Clomethiazole (BioDeep_00000271110)
代谢物信息卡片
Clomethiazole
化学式: C6H8ClNS (161.00659579999999)
中文名称: 氯甲唑
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC1=C(CCCl)SC=N1
InChI: InChI=1S/C6H8ClNS/c1-5-6(2-3-7)9-4-8-5/h4H,2-3H2,1H3
描述信息
D002491 - Central Nervous System Agents > D002492 - Central Nervous System Depressants > D006993 - Hypnotics and Sedatives
D018377 - Neurotransmitter Agents > D018682 - GABA Agents > D018757 - GABA Modulators
D002491 - Central Nervous System Agents > D018696 - Neuroprotective Agents
N - Nervous system > N05 - Psycholeptics > N05C - Hypnotics and sedatives
C78272 - Agent Affecting Nervous System > C29756 - Sedative and Hypnotic
D002491 - Central Nervous System Agents > D000927 - Anticonvulsants
D020011 - Protective Agents
Chlormethiazole is an potent and orally active GABAA?agonist[1]. Chlormethiazole inhibits cytochrome P450 isoforms: CYP2A6 and CYP2E1 in human liver microsomes. Chlormethiazole is an anticonvulsant agent and has the potential for treating convulsive status epilepticus[2].
同义名列表
1 个代谢物同义名
数据库引用编号
15 个数据库交叉引用编号
- ChEBI: CHEBI:92875
- KEGGdrug: D07330
- PubChem: 10783
- Metlin: METLIN1871
- DrugBank: DB06470
- ChEMBL: CHEMBL315795
- MeSH: Chlormethiazole
- CAS: 533-45-9
- MoNA: WA000428
- MoNA: WA000427
- MoNA: WA000426
- MoNA: WA000425
- MoNA: WA000424
- PMhub: MS000001486
- medchemexpress: HY-129105
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
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- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
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文献列表
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Molecular pharmacology.
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10.3109/00498258209038953. [PMID: 7170791] - M B Kristoffersen, E K Kjaer Hansen, K G Jostell, O Stockman. Chlormethiazole (Heminevrin), pethidine and nitrous oxide as compared to halothane for general anesthesia.
Acta anaesthesiologica Scandinavica.
1982 Aug; 26(4):337-43. doi:
10.1111/j.1399-6576.1982.tb01778.x. [PMID: 7124309] - A Grupe, G Spiteller. Unexpected metabolites produced from clomethiazole.
Journal of chromatography.
1982 Jul; 230(2):335-44. doi:
10.1016/s0378-4347(00)80483-1. [PMID: 7107779] - L T Seow, R G Ryall. Minimal haemolytic effects from 0.8\% chlormethiazole infusion in volunteer subjects. Chlormethiazole infusion and haemolysis.
Anaesthesia.
1982 Jun; 37(6):646-50. doi:
10.1111/j.1365-2044.1982.tb01276.x. [PMID: 7091623] - S K Majumdar. The effect of chlormethiazole on plasma adrenocorticotrophic hormone concentrations in chronic alcoholics.
European journal of clinical pharmacology.
1982; 22(4):333-5. doi:
10.1007/bf00548402. [PMID: 6286316] - S K Majumdar, G K Shaw, A D Thomson, P K Bridges. Serum cortisol concentrations and the effect of chlormethiazole on them in chronic alcoholics.
Neuropharmacology.
1981 Dec; 20(12B):1357-9. doi:
NULL. [PMID: 7198725] - L E Mather, W B Runciman, A H Ilsley, K R Thomson, A R Goldin. Direct measurement of chlormethiazole extraction by liver, lung and kidney in man.
British journal of clinical pharmacology.
1981 Sep; 12(3):319-25. doi:
10.1111/j.1365-2125.1981.tb01220.x. [PMID: 7295462] - T Zysset, J Bircher. Preferential reduction of first-pass elimination by ethanol. Model experiments with clomethiazole in the rabbit.
The Journal of pharmacology and experimental therapeutics.
1981 Apr; 217(1):198-203. doi:
NULL. [PMID: 7205653] - R Heipertz, C Reimer. A rapid gas-chromatographic method for the quantitative determination of clomethiazole in human serum.
Clinica chimica acta; international journal of clinical chemistry.
1981 Mar; 110(2-3):131-8. doi:
10.1016/0009-8981(81)90342-9. [PMID: 7226525] - W B Runciman, A H Ilsley, R G Ryall, K S Parkin, R Heinrich. Intravenous chlormethiazole- haemolysis with concentrated solutions.
Anaesthesia and intensive care.
1981 Feb; 9(1):34-9. doi:
10.1177/0310057x8100900105. [PMID: 7258597] - S E Tsuei, R L Nation, J Thomas. Design of infusion regimens to achieve and maintain a predetermined plasma drug level range.
Clinical pharmacology and therapeutics.
1980 Sep; 28(3):289-95. doi:
10.1038/clpt.1980.164. [PMID: 7408388] - D B Scott, D Beamish, I N Hudson, K G Jostell. Prolonged infusion of chlormethiazole in intensive care.
British journal of anaesthesia.
1980 May; 52(5):541-5. doi:
10.1093/bja/52.5.541. [PMID: 7387809] - S E Tsuei, J Thomas, R L Nation. Simultaneous quantitation of chlormethiazole and two of its metabolites in blood and plasma by gas--liquid chromatography.
