Fludarabine (BioDeep_00000027100)

human metabolite blood metabolite Chemicals and Drugs

代谢物信息卡片

{[(2R,3S,4S,5R)-5-(6-amino-2-fluoro-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}phosphonic acid

化学式: C10H13FN5O7P (365.05366100000003)
中文名称: 磷酸氟达拉滨
谱图信息: 最多检出来源 Homo sapiens(blood) 99.48%

分子结构信息

SMILES: C1=NC2=C(N=C(N=C2N1C3C(C(C(O3)COP(=O)(O)O)O)O)F)N
InChI: InChI=1S/C10H13FN5O7P/c11-10-14-7(12)4-8(15-10)16(2-13-4)9-6(18)5(17)3(23-9)1-22-24(19,20)21/h2-3,5-6,9,17-18H,1H2,(H2,12,14,15)(H2,19,20,21)

描述信息

Fludarabine is only found in individuals that have used or taken this drug. Fludarabine (marketed as fludarabine phosphate under the trade name Fludara) is a chemotherapy drug used in the treatment of hematological malignancies. [Wikipedia]Fludarabine phosphate is rapidly dephosphorylated to 2-fluoro-ara-A and then phosphorylated intracellularly by deoxycytidine kinase to the active triphosphate, 2-fluoro-ara-ATP. This metabolite appears to act by inhibiting DNA polymerase alpha, ribonucleotide reductase and DNA primase, thus inhibiting DNA synthesis. The mechanism of action of this antimetabolite is not completely characterized and may be multi-faceted.
C274 - Antineoplastic Agent > C186664 - Cytotoxic Chemotherapeutic Agent > C272 - Antimetabolite
C471 - Enzyme Inhibitor > C2150 - Ribonucleotide Reductase Inhibitor
D007155 - Immunologic Factors > D007166 - Immunosuppressive Agents
D009676 - Noxae > D000963 - Antimetabolites
D000970 - Antineoplastic Agents
Fludarabine (phosphate) is an analogue of adenosine and deoxyadenosine, which is able to compete with dATP for incorporation into DNA and inhibit DNA synthesis.

同义名列表

39 个代谢物同义名

数据库引用编号

12 个数据库交叉引用编号

ChEBI: CHEBI:63599
PubChem: 30751
PubChem: 3368
HMDB: HMDB0015206
DrugBank: DBSALT000425
ChEMBL: CHEMBL1965242
ChEMBL: CHEMBL1096882
Wikipedia: Fludarabine
chemspider: 28532
CAS: 75607-67-9
PMhub: MS000243155
medchemexpress: HY-B0028

