alminoprofen (BioDeep_00000271081)
代谢物信息卡片
化学式: C13H17NO2 (219.1259)
中文名称: 阿明洛芬
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C=C(C)CNc1ccc(C(C)C(=O)O)cc1
InChI: InChI=1S/C13H17NO2/c1-9(2)8-14-12-6-4-11(5-7-12)10(3)13(15)16/h4-7,10,14H,1,8H2,2-3H3,(H,15,16)
描述信息
M - Musculo-skeletal system > M01 - Antiinflammatory and antirheumatic products > M01A - Antiinflammatory and antirheumatic products, non-steroids > M01AE - Propionic acid derivatives
C78272 - Agent Affecting Nervous System > C241 - Analgesic Agent > C2198 - Nonnarcotic Analgesic
D018373 - Peripheral Nervous System Agents > D018689 - Sensory System Agents
D002491 - Central Nervous System Agents > D000700 - Analgesics
D000893 - Anti-Inflammatory Agents
D018501 - Antirheumatic Agents
Alminoprofen (EB-382) is a nonsteroidal anti-inflammatory agent (NSAID) of the phenylpropionic acid class. Alminoprofen possesses a dual anti-inflammatory action, by inhibiting both secretory phospholipase A2 (sPLA2) and COX-2[1].
同义名列表
2 个代谢物同义名
数据库引用编号
9 个数据库交叉引用编号
- ChEBI: CHEBI:31190
- KEGGdrug: D01513
- PubChem: 2097
- DrugBank: DB13314
- ChEMBL: CHEMBL1765293
- CAS: 54362-71-9
- CAS: 39718-89-3
- PMhub: MS000001386
- medchemexpress: HY-17485
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
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| 亚细胞结构定位 | 关联基因列表 |
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文献列表
- Jiayi Sun, Yuanyuan Zhu, Bin Lin, Jia Yu. Enantioseparation and determination of alminoprofen in rat plasma and its application to a stereoselective pharmacokinetic study.
Journal of pharmaceutical and biomedical analysis.
2020 Nov; 191(?):113552. doi:
10.1016/j.jpba.2020.113552. [PMID: 32877823] - Nawazish-I-Husain Syed, Farnaz Zehra, Amir Ali-Rizvi Syed, Sabiha Karim, Farrakh Zia Khan. Comparing the effects of salts of diclofenac and alminoprofen with aspirin on serum electrolytes, creatinine and urea levels in rabbits.
Pakistan journal of pharmaceutical sciences.
2012 Oct; 25(4):777-82. doi:
NULL. [PMID: 23009994] - Jean-Pascal Fournier, Maryse Lapeyre-Mestre, Agnès Sommet, Julie Dupouy, Jean-Christophe Poutrain, Jean-Louis Montastruc. Laboratory monitoring of patients treated with antihypertensive drugs and newly exposed to non steroidal anti-inflammatory drugs: a cohort study.
PloS one.
2012; 7(3):e34187. doi:
10.1371/journal.pone.0034187. [PMID: 22479557] - M Tod, C Pobel, V Le Gros, K Louchahi, O Petitjean, N Brion, J L Garcia-Mace. A population pharmacokinetic study of alminoprofen penetration into synovial fluid.
Biopharmaceutics & drug disposition.
1995 Nov; 16(8):627-34. doi:
10.1002/bdd.2510160803. [PMID: 8573683] - K Shin, M Takasaki, H Katsunuma, K Sato, T Shibuya, S Sato, H Hirayama. [Pharmacokinetics of oral alminoprofen (Minalfen) in elderly patients with rheumatoid arthritis and spondylosis deformans].
Nihon Ronen Igakkai zasshi. Japanese journal of geriatrics.
1992 Nov; 29(11):881-7. doi:
10.3143/geriatrics.29.881. [PMID: 1491485] - T Fujiyoshi, H Iida, M Murakami, M Kuwashima, T Uematsu. Pharmacological studies on EB-382, a new non-steroidal antiinflammatory agent: mode of action of the antiinflammatory effects.
Chemical & pharmaceutical bulletin.
1989 Mar; 37(3):771-4. doi:
10.1248/cpb.37.771. [PMID: 2752492] - M Paillet, H Merdjan, A Brouard, D Doucet, H Barreteau, G Fredj. Rapid determination of alminoprofen in plasma by high-performance liquid chromatography.
Journal of chromatography.
1985 Oct; 343(2):455-9. doi:
10.1016/s0378-4347(00)84619-8. [PMID: 4066887] - A Premel-Cabic, D Chaleil, R Bonniot, P Riberi, G Streichenberger, P Allain. [Comparative study of alminoprofene elimination in healthy subjects and in patients with renal or hepatic insufficiency (author's transl)].
Therapie.
1981 Jan; 36(1):41-6. doi:
NULL. [PMID: 7233371] - A Premel-Cabic, P Allain, L Pidhorz, G Streichenberger. Pharmacokinetics of 2-(p-methylallylaminophenyl) propionic acid, alminoprofene, in man after single and multiple oral doses.
European journal of clinical pharmacology.
1980 Nov; 18(5):419-22. doi:
10.1007/bf00636796. [PMID: 7439265] - T Uemura, G Sakaguchi, T Ito, K Okazawa, S Sakai. Experimental diarrhea in cynomolgus monkeys by oral administration with Clostridium perfringens type A viable cells or enterotoxin.
Japanese journal of medical science & biology.
1975 Jun; 28(3):165-77. doi:
10.7883/yoken1952.28.165. [PMID: 525]
