Cimaterol (BioDeep_00000271104)

   


代谢物信息卡片


Cimaterol

化学式: C12H17N3O (219.1372)
中文名称: 西马特罗
谱图信息: 最多检出来源 Viridiplantae(plant) 100%

分子结构信息

SMILES: CC(C)NCC(C1=CC(=C(C=C1)N)C#N)O
InChI: InChI=1S/C12H17N3O/c1-8(2)15-7-12(16)9-3-4-11(14)10(5-9)6-13/h3-5,8,12,15-16H,7,14H2,1-2H3

描述信息

C78272 - Agent Affecting Nervous System > C29747 - Adrenergic Agent > C87053 - Adrenergic Agonist
D018377 - Neurotransmitter Agents > D018663 - Adrenergic Agents > D000322 - Adrenergic Agonists
CONFIDENCE standard compound; EAWAG_UCHEM_ID 3657

同义名列表

2 个代谢物同义名

Cimaterol; Cimaterol



数据库引用编号

15 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表


文献列表

  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
  • Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology. 2019 11; 96(5):629-640. doi: 10.1124/mol.119.115964. [PMID: 31515284]
  • Xiang-Dang Du, Yin-Liang Wu, Hong-Ju Yang, Ting Yang. Simultaneous determination of 10 β2-agonists in swine urine using liquid chromatography-tandem mass spectrometry and multi-walled carbon nanotubes as a reversed dispersive solid phase extraction sorbent. Journal of chromatography. A. 2012 Oct; 1260(?):25-32. doi: 10.1016/j.chroma.2012.08.066. [PMID: 22959774]
  • P Garcia, A-C Paris, J Gil, M-A Popot, Y Bonnaire. Analysis of β-agonists by HPLC/ESI-MS(n) in horse doping control. Biomedical chromatography : BMC. 2011 Jan; 25(1-2):147-54. doi: 10.1002/bmc.1562. [PMID: 21204111]
  • Jianrong Nie, Mingli Zhu, Jin Lian, Yunshan Pan, Xianglian Deng, Cuiping Hu. [Determination of fifteen beta-agonists in animal urine by high performance liquid chromatography-tandem mass spectrometry]. Se pu = Chinese journal of chromatography. 2010 Aug; 28(8):759-64. doi: 10.3724/sp.j.1123.2010.00759. [PMID: 21261043]
  • R J B Peters, J E Oosterink, A A M Stolker, C Georgakopoulos, M W F Nielen. Generic sample preparation combined with high-resolution liquid chromatography-time-of-flight mass spectrometry for unification of urine screening in doping-control laboratories. Analytical and bioanalytical chemistry. 2010 Apr; 396(7):2583-98. doi: 10.1007/s00216-010-3484-3. [PMID: 20155493]
  • F Ramos, M L Baeta, J Reis, M I N Silveira. Evaluation of the illegal use of clenbuterol in Portuguese cattle farms from drinking water, urine, hair and feed samples. Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment. 2009 Jun; 26(6):814-20. doi: 10.1080/02652030902729908. [PMID: 19680955]
  • Yanfang Shi, Ying Huang, Jianping Duan, Hongqing Chen, Guonan Chen. Field-amplified on-line sample stacking for separation and determination of cimaterol, clenbuterol and salbutamol using capillary electrophoresis. Journal of chromatography. A. 2006 Aug; 1125(1):124-8. doi: 10.1016/j.chroma.2006.04.061. [PMID: 16828108]
  • Leslie C Dickson, James D MacNeil, Stephen Lee, Adrian C E Fesser. Determination of beta-agonist residues in bovine urine using liquid chromatography-tandem mass spectrometry. Journal of AOAC International. 2005 Jan; 88(1):46-56. doi: . [PMID: 15759725]
  • R M Cleale, J M Ingling, D J Search, J R Hadcock, M H Pausch. Effects of alpha2-adrenoceptor antagonists on metabolic processes of swine: II. Nitrogen balance responses. Journal of animal science. 1998 Jul; 76(7):1849-58. doi: 10.2527/1998.7671849x. [PMID: 9690640]
