bromperidol (BioDeep_00000271094)
代谢物信息卡片
bromperidol
化学式: C21H23BrFNO2 (419.089609)
中文名称: 溴哌利多
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1CN(CCC1(C2=CC=C(C=C2)Br)O)CCCC(=O)C3=CC=C(C=C3)F
InChI: InChI=1S/C21H23BrFNO2/c22-18-7-5-17(6-8-18)21(26)11-14-24(15-12-21)13-1-2-20(25)16-3-9-19(23)10-4-16/h3-10,26H,1-2,11-15H2
描述信息
D002492 - Central Nervous System Depressants > D014149 - Tranquilizing Agents > D014150 - Antipsychotic Agents
D002491 - Central Nervous System Agents > D011619 - Psychotropic Drugs > D014149 - Tranquilizing Agents
N - Nervous system > N05 - Psycholeptics > N05A - Antipsychotics > N05AD - Butyrophenone derivatives
D002491 - Central Nervous System Agents > D002492 - Central Nervous System Depressants
C78272 - Agent Affecting Nervous System > C29710 - Antipsychotic Agent
Bromperidol (R-11333) possesses antipsychotic activity, with a high affinity for central dopamine receptors D2. Bromperidol can kill Mycobacteria in a synergistic manner with Spectinomycin[1][2].
同义名列表
2 个代谢物同义名
数据库引用编号
8 个数据库交叉引用编号
- ChEBI: CHEBI:31305
- KEGGdrug: D01101
- PubChem: 2448
- DrugBank: DB12401
- ChEMBL: CHEMBL28218
- CAS: 10457-90-6
- PMhub: MS000001431
- medchemexpress: HY-B0901
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome.
Cell reports.
2021 04; 35(4):109040. doi:
10.1016/j.celrep.2021.109040. [PMID: 33910017] - Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
Molecular pharmacology.
2019 11; 96(5):629-640. doi:
10.1124/mol.119.115964. [PMID: 31515284] - Takeshi Kumazawa, Koichi Saeki, Isao Yanagisawa, Seisaku Uchigasaki, Chika Hasegawa, Hiroshi Seno, Osamu Suzuki, Keizo Sato. Automated on-line in-tube solid-phase microextraction coupled with HPLC/MS/MS for the determination of butyrophenone derivatives in human plasma.
Analytical and bioanalytical chemistry.
2009 Jun; 394(4):1161-70. doi:
10.1007/s00216-009-2774-0. [PMID: 19387622] - Linda Hanssens, Gilbert L'Italien, Jean-Yves Loze, Ronald N Marcus, Miranda Pans, Wendy Kerselaers. The effect of antipsychotic medication on sexual function and serum prolactin levels in community-treated schizophrenic patients: results from the Schizophrenia Trial of Aripiprazole (STAR) study (NCT00237913).
BMC psychiatry.
2008 Dec; 8(?):95. doi:
10.1186/1471-244x-8-95. [PMID: 19102734] - Yasuhiko Higashi, Shota Nakamura, Youichi Fujii. Sensitive determination of 4-(4-bromophenyl)-4-hydroxypiperidine, a metabolite of bromperidol, in rat plasma by HPLC with fluorescence detection after pre-column derivatization using 4-fluoro-7-nitro-2,1,3-benzoxadiazole.
Biological & pharmaceutical bulletin.
2006 Dec; 29(12):2479-82. doi:
10.1248/bpb.29.2479. [PMID: 17142985] - Norio Yasui-Furukori, Manabu Saito, Taku Nakagami, Ayako Kaneda, Tomonori Tateishi, Sunao Kaneko. Association between multidrug resistance 1 (MDR1) gene polymorphisms and therapeutic response to bromperidol in schizophrenic patients: a preliminary study.
Progress in neuro-psychopharmacology & biological psychiatry.
