Amineptine (BioDeep_00000271083)
代谢物信息卡片
化学式: C22H27NO2 (337.2041682)
中文名称: 安扑丁
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1CC2=CC=CC=C2C(C3=CC=CC=C31)NCCCCCCC(=O)O
InChI: InChI=1S/C22H27NO2/c24-21(25)13-3-1-2-8-16-23-22-19-11-6-4-9-17(19)14-15-18-10-5-7-12-20(18)22/h4-7,9-12,22-23H,1-3,8,13-16H2,(H,24,25)
描述信息
A carbocyclic fatty acid that is 5-aminoheptanoic acid in which one of the hydrogens attached to the nitrogen is replaced by a 10,11-dihydro-5H-dibenzo[a,d][7]annulen-5-yl group. A tricyclic antidepressant, it was never approved in the US and was withdrawn from the French market in 1999 due to concerns over abuse, dependence and severe acne.
N - Nervous system > N06 - Psychoanaleptics > N06A - Antidepressants > N06AA - Non-selective monoamine reuptake inhibitors
D002491 - Central Nervous System Agents > D011619 - Psychotropic Drugs > D000928 - Antidepressive Agents
C78272 - Agent Affecting Nervous System > C265 - Antidepressant Agent
同义名列表
1 个代谢物同义名
数据库引用编号
8 个数据库交叉引用编号
- ChEBI: CHEBI:32499
- KEGGdrug: D07335
- PubChem: 34870
- DrugBank: DB04836
- ChEMBL: CHEMBL418995
- CAS: 57574-09-1
- PMhub: MS000001389
- MetaboLights: MTBLC32499
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Christopher Balchin, Ai Lyn Tan, Oliver J Wilson, Jim McKenna, Antonios Stavropoulos-Kalinoglou. Participation in physical activity decreased more in people with rheumatoid arthritis than the general population during the COVID-19 lockdown: a cross-sectional study.
Rheumatology international.
2022 02; 42(2):241-250. doi:
10.1007/s00296-021-05054-4. [PMID: 34846554] - Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
Molecular pharmacology.
2019 11; 96(5):629-640. doi:
10.1124/mol.119.115964. [PMID: 31515284] - Marcin Kolaczkowski, Anna Kolaczkowska, Noboru Motohashi, Krystyna Michalak. New high-throughput screening assay to reveal similarities and differences in inhibitory sensitivities of multidrug ATP-binding cassette transporters.
Antimicrobial agents and chemotherapy.
2009 Apr; 53(4):1516-27. doi:
10.1128/aac.00956-08. [PMID: 19188399] - Guido Steiner, Laura Suter, Franziska Boess, Rodolfo Gasser, Maria Cristina de Vera, Silvio Albertini, Stefan Ruepp. Discriminating different classes of toxicants by transcript profiling.
Environmental health perspectives.
2004 Aug; 112(12):1236-48. doi:
10.1289/txg.7036. [PMID: 15345370] - Philippe Lettéron, Angela Sutton, Abdellah Mansouri, Bernard Fromenty, Dominique Pessayre. Inhibition of microsomal triglyceride transfer protein: another mechanism for drug-induced steatosis in mice.
Hepatology (Baltimore, Md.).
2003 Jul; 38(1):133-40. doi:
10.1053/jhep.2003.50309. [PMID: 12829995] - F Brambilla. Social stress in anorexia nervosa: a review of immuno-endocrine relationships.
Physiology & behavior.
2001 Jun; 73(3):365-9. doi:
10.1016/s0031-9384(01)00457-7. [PMID: 11438363] - C Quiñones-Torrelo, S Sagrado, R M Villanueva-Camañas, M J Medina-Hernández. Development of predictive retention-activity relationship models of tricyclic antidepressants by micellar liquid chromatography.
Journal of medicinal chemistry.
1999 Aug; 42(16):3154-62. doi:
10.1021/jm9910369. [PMID: 10447960] - D Raucoules, C Levy, J M Azorin, M Bruno, M Valli. [Plasma levels of MHPG, HVA and total 5-HIAA in depression. Preliminary study].
L'Encephale.
