ZOLAZEPAM (BioDeep_00000271096)

   


代谢物信息卡片


4-(2-fluorophenyl)-1,3,8-trimethyl-6H-pyrazolo[3,4-e][1,4]diazepin-7-one

化学式: C15H15FN4O (286.12298319999996)
中文名称: 唑拉西泮
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC1=NN(C2=C1C(=NCC(=O)N2C)C3=CC=CC=C3F)C
InChI: InChI=1S/C15H15FN4O/c1-9-13-14(10-6-4-5-7-11(10)16)17-8-12(21)19(2)15(13)20(3)18-9/h4-7H,8H2,1-3H3

描述信息

D002492 - Central Nervous System Depressants > D014149 - Tranquilizing Agents > D014151 - Anti-Anxiety Agents
D002491 - Central Nervous System Agents > D011619 - Psychotropic Drugs > D014149 - Tranquilizing Agents
C78272 - Agent Affecting Nervous System > C29756 - Sedative and Hypnotic > C1012 - Benzodiazepine
D002491 - Central Nervous System Agents > D002492 - Central Nervous System Depressants
D018377 - Neurotransmitter Agents > D018682 - GABA Agents > D018757 - GABA Modulators
C78272 - Agent Affecting Nervous System > C28197 - Antianxiety Agent

同义名列表

2 个代谢物同义名

ZOLAZEPAM; 4-(2-fluorophenyl)-1,3,8-trimethyl-6H-pyrazolo[3,4-e][1,4]diazepin-7-one