2006 Mar; 30(2):286-91. doi:
10.1016/j.pnpbp.2005.06.019. [PMID: 16386826] - Norio Yasui-Furukori, Yoshimasa Inoue, Misturu Chiba, Tomonori Tateishi. Simultaneous determination of haloperidol and bromperidol and their reduced metabolites by liquid-liquid extraction and automated column-switching high-performance liquid chromatography.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2004 Jun; 805(1):175-80. doi:
10.1016/j.jchromb.2004.02.043. [PMID: 15113555] - Norio Yasui-Furukori, Manabu Saito, Hanako Furukori, Yoshimasa Inoue, Toshiyuki Someya, Sunao Kaneko, Tomonori Tateishi. Establishment of new cloned enzyme donor immunoassays (CEDIA) for haloperidol and bromperidol.
Therapeutic drug monitoring.
2004 Jun; 26(3):336-41. doi:
10.1097/00007691-200406000-00020. [PMID: 15167638] - Norio Yasui-Furukori, Hanako Furukori, Manabu Saito, Yoshimasa Inoue, Sunao Kaneko, Tomonori Tateishi. Poor reliability of therapeutic drug monitoring data for haloperidol and bromperidol using enzyme immunoassay.
Therapeutic drug monitoring.
2003 Dec; 25(6):709-14. doi:
10.1097/00007691-200312000-00009. [PMID: 14639057] - F Vanderzeypen, J C Bier, C Genevrois, J Mendlewicz, F Lotstra. [Frontal dementia or dementia praecox? A case report of a psychotic disorder with a severe decline].
L'Encephale.
2003 Mar; 29(2):172-80. doi:
NULL. [PMID: 14567169] - Carsten Kratzsch, Frank T Peters, Thomas Kraemer, Armin A Weber, Hans H Maurer. Screening, library-assisted identification and validated quantification of fifteen neuroleptics and three of their metabolites in plasma by liquid chromatography/mass spectrometry with atmospheric pressure chemical ionization.
Journal of mass spectrometry : JMS.
2003 Mar; 38(3):283-95. doi:
10.1002/jms.440. [PMID: 12644990] - Norio Yasui-Furukori, Tsuyoshi Kondo, Akihito Suzuki, Kazuo Mihara, Sunao Kaneko, Koichi Otani. Comparison of prolactin concentrations between haloperidol and bromperidol treatments in schizophrenic patients.
Progress in neuro-psychopharmacology & biological psychiatry.
2002 Apr; 26(3):575-8. doi:
10.1016/s0278-5846(01)00310-4. [PMID: 11999910] - Norio Yasui-Furukori, Tsuyoshi Kondo, Masayuki Ishida, Osamu Tanaka, Kazuo Mihara, Sunao Kaneko, Koichi Otani. The characteristics of side-effects of bromperidol in schizophrenic patients.
Psychiatry and clinical neurosciences.
2002 Feb; 56(1):103-6. doi:
10.1046/j.1440-1819.2002.00936.x. [PMID: 11929578] - Norio Yasui-Furukori, Tsuyoshi Kondo, Masayuki Ishida, Hanako Furukori, Akihito Suzuki, Sunao Kaneko, Masayoshi Inoue, Koichi Otani. Therapeutic effects of bromperidol on the five dimensions of schizophrenic symptoms.
Progress in neuro-psychopharmacology & biological psychiatry.
2002 Jan; 26(1):53-7. doi:
10.1016/s0278-5846(01)00218-4. [PMID: 11853119] - K Mihara, A Suzuki, T Kondo, N Yasui-Furukori, S Ono, K Otani, S Kaneko, Y Inoue. Relationship between Taq1 A dopamine D2 receptor (DRD2) polymorphism and prolactin response to bromperidol.
American journal of medical genetics.
2001 Apr; 105(3):271-4. doi:
10.1002/ajmg.1303. [PMID: 11353448] - T Tateishi, M Watanabe, T Kumai, M Tanaka, H Moriya, S Yamaguchi, T Satoh, S Kobayashi. CYP3A is responsible for N-dealkylation of haloperidol and bromperidol and oxidation of their reduced forms by human liver microsomes.
Life sciences.
2000 Nov; 67(24):2913-20. doi:
10.1016/s0024-3205(00)00874-2. [PMID: 11133003] - T Someya, T Muratake, G Hirokane, M Shibasaki, K Shimoda, S Takahashi. Interindividual variation in bromperidol metabolism and relationship to therapeutic effects.
