C2-ceramide (BioDeep_00000270975)
代谢物信息卡片
C2-ceramide
化学式: C20H39NO3 (341.29297840000004)
中文名称:
谱图信息:
最多检出来源 Mentha canadensis(plant) 85.71%
分子结构信息
SMILES: CCCCCCCCCCCCCC=CC(O)C(CO)NC(C)=O
InChI:
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Micah M Ross, Ted B Piorczynski, Jamison Harvey, Tyson S Burnham, Morgan Francis, Madison W Larsen, Kyle Roe, Jason M Hansen, Michael R Stark. Ceramide: a novel inducer for neural tube defects.
Developmental dynamics : an official publication of the American Association of Anatomists.
2019 10; 248(10):979-996. doi:
10.1002/dvdy.93. [PMID: 31390103] - L Shi, D Banerjee, A Dobierzewska, S Sathishkumar, A A Karakashian, N V Giltiay, M N Nikolova-Karakashian. Direct regulation of IGF-binding protein 1 promoter by interleukin-1β via an insulin- and FoxO-1-independent mechanism.
American journal of physiology. Endocrinology and metabolism.
2016 Apr; 310(8):E612-E623. doi:
10.1152/ajpendo.00289.2015. [PMID: 26884383] - Zhihui Zhu, Rongyu Li, Rolf Stricker, Georg Reiser. Extracellular α-crystallin protects astrocytes from cell death through activation of MAPK, PI3K/Akt signaling pathway and blockade of ROS release from mitochondria.
Brain research.
2015 Sep; 1620(?):17-28. doi:
10.1016/j.brainres.2015.05.011. [PMID: 25998538] - Hideo Ogiso, Makoto Taniguchi, Toshiro Okazaki. Analysis of lipid-composition changes in plasma membrane microdomains.
Journal of lipid research.
2015 Aug; 56(8):1594-605. doi:
10.1194/jlr.m059972. [PMID: 26116739] - Luigi Leanza, Paul O'Reilly, Anne Doyle, Elisa Venturini, Mario Zoratti, Eva Szegezdi, Ildiko Szabo. Correlation between potassium channel expression and sensitivity to drug-induced cell death in tumor cell lines.
Current pharmaceutical design.
2014; 20(2):189-200. doi:
10.2174/13816128113199990032. [PMID: 23701546] - H Li, Y Zhou, A Zhao, Y Qiu, G Xie, Q Jiang, X Zheng, W Zhong, X Sun, Z Zhou, W Jia. Asymmetric dimethylarginine attenuates serum starvation-induced apoptosis via suppression of the Fas (APO-1/CD95)/JNK (SAPK) pathway.
Cell death & disease.
2013 Oct; 4(?):e830. doi:
10.1038/cddis.2013.345. [PMID: 24091673] - Hideyuki Iwayama, Norishi Ueda. Role of mitochondrial Bax, caspases, and MAPKs for ceramide-induced apoptosis in renal proximal tubular cells.
Molecular and cellular biochemistry.
2013 Jul; 379(1-2):37-42. doi:
10.1007/s11010-013-1624-8. [PMID: 23543151] - Tim Ting Chiu, Yi Sun, Alexandra Koshkina, Amira Klip. Rac-1 superactivation triggers insulin-independent glucose transporter 4 (GLUT4) translocation that bypasses signaling defects exerted by c-Jun N-terminal kinase (JNK)- and ceramide-induced insulin resistance.
The Journal of biological chemistry.
2013 Jun; 288(24):17520-31. doi:
10.1074/jbc.m113.467647. [PMID: 23640896] - Mark J Dekker, Chris Baker, Mark Naples, Josh Samsoondar, Rianna Zhang, Wei Qiu, Jennifer Sacco, Khosrow Adeli. Inhibition of sphingolipid synthesis improves dyslipidemia in the diet-induced hamster model of insulin resistance: evidence for the role of sphingosine and sphinganine in hepatic VLDL-apoB100 overproduction.
Atherosclerosis.