1992 Nov; 18(6):611-6. doi:
NULL. [PMID: 1285270] - J F Duriot, J P Dutertre, J M Grenier, A Autret, A Martin. [Amineptin dependence and iatrogenic acne. Review of the literature apropos of a case].
Annales medico-psychologiques.
1991 Dec; 149(10):795-7. doi:
NULL. [PMID: 1839203] - P P Rop, J Spinazzola, M Bresson, T Conquy, A Viala. Determination of amineptine and its main metabolite in plasma by high-performance liquid chromatography after solid-phase extraction.
Journal of chromatography.
1990 Nov; 532(2):351-61. doi:
10.1016/s0378-4347(00)83784-6. [PMID: 2084131] - L Grislain, P Gelé, N Bromet, W Luijten, J P Volland, E Mocaer, A Kamoun. Metabolism of amineptine in rat, dog and man.
European journal of drug metabolism and pharmacokinetics.
1990 Oct; 15(4):339-45. doi:
10.1007/bf03190224. [PMID: 2088771] - D Larrey, A Berson, F Habersetzer, M Tinel, A Castot, G Babany, P Lettéron, E Freneaux, J Loeper, P Dansette. Genetic predisposition to drug hepatotoxicity: role in hepatitis caused by amineptine, a tricyclic antidepressant.
Hepatology (Baltimore, Md.).
1989 Aug; 10(2):168-73. doi:
10.1002/hep.1840100208. [PMID: 2744728] - C Tsaconas, P Padieu, P d'Athis, E Mocaer, N Bromet. Gas chromatographic-mass spectrometric assessment of the pharmacokinetics of amineptine and its main metabolite in volunteers with liver impairment.
Journal of chromatography.
1989 Feb; 487(2):313-29. doi:
10.1016/s0378-4347(00)83040-6. [PMID: 2722999] - G Lachatre, C Piva, C Riche, D Dumont, R Defrance, E Mocaer, G Nicot. Single-dose pharmacokinetics of amineptine and of its main metabolite in healthy young adults.
Fundamental & clinical pharmacology.
1989; 3(1):19-26. doi:
10.1111/j.1472-8206.1989.tb00026.x. [PMID: 2714729] - C Riché, G Lachatre, Y Guedes, E Mocaër, G Nicot. Pharmacokinetics of amineptine after single-dose, repeated treatment and study of the at-risk populations.
Clinical neuropharmacology.
1989; 12 Suppl 2(?):S32-40. doi:
10.1097/00002826-198912002-00005. [PMID: 2698269] - J Geneve, D Larrey, P Letteron, V Descatoire, M Tinel, G Amouyal, D Pessayre. Metabolic activation of the tricyclic antidepressant amineptine--I. Cytochrome P-450-mediated in vitro covalent binding.
Biochemical pharmacology.
1987 Feb; 36(3):323-9. doi:
10.1016/0006-2952(87)90289-9. [PMID: 3814174] - V Lampronti, L Niosi, E Campisi, E Faggi, F Cecchi. [A case of mycotic endocarditis. Clinical, diagnostic and therapeutic considerations].
Minerva medica.
1985 Apr; 76(16):783-7. doi:
NULL. [PMID: 4000522] - G Nicot, G Lachatre, C Gonnet, J P Valette, L Merle, Y Nouaille, N Bromet. High-performance liquid chromatographic method for the determination of amineptine and its main metabolite in human plasma.
Journal of chromatography.
1984 Mar; 306(?):279-90. doi:
10.1016/s0378-4347(00)80890-7. [PMID: 6715466] - J C Poignant. [Amineptine, a new antidepressant: pharmacological review (author's transl)].
L'Encephale.
1979; 5(5 Suppl):709-20. doi:
. [PMID: 44871] - S B Jones, X J Musacchia. Tissue catecholamine levels of the golden hamster (Mesocricetus auratus) acclimated to 7, 22 and 34 degrees C.
Comparative biochemistry and physiology. C: Comparative pharmacology.
1975 Dec; 52(2):91-4. doi:
10.1016/0306-4492(75)90019-2. [PMID: 3371]