Journal of clinical psychopharmacology.
2000 Apr; 20(2):175-80. doi:
10.1097/00004714-200004000-00009. [PMID: 10770455] - M Watanabe, T Tateishi, M Tanaka, T Kumai, S Kobayashi. Role of CYP3A in bromperidol metabolism in rat in vitro and in vivo.
Xenobiotica; the fate of foreign compounds in biological systems.
1999 Aug; 29(8):839-46. doi:
10.1080/004982599238281. [PMID: 10553724] - H Furukori, T Kondo, N Yasui, K Otani, N Tokinaga, U Nagashima, S Kaneko, Y Inoue. Effects of itraconazole on the steady-state plasma concentrations of bromperidol and reduced bromperidol in schizophrenic patients.
Psychopharmacology.
1999 Jul; 145(2):189-92. doi:
10.1007/s002130051048. [PMID: 10463320] - K Mihara, K Otani, N Yasui, M Ishida, T Kondo, A Suzuki, H Furukori, U Nagashima, S Kaneko, Y Inoue. No pharmacokinetic but pharmacodynamic interactions between cisapride and bromperidol or haloperidol.
Therapeutic drug monitoring.
1999 Jun; 21(3):297-300. doi:
10.1097/00007691-199906000-00007. [PMID: 10365640] - N Yasui, K Otani, T Kondo, A Suzuki, H Furukori, S Kaneko, Y Inoue. Correlation between steady-state plasma concentrations (Css) of bromperidol and haloperidol.
Progress in neuro-psychopharmacology & biological psychiatry.
1998 Apr; 22(3):485-92. doi:
10.1016/s0278-5846(98)00019-0. [PMID: 9612845] - N Yasui, T Kondo, K Otani, M Ishida, K Mihara, A Suzuki, S Kaneko, Y Inoue. Prolactin response to bromperidol treatment in schizophrenic patients.
Pharmacology & toxicology.
1998 Mar; 82(3):153-6. doi:
10.1111/j.1600-0773.1998.tb01416.x. [PMID: 9553995] - A Suzuki, K Otani, K Mihara, N Yasui, T Kondo, N Tokinaga, H Furukori, S Kaneko, Y Inoue, K Hayashi. Effects of various factors including the CYP2D6 genotype and coadministration of flunitrazepam on the steady-state plasma concentrations of bromperidol and its reduced metabolite.
Psychopharmacology.
1998 Feb; 135(4):333-7. doi:
10.1007/s002130050519. [PMID: 9539256] - H Furukori. [Involvement of cytochromeP4503A4 in the metabolism of haloperidol and bromperidol].
Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology.
1998 Feb; 18(1):9-14. doi:
NULL. [PMID: 9592806] - A Suzuki, K Otani, M Ishida, N Yasui, T Kondo, K Mihara, S Kaneko, Y Inoue, M Shibata, K Ikeda. Increased plasma concentrations of bromperidol and its reduced metabolite with levomepromazine, but not with thioridazine.
Therapeutic drug monitoring.
1997 Jun; 19(3):261-4. doi:
10.1097/00007691-199706000-00003. [PMID: 9200764] - K Otani, M Ishida, N Yasui, T Kondo, K Mihara, A Suzuki, S Kaneko, Y Inoue, M Shibata, K Ikeda. No effect of the anticholinergic drugs trihexyphenidyl and biperiden on the plasma concentrations of bromperidol and its reduced metabolite.
Therapeutic drug monitoring.
1997 Apr; 19(2):165-8. doi:
10.1097/00007691-199704000-00008. [PMID: 9108644] - M Ishida, K Otani, N Yasui, Y Inoue, S Kaneko. Possible interaction between cisapride and bromperidol.
Progress in neuro-psychopharmacology & biological psychiatry.
1997 Jan; 21(1):235-8. doi:
10.1016/s0278-5846(96)00165-0. [PMID: 9075269] - K Otani, M Ishida, N Yasui, T Kondo, K Mihara, A Suzuki, H Furukori, S Kaneko, Y Inoue. Interaction between carbamazepine and bromperidol.