分类词条

Purine ribonucleoside monophosphates

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

9606 - Homo sapiens: -

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

文献列表

Jianyuan Zhao, Qian Liu, Dongrong Yi, Quanjie Li, SaiSai Guo, Ling Ma, Yongxin Zhang, Dongxin Dong, Fei Guo, Zhenlong Liu, Tao Wei, Xiaoyu Li, Shan Cen. 5-Iodotubercidin inhibits SARS-CoV-2 RNA synthesis. Antiviral research. 2022 02; 198(?):105254. doi: 10.1016/j.antiviral.2022.105254. [PMID: 35101534]
Ilona Tsybulskaya, Tamara Kulak, Elena Kalinichenko, Alexander Baranovsky, Svetlana Bogushevich, Marina Golubeva, Boleslav Kuzmitsky. Phospholipid derivatives of cladribine and fludarabine: synthesis and biological properties. Bioorganic & medicinal chemistry. 2015 Jul; 23(13):3287-96. doi: 10.1016/j.bmc.2015.04.059. [PMID: 25960323]
J Sanz, J C H Boluda, C Martín, M González, C Ferrá, D Serrano, C D de Heredia, C Barrenetxea, A M Martinez, C Solano, M A Sanz, G F Sanz. Single-unit umbilical cord blood transplantation from unrelated donors in patients with hematological malignancy using busulfan, thiotepa, fludarabine and ATG as myeloablative conditioning regimen. Bone marrow transplantation. 2012 Oct; 47(10):1287-93. doi: 10.1038/bmt.2012.13. [PMID: 22327127]
Philippa L Kohnke, Swetlana Mactier, Juhura G Almazi, Ben Crossett, Richard I Christopherson. Fludarabine and cladribine induce changes in surface proteins on human B-lymphoid cell lines involved with apoptosis, cell survival, and antitumor immunity. Journal of proteome research. 2012 Sep; 11(9):4436-48. doi: 10.1021/pr300079c. [PMID: 22839105]
Ulrich Jäger, Michael Fridrik, Markus Zeitlinger, Daniel Heintel, Georg Hopfinger, Sonja Burgstaller, Christine Mannhalter, Wilhelm Oberaigner, Edit Porpaczy, Cathrin Skrabs, Christine Einberger, Johannes Drach, Markus Raderer, Alexander Gaiger, Monique Putman, Richard Greil. Rituximab serum concentrations during immuno-chemotherapy of follicular lymphoma correlate with patient gender, bone marrow infiltration and clinical response. Haematologica. 2012 Sep; 97(9):1431-8. doi: 10.3324/haematol.2011.059246. [PMID: 22511498]
T Guillaume, B Gaugler, P Chevallier, J Delaunay, S Ayari, A Clavert, F Rialland, S Le Gouill, N Blin, T Gastinne, B Mahé, V Dubruille, P Moreau, M Mohty. Escalated lymphodepletion followed by donor lymphocyte infusion can induce a graft-versus-host response without overwhelming toxicity. Bone marrow transplantation. 2012 Aug; 47(8):1112-7. doi: 10.1038/bmt.2011.231. [PMID: 22120986]
Hiroshi Akasaka, Kisako Imaizumi, Emiko Sakane, Hiroko Tsunemine, Kiminari Ito, Taiichi Kodaka, Mayumi Matsumoto, Masao Matsuoka, Takayuki Takahashi. [Alleviation of palmoplantar pustulosis associated with adult T cell leukemia/lymphoma after allogeneic hematopoietic stem cell transplantation]. [Rinsho ketsueki] The Japanese journal of clinical hematology. 2012 Aug; 53(8):779-84. doi: NULL. [PMID: 22975820]
Jakub Tolar, H Joachim Deeg, Sally Arai, Mitchell Horwitz, Joseph H Antin, John M McCarty, Roberta H Adams, Marian Ewell, Eric S Leifer, Iris D Gersten, Shelly L Carter, Mary M Horowitz, Ryotaro Nakamura, Michael A Pulsipher, Nancy L Difronzo, Dennis L Confer, Mary Eapen, Paolo Anderlini. Fludarabine-based conditioning for marrow transplantation from unrelated donors in severe aplastic anemia: early results of a cyclophosphamide dose deescalation study show life-threatening adverse events at predefined cyclophosphamide dose levels. Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation. 2012 Jul; 18(7):1007-11. doi: 10.1016/j.bbmt.2012.04.014. [PMID: 22546497]
Aibin Liang, Hong Zhang, Yu Fang, Ying Li, Deqiu Zhu, Fangyuan Chen, Huina Lu, Jianfei Fu, Lanjun Bo. Sequential arabinosylcytosin with or without fludarabine in paracmastic patients with acute myeloid leukemia. Die Pharmazie. 2012 Jul; 67(7):635-8. doi: NULL. [PMID: 22888522]
Paula X Fernández-Calotti, Mónica Lopez-Guerra, Dolors Colomer, Marçal Pastor-Anglada. Enhancement of fludarabine sensitivity by all-trans-retinoic acid in chronic lymphocytic leukemia cells. Haematologica. 2012 Jun; 97(6):943-51. doi: 10.3324/haematol.2011.051557. [PMID: 22180426]
Zhen-Shu Xu, Jin-Yan Zhang, Rong Zhan, Zhi-Hong Zheng, Shun-Quan Wu, Zhi-Zhe Chen. [Clinical analysis on 40 patients with chronic lymphocytic leukemia]. Zhongguo shi yan xue ye xue za zhi. 2012 Jun; 20(3):583-6. doi: NULL. [PMID: 22739160]
Jia-Shiong Chen, Yung-Hsiang Chen, Po-Hsun Huang, Hsiao-Ya Tsai, Yuh-Lien Chen, Shing-Jong Lin, Jaw-Wen Chen. Ginkgo biloba extract reduces high-glucose-induced endothelial adhesion by inhibiting the redox-dependent interleukin-6 pathways. Cardiovascular diabetology. 2012 May; 11(?):49. doi: 10.1186/1475-2840-11-49. [PMID: 22553973]
