DECOQUINATE (BioDeep_00000271016)
代谢物信息卡片
DECOQUINATE
化学式: C24H35NO5 (417.2515)
中文名称: 癸氧喹酯
谱图信息:
最多检出来源 Viridiplantae(plant) 93.33%
分子结构信息
SMILES: CCCCCCCCCCOC1=C(C=C2C(=C1)C(=O)C(=CN2)C(=O)OCC)OCC
InChI: InChI=1S/C24H35NO5/c1-4-7-8-9-10-11-12-13-14-30-21-15-18-20(16-22(21)28-5-2)25-17-19(23(18)26)24(27)29-6-3/h15-17H,4-14H2,1-3H3,(H,25,26)
描述信息
D000890 - Anti-Infective Agents > D000977 - Antiparasitic Agents > D000981 - Antiprotozoal Agents
C254 - Anti-Infective Agent > C258 - Antibiotic > C795 - Quinolone Antibiotic
CONFIDENCE standard compound; INTERNAL_ID 1087
同义名列表
1 个代谢物同义名
数据库引用编号
13 个数据库交叉引用编号
- KEGGdrug: D03667
- PubChem: 29112
- Metlin: METLIN3973
- DrugBank: DB11394
- ChEMBL: CHEMBL416230
- MeSH: Decoquinate
- CAS: 18507-89-6
- MoNA: AU108705
- MoNA: AU108704
- MoNA: AU108703
- MoNA: AU108702
- MoNA: AU108701
- PMhub: MS000001154
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
| 亚细胞结构定位 | 关联基因列表 |
|---|
文献列表
- Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome.
Cell reports.
2021 04; 35(4):109040. doi:
10.1016/j.celrep.2021.109040. [PMID: 33910017] - Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
Molecular pharmacology.
2019 11; 96(5):629-640. doi:
10.1124/mol.119.115964. [PMID: 31515284] - Ane Odden, Snorre Stuen, Heidi L Enemark, Lucy J Robertson, José Manuel Molina, Antonio Ruiz. Preliminary studies on in vitro methods for the evaluation of anticoccidial efficacy/resistance in ruminants.
Experimental parasitology.
2019 Jun; 201(?):34-41. doi:
10.1016/j.exppara.2019.04.009. [PMID: 31034815] - David S Lindsay, M Mudasser Nazir, Azhar Maqbool, Siobhan P Ellison, Jeannine S Strobl. Efficacy of decoquinate against Sarcocystis neurona in cell cultures.
Veterinary parasitology.
2013 Sep; 196(1-2):21-3. doi:
10.1016/j.vetpar.2013.02.008. [PMID: 23523012] - Seongbeom Cho, Charles P Fossler, Francisco Diez-Gonzalez, Scott J Wells, Craig W Hedberg, John B Kaneene, Pamela L Ruegg, Lorin D Warnick, Jeffrey B Bender. Herd-level risk factors associated with fecal shedding of Shiga toxin-encoding bacteria on dairy farms in Minnesota, USA.
The Canadian veterinary journal = La revue veterinaire canadienne.
2013 Jul; 54(7):693-7. doi:
NULL. [PMID: 24155466] - Klaus Teichmann, Maxime Kuliberda, Gerd Schatzmayr, Franz Hadacek, Anja Joachim. In vitro determination of anticryptosporidial activity of phytogenic extracts and compounds.
Parasitology research.
2012 Jul; 111(1):231-40. doi:
10.1007/s00436-012-2824-y. [PMID: 22278729] - Gürbüz Daş, Cengiz Ataşoğlu, Hande Işıl Akbağ, Cemil Tölü, Ismail Yaman Yurtman, Türker Savaş. Effects of kefir on coccidial oocysts excretion and performance of dairy goat kids following weaning.
Tropical animal health and production.
2012 Jun; 44(5):1049-55. doi:
10.1007/s11250-011-0039-3. [PMID: 22189816] - J E Sykes, J P Dubey, L L Lindsay, P Prato, M R Lappin, L T Guo, A P Mizisin, G D Shelton. Severe myositis associated with Sarcocystis spp. infection in 2 dogs.
Journal of veterinary internal medicine.
2011 Nov; 25(6):1277-83. doi:
10.1111/j.1939-1676.2011.00828.x. [PMID: 22092617] - Bruce R Hoar, Robert R Paul, Jennifer Siembieda, Maria das Gracas C Pereira, Edward R Atwill. Giardia duodenalis in feedlot cattle from the central and western United States.
BMC veterinary research.
2009 Oct; 5(?):37. doi:
10.1186/1746-6148-5-37. [PMID: 19799795] - F C Guo, X Suo, G Z Zhang, J Z Shen. Efficacy of decoquinate against drug sensitive laboratory strains of Eimeria tenella and field isolates of Eimeria spp. in broiler chickens in China.
Veterinary parasitology.
2007 Jul; 147(3-4):239-45. doi:
10.1016/j.vetpar.2007.04.002. [PMID: 17485176] - M Lallemand, A Villeneuve, J Belda, P Dubreuil. Field study of the efficacy of halofuginone and decoquinate in the treatment of cryptosporidiosis in veal calves.
The Veterinary record.
2006 Nov; 159(20):672-6. doi:
10.1136/vr.159.20.672. [PMID: 17099176] - R B Williams. Tracing the emergence of drug-resistance in coccidia (Eimeria spp.) of commercial broiler flocks medicated with decoquinate for the first time in the United Kingdom.
Veterinary parasitology.
2006 Jan; 135(1):1-14. doi:
10.1016/j.vetpar.2005.10.012. [PMID: 16289564] - Ihsan Ergün, M Cenk Akbostanci, Başol Canbakan, Bilge Koçer, Arzu Ensari, Gökhan Nergizoglu, Kenan Keven. Minimal change nephrotic syndrome with stiff-person syndrome: is there a link?.