数据库引用编号

7 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • P Kucharski, Z Kiełbowicz. Dissociative anaesthesia in dogs and cats with use of tiletamine and zolazepam combination. What we already know about it. Polish journal of veterinary sciences. 2021 Sep; 24(3):451-459. doi: 10.24425/pjvs.2021.138738. [PMID: 34730303]
  • S Y He, F J Gong, R Lian, Z H Sheng, J L Xu, W J Sun, S Q Zheng. Identification of Tiletamine, Zolazepam and Their Metabolites in Drug Facilitated Sexual Assault by GC-QTOF-MS. Fa yi xue za zhi. 2019 Oct; 35(5):581-585. doi: 10.12116/j.issn.1004-5619.2019.05.013. [PMID: 31833293]
  • Oksana N Khokhlova, Elena A Tukhovskaya, Irina N Kravchenko, Elena S Sadovnikova, Irina A Pakhomova, Elena A Kalabina, Alexander V Lobanov, Elvira R Shaykhutdinova, Alina M Ismailova, Arkady N Murashev. Using Tiletamine-Zolazepam-Xylazine Anesthesia Compared to CO2-inhalation for Terminal Clinical Chemistry, Hematology, and Coagulation Analysis in Mice. Journal of pharmacological and toxicological methods. 2017 Mar; 84(?):11-19. doi: 10.1016/j.vascn.2016.10.005. [PMID: 27773843]
  • Jihyun Kim, Hyesun Yum, Moonhee Jang, Ilchung Shin, Wonkyung Yang, Seungkyung Baeck, Joon Hyuk Suh, Sooyeun Lee, Sang Beom Han. A comprehensive and sensitive method for hair analysis in drug-facilitated crimes and incorporation of zolazepam and tiletamine into hair after a single exposure. Analytical and bioanalytical chemistry. 2016 Jan; 408(1):251-63. doi: 10.1007/s00216-015-9099-y. [PMID: 26454443]
  • J C M Lewis, P Teale, G Webber, J W Sear, P M Taylor. Comparison of tiletamine and zolazepam pharmacokinetics in tigers (Panthera tigris) and leopards (Panthera pardus): do species differences account for adverse effects in tigers?. Veterinary journal (London, England : 1997). 2014 Sep; 201(3):302-6. doi: 10.1016/j.tvjl.2014.05.041. [PMID: 25011709]
  • Atul Kumar, Henry J Mann, Rory P Remmel, Greg J Beilman, Nitin Kaila. Pharmacokinetic study in pigs and in vitro metabolic characterization in pig- and human-liver microsomes reveal marked differences in disposition and metabolism of tiletamine and zolazepam (Telazol). Xenobiotica; the fate of foreign compounds in biological systems. 2014 Apr; 44(4):379-90. doi: 10.3109/00498254.2013.833362. [PMID: 24020890]
  • Il-Woo Shin, Young-Sool Hah, Cheol Kim, Jungchul Park, Heewon Shin, Kyeong-Eon Park, Seong-Ho Ok, Heon-Keun Lee, Young-Kyun Chung, Haeng Seon Shim, Dong Hoon Lim, Ju-Tae Sohn. Systemic blockage of nitric oxide synthase by L-NAME increases left ventricular systolic pressure, which is not augmented further by Intralipid®. International journal of biological sciences. 2014; 10(4):367-76. doi: 10.7150/ijbs.8048. [PMID: 24719554]
  • José Angel Barasona, Jorge Ramón López-Olvera, Beatriz Beltrán-Beck, Christian Gortázar, Joaquín Vicente. Trap-effectiveness and response to tiletamine-zolazepam and medetomidine anaesthesia in Eurasian wild boar captured with cage and corral traps. BMC veterinary research. 2013 May; 9(?):107. doi: 10.1186/1746-6148-9-107. [PMID: 23702232]
  • Kyeumhan Noh, Kil-Soo Kim, Byoungki Ahn, Pillippe Archimbault, Tae-Ho Oh, Wonku Kang. Simultaneous determination of zolazepam and tiletamine in dog plasma by liquid chromatography coupled to a tandem mass spectrometry. Biomedical chromatography : BMC. 2012 Oct; 26(10):1133-6. doi: 10.1002/bmc.2692. [PMID: 22259017]
  • Akari Kamine, Michito Shimozuru, Haruki Shibata, Toshio Tsubota. Effects of intramuscular administration of tiletamine-zolazepam with and without sedative pretreatment on plasma and serum biochemical values and glucose tolerance test results in Japanese black bears (Ursus thibetanus japonicus). American journal of veterinary research. 2012 Aug; 73(8):1282-9. doi: 10.2460/ajvr.73.8.1282. [PMID: 22849689]