Stefan O Ciurea, Rima M Saliba, Nelson Hamerschlak, Amado J Karduss Aurueta, Roland Bassett, Marcelo Fernandez-Vina, Demetrios Petropoulos, Laura L Worth, Ka Wah Chan, Daniel R Couriel, Gabriela Rondon, Manish Sharma, Muzaffar Qazilbash, Roy B Jones, Partow Kebriaei, John McMannis, Chitra M Hosing, Yago Nieto, Richard E Champlin, Elizabeth J Shpall, Marcos de Lima. Fludarabine, melphalan, thiotepa and anti-thymocyte globulin conditioning for unrelated cord blood transplant. Leukemia & lymphoma. 2012 May; 53(5):901-6. doi: 10.3109/10428194.2011.631159. [PMID: 21988645]
Chunfu Li, Yanhua Wang, Xuedong Wu, Fuyu Pei, Yuelin He, Xiaoqin Feng, Huaying Liu. [Pretreatment doses of antithymocyte globubin-fresenius for allogeneic hematopoietic stem cell transplantation for beta-thalassemia major]. Nan fang yi ke da xue xue bao = Journal of Southern Medical University. 2012 May; 32(5):691-4. doi: NULL. [PMID: 22588927]
Sujith Samarasinghe, Colin Steward, Prashant Hiwarkar, Muhammad Ameer Saif, Rachael Hough, David Webb, Alice Norton, Sarah Lawson, Amrana Qureshi, Philip Connor, Peter Carey, Rod Skinner, Ajay Vora, Maria Pelidis, Brenda Gibson, Graham Stewart, Steve Keogh, Nick Goulden, Denise Bonney, Mathew Stubbs, Persis Amrolia, Kanchan Rao, Stefan Meyer, Rob Wynn, Paul Veys. Excellent outcome of matched unrelated donor transplantation in paediatric aplastic anaemia following failure with immunosuppressive therapy: a United Kingdom multicentre retrospective experience. British journal of haematology. 2012 May; 157(3):339-46. doi: 10.1111/j.1365-2141.2012.09066.x. [PMID: 22372373]
Morie A Gertz. Waldenström macroglobulinemia. Hematology (Amsterdam, Netherlands). 2012 Apr; 17 Suppl 1(?):S112-6. doi: 10.1179/102453312x13336169156212. [PMID: 22507796]
Rachel B Salit, Daniel H Fowler, Wyndham H Wilson, Robert M Dean, Steven Z Pavletic, Kieron Dunleavy, Frances Hakim, Terry J Fry, Seth M Steinberg, Thomas E Hughes, Jeanne Odom, Kelly Bryant, Ronald E Gress, Michael R Bishop. Dose-adjusted EPOCH-rituximab combined with fludarabine provides an effective bridge to reduced-intensity allogeneic hematopoietic stem-cell transplantation in patients with lymphoid malignancies. Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 2012 Mar; 30(8):830-6. doi: 10.1200/jco.2011.37.0296. [PMID: 22312100]
Lubica Roziakova, Eva Bojtarova, Martin Mistrik, Juraj Dubrava, Jozef Gergel, Nadezda Lenkova, Beata Mladosievicova. Serial measurements of cardiac biomarkers in patients after allogeneic hematopoietic stem cell transplantation. Journal of experimental & clinical cancer research : CR. 2012 Feb; 31(?):13. doi: 10.1186/1756-9966-31-13. [PMID: 22321767]
S Bill Kangarloo, Farrukh Naveed, Ella S M Ng, M Ahsan Chaudhry, Judy Wu, Nizar J Bahlis, Christopher B Brown, Andrew Daly, Peter Duggan, Michelle Geddes, Diana Quinlan, Mary Lynn Savoie, Mona Shafey, Douglas A Stewart, Jan Storek, Maggie Yang, Nancy Zacarias, Ping Yue, Anthony M Magliocco, James A Russell. Development and validation of a test dose strategy for once-daily i.v. busulfan: importance of fixed infusion rate dosing. Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation. 2012 Feb; 18(2):295-301. doi: 10.1016/j.bbmt.2011.07.015. [PMID: 21801704]
Elisabeth H Javazon, Mohamed Radhi, Bagirath Gangadharan, Jennifer Perry, David R Archer. Hematopoietic stem cell function in a murine model of sickle cell disease. Anemia. 2012; 2012(?):387385. doi: 10.1155/2012/387385. [PMID: 22701784]
Rajat Singh, Yujian Zhang, Ira Pastan, Robert J Kreitman. Synergistic antitumor activity of anti-CD25 recombinant immunotoxin LMB-2 with chemotherapy. Clinical cancer research : an official journal of the American Association for Cancer Research. 2012 Jan; 18(1):152-60. doi: 10.1158/1078-0432.ccr-11-1839. [PMID: 22068660]
Jeannine S McCune, Erica L Woodahl, Terry Furlong, Barry Storer, Joanne Wang, Shelly Heimfeld, H Joachim Deeg, Paul V O'Donnell. A pilot pharmacologic biomarker study of busulfan and fludarabine in hematopoietic cell transplant recipients. Cancer chemotherapy and pharmacology. 2012 Jan; 69(1):263-72. doi: 10.1007/s00280-011-1736-3. [PMID: 21909959]
Barbara Renga, Daniela Francisci, Claudio D'Amore, Elisabetta Schiaroli, Andrea Mencarelli, Sabrina Cipriani, Franco Baldelli, Stefano Fiorucci. The HIV matrix protein p17 subverts nuclear receptors expression and induces a STAT1-dependent proinflammatory phenotype in monocytes. PloS one. 2012; 7(4):e35924. doi: 10.1371/journal.pone.0035924. [PMID: 22558273]
Jovana Cukuranovic, Sladjana Ugrenovic, Ivan Jovanovic, Milan Visnjic, Vladisav Stefanovic. Viral infection in renal transplant recipients. TheScientificWorldJournal. 2012; 2012(?):820621. doi: 10.1100/2012/820621. [PMID: 22654630]
Michelle Wong, Lars Öhrmalm, Kristina Broliden, Carl Aust, Martin Hibberd, Thomas Tolfvenstam. Mannose-binding lectin 2 polymorphisms do not influence frequency or type of infection in adults with chemotherapy induced neutropaenia. PloS one. 2012; 7(2):e30819. doi: 10.1371/journal.pone.0030819. [PMID: 22363494]