Journal of chromatography.
1980 Apr; 182(1):55-62. doi:
10.1016/s0378-4347(00)81650-3. [PMID: 7380902] - R S Briggs, C M Castleden, C A Kraft. Improved hypnotic treatment using chlormethiazole and temazepam.
British medical journal.
1980 Mar; 280(6214):601-4. doi:
10.1136/bmj.280.6214.601. [PMID: 6102878] - A L Myrsten, U Rydberg, C M Ideström, R Lamble. Alcohol intoxication and hangover: modification of hangover by chlormethiazole.
Psychopharmacology.
1980; 69(2):117-25. doi:
10.1007/bf00427636. [PMID: 6779303] - D J Witts, A A Bowhay, M Garland, A E McLean, A N Exton-Smith. Studies of chlormethiazole in the elderly: pharmacokinetic aspects.
Age and ageing.
1979 Nov; 8(4):271-84. doi:
10.1093/ageing/8.4.271. [PMID: 517322] - S K Majumdar. The effect of chlormethiazole on serum gonadotrophins and testosterone in chronic alcoholics.
Current medical research and opinion.
1979; 6(3):213-6. doi:
10.1185/03007997909109425. [PMID: 520029] - M Ende, G Spiteller, G Remberg, R Heipertz. Urinary metabolites of clomethiazole. Detection and structural analysis by gas chromatography-mass spectrometry.
Arzneimittel-Forschung.
1979; 29(11):1655-8. doi:
NULL. [PMID: 543872] - S K Majumdar, G K Shaw, A D Thomson. Effect of chlormethiazole on serum prolactin.
British medical journal.
1978 Nov; 2(6147):1266-7. doi:
10.1136/bmj.2.6147.1266. [PMID: 709310] - E Klug, P Toffel. [On the detection of clomethiazole in urine (author's transl)].
Zeitschrift fur Rechtsmedizin. Journal of legal medicine.
1978 Sep; 82(1):37-41. doi:
10.1007/bf02114499. [PMID: 706846] - R J Flanagan, T D Lee, D M Rutherford. Analysis of chlormethiazole, ethchlorvynol and trichloroethanol in biological fluids by gas-liquid chromatography as an aid to the diagnosis of acute poisoning.
Journal of chromatography.
1978 Jun; 153(2):473-9. doi:
10.1016/s0021-9673(00)95507-9. [PMID: 659564] - K G Jostell, S Agurell, L E Hollister, B Wermuth. Kinetics of chlormethiazole in patients with alcohol withdrawal manifestations.
Clinical pharmacology and therapeutics.
1978 Feb; 23(2):181-7. doi:
10.1002/cpt1978232181. [PMID: 620478] - R L Nation, J Vine, E J Triggs, B Learoyd. Plasma level of chlormethiazole and two metabolites after oral administration to young and aged human subjects.
European journal of clinical pharmacology.
1977 Oct; 12(2):137-45. doi:
10.1007/bf00645135. [PMID: 923627] - R Iffland. [Therapeutic concentrations of chlormethiazol in blood and their detection (author's transl)].
Zeitschrift fur Rechtsmedizin. Journal of legal medicine.
1977 Jul; 80(1):27-33. doi:
10.1007/bf02332344. [PMID: 883424] - W Poser, S Poser, G Ritter. [Drug therapy of epilepsy].
Der Internist.
1977 Feb; 18(2):101-7. doi:
NULL. [PMID: 320143] - B M Hibbard, M Rosen. The management of severe pre-eclampsia and eclampsia.
British journal of anaesthesia.
1977 Jan; 49(1):3-9. doi:
10.1093/bja/49.1.3. [PMID: 831744] - T Dobrzański, D Pieschl. [Plasma ACTH, STH and other hormone levels in various groups under chlormethiazole, haloperidol or reserpine load in alchohol delirium, alcoholic hallucinations, and chronic alcoholism].
Psychiatrie, Neurologie, und medizinische Psychologie.
1976 Jan; 28(1):26-32. doi:
NULL. [PMID: 181772] - R L Nation, B Learoyd, J Barber, E J Triggs. The pharmacokinetics of chlormethiazole following intravenous administration in the aged.
European journal of clinical pharmacology.
1976; 10(6):407-15. doi:
10.1007/bf00563077. [PMID: 1001356] - R G Moore, A V Robertson, M P Smyth, J Thomas, J Vine. Metabolism and urinary excretion of chlormethiazole in humans.
Xenobiotica; the fate of foreign compounds in biological systems.
1975 Nov; 5(11):687-96. doi:
10.3109/00498257509056138. [PMID: 1189463] - R G Moore, E J Triggs, C A Shanks, J Thomas. Pharmacokinetics of chlormethiazole in humans.
European journal of clinical pharmacology.
1975 Jun; 8(5):353-7. doi:
10.1007/bf00562662. [PMID: 1233235] - H Kyank, H D Herre, U Retzke, H P Wilken. [Treatment of eclampsia].
Zentralblatt fur Gynakologie.
1973 Dec; 95(51):1806-12. doi:
NULL. [PMID: 4793614] - M Fischler, E P Frisch, B Ortengren. Plasma concentrations after oral administration of different pharmaceutical preparations of clomethiazole.
Acta pharmaceutica Suecica.
1973 Dec; 10(6):483-92. doi:
NULL. [PMID: 4773115]