  • Akari Kamine, Michito Shimozuru, Haruki Shibata, Toshio Tsubota. Changes in blood glucose and insulin responses to intravenous glucose tolerance tests and blood biochemical values in adult female Japanese black bears (Ursus thibetanus japonicus). The Japanese journal of veterinary research. 2012 Feb; 60(1):5-13. doi: NULL. [PMID: 22458193]
  • Cory D Champagne, Dorian S Houser, Daniel P Costa, Daniel E Crocker. The effects of handling and anesthetic agents on the stress response and carbohydrate metabolism in northern elephant seals. PloS one. 2012; 7(5):e38442. doi: 10.1371/journal.pone.0038442. [PMID: 22693622]
  • Susanna J Fenwick, James P Scarth. In vitro metabolism of tiletamine, zolazepam and nonbenzodiazepine sedatives: Identification of target metabolites for equine doping control. Drug testing and analysis. 2011 Oct; 3(10):705-16. doi: 10.1002/dta.300. [PMID: 21916022]
  • Wen Ji Li, Jong Min Kim, Seung-June Oh. Effects of level of consciousness on urodynamic procedure in female cats. Journal of Korean medical science. 2011 Jun; 26(6):803-6. doi: 10.3346/jkms.2011.26.6.803. [PMID: 21655068]
  • Asa Fahlman, Jon M Arnemo, Jon E Swenson, John Pringle, Sven Brunberg, Görel Nyman. Physiologic evaluation of capture and anesthesia with medetomidine-zolazepam-tiletamine in brown bears (Ursus arctos). Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians. 2011 Mar; 42(1):1-11. doi: 10.1638/2008-0117.1. [PMID: 22946363]
  • Jin A Choi, Jun-Sub Choi, Choun-Ki Joo. Effects of amniotic membrane suspension in the rat alkali burn model. Molecular vision. 2011 Feb; 17(?):404-12. doi: NULL. [PMID: 21311604]
  • J Santiago-Moreno, A Toledano-Díaz, A Sookhthezary, F Gómez-Guillamón, R Salas de la Vega, A Pulido-Pastor, A López-Sebastián. Effects of anesthetic protocols on electroejaculation variables of Iberian ibex (Capra pyrenaica). Research in veterinary science. 2011 Feb; 90(1):150-5. doi: 10.1016/j.rvsc.2010.05.011. [PMID: 20542308]
  • Abishek Iyer, Lindsay Brown. Fermented wheat germ extract (avemar) in the treatment of cardiac remodeling and metabolic symptoms in rats. Evidence-based complementary and alternative medicine : eCAM. 2011; 2011(?):508957. doi: 10.1093/ecam/nep090. [PMID: 19622599]
  • Byeong-Seong Ko, Joung-Ho Han, Jee-In Jeong, Hee-Bok Chae, Seon-Mee Park, Sei-Jin Youn, Kae-Yol Lee. Mechanism of action of cholecystokinin on colonic motility in isolated, vascularly perfused rat colon. Journal of neurogastroenterology and motility. 2011 Jan; 17(1):73-81. doi: 10.5056/jnm.2011.17.1.73. [PMID: 21369495]
  • Mario Bortolozzi, Marisa Brini, Nick Parkinson, Giulia Crispino, Pietro Scimemi, Romolo Daniele De Siati, Francesca Di Leva, Andrew Parker, Saida Ortolano, Edoardo Arslan, Steve D Brown, Ernesto Carafoli, Fabio Mammano. The novel PMCA2 pump mutation Tommy impairs cytosolic calcium clearance in hair cells and links to deafness in mice. The Journal of biological chemistry. 2010 Nov; 285(48):37693-703. doi: 10.1074/jbc.m110.170092. [PMID: 20826782]
  • Olaf Sørensen, Anders Andersen, Harald Olsen, Kristian Alexandr, Per Olaf Ekstrøm, Karl-Erik Giercksky, Kjersti Flatmark. Validation and use of microdialysis for determination of pharmacokinetic properties of the chemotherapeutic agent mitomycin C - an experimental study. BMC cancer. 2010 Sep; 10(?):469. doi: 10.1186/1471-2407-10-469. [PMID: 20809961]
  • E F A Machado, A C R Normand, L A S Nunes, R Brenzikofer, D V Macedo. Effects of different general anesthetics on serum hemolysis and hepatic and muscular glycogenolysis in rats. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas. 2009 Nov; 42(11):1035-8. doi: 10.1590/s0100-879x2009005000030. [PMID: 19802466]