American journal of kidney diseases : the official journal of the National Kidney Foundation.
2005 Jul; 46(1):e11-4. doi:
10.1053/j.ajkd.2005.03.009. [PMID: 15983949] - Dale A Moore, E Robert Atwill, John H Kirk, Dipa Brahmbhatt, Laura Herrera Alonso, Lingling Hou, Matthew D Singer, Tracy D Miller. Prophylactic use of decoquinate for infections with Cryptosporidium parvum in experimentally challenged neonatal calves.
Journal of the American Veterinary Medical Association.
2003 Sep; 223(6):839-45. doi:
10.2460/javma.2003.223.839. [PMID: 14507102] - D K Macintire, N A Vincent-Johnson, C W Kane, D S Lindsay, B L Blagburn, A R Dillon. Treatment of dogs infected with Hepatozoon americanum: 53 cases (1989-1998).
Journal of the American Veterinary Medical Association.
2001 Jan; 218(1):77-82. doi:
10.2460/javma.2001.218.77. [PMID: 11149719] - J K Waggoner, M J Cecava, K R Kazacos. Efficacy of lasalocid and decoquinate against coccidiosis in naturally infected dairy calves.
Journal of dairy science.
1994 Jan; 77(1):349-53. doi:
10.3168/jds.s0022-0302(94)76961-7. [PMID: 8120204] - A J Heinrichs, G J Bush. Evaluation of decoquinate or lasalocid against coccidiosis from natural exposure in neonatal dairy calves.
Journal of dairy science.
1991 Sep; 74(9):3223-7. doi:
10.3168/jds.s0022-0302(91)78508-1. [PMID: 1779071] - A J Heinrichs, L A Swartz, T R Drake, P A Travis. Influence of decoquinate fed to neonatal dairy calves on early and conventional weaning systems.
Journal of dairy science.
1990 Jul; 73(7):1851-6. doi:
10.3168/jds.s0022-0302(90)78865-0. [PMID: 2229594] - P R Fitzgerald, M E Mansfield. Effects of inoculations with Eimeria zuernii on young calves treated with decoquinate or narasin with or without dexamethasone.
American journal of veterinary research.
1989 Jul; 50(7):1056-9. doi:
NULL. [PMID: 2774323] - K H Hoblet, T P Charles, R R Howard. Evaluation of lasalocid and decoquinate against coccidiosis resulting from natural exposure in weaned dairy calves.
American journal of veterinary research.
1989 Jul; 50(7):1060-3. doi:
NULL. [PMID: 2774324] - P R Fitzgerald, M E Mansfield. Effects of intermittent and continuous administration of decoquinate on bovine coccidiosis in male calves.
American journal of veterinary research.
1989 Jun; 50(6):961-4. doi:
NULL. [PMID: 2764351] - D H Seman, D R Catherman, T Matsui, M G Hayek, D B Batson, A H Cantor, R E Tucker, R B Muntifering, M L Westendorf, G E Mitchell. Metabolism of decoquinate in chickens and Japanese quail.
Poultry science.
1989 May; 68(5):670-5. doi:
10.3382/ps.0680670. [PMID: 2755893] - E A Perry, P L Long. The extraintestinal stages of Eimeria tenella and E. maxima in the chicken.
Veterinary parasitology.
1987 Jun; 25(1):9-17. doi:
10.1016/0304-4017(87)90060-4. [PMID: 3629905] - D L Harmon, T G Nagaraja, R T Brandt, R W Lee, T B Avery. Influence of decoquinate on ruminal fermentation, diet digestibility and cattle performance.
Journal of animal science.
1987 Apr; 64(4):1227-34. doi:
10.2527/jas1987.6441227x. [PMID: 3571027] - W J Foreyt, D H Rice, R B Wescott. Evaluation of lasalocid as a coccidiostat in calves: titration, efficacy, and comparison with monensin and decoquinate.
American journal of veterinary research.
1986 Sep; 47(9):2031-5. doi:
NULL. [PMID: 3767108] - D H Seman, M G Hayek, D B Batson, A H Cantor, R E Tucker, R B Muntifering, D G Ely, B L Soler, G E Mitchell. Comparative metabolism of 14C-decoquinate in chickens, quail and sheep.
Veterinary and human toxicology.
1986 Aug; 28(4):325-7. doi:
NULL. [PMID: 3750815] - W J Foreyt, D Hancock, R B Wescott. Prevention and control of coccidiosis in goats with decoquinate.
American journal of veterinary research.
1986 Feb; 47(2):333-5. doi:
NULL. [PMID: 3954215] - G Conlogue, W J Foreyt, R B Wescott. Bovine coccidiosis: protective effects of low-level infection and coccidiostat treatments in calves.
American journal of veterinary research.
1984 May; 45(5):863-6. doi:
NULL. [PMID: 6732015] - A Hobson-Frohock, H A Johnson. Coccidiostat residues in poultry excreta.
Journal of the science of food and agriculture.
1983 Jan; 34(1):37-44. doi:
10.1002/jsfa.2740340107. [PMID: 6843092] - L R McDougald, R B Galloway. Eimeria tenella: inhibition of development in cell culture by serum from chickens fed anticoccidial drugs.
Zeitschrift fur Parasitenkunde (Berlin, Germany).
1977 Dec; 54(1):95-100. doi:
10.1007/bf00380642. [PMID: 602371] - L R McDougald, R B Galloway. Anticoccidial drugs: effects on infectivity and survival intracellularly of Eimeria tenella sporozoites.
Experimental parasitology.
1976 Dec; 40(3):314-9. doi:
10.1016/0014-4894(76)90098-9. [PMID: 976419]