S Jennane, K Doghmi, E M Mahtat, N Messaoudi, B Varet, M Mikdame. Bing and neel syndrome. Case reports in hematology. 2012; 2012(?):845091. doi: 10.1155/2012/845091. [PMID: 22988532]
Claudia Langebrake, Friederike Bernhardt, Michael Baehr, Nicolaus Kröger, Axel R Zander. Drug dosing and monitoring in obese patients undergoing allogenic stem cell transplantation. International journal of clinical pharmacy. 2011 Dec; 33(6):918-24. doi: 10.1007/s11096-011-9568-0. [PMID: 21960151]
Ludek Raida, Pavel Tucek, Edgar Faber, Jana Vondrakova, Zuzana Rusinakova, Iva Skoumalova, Jaromir Hubacek, Marie Jarosova, Beata Katrincsakova, Zuzana Pikalova, Pavel Kurfurst, Karel Indrak. Comparison of new flu-bu12-tg conditioning with the standard bu-cy myeloablative regimen in patients undergoing allogeneic stem cell transplantation for acute myeloid leukemia. Biomedical papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia. 2011 Dec; 155(4):327-32. doi: 10.5507/bp.2011.040. [PMID: 22336644]
Benjamin Lee, Rona S Smith, Natthavat Tanphaichitr, Robert Novak, Stephanie Robertson, Nairmeen Awad Haller. Waldenström's macroglobulinemia and nephrotic syndrome with membranous nephropathy. Scandinavian journal of urology and nephrology. 2011 Dec; 45(6):473-7. doi: 10.3109/00365599.2011.568954. [PMID: 21612326]
S Lejniece, M Murovska, S Chapenko, B Breikša, Z Jaunmuktane, L Feldmane, I Ziediņa, J Gomez-Roman, M Garcia-Cabeza, A Lejnieks. Progressive multifocal leukoencephalopathy following fludarabine treatment in a chronic lymphocytic leukemia patient. Experimental oncology. 2011 Dec; 33(4):239-41. doi: NULL. [PMID: 22217715]
Xianrui Dou, Haitang Hu, Yongle Ju, Yongdong Liu, Kaifu Kang, Shufeng Zhou, Wenfang Chen. Concurrent nephrotic syndrome and acute renal failure caused by chronic lymphocytic leukemia (CLL): a case report and literature review. Diagnostic pathology. 2011 Oct; 6(?):99. doi: 10.1186/1746-1596-6-99. [PMID: 21995711]
Francesca Merchionne, Pasquale Procaccio, Franco Dammacco. Waldenström's macroglobulinemia. An overview of its clinical, biochemical, immunological and therapeutic features and our series of 121 patients collected in a single center. Critical reviews in oncology/hematology. 2011 Oct; 80(1):87-99. doi: 10.1016/j.critrevonc.2010.09.007. [PMID: 21036057]
Yue Han, Li Zhu, Aining Sun, Xiaoxu Lu, Luping Hu, Lili Zhou, Yongya Ren, Xiaohui Hu, Xiaojin Wu, Zhaoyue Wang, Changgeng Ruan, Depei Wu. Alterations of hemostatic parameters in the early development of allogeneic hematopoietic stem cell transplantation-related complications. Annals of hematology. 2011 Oct; 90(10):1201-8. doi: 10.1007/s00277-011-1273-5. [PMID: 21674145]
Seok Hui Kang, Hyeon Seok Hwang, Hoon Suk Park, In O Sun, Sun Ryoung Choi, Byung Ha Chung, Bum Soon Choi, Chul Woo Yang, Yong Soo Kim, Chang Ki Min, Cheol Whee Park. Changes in renal function after different tandem hematopoietic stem-cell transplantation approaches in patients with multiple myeloma. Journal of Korean medical science. 2011 Oct; 26(10):1310-5. doi: 10.3346/jkms.2011.26.10.1310. [PMID: 22022183]
Thomas Mueller, Wieland Voigt. Fermented wheat germ extract--nutritional supplement or anticancer drug?. Nutrition journal. 2011 Sep; 10(?):89. doi: 10.1186/1475-2891-10-89. [PMID: 21892933]
Polina Stepensky, Michael Y Shapira, Dmitry Balashov, Pavel Trakhtman, Elena Skorobogatova, Lyudmila Rheingold, Rebecca Brooks, Shoshana Revel-Vilk, Michael Weintraub, Jerry Stein, Alexey Maschan, Reuven Or, Igor B Resnick. Bone marrow transplantation for Fanconi anemia using fludarabine-based conditioning. Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation. 2011 Sep; 17(9):1282-8. doi: 10.1016/j.bbmt.2011.01.001. [PMID: 21220033]
Jonathan Hebb, Sarit Assouline, Caroline Rousseau, Pierre Desjardins, Stephen Caplan, Merrill J Egorin, Lilian Amrein, Raquel Aloyz, Lawrence Panasci. A phase I study of imatinib mesylate in combination with chlorambucil in previously treated chronic lymphocytic leukemia patients. Cancer chemotherapy and pharmacology. 2011 Sep; 68(3):643-51. doi: 10.1007/s00280-010-1530-7. [PMID: 21120481]
Maria M Choudhary, Maureen G Metcalfe, Kathryn Arrambide, Caryn Bern, Govinda S Visvesvara, Norman J Pieniazek, Rebecca D Bandea, Marlene Deleon-Carnes, Patricia Adem, Moaz M Choudhary, Sherif R Zaki, Musab U Saeed. Tubulinosema sp. microsporidian myositis in immunosuppressed patient. Emerging infectious diseases. 2011 Sep; 17(9):1727-30. doi: 10.3201/eid1709.101926. [PMID: 21888805]
Kyoo-Hyung Lee, Je-Hwan Lee, Jung-Hee Lee, Dae-Young Kim, Miee Seol, Young-Shin Lee, Young-Ah Kang, Mijin Jeon, Hyun-Ju Hwang, Ah-Rang Jung, Sung-Han Kim, Sung-Cheol Yun, Ho-Jin Shin. Reduced-intensity conditioning therapy with busulfan, fludarabine, and antithymocyte globulin for HLA-haploidentical hematopoietic cell transplantation in acute leukemia and myelodysplastic syndrome. Blood. 2011 Sep; 118(9):2609-17. doi: 10.1182/blood-2011-02-339838. [PMID: 21715313]