  • Ju-Hee Oh, Se-Eun Park, Chang-Koo Shim, Young-Joo Lee. Biliary clearance of bromosulfophthalein in anesthetized and freely moving conscious rat. Biopharmaceutics & drug disposition. 2009 Mar; 30(2):94-8. doi: 10.1002/bdd.646. [PMID: 19226651]
  • James Jauchem, Charles W Beason, Michael C Cook. Acute effects of an alternative electronic-control-device waveform in swine. Forensic science, medicine, and pathology. 2009; 5(1):2-10. doi: 10.1007/s12024-009-9076-x. [PMID: 19330471]
  • S F Anestis. Urinary cortisol responses to unusual events in captive chimpanzees (Pan troglodytes). Stress (Amsterdam, Netherlands). 2009 Jan; 12(1):49-57. doi: 10.1080/10253890802041308. [PMID: 18850493]
  • Massimo Collino, Manuela Aragno, Sara Castiglia, Chiara Tomasinelli, Christoph Thiemermann, Giuseppe Boccuzzi, Roberto Fantozzi. Insulin reduces cerebral ischemia/reperfusion injury in the hippocampus of diabetic rats: a role for glycogen synthase kinase-3beta. Diabetes. 2009 Jan; 58(1):235-42. doi: 10.2337/db08-0691. [PMID: 18840784]
  • Christopher J Dutton, Randall E Junge, Edward E Louis. Biomedical evaluation of free-ranging red ruffed lemurs (Varecia rubra) within the Masoala National Park, Madagascar. Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians. 2008 Mar; 39(1):76-85. doi: 10.1638/06-062.1. [PMID: 18432099]
  • Jeffrey A Clapper. Effects of two different anaesthetics on serum concentrations of cortisol and luteinizing hormone in barrows and gilts. Laboratory animals. 2008 Jan; 42(1):83-91. doi: 10.1258/la.2007.006001. [PMID: 18348769]
  • M-J Kim, C-S Park, M-H Jun, M-C Kim. Antagonistic effects of yohimbine in pigs anaesthetised with tiletamine/zolazepam and xylazine. The Veterinary record. 2007 Nov; 161(18):620-4. doi: 10.1136/vr.161.18.620. [PMID: 17982141]
  • C Ceylan, N Aydilek, H Ipek. Effects of tiletamine-zolazepam anaesthesia on plasma antioxidative status and some haematological parameters in sheep. Acta veterinaria Hungarica. 2007 Jun; 55(2):191-7. doi: 10.1556/avet.55.2007.2.4. [PMID: 17555283]
  • Atul Kumar, Henry J Mann, Rory P Remmel. Determination of constituents of Telazol--tiletamine and zolazepam by a gas chromatography/mass spectrometry-based method. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2006 Oct; 842(2):131-5. doi: 10.1016/j.jchromb.2006.05.014. [PMID: 16769259]
  • Kathryn E Wheatley, Corey J A Bradshaw, Robert G Harcourt, Lloyd S Davis, Mark A Hindell. Chemical immobilization of adult female Weddell seals with tiletamine and zolazepam: effects of age, condition and stage of lactation. BMC veterinary research. 2006 Feb; 2(?):8. doi: 10.1186/1746-6148-2-8. [PMID: 16469105]
  • L M Malavasi, G Nyman, H Augustsson, M Jacobson, M Jensen-Waern. Effects of epidural morphine and transdermal fentanyl analgesia on physiology and behaviour after abdominal surgery in pigs. Laboratory animals. 2006 Jan; 40(1):16-27. doi: 10.1258/002367706775404453. [PMID: 16460586]
  • L M Malavasi, H Augustsson, M Jensen-Waern, G Nyman. The effect of transdermal delivery of fentanyl on activity in growing pigs. Acta veterinaria Scandinavica. 2005; 46(3):149-57. doi: 10.1186/1751-0147-46-149. [PMID: 16261927]
  • Manabu Onuma. Immobilization of sun bears (Helarctos malayanus) with medetomidine-zolazepam-tiletamine. Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians. 2003 Jun; 34(2):202-5. doi: 10.1638/1042-7260(2003)034[0202:iosbhm]2.0.co;2. [PMID: 12885141]
  • Christopher J Dutton, Randall E Junge, Edward E Louis. Biomedical evaluation of free-ranging ring-tailed lemurs (Lemur catta) in Tsimanampetsotsa Strict Nature Reserve, Madagascar. Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians. 2003 Mar; 34(1):16-24. doi: 10.1638/1042-7260(2003)34[0016:beofrl]2.0.co;2. [PMID: 12723796]