2013 May; 228(1):98-109. doi:
10.1016/j.atherosclerosis.2013.01.041. [PMID: 23466071] - Chin Siang Kue, Mi Young Jung, Daeho Cho, Tae Sung Kim. C6-ceramide enhances Interleukin-12-mediated T helper type 1 cell responses through a cyclooxygenase-2-dependent pathway.
Immunobiology.
2012 Jun; 217(6):601-9. doi:
10.1016/j.imbio.2011.10.021. [PMID: 22112438] - Anjaneyulu Kowluru. Friendly, and not so friendly, roles of Rac1 in islet β-cell function: lessons learnt from pharmacological and molecular biological approaches.
Biochemical pharmacology.
2011 Apr; 81(8):965-75. doi:
10.1016/j.bcp.2011.01.013. [PMID: 21300027] - M Pozuelo-Rubio. Regulation of autophagic activity by 14-3-3ζ proteins associated with class III phosphatidylinositol-3-kinase.
Cell death and differentiation.
2011 Mar; 18(3):479-92. doi:
10.1038/cdd.2010.118. [PMID: 20885446] - William Weidong Du, Burton B Yang, Bing L Yang, Zhaoqun Deng, Ling Fang, Sze Wan Shan, Zina Jeyapalan, Yaou Zhang, Arun Seth, Albert J Yee. Versican G3 domain modulates breast cancer cell apoptosis: a mechanism for breast cancer cell response to chemotherapy and EGFR therapy.
PloS one.
2011; 6(11):e26396. doi:
10.1371/journal.pone.0026396. [PMID: 22096483] - Wei-Ching Huang, Chia-Ling Chen, Yee-Shin Lin, Chiou-Feng Lin. Apoptotic sphingolipid ceramide in cancer therapy.
Journal of lipids.
2011; 2011(?):565316. doi:
10.1155/2011/565316. [PMID: 21490804] - Chia-Yang Lu, Chien-Chun Li, Kai-Li Liu, Chia-Wen Tsai, Chong-Kuei Lii, Haw-Wen Chen. Docosahexaenoic acid down-regulates phenobarbital-induced cytochrome P450 2B1 gene expression in rat primary hepatocytes via the sphingomyelinase/ceramide pathway.
The Journal of nutritional biochemistry.
2010 Apr; 21(4):338-44. doi:
10.1016/j.jnutbio.2009.01.007. [PMID: 19427778] - Frank J Raucci, Dayanjan S Wijesinghe, Charles E Chalfant, Clive M Baumgarten. Exogenous and endogenous ceramides elicit volume-sensitive chloride current in ventricular myocytes.
Cardiovascular research.
2010 Apr; 86(1):55-62. doi:
10.1093/cvr/cvp399. [PMID: 20008476] - Lide Arana, Patricia Gangoiti, Alberto Ouro, Miguel Trueba, Antonio Gómez-Muñoz. Ceramide and ceramide 1-phosphate in health and disease.
Lipids in health and disease.
2010 Feb; 9(?):15. doi:
10.1186/1476-511x-9-15. [PMID: 20137073] - Isabelle Martins, Antoine Tesniere, Oliver Kepp, Mickael Michaud, Frederic Schlemmer, Laura Senovilla, Claire Séror, Didier Métivier, Jean-Luc Perfettini, Laurence Zitvogel, Guido Kroemer. Chemotherapy induces ATP release from tumor cells.
Cell cycle (Georgetown, Tex.).
2009 Nov; 8(22):3723-8. doi:
10.4161/cc.8.22.10026. [PMID: 19855167] - Albert Gubern, Miquel Barceló-Torns, Javier Casas, David Barneda, Roser Masgrau, Fernando Picatoste, Jesús Balsinde, María A Balboa, Enrique Claro. Lipid droplet biogenesis induced by stress involves triacylglycerol synthesis that depends on group VIA phospholipase A2.
The Journal of biological chemistry.
2009 Feb; 284(9):5697-708. doi:
10.1074/jbc.m806173200. [PMID: 19117952] - Akira Abe, Miki Hiraoka, James A Shayman. The acylation of lipophilic alcohols by lysosomal phospholipase A2.
Journal of lipid research.