  • T M Byrem, D H Beermann, T F Robinson. Characterization of dose-dependent metabolic responses to close arterial infusion of cimaterol in the hindlimb of steers. Journal of animal science. 1996 Dec; 74(12):2907-16. doi: 10.2527/1996.74122907x. [PMID: 8994904]
  • G Van Vyncht, S Preece, P Gaspar, G Maghuin-Rogister, E DePauw. Gas and liquid chromatography coupled to tandem mass spectrometry for the multiresidue analysis of beta-agonists in biological matrices. Journal of chromatography. A. 1996 Oct; 750(1-2):43-9. doi: 10.1016/0021-9673(96)00540-7. [PMID: 8938381]
  • J M Dawson, J Craigon, P J Buttery, D E Beever. Influence of diet and beta-agonist administration on plasma concentrations of growth hormone and insulin-like growth factor-1 in young steers. The British journal of nutrition. 1993 Jul; 70(1):93-102. doi: 10.1079/bjn19930107. [PMID: 8104477]
  • F H Chikhou, A P Moloney, P Allen, J F Quirke, F H Austin, J F Roche. Long-term effects of cimaterol in Friesian steers: I. Growth, feed efficiency, and selected carcass traits. Journal of animal science. 1993 Apr; 71(4):906-13. doi: 10.2527/1993.714906x. [PMID: 8097508]
  • T M Byrem, T F Robinson, Y R Boisclair, A W Bell, W S Schwark, D H Beermann. Analysis and pharmacokinetics of cimaterol in growing Holstein steers. Journal of animal science. 1992 Dec; 70(12):3812-9. doi: 10.2527/1992.70123812x. [PMID: 1361928]
  • F Chikhou, A P Moloney, F H Austin, J F Roche, W J Enright. Effects of cimaterol administration on plasma concentrations of various hormones and metabolites in Friesian steers. Domestic animal endocrinology. 1991 Oct; 8(4):471-80. doi: 10.1016/0739-7240(91)90016-d. [PMID: 1686220]
  • R M O'Connor, W R Butler, K D Finnerty, D E Hogue, D H Beermann. Acute and chronic hormone and metabolite changes in lambs fed the beta-agonist, cimaterol. Domestic animal endocrinology. 1991 Oct; 8(4):537-48. doi: 10.1016/0739-7240(91)90023-d. [PMID: 1686222]
  • J M Dawson, P J Buttery, M J Lammiman, J B Soar, C P Essex, M Gill, D E Beever. Nutritional and endocrinological manipulation of lean deposition in forage-fed steers. The British journal of nutrition. 1991 Sep; 66(2):171-85. doi: 10.1079/bjn19910023. [PMID: 1684723]
  • K A Akanbi, C Y Hu. Effect of dietary cimaterol on Na(+)-K+ ATPase activity in rabbit tissues. Journal of animal science. 1991 Sep; 69(9):3597-602. doi: 10.2527/1991.6993597x. [PMID: 1657851]
  • D Courtheyn, C Desaever, R Verhe. High-performance liquid chromatographic determination of clenbuterol and cimaterol using post-column derivatization. Journal of chromatography. 1991 Apr; 564(2):537-49. doi: 10.1016/0378-4347(91)80522-e. [PMID: 1678745]
  • H H Meyer, L Rinke, I Dürsch. Residue screening for the beta-agonists clenbuterol, salbutamol and cimaterol in urine using enzyme immunoassay and high-performance liquid chromatography. Journal of chromatography. 1991 Apr; 564(2):551-6. doi: 10.1016/0378-4347(91)80523-f. [PMID: 1678746]
  • K L Rogers, J M Fagan. Effect of beta agonists on protein turnover in adipose tissue. Life sciences. 1991; 48(2):143-8. doi: 10.1016/0024-3205(91)90407-3. [PMID: 1671609]
