Articaine (BioDeep_00000271084)

   

Volatile Flavor Compounds


代谢物信息卡片


Articaine

化学式: C13H20N2O3S (284.119457)
中文名称: 阿替卡因
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CCCNC(C)C(=O)NC1=C(SC=C1C)C(=O)OC
InChI: InChI=1S/C13H20N2O3S/c1-5-6-14-9(3)12(16)15-10-8(2)7-19-11(10)13(17)18-4/h7,9,14H,5-6H2,1-4H3,(H,15,16)

描述信息

D002491 - Central Nervous System Agents > D002492 - Central Nervous System Depressants > D000777 - Anesthetics
N - Nervous system > N01 - Anesthetics > N01B - Anesthetics, local > N01BB - Amides
D018373 - Peripheral Nervous System Agents > D018689 - Sensory System Agents
C78272 - Agent Affecting Nervous System > C245 - Anesthetic Agent

同义名列表

2 个代谢物同义名

Articaine; Articaine



数据库引用编号

8 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Dinakaran Venkatachalam, John Paul Chambers, Kavitha Kongara, Neil Ward, Antony Jacob, Preet Mohinder Singh. Pharmacokinetics, efficacy and convulsive dose of articaine hydrochloride in goat kids. Veterinary anaesthesia and analgesia. 2021 Mar; 48(2):264-271. doi: 10.1016/j.vaa.2019.12.012. [PMID: 33593682]
  • Gustavo H Rodrigues da Silva, Gabriela Geronimo, Juan P García-López, Lígia N M Ribeiro, Ludmilla D de Moura, Márcia C Breitkreitz, Carmen G Feijóo, Eneida de Paula. Articaine in functional NLC show improved anesthesia and anti-inflammatory activity in zebrafish. Scientific reports. 2020 11; 10(1):19733. doi: 10.1038/s41598-020-76751-6. [PMID: 33184457]
  • Guanjie Zhao, Shan Lu, Linlin Li, Xiaodi Fan. Local anesthetic articaine ameliorates LPS-induced acute kidney injury via inhibition of NF-ĸB activation and the NLRP3 inflammasome pathway. Journal of biochemical and molecular toxicology. 2020 Oct; 34(10):e22554. doi: 10.1002/jbt.22554. [PMID: 32687258]
  • Nathalie Ferreira Silva de Melo, Estefânia Vangelie Ramos Campos, Michelle Franz-Montan, Eneida de Paula, Camila Morais Gonçalves da Silva, Cíntia Rodrigues Maruyama, Tatiane Pasquoto Stigliani, Renata de Lima, Daniele Ribeiro de Araújo, Leonardo Fernandes Fraceto. Characterization of Articaine-Loaded Poly(ε-caprolactone) Nanocapsules and Solid Lipid Nanoparticles in Hydrogels for Topical Formulations. Journal of nanoscience and nanotechnology. 2018 Jun; 18(6):4428-4438. doi: 10.1166/jnn.2018.15235. [PMID: 29442800]
  • Yoann Cazaubon, Cédric Mauprivez, Catherine Feliu, Laurent Binet, Olivier Oget, Claire Gozalo, Zoubir Djerada. Population pharmacokinetics of articaine with 1:200,000 epinephrine during third molar surgery and simulation of high-dose regimens. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. 2018 Mar; 114(?):38-45. doi: 10.1016/j.ejps.2017.11.027. [PMID: 29197630]
  • D Venkatachalam, J P Chambers, K Kongara, P Singh. Pharmacokinetics of articaine hydrochloride and its metabolite articainic acid after subcutaneous administration in red deer (Cervus elaphus). New Zealand veterinary journal. 2018 Jan; 66(1):16-20. doi: 10.1080/00480169.2017.1391141. [PMID: 29020878]
  • D Végh, A Somogyi, D Bányai, M Lakatos, M Balogh, M Al-Khrasani, S Fürst, E S Vizi, P Hermann. Effects of articaine on [3H]noradrenaline release from cortical and spinal cord slices prepared from normal and streptozotocin-induced diabetic rats and compared to lidocaine. Brain research bulletin. 2017 Oct; 135(?):157-162. doi: 10.1016/j.brainresbull.2017.10.011. [PMID: 29054696]