  • Morten Tryland, Edgar Brun, Andrew E Derocher, Jon M Arnemo, Peter Kierulf, Rolf-Arne Ølberg, Øystein Wiig. Plasma biochemical values from apparently healthy free-ranging polar bears from Svalbard. Journal of wildlife diseases. 2002 Jul; 38(3):566-75. doi: 10.7589/0090-3558-38.3.566. [PMID: 12238374]
  • M T Quail, P Weimersheimer, A D Woolf, B Magnani. Abuse of telazol: an animal tranquilizer. Journal of toxicology. Clinical toxicology. 2001; 39(4):399-402. doi: 10.1081/clt-100105161. [PMID: 11527235]
  • H A Semple, D K Gorecki, S D Farley, M A Ramsay. Pharmacokinetics and tissue residues of Telazol in free-ranging polar bears. Journal of wildlife diseases. 2000 Oct; 36(4):653-62. doi: 10.7589/0090-3558-36.4.653. [PMID: 11085426]
  • H Chung, H Choi, E Kim, W Jin, H Lee, Y Yoo. A fatality due to injection of tiletamine and zolazepam. Journal of analytical toxicology. 2000 May; 24(4):305-8. doi: 10.1093/jat/24.4.305. [PMID: 10872580]
  • J Fernández-Morán, J Palomeque, V I Peinado. Medetomidine/tiletamine/zolazepam and xylazine/tiletamine/zolazepam combinations for immobilization of fallow deer (Cervus dama). Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians. 2000 Mar; 31(1):62-4. doi: 10.1638/1042-7260(2000)031[0062:mtzaxt]2.0.co;2. [PMID: 10884126]
  • C J Cording, R DeLuca, T Camporese, E Spratt. A fatality related to the veterinary anesthetic telazol. Journal of analytical toxicology. 1999 Oct; 23(6):552-5. doi: 10.1093/jat/23.6.552. [PMID: 10517567]
  • D C Rankin, S A Greene, R D Keegan, A B Weil, R K Schneider, W M Bayly. Anesthesia of horses with a combination of detomidine, zolazepam, tiletamine, and isoflurane immediately after strenuous treadmill exercise. American journal of veterinary research. 1999 Jun; 60(6):743-8. doi: NULL. [PMID: 10376905]
  • W B Karesh, M M Uhart, E S Dierenfeld, W E Braselton, A Torres, C House, H Puche, R A Cook. Health evaluation of free-ranging guanaco (Lama guanicoe). Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians. 1998 Jun; 29(2):134-41. doi: NULL. [PMID: 9732026]
  • P L Whitten, R Stavisky, F Aureli, E Russell. Response of fecal cortisol to stress in captive chimpanzees (Pan troglodytes). American journal of primatology. 1998; 44(1):57-69. doi: 10.1002/(sici)1098-2345(1998)44:1<57::aid-ajp5>3.0.co;2-w. [PMID: 9444323]
  • G L Carroll, S M Hartsfield, R Hambleton. Anesthetic effects of tiletamine-zolazepam, alone or in combination with butorphanol, in goats. Journal of the American Veterinary Medical Association. 1997 Sep; 211(5):593-7. doi: NULL. [PMID: 9290827]
  • K D Evans, D L Dillehay, M J Huerkamp, S K Webb. Diagnostic exercise: azotemia in a rabbit (Oryctolagus cuniculus). Laboratory animal science. 1996 Aug; 46(4):442-3. doi: NULL. [PMID: 8872998]
  • D W Brammer, B J Doerning, C E Chrisp, H G Rush. Anesthetic and nephrotoxic effects of Telazol in New Zealand white rabbits. Laboratory animal science. 1991 Oct; 41(5):432-5. doi: NULL. [PMID: 1666143]
  • J Van Heerden, R E Burroughs, J Dauth, M J Dreyer. Immobilization of wild dogs (Lycaon pictus) with a tiletamine hydrochloride/zolazepam hydrochloride combination and subsequent evaluation of selected blood chemistry parameters. Journal of wildlife diseases. 1991 Apr; 27(2):225-9. doi: 10.7589/0090-3558-27.2.225. [PMID: 2067044]
  • M Bush, R S Custer, E E Smith. Use of dissociative anesthetics for the immobilization of captive bears: blood gas, hematology and biochemistry values. Journal of wildlife diseases. 1980 Oct; 16(4):481-9. doi: 10.7589/0090-3558-16.4.481. [PMID: 7463600]