S El Kourashy, T Williamson, M A Chaudhry, M L Savoie, A R Turner, L Larratt, J Storek, N J Bahlis, C B Brown, M Yang, D Quinlan, M Geddes, N Zacarias, A Daly, P Duggan, D A Stewart, J A Russell. Influence of comorbidities on transplant outcomes in patients aged 50 years or more after myeloablative conditioning incorporating fludarabine, BU and ATG. Bone marrow transplantation. 2011 Aug; 46(8):1077-83. doi: 10.1038/bmt.2010.257. [PMID: 21057555]
Spyridon Arampatzis, Nikolaos Giannakoulas, Vassilios Liakopoulos, Theodoros Eleftheriadis, Panagiota Kourti, Foteini Karasavvidou, Panagiota Matsouka, Ioannis Stefanidis. Simultaneous clinical resolution of focal segmental glomerulosclerosis associated with chronic lymphocytic leukaemia treated with fludarabine, cyclophosphamide and rituximab. BMC nephrology. 2011 Jul; 12(?):33. doi: 10.1186/1471-2369-12-33. [PMID: 21729272]
Qaiser Bashir, Borje S Andersson, Marcelo Fernandez-Vina, Leandro de Padua Silva, Sergio Giralt, Alexandre Chiattone, Wei Wei, Manish Sharma, Paolo Anderlini, Elizabeth J Shpall, Uday Popat, Morgani Rodrigues, Richard E Champlin, Marcos de Lima. Unrelated donor transplantation for acute myelogenous leukemia in first remission. Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation. 2011 Jul; 17(7):1067-71. doi: 10.1016/j.bbmt.2010.11.012. [PMID: 21087679]
Wenyan Xiao, Ganchimeg Ishdorj, Jinmei Sun, James B Johnston, Spencer B Gibson. Death receptor 4 is preferentially recruited to lipid rafts in chronic lymphocytic leukemia cells contributing to tumor necrosis related apoptosis inducing ligand-induced synergistic apoptotic responses. Leukemia & lymphoma. 2011 Jul; 52(7):1290-301. doi: 10.3109/10428194.2011.567317. [PMID: 21699383]
Kelvin S H Loke, Ajit K Padhy, David C E Ng, Anthony S W Goh, Chaitanya Divgi. Dosimetric considerations in radioimmunotherapy and systemic radionuclide therapies: a review. World journal of nuclear medicine. 2011 Jul; 10(2):122-38. doi: 10.4103/1450-1147.89780. [PMID: 22144871]
Letizia Polito, Massimo Bortolotti, Manuela Pedrazzi, Andrea Bolognesi. Immunotoxins and other conjugates containing saporin-s6 for cancer therapy. Toxins. 2011 06; 3(6):697-720. doi: 10.3390/toxins3060697. [PMID: 22069735]
Wei Xu, Kou-Rong Miao, Dan-Xia Zhu, Cheng Fang, Hua-Yuan Zhu, Hua-Jie Dong, Dong-Mei Wang, Yu-Jie Wu, Chun Qiao, Jian-Yong Li. Enhancing the action of rituximab by adding fresh frozen plasma for the treatment of fludarabine refractory chronic lymphocytic leukemia. International journal of cancer. 2011 May; 128(9):2192-201. doi: 10.1002/ijc.25560. [PMID: 20635386]
Thomas Mueller, Karin Jordan, Wieland Voigt. Promising cytotoxic activity profile of fermented wheat germ extract (Avemar®) in human cancer cell lines. Journal of experimental & clinical cancer research : CR. 2011 Apr; 30(?):42. doi: 10.1186/1756-9966-30-42. [PMID: 21496306]
Hideo Koh, Hirohisa Nakamae, Kiyoyuki Hagihara, Takahiko Nakane, Masahiro Manabe, Yoshiki Hayashi, Mitsutaka Nishimoto, Yukari Umemoto, Mika Nakamae, Asao Hirose, Eri Inoue, Atsushi Inoue, Masahiro Yoshida, Masato Bingo, Hiroshi Okamura, Ran Aimoto, Mizuki Aimoto, Yoshiki Terada, Ki-Ryang Koh, Takahisa Yamane, Masahiko Ohsawa, Masayuki Hino. Factors that contribute to long-term survival in patients with leukemia not in remission at allogeneic hematopoietic cell transplantation. Journal of experimental & clinical cancer research : CR. 2011 Apr; 30(?):36. doi: 10.1186/1756-9966-30-36. [PMID: 21477348]
Monika Podhorecka, Dorota Halicka, Piotr Klimek, Malgorzata Kowal, Sylwia Chocholska, Anna Dmoszynska. Resveratrol increases rate of apoptosis caused by purine analogues in malignant lymphocytes of chronic lymphocytic leukemia. Annals of hematology. 2011 Feb; 90(2):173-83. doi: 10.1007/s00277-010-1045-7. [PMID: 20714724]
Bichoy H Gabra, Muneer H Abidi, Zaid Al-Khadimi, David J Edwards, Rami B Ibrahim. Systemic absorption of topical lidocaine in a bone marrow transplant recipient with hepatic sinusoidal obstruction syndrome. American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists. 2011 Jan; 68(2):135-7. doi: 10.2146/ajhp100026. [PMID: 21200060]
Rong Chen, Lei Guo, Yuling Chen, Yingjun Jiang, William G Wierda, William Plunkett. Homoharringtonine reduced Mcl-1 expression and induced apoptosis in chronic lymphocytic leukemia. Blood. 2011 Jan; 117(1):156-64. doi: 10.1182/blood-2010-01-262808. [PMID: 20971952]
Shlomo Almog, Daniel Kurnik, Avichai Shimoni, Ronen Loebstein, Eyal Hassoun, Asher Gopher, Hillel Halkin, Arnon Nagler. Linearity and stability of intravenous busulfan pharmacokinetics and the role of glutathione in busulfan elimination. Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation. 2011 Jan; 17(1):117-23. doi: 10.1016/j.bbmt.2010.06.017. [PMID: 20601034]