  • Iciar Arteagoitia, Mercedes Zumarraga, Ricardo Dávila, Luis Barbier, Gorka Santamaría, Joseba Santamaria. Plasma variations in stress markers: clinical trial of two anesthetics used in regional block in the extraction of impacted inferior third molars. Medicina oral, patologia oral y cirugia bucal. 2014 May; 19(3):e274-9. doi: 10.4317/medoral.19362. [PMID: 24316704]
  • Sepideh Amjad-Iranagh, Abbas Yousefpour, Parto Haghighi, Hamid Modarress. Effects of protein binding on a lipid bilayer containing local anesthetic articaine, and the potential of mean force calculation: a molecular dynamics simulation approach. Journal of molecular modeling. 2013 Sep; 19(9):3831-42. doi: 10.1007/s00894-013-1917-6. [PMID: 23798311]
  • Signe Steinkopf, Linda Hanekam, Marit Schaathun, Adnan Budnjo, Bengt Erik Haug, Willy Nerdal. Interaction of local anaesthetic articaine enantiomers with brain lipids: a Langmuir monolayer study. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. 2012 Sep; 47(2):394-401. doi: 10.1016/j.ejps.2012.06.010. [PMID: 22750081]
  • Sarah Ciechanowicz, Vinod Patil. Lipid emulsion for local anesthetic systemic toxicity. Anesthesiology research and practice. 2012; 2012(?):131784. doi: 10.1155/2012/131784. [PMID: 21969824]
  • Andreas Leffler, Anja Lattrell, Sergej Kronewald, Florian Niedermirtl, Carla Nau. Activation of TRPA1 by membrane permeable local anesthetics. Molecular pain. 2011 Aug; 7(?):62. doi: 10.1186/1744-8069-7-62. [PMID: 21861907]
  • N Nizharadze, M Mamaladze, N Chipashvili, D Vadachkoria. Articaine - the best choice of local anesthetic in contemporary dentistry. Georgian medical news. 2011 Jan; ?(190):15-23. doi: NULL. [PMID: 21346262]
  • Enamul H Mojumdar, Alexander P Lyubartsev. Molecular dynamics simulations of local anesthetic articaine in a lipid bilayer. Biophysical chemistry. 2010 Dec; 153(1):27-35. doi: 10.1016/j.bpc.2010.10.001. [PMID: 21041015]
  • Paul A Moore, Elliot V Hersh. Local anesthetics: pharmacology and toxicity. Dental clinics of North America. 2010 Oct; 54(4):587-99. doi: 10.1016/j.cden.2010.06.015. [PMID: 20831923]
  • J G Meechan. Aspirations and solutions--a 20 year journey through dental local anaesthetics. The surgeon : journal of the Royal Colleges of Surgeons of Edinburgh and Ireland. 2009 Dec; 7(6):358-61. doi: 10.1016/s1479-666x(09)80110-8. [PMID: 20681379]
  • Guillaume Hoizey, Denis Lamiable, Claire Gozalo, Thomas Miric, Aurélie Thomas, Laurent Binet, Olivier Oget, Hervé Millart, Cédric Mauprivez. Determination of articaine in human plasma by liquid chromatography-mass spectrometry and its application in a preliminary pharmacokinetic study. Journal of pharmaceutical and biomedical analysis. 2009 May; 49(4):1082-7. doi: 10.1016/j.jpba.2009.01.028. [PMID: 19237257]
  • E E Stoliarov, Iu N Karpenko, T L Malkova. [Detection of certain local anesthetics in biological fluids by chemo-toxicological analysis]. Sudebno-meditsinskaia ekspertiza. 2009 May; 52(3):24-7. doi: NULL. [PMID: 19569536]
  • Henning Lygre, Grete Moe, Willy Nerdal, Holm Holmsen. Interaction of articaine hydrochloride with prokaryotic membrane lipids. Acta odontologica Scandinavica. 2009; 67(1):1-7. doi: 10.1080/00016350802443466. [PMID: 18941950]
  • Chen Song, Henning Lygre, Willy Nerdal. Articaine interaction with DSPC bilayer: a 13C and 31P solid-state NMR study. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. 2008 Apr; 33(4-5):399-408. doi: 10.1016/j.ejps.2008.01.010. [PMID: 18343644]
