479533]
  • Frédérique Lancelin, Elsa Bourcier, Valérie Le Masson, Yolande Lemeille, Sophie Brovedani, Pascal Paubel, Marie-Liesse Piketty. Effect of cyamemazine on the steady-state plasma concentrations of risperidone and 9-hydroxyrisperidone: a preliminary retrospective study. Therapeutic drug monitoring. 2010 Dec; 32(6):757-61. doi: 10.1097/ftd.0b013e3181fa57fe. [PMID: 21068648]
  • Marjorie Chèze, Aurélie Muckensturm, Guillaume Hoizey, Gilbert Pépin, Marc Deveaux. A tendency for re-offending in drug-facilitated crime. Forensic science international. 2010 Mar; 196(1-3):14-7. doi: 10.1016/j.forsciint.2009.12.037. [PMID: 20116946]
  • Linda Hanssens, Gilbert L'Italien, Jean-Yves Loze, Ronald N Marcus, Miranda Pans, Wendy Kerselaers. The effect of antipsychotic medication on sexual function and serum prolactin levels in community-treated schizophrenic patients: results from the Schizophrenia Trial of Aripiprazole (STAR) study (NCT00237913). BMC psychiatry. 2008 Dec; 8(?):95. doi: 10.1186/1471-244x-8-95. [PMID: 19102734]
  • Bernard Marc, Antoine Martis, Céline Moreau, Gilles Arlie, Pascal Kintz, Johan Leclerc. [Acute Datura stramonium poisoning in an emergency department]. Presse medicale (Paris, France : 1983). 2007 Oct; 36(10 Pt 1):1399-403. doi: 10.1016/j.lpm.2007.04.017. [PMID: 17560071]
  • Frédérique Lancelin, Linda Kraoul, Nadia Flatischler, Sophie Brovedani-Rousset, Marie-Liesse Piketty. False-positive results in the detection of methadone in urines of patients treated with psychotropic substances. Clinical chemistry. 2005 Nov; 51(11):2176-7. doi: 10.1373/clinchem.2005.055350. [PMID: 16244295]
  • Y Hodé, M Reimold, A Demazières, G Reischl, F Bayle, P Nuss, A Hameg, M Dib, J P Macher. A positron emission tomography (PET) study of cerebral dopamine D2 and serotonine 5-HT2A receptor occupancy in patients treated with cyamemazine (Tercian). Psychopharmacology. 2005 Jul; 180(2):377-84. doi: 10.1007/s00213-005-2172-z. [PMID: 15948013]
  • Paulo Filipe, João N Silva, Josiane Haigle, João P Freitas, Afonso Fernandes, René Santus, Patrice Morlière. Contrasting action of flavonoids on phototoxic effects induced in human skin fibroblasts by UVA alone or UVA plus cyamemazine, a phototoxic neuroleptic. Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology. 2005 May; 4(5):420-8. doi: 10.1039/b416811a. [PMID: 15875075]
  • Patrice Morlière, Josiane Haigle, Karim Aissani, Paulo Filipe, João Nuno Silva, René Santus. An insight into the mechanisms of the phototoxic response induced by cyamemazine in cultured fibroblasts and keratinocytes. Photochemistry and photobiology. 2004 Feb; 79(2):163-71. doi: 10.1562/0031-8655(2004)079<0163:aiitmo>2.0.co;2. [PMID: 15068029]
  • A J Remy, D Larrey, G P Pageaux, J Ribstein, J Ramos, H Michel. Cross hepatotoxicity between tricyclic antidepressants and phenothiazines. European journal of gastroenterology & hepatology. 1995 Apr; 7(4):373-6. doi: NULL. [PMID: 7600146]
  • J Gaillot, A Bieder, J Ghaye Roquet, A Le Liboux, L Mazeau. [A cyamepromazine-trifluoperazine combination: changes in metabolism during chronic administration in the rat]. Therapie. 1975 Mar; 30(2):267-76. doi: NULL. [PMID: 240218]