European journal of clinical pharmacology.
1997; 52(3):219-22. doi:
10.1007/s002280050277. [PMID: 9218929] - A Suzuki, K Otani, M Ishida, N Yasui, T Kondo, K Mihara, S Kaneko, Y Inoue. No interaction between desipramine and bromperidol.
Progress in neuro-psychopharmacology & biological psychiatry.
1996 Oct; 20(7):1265-71. doi:
10.1016/s0278-5846(96)00111-x. [PMID: 8938825] - E Suzuki, S Kanba, H Koshikawa, M Nibuya, G Yagi, M Asai. Negative symptoms in nondeficit syndrome respond to neuroleptic treatment with changes in plasma homovanillic acid concentrations.
Journal of psychiatry & neuroscience : JPN.
1996 May; 21(3):167-71. doi:
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No to shinkei = Brain and nerve.
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Nihon hoigaku zasshi = The Japanese journal of legal medicine.
1993 Oct; 47(5):367-71. doi:
NULL. [PMID: 8258900] - M Hariharan, E K Kindt, T VanNoord, R Tandon. An improved sensitive assay for simultaneous determination of plasma haloperidol and reduced haloperidol levels by liquid chromatography using a coulometric detector.
Therapeutic drug monitoring.
1989 Nov; 11(6):701-7. doi:
10.1097/00007691-198911000-00016. [PMID: 2595753] - K Hikida, Y Inoue, T Miyazaki, N Kojima, Y Ohkura. Determination of bromperidol in serum by automated column-switching high-performance liquid chromatography.
Journal of chromatography.
1989 Oct; 495(?):227-34. doi:
10.1016/s0378-4347(00)82624-9. [PMID: 2613807] - H Seno, O Suzuki, T Kumazawa, M Asano. Rapid isolation with Sep-Pak C18 cartridges and wide-bore capillary gas chromatography of some butyrophenones.
Zeitschrift fur Rechtsmedizin. Journal of legal medicine.
1989; 102(2-3):127-32. doi:
10.1007/bf00200506. [PMID: 2565634] - S M Moerlein, G L Stöcklin. Synthesis of high specific activity [75Br]- and [77Br]bromperidol and tissue distribution studies in the rat.
Journal of medicinal chemistry.
1985 Sep; 28(9):1319-24. doi:
10.1021/jm00147a035. [PMID: 4032434] - M Suárez Richards. [Chronic treatment of schizophrenia with injectable bromperidol decanoate].
Acta psiquiatrica y psicologica de America latina.
1985 Sep; 31(3):222-8. doi:
NULL. [PMID: 2870608] - J Tischio, N Hetyei, J Patrick. Bromperidol radioimmunoassay: human plasma levels.
Journal of pharmaceutical sciences.
1984 Apr; 73(4):546-8. doi:
10.1002/jps.2600730428. [PMID: 6726642] - Y Fujii, M Tateyama, M Kamisada, A Tanoue, M Takamiya, S Nakajima, H Itoh. Clinical efficacy, extrapyramidal symptoms and serum levels: influence of administration schedules and concomitant drugs on serum bromperidol concentrations.
Folia psychiatrica et neurologica japonica.
1984; 38(2):121-36. doi:
10.1111/j.1440-1819.1984.tb00360.x. [PMID: 6152433] - F A Wong, C P Bateman, C J Shaw, J E Patrick. Biotransformation of bromperidol in rat, dog, and man.
Drug metabolism and disposition: the biological fate of chemicals.
1983 Jul; 11(4):301-7. doi:
NULL. [PMID: 6137334] - D R Hawkins, S R Biggs, R R Brodie, L F Chasseaud, I Midgley. A novel conjugate as a major metabolite of bromperidol in man.
The Journal of pharmacy and pharmacology.
1982 May; 34(5):299-303. doi:
10.1111/j.2042-7158.1982.tb04711.x. [PMID: 6123567] - E Van Den Eeckhout, F M Belpaire, M G Bogaert, P De Moerloose. Radioimmunoassay of bromperidol and haloperidol in human and canine plasma.
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