2007 Oct; 48(10):2255-63. doi:
10.1194/jlr.m700277-jlr200. [PMID: 17626977] - Abbas Samadi. Ceramide-induced cell death in lens epithelial cells.
Molecular vision.
2007 Sep; 13(?):1618-26. doi:
". [PMID: 17893663] - Gonzalo Arboleda, Tze-Jen Huang, Catherine Waters, Alex Verkhratsky, Paul Fernyhough, Rosemary M Gibson. Insulin-like growth factor-1-dependent maintenance of neuronal metabolism through the phosphatidylinositol 3-kinase-Akt pathway is inhibited by C2-ceramide in CAD cells.
The European journal of neuroscience.
2007 May; 25(10):3030-8. doi:
10.1111/j.1460-9568.2007.05557.x. [PMID: 17561816] - Helena Van Overloop, Yves Denizot, Myriam Baes, Paul P Van Veldhoven. On the presence of C2-ceramide in mammalian tissues: possible relationship to etherphospholipids and phosphorylation by ceramide kinase.
Biological chemistry.
2007 Mar; 388(3):315-24. doi:
10.1515/bc.2007.035. [PMID: 17338639] - Lellean JeBailey, Oshrit Wanono, Wenyan Niu, Jessica Roessler, Assaf Rudich, Amira Klip. Ceramide- and oxidant-induced insulin resistance involve loss of insulin-dependent Rac-activation and actin remodeling in muscle cells.
Diabetes.
2007 Feb; 56(2):394-403. doi:
10.2337/db06-0823. [PMID: 17259384] - Amy B Ghering, W Sean Davidson. Ceramide structural features required to stimulate ABCA1-mediated cholesterol efflux to apolipoprotein A-I.
Journal of lipid research.
2006 Dec; 47(12):2781-8. doi:
10.1194/jlr.m600380-jlr200. [PMID: 16990644] - V E MacRae, T Burdon, S F Ahmed, C Farquharson. Ceramide inhibition of chondrocyte proliferation and bone growth is IGF-I independent.
The Journal of endocrinology.
2006 Nov; 191(2):369-77. doi:
10.1677/joe.1.06958. [PMID: 17088406] - Akira Abe, Miki Hiraoka, James A Shayman. Positional specificity of lysosomal phospholipase A2.
Journal of lipid research.
2006 Oct; 47(10):2268-79. doi:
10.1194/jlr.m600183-jlr200. [PMID: 16837646] - Bernhard Kniep, Eva Kniep, Nurdan Ozkucur, Steffen Barz, Michael Bachmann, Florence Malisan, Roberto Testi, Ernst Peter Rieber. 9-O-acetyl GD3 protects tumor cells from apoptosis.
International journal of cancer.
2006 Jul; 119(1):67-73. doi:
10.1002/ijc.21788. [PMID: 16432837] - Cynthia Detre, Endre Kiss, Zoltán Varga, Katalin Ludányi, Katalin Pászty, Agnes Enyedi, Dorottya Kövesdi, György Panyi, Eva Rajnavölgyi, János Matkó. Death or survival: membrane ceramide controls the fate and activation of antigen-specific T-cells depending on signal strength and duration.
Cellular signalling.
2006 Mar; 18(3):294-306. doi:
10.1016/j.cellsig.2005.05.012. [PMID: 16099142] - Natalia V Giltiay, Alexander A Karakashian, Alexander P Alimov, Sandy Ligthle, Mariana N Nikolova-Karakashian. Ceramide- and ERK-dependent pathway for the activation of CCAAT/enhancer binding protein by interleukin-1beta in hepatocytes.
Journal of lipid research.
2005 Nov; 46(11):2497-505. doi:
10.1194/jlr.m500337-jlr200. [PMID: 16106045] - R Goswami, D Singh, G Phillips, J Kilkus, G Dawson. Ceramide regulation of the tumor suppressor phosphatase PTEN in rafts isolated from neurotumor cell lines.
Journal of neuroscience research.
2005 Aug; 81(4):541-50. doi:
10.1002/jnr.20550. [PMID: 15968641] - Jesús Sot, Félix M Goñi, Alicia Alonso. Molecular associations and surface-active properties of short- and long-N-acyl chain ceramides.