J R Long-Boyle, K G Green, C G Brunstein, Q Cao, J Rogosheske, D J Weisdorf, J S Miller, J E Wagner, P B McGlave, P A Jacobson. High fludarabine exposure and relationship with treatment-related mortality after nonmyeloablative hematopoietic cell transplantation. Bone marrow transplantation. 2011 Jan; 46(1):20-6. doi: 10.1038/bmt.2010.53. [PMID: 20383215]
Melissa A Geller, Sarah Cooley, Patricia L Judson, Rahel Ghebre, Linda F Carson, Peter A Argenta, Amy L Jonson, Angela Panoskaltsis-Mortari, Julie Curtsinger, David McKenna, Kathryn Dusenbery, Robin Bliss, Levi S Downs, Jeffrey S Miller. A phase II study of allogeneic natural killer cell therapy to treat patients with recurrent ovarian and breast cancer. Cytotherapy. 2011 Jan; 13(1):98-107. doi: 10.3109/14653249.2010.515582. [PMID: 20849361]
Amir Sharabi, Nechama Haran-Ghera. Immune recovery after cyclophosphamide treatment in multiple myeloma: implication for maintenance immunotherapy. Bone marrow research. 2011; 2011(?):269519. doi: 10.1155/2011/269519. [PMID: 22046558]
M Hadjibabaie, S Rahimian, Z Jahangard-Rafsanjani, M Amini, K Alimoghaddam, M Iravani, A Ghavamzadeh, S Sadrai. Population pharmacokinetics of oral high-dose busulfan in adult patients undergoing hematopoietic stem cell transplantation. Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences. 2011; 19(3):216-23. doi: NULL. [PMID: 22615660]
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Albert Gutierrez, Bonnie K Arendt, Renee C Tschumper, Neil E Kay, Clive S Zent, Diane F Jelinek. Differentiation of chronic lymphocytic leukemia B cells into immunoglobulin secreting cells decreases LEF-1 expression. PloS one. 2011; 6(10):e26056. doi: 10.1371/journal.pone.0026056. [PMID: 21998751]
Catherine Toong, Stephen Adelstein, Tri Giang Phan. Clearing the complexity: immune complexes and their treatment in lupus nephritis. International journal of nephrology and renovascular disease. 2011; 4(?):17-28. doi: 10.2147/ijnrd.s10233. [PMID: 21694945]
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Séverine Loisel, Karine Le Ster, Michèle Meyer, Christian Berthou, Pierre Youinou, Jean-Pierre Kolb, Christian Billard. Therapeutic activity of two xanthones in a xenograft murine model of human chronic lymphocytic leukemia. Journal of hematology & oncology. 2010 Dec; 3(?):49. doi: 10.1186/1756-8722-3-49. [PMID: 21138552]
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Konstantin Tsoyi, Irina Tsoy Nizamutdinova, Hwa Jin Jang, Lidiya Mun, Hye Jung Kim, Han Geuk Seo, Jae Heun Lee, Ki Churl Chang. Carbon monoxide from CORM-2 reduces HMGB1 release through regulation of IFN-β/JAK2/STAT-1/INOS/NO signaling but not COX-2 in TLR-activated macrophages. Shock (Augusta, Ga.). 2010 Dec; 34(6):608-14. doi: 10.1097/shk.0b013e3181e46f15. [PMID: 20442692]
Iwona Bil-Lula, Marek Ussowicz, Blanka Rybka, Danuta Wendycz-Domalewska, Renata Ryczan, Ewa Gorczyńska, Krzysztof Kałwak, Mieczysław Woźniak. PCR diagnostics and monitoring of adenoviral infections in hematopoietic stem cell transplantation recipients. Archives of virology. 2010 Dec; 155(12):2007-15. doi: 10.1007/s00705-010-0802-1. [PMID: 20848295]
Wen-Chi Foo, Qin Huang, Siby Sebastian, Charles B Hutchinson, Jim Burchette, Endi Wang. Concurrent classical Hodgkin lymphoma and plasmablastic lymphoma in a patient with chronic lymphocytic leukemia/small lymphocytic lymphoma treated with fludarabine: a dimorphic presentation of iatrogenic immunodeficiency-associated lymphoproliferative disorder with evidence suggestive of multiclonal transformability of B cells by Epstein-Barr virus. Human pathology. 2010 Dec; 41(12):1802-8. doi: 10.1016/j.humpath.2010.04.019. [PMID: 20869749]
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Giampaolo Talamo, William Castellani, Nathan G Dolloff. Prozone effect of serum IgE levels in a case of plasma cell leukemia. Journal of hematology & oncology. 2010 Sep; 3(?):32. doi: 10.1186/1756-8722-3-32. [PMID: 20828419]
Rachel J Bishop, Xiaoyan Ding, Charles K Heller, Gabor Illei, Rafael C Caruso, Denise Cunningham, Steven Pavletic, Chi-Chao Chan. Rapid vision loss associated with fludarabine administration. Retina (Philadelphia, Pa.). 2010 Sep; 30(8):1272-7. doi: 10.1097/iae.0b013e3181d20589. [PMID: 20224467]
Kumudha Balakrishnan, Dushyant Verma, Susan O'Brien, John Michael Kilpatrick, Yuling Chen, Brenita F Tyler, Susan Bickel, Shanta Bantia, Michael J Keating, Hagop Kantarjian, Varsha Gandhi, Farhad Ravandi. Phase 2 and pharmacodynamic study of oral forodesine in patients with advanced, fludarabine-treated chronic lymphocytic leukemia. Blood. 2010 Aug; 116(6):886-92. doi: 10.1182/blood-2010-02-272039. [PMID: 20427701]
Sara Nannizzi, Gareth J Veal, Elisa Giovannetti, Valentina Mey, Simona Ricciardi, Christopher J Ottley, Mario Del Tacca, Romano Danesi. Cellular and molecular mechanisms for the synergistic cytotoxicity elicited by oxaliplatin and pemetrexed in colon cancer cell lines. Cancer chemotherapy and pharmacology. 2010 Aug; 66(3):547-58. doi: 10.1007/s00280-009-1195-2. [PMID: 20020129]