  • Peter G Schnabel, Wilma Bagchus, Holger Lass, Torben Thomsen, T B Paul Geurts. The effect of food composition on serum testosterone levels after oral administration of Andriol Testocaps. Clinical endocrinology. 2007 Apr; 66(4):579-85. doi: 10.1111/j.1365-2265.2007.02781.x. [PMID: 17371478]
  • Elliot V Hersh, Helen Giannakopoulos, Lawrence M Levin, Stacey Secreto, Paul A Moore, Carrie Peterson, Matthew Hutcheson, Mohammed Bouhajib, Ari Mosenkis, Raymond R Townsend. The pharmacokinetics and cardiovascular effects of high-dose articaine with 1:100,000 and 1:200,000 epinephrine. Journal of the American Dental Association (1939). 2006 Nov; 137(11):1562-71. doi: 10.14219/jada.archive.2006.0092. [PMID: 17082283]
  • Matthias Grossmann, Gerhard Sattler, Hans Pistner, Reinhard Oertel, Klaus Richter, Stefan Schinzel, Laurent-Didier Jacobs. Pharmacokinetics of articaine hydrochloride in tumescent local anesthesia for liposuction. Journal of clinical pharmacology. 2004 Nov; 44(11):1282-9. doi: 10.1177/0091270004269014. [PMID: 15496646]
  • G Heine, H Gabriel, J Weindler, K W Ruprecht, W Kindermann. Painful regional anaesthesia induces an immunological stress reaction: the model of retrobulbar anaesthesia. European journal of anaesthesiology. 2001 Aug; 18(8):505-10. doi: 10.1046/j.1365-2346.2001.00873.x. [PMID: 11473556]
  • R Oertel, U Ebert, R Rahn, W Kirch. The effect of age on pharmacokinetics of the local anesthetic drug articaine. Regional anesthesia and pain medicine. 1999 Nov; 24(6):524-8. doi: 10.1016/s1098-7339(99)90043-3. [PMID: 10588556]
  • K Richter, R Oertel. Solid-phase extraction and high-performance liquid chromatographic determination of articainic and its metabolite articainic acid in human serum. Journal of chromatography. B, Biomedical sciences and applications. 1999 Mar; 724(1):109-15. doi: 10.1016/s0378-4347(98)00563-5. [PMID: 10202963]
  • R Oertel, K Richter. Plasma protein binding of the local anaesthetic drug articaine and its metabolite articainic acid. Die Pharmazie. 1998 Sep; 53(9):646-7. doi: NULL. [PMID: 9770216]
  • R Oertel, R Rahn, W Kirch. Clinical pharmacokinetics of articaine. Clinical pharmacokinetics. 1997 Dec; 33(6):417-25. doi: 10.2165/00003088-199733060-00002. [PMID: 9435991]
  • T B Vree, M A Simon, M J Gielen, L H Booij. Regional metabolism of articaine in 10 patients undergoing intravenous regional anaesthesia during day case surgery. British journal of clinical pharmacology. 1997 Jul; 44(1):29-34. doi: 10.1046/j.1365-2125.1997.00621.x. [PMID: 9241093]
  • T B Vree, G E Van Oss, M J Gielen, L H Booij. Epidural metabolism of articaine to its metabolite articainic acid in five patients after epidural administration of 600 mg articaine. The Journal of pharmacy and pharmacology. 1997 Feb; 49(2):158-63. doi: 10.1111/j.2042-7158.1997.tb06772.x. [PMID: 9055188]
  • M A Simon, M J Gielen, N Alberink, T B Vree, J van Egmond. Intravenous regional anesthesia with 0.5\% articaine, 0.5\% lidocaine, or 0.5\% prilocaine. A double-blind randomized clinical study. Regional anesthesia. 1997 Jan; 22(1):29-34. doi: 10.1016/s1098-7339(06)80053-2. [PMID: 9010944]
  • R Oertel, A Berndt, W Kirch. Saturable in vitro metabolism of articaine by serum esterases. Does it contribute to the persistence of the local anesthetic effect?. Regional anesthesia. 1996 Nov; 21(6):576-81. doi: NULL. [PMID: 8956396]
  • W Jakobs, B Ladwig, P Cichon, R Ortel, W Kirch. Serum levels of articaine 2\% and 4\% in children. Anesthesia progress. 1995; 42(3-4):113-5. doi: NULL. [PMID: 8934976]