Biochimica et biophysica acta.
2005 Jun; 1711(1):12-9. doi:
10.1016/j.bbamem.2005.02.014. [PMID: 15904658] - Paul Gutwein, Alexander Stoeck, Svenja Riedle, Daniela Gast, Steffen Runz, Thomas P Condon, Alexander Marmé, Minh-Chau Phong, Otwin Linderkamp, Alexander Skorokhod, Peter Altevogt. Cleavage of L1 in exosomes and apoptotic membrane vesicles released from ovarian carcinoma cells.
Clinical cancer research : an official journal of the American Association for Cancer Research.
2005 Apr; 11(7):2492-501. doi:
10.1158/1078-0432.ccr-04-1688. [PMID: 15814625] - Helen E Townley, Kerrie McDonald, Gareth I Jenkins, Marc R Knight, Christopher J Leaver. Ceramides induce programmed cell death in Arabidopsis cells in a calcium-dependent manner.
Biological chemistry.
2005 Feb; 386(2):161-6. doi:
10.1515/bc.2005.020. [PMID: 15843160] - Lu-Cheng Cao, Thomas W Honeyman, Rachel Cooney, Lori Kennington, Cheryl R Scheid, Julie A Jonassen. Mitochondrial dysfunction is a primary event in renal cell oxalate toxicity.
Kidney international.
2004 Nov; 66(5):1890-900. doi:
10.1111/j.1523-1755.2004.00963.x. [PMID: 15496160] - Nan Yao, Bartholomew J Eisfelder, James Marvin, Jean T Greenberg. The mitochondrion--an organelle commonly involved in programmed cell death in Arabidopsis thaliana.
The Plant journal : for cell and molecular biology.
2004 Nov; 40(4):596-610. doi:
10.1111/j.1365-313x.2004.02239.x. [PMID: 15500474] - Erika Suzuki, Kazuko Handa, Marcos S Toledo, Senitiroh Hakomori. Sphingosine-dependent apoptosis: a unified concept based on multiple mechanisms operating in concert.
Proceedings of the National Academy of Sciences of the United States of America.
2004 Oct; 101(41):14788-93. doi:
10.1073/pnas.0406536101. [PMID: 15466700] - Masanobu Hayashi, Taku Hamasu, Daiji Endoh, Ai Kawana, Minako Matsumoto, Toyo Okui. High sensitivity of fibroblast cell lines derived from LEC rats to heat treatment.
The Journal of veterinary medical science.
2004 Oct; 66(10):1177-82. doi:
10.1292/jvms.66.1177. [PMID: 15528845] - Malgorzata Czarny, Jan E Schnitzer. Neutral sphingomyelinase inhibitor scyphostatin prevents and ceramide mimics mechanotransduction in vascular endothelium.
American journal of physiology. Heart and circulatory physiology.
2004 Sep; 287(3):H1344-52. doi:
10.1152/ajpheart.00222.2004. [PMID: 15142848] - Pamela J Mansfield, Shannon S Carey, Vania Hinkovska-Galcheva, James A Shayman, Laurence A Boxer. Ceramide inhibition of phospholipase D and its relationship to RhoA and ARF1 translocation in GTP gamma S-stimulated polymorphonuclear leukocytes.
Blood.
2004 Mar; 103(6):2363-8. doi:
10.1182/blood-2002-11-3341. [PMID: 14615385] - Yashin Sreenivasan, Abira Sarkar, Sunil Kumar Manna. Oleandrin suppresses activation of nuclear transcription factor-kappa B and activator protein-1 and potentiates apoptosis induced by ceramide.
Biochemical pharmacology.
2003 Dec; 66(11):2223-39. doi:
10.1016/j.bcp.2003.07.010. [PMID: 14609747] - C M Perks, P V Newcomb, M Grohmann, R J Wright, H D Mason, J M P Holly. Prolactin acts as a potent survival factor against C2-ceramide-induced apoptosis in human granulosa cells.
Human reproduction (Oxford, England).