Xiang-Juan Ma, Han-Yun Ren, Zhi-Xiang Qiu, Xi-Nan Cen, Jin-Ping Ou, Wen-Sheng Wang, Wei-Lin Xu, Li-Hong Wang, Yu-Jun Dong, Yu-Hua Sun, Yuan Li, Yue Yin. [Incidence and risk factors of hemorrhagic cystitis after hematopoietic stem cell transplantation]. Zhongguo shi yan xue ye xue za zhi. 2010 Aug; 18(4):1007-12. doi: NULL. [PMID: 20723318]
Antoinette D Ajavon, Peter L Bonate, David R Taft. Renal excretion of clofarabine: assessment of dose-linearity and role of renal transport systems on drug excretion. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. 2010 Jun; 40(3):209-16. doi: 10.1016/j.ejps.2010.03.014. [PMID: 20347037]
Andrea Bacigalupo, Gerard Socie', Edoardo Lanino, Arcangelo Prete, Franco Locatelli, Anna Locasciulli, Simone Cesaro, Avichai Shimoni, Judith Marsh, Mats Brune, Maria Teresa Van Lint, Rosi Oneto, Jacob Passweg. Fludarabine, cyclophosphamide, antithymocyte globulin, with or without low dose total body irradiation, for alternative donor transplants, in acquired severe aplastic anemia: a retrospective study from the EBMT-SAA Working Party. Haematologica. 2010 Jun; 95(6):976-82. doi: 10.3324/haematol.2009.018267. [PMID: 20494932]
Kiriko Terasako, Ken Sato, Miki Sato, Shun-ichi Kimura, Hideki Nakasone, Shinya Okuda, Shinichi Kako, Yukie Tanaka, Rie Yamazaki, Kumi Oshima, Aki Tanihara, Takakazu Higuchi, Junji Nishida, Yoshinobu Kanda. The effect of different ATG preparations on immune recovery after allogeneic hematopoietic stem cell transplantation for severe aplastic anemia. Hematology (Amsterdam, Netherlands). 2010 Jun; 15(3):165-9. doi: 10.1179/102453309x12583347113852. [PMID: 20557676]
Aleksandra Sretenovic, Darko Antic, Snezana Jankovic, Mirjana Gotic, Maja Perunicic-Jovanovic, Ljubomir Jakovic, Biljana Mihaljevic. T-cell large granular lymphocytic (T-LGL) leukemia: a single institution experience. Medical oncology (Northwood, London, England). 2010 Jun; 27(2):286-90. doi: 10.1007/s12032-009-9206-z. [PMID: 19306076]
Daniele Santini, Bruno Vincenzi, Maria Elisabetta Fratto, Giuseppe Perrone, Raymond Lai, Vincenzo Catalano, Carol Cass, Pier Adelchi Ruffini, Chiara Spoto, Pietro Muretto, Sergio Rizzo, Andrea Onetti Muda, John R Mackey, Antonio Russo, Giuseppe Tonini, Francesco Graziano. Prognostic role of human equilibrative transporter 1 (hENT1) in patients with resected gastric cancer. Journal of cellular physiology. 2010 May; 223(2):384-8. doi: 10.1002/jcp.22045. [PMID: 20082300]
C Schilthuizen, H W A Berenschot, M-D Levin. Enteroviral encephalitis in a patient with a marginal zone lymphomatreated with rituximab. The Netherlands journal of medicine. 2010 May; 68(5):221-3. doi: NULL. [PMID: 20508271]
Paula Fernández-Calotti, Marçal Pastor-Anglada. All-trans-retinoic acid promotes trafficking of human concentrative nucleoside transporter-3 (hCNT3) to the plasma membrane by a TGF-beta1-mediated mechanism. The Journal of biological chemistry. 2010 Apr; 285(18):13589-98. doi: 10.1074/jbc.m109.055673. [PMID: 20172853]
Liia D Vainchtein, Hilde Rosing, Jan H M Schellens, Jos H Beijnen. A new, validated HPLC-MS/MS method for the simultaneous determination of the anti-cancer agent capecitabine and its metabolites: 5'-deoxy-5-fluorocytidine, 5'-deoxy-5-fluorouridine, 5-fluorouracil and 5-fluorodihydrouracil, in human plasma. Biomedical chromatography : BMC. 2010 Apr; 24(4):374-86. doi: 10.1002/bmc.1302. [PMID: 19650151]
M Harnalikar, S Pande, V Kharkar, U Khopkar. Keratotic vascular papules over the feet: a case of Waldenström's macroglobulinaemia-associated cutaneous macroglobulinosis. Clinical and experimental dermatology. 2010 Apr; 35(3):278-81. doi: 10.1111/j.1365-2230.2009.03651.x. [PMID: 19874364]
Nives Dzeko Skugor, Zinaida Perić, Radovan Vrhovac, Delfa Radić-Kristo, Ika Kardum-Skelin, Branimir Jaksić. Diffuse large B-cell lymphoma in patient after treatment of angioimmunoblastic T-cell lymphoma. Collegium antropologicum. 2010 Mar; 34(1):241-5. doi: NULL. [PMID: 20432757]
Kefei Hu, Saideh Berenjian, Rolf Larsson, Joachim Gullbo, Peter Nygren, Tanja Lövgren, Bror Morein. Nanoparticulate Quillaja saponin induces apoptosis in human leukemia cell lines with a high therapeutic index. International journal of nanomedicine. 2010 Feb; 5(?):51-62. doi: . [PMID: 20161987]
Gheath Alatrash, Maher Albitar, Susan O'Brien, Xuemei Wang, Taghi Manshouri, Stefan Faderl, Alessandra Ferrajoli, Jan Burger, Guillermo Garcia-Manero, Hagop M Kantarjian, Susan Lerner, Michael J Keating, William G Wierda. Circulating CD52 and CD20 levels at end of treatment predict for progression and survival in patients with chronic lymphocytic leukaemia treated with fludarabine, cyclophosphamide and rituximab (FCR). British journal of haematology. 2010 Feb; 148(3):386-93. doi: 10.1111/j.1365-2141.2009.07965.x. [PMID: 19895616]