  • M E Symonds, J A Roe, C M Heywood, J M Harper, P J Buttery. Beta-adrenoceptors and the effect of beta-agonists on protein metabolism in ovine primary muscle cultures. Biochemical pharmacology. 1990 Nov; 40(10):2271-6. doi: 10.1016/0006-2952(90)90722-w. [PMID: 1978776]
  • J T Yen, H J Mersmann, J A Nienaber, D A Hill, W G Pond. Responses to cimaterol in genetically obese and lean pigs. Journal of animal science. 1990 Sep; 68(9):2698-706. doi: 10.2527/1990.6892698x. [PMID: 1976617]
  • N E Forsberg, N B Wehr. Effects of cimaterol on muscle protein metabolism and its actions in hypothyroid and hyperthyroid rats. Domestic animal endocrinology. 1990 Apr; 7(2):149-63. doi: 10.1016/0739-7240(90)90021-q. [PMID: 1695129]
  • N E Forsberg, M A Ilian, A Ali-Bar, P R Cheeke, N B Wehr. Effects of cimaterol on rabbit growth and myofibrillar protein degradation and on calcium-dependent proteinase and calpastatin activities in skeletal muscle. Journal of animal science. 1989 Dec; 67(12):3313-21. doi: 10.2527/jas1989.67123313x. [PMID: 2482286]
  • J B Morgan, S J Jones, C R Calkins. Muscle protein turnover and tenderness in broiler chickens fed cimaterol. Journal of animal science. 1989 Oct; 67(10):2646-54. doi: 10.2527/jas1989.67102646x. [PMID: 2478518]
  • J K Eadara, R H Dalrymple, R L DeLay, C A Ricks, D R Romsos. Effects of cimaterol, a beta-adrenergic agonist, on protein metabolism in rats. Metabolism: clinical and experimental. 1989 Sep; 38(9):883-90. doi: 10.1016/0026-0495(89)90236-9. [PMID: 2475743]
  • J K Eadara, R H Dalrymple, R L DeLay, C A Ricks, D R Romsos. Effects of cimaterol, a beta-adrenergic agonist, on lipid metabolism in rats. Metabolism: clinical and experimental. 1989 Jun; 38(6):522-9. doi: 10.1016/0026-0495(89)90211-4. [PMID: 2566888]
  • J W Merkley, A L Cartwright. Adipose tissue deposition and cellularity in cimaterol-treated female broilers. Poultry science. 1989 Jun; 68(6):762-70. doi: 10.3382/ps.0680762. [PMID: 2570415]
  • Y S Kim, Y B Lee, W N Garrett, R H Dalrymple. Effects of cimaterol on nitrogen retention and energy utilization in lambs. Journal of animal science. 1989 Mar; 67(3):674-81. doi: 10.2527/jas1989.673674x. [PMID: 2566593]
  • H C Walker, D R Romsos. Effects of cimaterol, a beta-adrenergic agonist, on energy metabolism in ob/ob mice. The American journal of physiology. 1988 Dec; 255(6 Pt 2):R952-60. doi: 10.1152/ajpregu.1988.255.6.r952. [PMID: 2904775]
  • C Y Hu, A Suryawan, N E Forsberg, R H Dalrymple, C A Ricks. Effect of cimaterol on sheep adipose tissue lipid metabolism. Journal of animal science. 1988 Jun; 66(6):1393-400. doi: 10.2527/jas1988.6661393x. [PMID: 2899577]
  • M Lafontan, M Berlan, M Prud'Hon. [Beta adrenergic agonists. Mechanisms of action: lipid mobilization and anabolism]. Reproduction, nutrition, developpement. 1988; 28(1):61-84. doi: ". [PMID: 2895488]
  • D H Beermann, W R Butler, D E Hogue, V K Fishell, R H Dalrymple, C A Ricks, C G Scanes. Cimaterol-induced muscle hypertrophy and altered endocrine status in lambs. Journal of animal science. 1987 Dec; 65(6):1514-24. doi: 10.2527/jas1987.6561514x. [PMID: 2895097]
  • H J Mersmann, C Y Hu, W G Pond, D C Rule, J E Novakofski, S B Smith. Growth and adipose tissue metabolism in young pigs fed cimaterol with adequate or low dietary protein. Journal of animal science. 1987 May; 64(5):1384-94. doi: 10.2527/jas1987.6451384x. [PMID: 2884207]