2003 Dec; 18(12):2672-7. doi:
10.1093/humrep/deg496. [PMID: 14645190] - Scott R Witting, J Nicholas Maiorano, W Sean Davidson. Ceramide enhances cholesterol efflux to apolipoprotein A-I by increasing the cell surface presence of ATP-binding cassette transporter A1.
The Journal of biological chemistry.
2003 Oct; 278(41):40121-7. doi:
10.1074/jbc.m305193200. [PMID: 12890677] - Xue Qing Wang, Ai Ying Xiao, Christian Sheline, Krzystztof Hyrc, Aizhen Yang, Mark P Goldberg, Dennis W Choi, Shan Ping Yu. Apoptotic insults impair Na+, K+-ATPase activity as a mechanism of neuronal death mediated by concurrent ATP deficiency and oxidant stress.
Journal of cell science.
2003 May; 116(Pt 10):2099-110. doi:
10.1242/jcs.00420. [PMID: 12679386] - Marianne Fillet, Mohamed Bentires-Alj, Valerie Deregowski, Roland Greimers, Jacques Gielen, Jacques Piette, Vincent Bours, Marie-Paule Merville. Mechanisms involved in exogenous C2- and C6-ceramide-induced cancer cell toxicity.
Biochemical pharmacology.
2003 May; 65(10):1633-42. doi:
10.1016/s0006-2952(03)00125-4. [PMID: 12754099] - Brad L Upham, Tyler R Koski, Alisa M Rummel, Melinda R Wilson, Anelia Horvath, James E Trosko. Differential roles of 2, 6, and 8 carbon ceramides on the modulation of gap junctional communication and apoptosis during carcinogenesis.
Cancer letters.
2003 Feb; 191(1):27-34. doi:
10.1016/s0304-3835(02)00620-1. [PMID: 12609706] - S Willaime-Morawek, K Brami-Cherrier, J Mariani, J Caboche, B Brugg. C-Jun N-terminal kinases/c-Jun and p38 pathways cooperate in ceramide-induced neuronal apoptosis.
Neuroscience.
2003; 119(2):387-97. doi:
10.1016/s0306-4522(02)00996-x. [PMID: 12770554] - Eduardo Latorre, M Pilar Collado, Inmaculada Fernández, M Dolores Aragonés, R Edgardo Catalán. Signaling events mediating activation of brain ethanolamine plasmalogen hydrolysis by ceramide.
European journal of biochemistry.
2003 Jan; 270(1):36-46. doi:
10.1046/j.1432-1033.2003.03356.x. [PMID: 12492473] - Mitsuru Itoh, Toshiyuki Kitano, Mitsumasa Watanabe, Tadakazu Kondo, Takeshi Yabu, Yoshimitu Taguchi, Kazuya Iwai, Masaro Tashima, Takashi Uchiyama, Toshiro Okazaki. Possible role of ceramide as an indicator of chemoresistance: decrease of the ceramide content via activation of glucosylceramide synthase and sphingomyelin synthase in chemoresistant leukemia.
Clinical cancer research : an official journal of the American Association for Cancer Research.
2003 Jan; 9(1):415-23. doi:
". [PMID: 12538495] - Madalina Condrescu, Kwabena Opuni, Basil M Hantash, John P Reeves. Cellular regulation of sodium-calcium exchange.
Annals of the New York Academy of Sciences.
2002 Nov; 976(?):214-23. doi:
10.1111/j.1749-6632.2002.tb04744.x. [PMID: 12502564] - Teresa Gómez Del Pulgar, Maria L De Ceballos, Manuel Guzmán, Guillermo Velasco. Cannabinoids protect astrocytes from ceramide-induced apoptosis through the phosphatidylinositol 3-kinase/protein kinase B pathway.
The Journal of biological chemistry.
2002 Sep; 277(39):36527-33. doi:
10.1074/jbc.m205797200. [PMID: 12133838] - Monika Poppe, Claus Reimertz, Gudrun Münstermann, Donat Kögel, Jochen H M Prehn. Ceramide-induced apoptosis of D283 medulloblastoma cells requires mitochondrial respiratory chain activity but occurs independently of caspases and is not sensitive to Bcl-xL overexpression.