Ana Carina Ferreira, Sandra Brum, Dulce Carvalho, Isabel Pataca, Fernanda Carvalho, Maria Céu Santos, João Ribeiro Santos. Renal dysfunction due to leukemic infiltration of kidneys in a case of chronic lymphocytic leukemia. Hemodialysis international. International Symposium on Home Hemodialysis. 2010 Jan; 14(1):87-90. doi: 10.1111/j.1542-4758.2009.00395.x. [PMID: 19758305]
Małgorzata Rogalińska, Jerzy Z Błoński, Oxana Komina, Paweł Góralski, Jolanta D Zołnierczyk, Henryk Piekarski, Tadeusz Robak, Zofia M Kiliańska, Józefa Wesierska-Gadek. R-roscovitine (Seliciclib) affects CLL cells more strongly than combinations of fludarabine or cladribine with cyclophosphamide: Inhibition of CDK7 sensitizes leukemic cells to caspase-dependent apoptosis. Journal of cellular biochemistry. 2010 Jan; 109(1):217-35. doi: 10.1002/jcb.22400. [PMID: 19911397]
Wei Yin, Elena V Karyagina, Ante S Lundberg, David J Greenblatt, John Lister-James. Pharmacokinetics, bioavailability and effects on electrocardiographic parameters of oral fludarabine phosphate. Biopharmaceutics & drug disposition. 2010 Jan; 31(1):72-81. doi: 10.1002/bdd.690. [PMID: 19862681]
Sekar Ashok Kumar, Xiaojie Hu, Michelle Brown, Brenda Kuschak, Tiffany A Hernandez, James B Johnston, Spencer B Gibson. Lysophosphatidic acid receptor expression in chronic lymphocytic leukemia leads to cell survival mediated though vascular endothelial growth factor expression. Leukemia & lymphoma. 2009 Dec; 50(12):2038-48. doi: 10.3109/10428190903275586. [PMID: 19860625]
Yi-Ni Wang, Zhao Wang, Lin Wu, Xi-Nan Cen, Bo-Tao Li, Feng Ning, Xue-Zhang Duan, Juan Li. [A multicenter retrospective analysis of diagnosis and treatment of 72 hemophagocytic syndrome patients.]. Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi. 2009 Dec; 30(12):793-8. doi: NULL. [PMID: 20193597]
Markus Zumbansen, Ludger M Altrogge, Nicole Ue Spottke, Sonja Spicker, Sheila M Offizier, Sandra Bs Domzalski, Allison L St Amand, Andrea Toell, Devin Leake, Herbert A Mueller-Hartmann. First siRNA library screening in hard-to-transfect HUVEC cells. Journal of RNAi and gene silencing : an international journal of RNA and gene targeting research. 2009 Oct; 6(1):354-60. doi: ". [PMID: 20628494]
V Zismanov, M Lishner, S Tartakover-Matalon, J Radnay, H Shapiro, L Drucker. Tetraspanin-induced death of myeloma cell lines is autophagic and involves increased UPR signalling. British journal of cancer. 2009 Oct; 101(8):1402-9. doi: 10.1038/sj.bjc.6605291. [PMID: 19755988]
Vicki A Morrison. Infectious complications in patients with chronic lymphocytic leukemia: pathogenesis, spectrum of infection, and approaches to prophylaxis. Clinical lymphoma & myeloma. 2009 Oct; 9(5):365-70. doi: 10.3816/clm.2009.n.071. [PMID: 19858055]
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Francesc Bosch, Pau Abrisqueta, Neus Villamor, María José Terol, Eva González-Barca, Christelle Ferra, Marcos González Diaz, Eugenia Abella, Julio Delgado, Félix Carbonell, José Antonio García Marco, Lourdes Escoda, Secundino Ferrer, Encarnación Monzó, Yolanda González, Cristina Estany, Isidro Jarque, Olga Salamero, Ana Muntañola, Emili Montserrat. Rituximab, fludarabine, cyclophosphamide, and mitoxantrone: a new, highly active chemoimmunotherapy regimen for chronic lymphocytic leukemia. Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 2009 Sep; 27(27):4578-84. doi: 10.1200/jco.2009.22.0442. [PMID: 19704063]
Hala Alshayeb, Barry M Wall. Non-Hodgkin's lymphoma associated membranoproliferative glomerulonephritis: rare case of long term remission with chemotherapy: a case report. Cases journal. 2009 Sep; 2(?):7201. doi: 10.1186/1757-1626-0002-0000007201. [PMID: 20181193]
Jonas A de Souza, Rima M Saliba, Poliana Patah, Gabriela Rondon, Rachel Ribeiro, Leandro de Padua Silva, Muzaffar H Qazilbash, Chitra Hosing, Uday Popat, Yvonne Efebera, Richard E Champlin, Marcos de Lima. Moderate renal function impairment does not affect outcomes of reduced-intensity conditioning with fludarabine and melphalan for allogeneic hematopoietic stem cell transplantation. Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation. 2009 Sep; 15(9):1094-9. doi: 10.1016/j.bbmt.2009.05.006. [PMID: 19660722]
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M Bregni, M Bernardi, P Servida, A Pescarollo, R Crocchiolo, E Treppiedi, P Corradini, F Ciceri, J Peccatori. Long-term follow-up of metastatic renal cancer patients undergoing reduced-intensity allografting. Bone marrow transplantation. 2009 Aug; 44(4):237-42. doi: 10.1038/bmt.2009.9. [PMID: 19234510]
Moo-Kon Song, Joo-Seop Chung, Young-Mi Seol, Bo-Ran Kwon, Ho-Jin Shin, Young-Jin Choi, Goon-Jae Cho. Influence of lactate dehydrogenase and cyclosporine A level on the incidence of acute graft-versus-host disease after allogeneic stem cell transplantation. Journal of Korean medical science. 2009 Aug; 24(4):555-60. doi: 10.3346/jkms.2009.24.4.555. [PMID: 19654932]