  • R Oertel, K Richter, K Weile, T Gramatté, A Berndt, K Feller. A simple method for the determination of articaine and its metabolite articainic acid in dentistry: application to a comparison of articaine and lidocaine concentrations in alveolus blood. Methods and findings in experimental and clinical pharmacology. 1993 Oct; 15(8):541-7. doi: NULL. [PMID: 8309318]
  • U Sack, P P Kleemann. Intraoral conduction anesthesia with epinephrine-containing local anesthetics and arterial epinephrine plasma concentration. Anesthesia & pain control in dentistry. 1992; 1(2):77-80. doi: NULL. [PMID: 1392688]
  • E Knoll-Köhler, K Brandt, M Knöller. [The beta-mimetic effects following the enoral injection of epinephrine with articaine]. Schweizer Monatsschrift fur Zahnmedizin = Revue mensuelle suisse d'odonto-stomatologie = Rivista mensile svizzera di odontologia e stomatologia. 1992; 102(2):172-7. doi: NULL. [PMID: 1321490]
  • W H Raab. Temperature related changes in pulpal microcirculation. Proceedings of the Finnish Dental Society. Suomen Hammaslaakariseuran toimituksia. 1992; 88 Suppl 1(?):469-79. doi: NULL. [PMID: 1508905]
  • E Knoll-Köhler, M Knöller, K Brandt, J Becker. Cardiohemodynamic and serum catecholamine response to surgical removal of impacted mandibular third molars under local anesthesia: a randomized double-blind parallel group and crossover study. Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons. 1991 Sep; 49(9):957-62. doi: 10.1016/0278-2391(91)90059-u. [PMID: 1653313]
  • W P Müller, P Weiser, K L Scholler. [Pharmacokinetics of articaine in mandibular nerve block]. Regional-Anaesthesie. 1991 May; 14(3):52-5. doi: NULL. [PMID: 1866476]
  • S M Fox, S C Chan, D H Van Middlesworth. Gas chromatographic and mass spectrometric analysis of articaine in urine. Journal of chromatography. 1989 Sep; 494(?):331-4. doi: 10.1016/s0378-4347(00)82684-5. [PMID: 2584330]
  • G E van Oss, T B Vree, A M Baars, E F Termond, L H Booij. Pharmacokinetics, metabolism, and renal excretion of articaine and its metabolite articainic acid in patients after epidural administration. European journal of anaesthesiology. 1989 Jan; 6(1):49-56. doi: NULL. [PMID: 2714265]
  • T B Vree, A M Baars, G E van Oss, L H Booij. High-performance liquid chromatography and preliminary pharmacokinetics of articaine and its 2-carboxy metabolite in human serum and urine. Journal of chromatography. 1988 Feb; 424(2):440-4. doi: 10.1016/s0378-4347(00)81126-3. [PMID: 3372637]
  • L Kaukinen, S Kaukinen, S Kärkkäinen. [Epidural anesthesia with carticaine in cesarean section. A comparison with bupivacaine]. Regional-Anaesthesie. 1986 Jul; 9(3):79-83. doi: NULL. [PMID: 3749548]
  • E Schutz, H Fuchs. [Hepatic tolerance to ultracaine. Effect on porphyria]. L' Information dentaire. 1986 Mar; 68(12):1031-8. doi: NULL. [PMID: 3462132]
  • I Hornke, H G Eckert, W Rupp. [Pharmacokinetics and metabolism of Articain after intramuscular injection in a male subject]. Deutsche Zeitschrift fur Mund-, Kiefer- und Gesichts-Chirurgie. 1984 Jan; 8(1):67-71. doi: NULL. [PMID: 6597015]
  • H Lüllmann, P B Timmermans, G M Weikert, A Ziegler. Accumulation of drugs by guinea pig isolated atria. Quantitative correlations. Journal of medicinal chemistry. 1980 May; 23(5):560-5. doi: 10.1021/jm00179a017. [PMID: 7381857]
  • U Borchard, H Drouin. Carticaine: action of the local anesthetic on myelinated nerve fibres. European journal of pharmacology. 1980 Mar; 62(1):73-9. doi: 10.1016/0014-2999(80)90482-3. [PMID: 6245896]