Journal of neurochemistry.
2002 Aug; 82(3):482-94. doi:
10.1046/j.1471-4159.2002.01007.x. [PMID: 12153473] - Leah J Siskind, Richard N Kolesnick, Marco Colombini. Ceramide channels increase the permeability of the mitochondrial outer membrane to small proteins.
The Journal of biological chemistry.
2002 Jul; 277(30):26796-803. doi:
10.1074/jbc.m200754200. [PMID: 12006562] - Pamela J Mansfield, Vania Hinkovska-Galcheva, James A Shayman, Laurence A Boxer. Granulocyte colony-stimulating factor primes NADPH oxidase in neutrophils through translocation of cytochrome b(558) by gelatinase-granule release.
The Journal of laboratory and clinical medicine.
2002 Jul; 140(1):9-16. doi:
10.1067/mlc.2002.124551. [PMID: 12080323] - Shampa Mallick, Samir Kumar Mandal, Ranjan Bhadra. Human placental lipid induces mitogenesis and melanogenesis in B16F10 melanoma cells.
Journal of biosciences.
2002 Jun; 27(3):243-9. doi:
10.1007/bf02704913. [PMID: 12089473] - T Kondo, T Kitano, K Iwai, M Watanabe, Y Taguchi, T Yabu, H Umehara, N Domae, T Uchiyama, T Okazaki. Control of ceramide-induced apoptosis by IGF-1: involvement of PI-3 kinase, caspase-3 and catalase.
Cell death and differentiation.
2002 Jun; 9(6):682-92. doi:
10.1038/sj.cdd.4401019. [PMID: 12032677] - Rachelle E Toman, Vilen Movsesyan, Shvetha K Murthy, Sheldon Milstien, Sarah Spiegel, Alan I Faden. Ceramide-induced cell death in primary neuronal cultures: upregulation of ceramide levels during neuronal apoptosis.
Journal of neuroscience research.
2002 May; 68(3):323-30. doi:
10.1002/jnr.10190. [PMID: 12111862] - L Ruth Montes, M Begoña Ruiz-Argüello, Félix M Goñi, Alicia Alonso. Membrane restructuring via ceramide results in enhanced solute efflux.
The Journal of biological chemistry.
2002 Apr; 277(14):11788-94. doi:
10.1074/jbc.m111568200. [PMID: 11796726] - Laura Colombaioni, Laura M Frago, Isabel Varela-Nieto, Rossana Pesi, Mercedes Garcia-Gil. Serum deprivation increases ceramide levels and induces apoptosis in undifferentiated HN9.10e cells.
Neurochemistry international.
2002 Apr; 40(4):327-36. doi:
10.1016/s0197-0186(01)00090-0. [PMID: 11792463] - Agatha Cabrero, Marta Alegret, Rosa M Sanchez, Tomas Adzet, Juan C Laguna, Manuel Vazquez Carrera. Increased reactive oxygen species production down-regulates peroxisome proliferator-activated alpha pathway in C2C12 skeletal muscle cells.
The Journal of biological chemistry.
2002 Mar; 277(12):10100-7. doi:
10.1074/jbc.m110321200. [PMID: 11792699] - Atsuko Itakura, Akane Tanaka, Akihiro Aioi, Hiroshi Tonogaito, Hiroshi Matsuda. Ceramide and sphingosine rapidly induce apoptosis of murine mast cells supported by interleukin-3 and stem cell factor.
Experimental hematology.
2002 Mar; 30(3):272-8. doi:
10.1016/s0301-472x(01)00790-1. [PMID: 11882365] - Tadakazu Kondo, Yoshiko Suzuki, Toshiyuki Kitano, Kazuya Iwai, Mitsumasa Watanabe, Hisanori Umehara, Naoharu Daido, Naochika Domae, Masaro Tashima, Takashi Uchiyama, Toshiro Okazaki. Vesnarinone causes oxidative damage by inhibiting catalase function through ceramide action in myeloid cell apoptosis.
Molecular pharmacology.
2002 Mar; 61(3):620-7. doi:
10.1124/mol.61.3.620. [PMID: 11854443] - Pamela J Mansfield, Vania Hinkovska-Galcheva, Shannon S Carey, James A Shayman, Laurence A Boxer. Regulation of polymorphonuclear leukocyte degranulation and oxidant production by ceramide through inhibition of phospholipase D.
Blood.
2002 Feb; 99(4):1434-41. doi:
10.1182/blood.v99.4.1434. [PMID: 11830497] - Abdelkarim Abousalham, Tom C Hobman, Jay Dewald, Michael Garbutt, David N Brindley. Cell-permeable ceramides preferentially inhibit coated vesicle formation and exocytosis in Chinese hamster ovary compared with Madin-Darby canine kidney cells by preventing the membrane association of ADP-ribosylation factor.
The Biochemical journal.
2002 Feb; 361(Pt 3):653-61. doi:
10.1042/0264-6021:3610653. [PMID: 11802796] - M Todaro, M Catalano, D Di Liberto, M Patti, M Zerilli, F Di Gaudio, G Di Gesù, G Vetri, G Modica, A Bono, M Ciaccio, Giorgio Stassi. High levels of exogenous C2-ceramide promote morphological and biochemical evidences of necrotic features in thyroid follicular cells.
Journal of cellular biochemistry.
2002; 86(1):162-73. doi:
10.1002/jcb.10203. [PMID: 12112027] - D K Kim, E S Cho, J K Seong, H D Um. Adaptive concentrations of hydrogen peroxide suppress cell death by blocking the activation of SAPK/JNK pathway.
Journal of cell science.
2001 Dec; 114(Pt 23):4329-34. doi:
10.1242/jcs.114.23.4329. [PMID: 11739664] - A Guidarelli, E Clementi, C De Nadai, R Bersacchi, O Cantoni. TNFalpha enhances the DNA single-strand breakage induced by the short-chain lipid hydroperoxide analogue tert-butylhydroperoxide via ceramide-dependent inhibition of complex III followed by enforced superoxide and hydrogen peroxide formation.
Experimental cell research.
2001 Oct; 270(1):56-65. doi:
10.1006/excr.2001.5323. [PMID: 11597127] - I N Singh, L M Stromberg, S G Bourgoin, V A Sciorra, A J Morris, D N Brindley. Ceramide inhibition of mammalian phospholipase D1 and D2 activities is antagonized by phosphatidylinositol 4,5-bisphosphate.
Biochemistry.
2001 Sep; 40(37):11227-33. doi:
10.1021/bi010787l. [PMID: 11551222] - G Ghosh Choudhury, J H Zhang, N Ghosh-Choudhury, H E Abboud. Ceramide blocks PDGF-induced DNA synthesis in mesangial cells via inhibition of Akt kinase in the absence of apoptosis.
Biochemical and biophysical research communications.
2001 Sep; 286(5):1183-90. doi:
10.1006/bbrc.2001.5483. [PMID: 11527425] - N Gupta, E Nodzenski, N N Khodarev, J Yu, L Khorasani, M A Beckett, D W Kufe, R R Weichselbaum. Angiostatin effects on endothelial cells mediated by ceramide and RhoA.
EMBO reports.
2001 Jun; 2(6):536-40. doi:
10.1093/embo-reports/kve115. [PMID: 11415988] - N Vitale, A S Caumont, S Chasserot-Golaz, G Du, S Wu, V A Sciorra, A J Morris, M A Frohman, M F Bader. Phospholipase D1: a key factor for the exocytotic machinery in neuroendocrine cells.
The EMBO journal.
2001 May; 20(10):2424-34. doi:
10.1093/emboj/20.10.2424. [PMID: 11350931] - I Spyridopoulos, P Mayer, K S Shook, D I Axel, R Viebahn, K R Karsch. Loss of cyclin A and G1-cell cycle arrest are a prerequisite of ceramide-induced toxicity in human arterial endothelial cells.
Cardiovascular research.
2001 Apr; 50(1):97-107. doi:
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The Journal of comparative neurology.
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Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society.
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The British journal of dermatology.
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